Nonalcoholic fatty liver disease (NAFLD) without insulin resistance: Is it different?

Clinics and Research in Hepatology and Gastroenterology

Volumn 39, Issue 4, 2015, Pages 482-488

  Singh, Shivaram Prasad ^a   Misra, Bijay ^a   Kar, Sanjib Kumar ^a   Panigrahi, Manas Kumar ^a   Misra, Debasis ^a   Bhuyan, Pallavi ^a   Pattnaik, Kaumudee ^a   Meher, Chudamani ^b   Agrawal, Omprakash ^b   Rout, Niranjan ^c   Swain, Manorama ^a  

^a S C B MEDICAL COLLEGE   (India)

^b Beam Diagnostics   (India)

^c A H Regional Cancer Center   (India)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; GLUCOSE; HIGH DENSITY LIPOPROTEIN; INSULIN; LOW DENSITY LIPOPROTEIN; TRIACYLGLYCEROL; GLUCOSE BLOOD LEVEL;

ADOLESCENT; ADULT; AGED; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANTHROPOMETRIC PARAMETERS; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BIOCHEMISTRY; BODY MASS; CONTROLLED STUDY; DIET RESTRICTION; ECHOGRAPHY; FEMALE; GLUCOSE BLOOD LEVEL; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; HYPERTRANSAMINASEMIA; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; LIPOPROTEIN BLOOD LEVEL; LIVER FIBROSIS; MAJOR CLINICAL STUDY; MALE; METABOLIC PARAMETERS; NONALCOHOLIC FATTY LIVER; OBESITY; PANCREAS ISLET BETA CELL; RETROSPECTIVE STUDY; TRIACYLGLYCEROL BLOOD LEVEL; ANALYSIS; BLOOD; CHOLELITHIASIS; COMPARATIVE STUDY; DