Enhanced lysis and accelerated establishment of viscoelastic properties of fibrin clots are associated with pulmonary embolism

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 306, Issue 5, 2014, Pages

  Martinez, Marissa R ^a   Cuker, Adam ^b   Mills, Angela M ^c   Crichlow, Amanda ^c   Lightfoot, Richard T ^a   Chernysh, Irina N ^c   Nagaswami, Chandrasekaran ^c   Weisel, John W ^c   Ischiropoulos, Harry ^a  

^a CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Deep vein thrombosis; Fibrin; Lysis; Pulmonary embolism

Indexed keywords

BLOOD CLOTTING FACTOR 13; PLASMINOGEN; BLOOD CLOTTING FACTOR 13A; CROSS LINKING REAGENT; FIBRIN; FIBRINOGEN;

ADULT; AGED; ARTICLE; BLOOD CLOT LYSIS; BLOOD CLOTTING; CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; CROSS LINKING; DEEP VEIN THROMBOSIS; DISEASE ASSOCIATION; ELECTRON MICROSCOPY; EUGLOBULIN LYSIS TEST; FIBRIN CLOT; HUMAN; LUNG EMBOLISM; MEDICAL DOCUMENTATION; PRIORITY JOURNAL; SCANNING ELECTRON MICROSCOPY; TURBIDITY; VENOUS THROMBOEMBOLISM; VISCOELASTICITY; CHEMISTRY; ELASTICITY; FEMALE; FIBRINOLYSIS; LYSIS; MALE; METABOLISM; MIDDLE AGED; PHYSIOLOGY; PROSPECTIVE STUDY; ULTRASTRUCTURE; VEIN THROMBOSIS;

DEEP VEIN THROMBOSIS; FIBRIN; LYSIS; PULMONARY EMBOLISM;

ADULT; AGED; BLOOD COAGULATION; CROSS-LINKING REAGENTS; ELASTICITY; FACTOR XIIIA; FEMALE; FIBRIN; FIBRINOGEN; FIBRINOLYSIS; HUMANS; MALE; MICROSCOPY, ELECTRON, SCANNING; MIDDLE AGED; PLASMINOGEN; PROSPECTIVE STUDIES; PULMONARY EMBOLISM; VENOUS THROMBOSIS;

EID: 84900550241     PISSN: 10400605     EISSN: 15221504     Source Type: Journal    
DOI: 10.1152/ajplung.00265.2013     Document Type: Article

References (26)

1. Anderson FA, Jr Wheeler HB, Goldberg RJ, Hosmer DW, Patwardhan NA, Jovanovic B, Forcier A, Dalen JE. A population-based perspective of the hospital incidence and case-fatality rates of deep vein thrombosis and pulmonary embolism. The Worcester DVT Study. Arch Intern Med 151: 933-938, 1991.
2. Bannish BE, Keener JP, Fogelson AL. Modelling fibrinolysis: a 3D stochastic multiscale model. Math Med Biol In press.
3. Carr ME, Jr, Hermans J. Size and density of fibrin fibers from turbidity. Macromolecules 11: 46-50, 1978.
4. Collet JP, Allali Y, Lesty C, Tanguy ML, Silvain J, Ankri A, Blanchet B, Dumaine R, Gianetti J, Payot L, Weisel JW, Montalescot G. Altered fibrin architecture is associated with hypofibrinolysis and premature coronary atherothrombosis. Arterioscler Thromb Vasc Biol 26: 2567-2573, 2006.
5. Collet JP, Park D, Lesty C, Soria J, Soria C, Montalescot G, Weisel JW. Influence of fibrin network conformation and fibrin fiber diameter on fibrinolysis speed: dynamic and structural approaches by confocal microscopy. Arterioscler Thromb Vasc Biol 20: 1354-1361, 2000.
6. Corrin B, Nicholson AG. Pathology of the Lungs. London, UK: Churchill Livingston, 2011, p. 778.
7. Gorham LW. A study of pulmonary embolism. I. A clinicopathological investigation of 100 cases of massive embolism of the pulmonary artery; diagosis by physical signs and differentiation from acute myocardial infarction. Arch Intern Med 108: 8-22, 1961.
8. Hoylaerts M, Rijken DC, Lijnen HR, Collen D. Kinetics of the activation of plasminogen by human tissue plasminogen activator. Role of fibrin. J Biol Chem 257: 2912-2919, 1982.
9. Kakkar VV, Howe CT, Flanc C, Clarke MB. Natural history of postoperative deep-vein thrombosis. Lancet 2: 230-232, 1969.
10. Lorand L, Jacobsen A. Accelerated lysis of blood clots. Nature 195: 911-912, 1962.
11. Machlus KR, Cardenas JC, Church FC, Wolberg AS. Causal relationship between hyperfibrinogenemia, thrombosis, and resistance to thrombolysis in mice. Blood 117: 4953-4963, 2011.
12. Martinez M, Cuker A, Mills A, Lightfoot R, Fan Y, Tang WH, Hazen SL, Ischiropoulos H. Nitrated fibrinogen is a biomarker of oxidative stress in venous thromboembolism. Free Radic Biol Med 53: 230-236, 2012.
13. Meltzer ME, Lisman T, de Groot PG, Meijers JC, le Cessie S, Doggen CJ, Rosendaal FR. Venous thrombosis risk associated with plasma hypofibrinolysis is explained by elevated plasma levels of TAFI and PAI-1. Blood 116: 113-121, 2010.
14. Moser KM, Fedullo PF, LitteJohn JK, Crawford R. Frequent asymptomatic pulmonary embolism in patients with deep venous thrombosis. J Am Med Assoc 271: 223-225, 1994.
15. Neyman M, Gewirtz J, Poncz M. Analysis of the spatial and temporal characteristics of platelet-delivered factor VIII-based clots. Blood 112: 1101-1108, 2008.
16. Pieters M, Covic N, van der Westhuizen FH, Nagaswami C, Baras Y, Toit Loots D, Jerling JC, Elgar D, Edmondson KS, van Zyl DG, Rheeder P, Weisel JW. Glycaemic control improves fibrin network characteristics in type 2 diabetes: a purified fibrinogen model. Thromb Haemost 99: 691-700, 2008.
17. Roberts WW, Kramer O, Rosser RW, Nestler FH, Ferry JD. Rheology of fibrin clots. I. Dynamic viscoelastic properties and fluid permeation. Biophys Chem 1: 152-160, 1974.
18. Ryan EA, Mockros LF, Weisel JW, Lorand L. Structural origins of fibrin clot rheology. Biophys J 77: 2813-2826, 1999.
19. Silvain J, Collet J, Nagaswami C, Beygui F, Edmondson KE, Bellemain-Appaix A, Cayla G, Pena A, Brugier D, Barthelemy O, Montalescot G, Weisel JW. Composition of coronary thrombus in acute myocardial infarction. J Am Coll Cardiol 57: 1359-1367, 2011.
20. Sorensen HT, Horvath-Puho E, Sogaard KK, Christensen S, Johnsen SP, Thomsen RW, Prandoni P, Baron JA. Arterial cardiovascular events, statins, low-dose aspirin and subsequent risk of venous thromboembolism: a population-based case-control study. J Thromb Haemost 7: 521-528, 2009.
21. Suenson E, Petersen LC. Fibrin and plasminogen structures essential to stimulation of plasmin formation by tissue-type plasminogen activator. Biochim Biophys Acta 870: 510-519, 1986.
22. Tait RC, Walker ID, Conkie JA, Islam SI, McCall F. Isolated familial plasminogen deficiency may not be a risk factor for thrombosis. Thromb Haemost 76: 1004-1008, 1996.
23. Undas A, Zawilska K, Ciesla-Dul M, Lehmann-Kopydlowska A, Skubiszak A, Ciepluch K, Tracz W. Altered fibrin clot structure/function in patients with idiopathic venous thromboembolism and in their relatives. Blood 114: 4272-4278, 2009.
24. von Bruhl ML, Stark K, Steinhart A, Chandraratne S, Konrad I, Lorenz M, Khandoga A, Tirniceriu A, Coletti R, Kollnberger M, Byrne RA, Laitinen I, Walch A, Brill A, Pfeiler S, Manukyan D, Braun S, Lange P, Riegger J, Ware J, Eckart A, Haidari S, Rudelius M, Schulz C, Echtler K, Brinkmann V, Schwaiger M, Preissner KT, Wagner DD, Mackman N, Engelmann B, Massberg S. Monocytes, neutrophils, and platelets cooperate to initiate and propagate venous thrombosis in mice in vivo. J Exp Med 209: 819-835, 2012.
25. Weisel JW, Nagaswami C. Computer modeling of fibrin polymerization kinetics correlated with electron microscope and turbidity observations: clot structure and assembly are kinetically controlled. Biophys J 63: 111-128, 1992.
26. Yamaki T, Nozaki M, Sakurai H, Takeuchi M, Soejima K, Kono T. Presence of lower limb deep vein thrombosis and prognosis in patients with symptomatic pulmonary embolism: preliminary report. Eur J Vasc Endovasc Surg 37: 225-231, 2009.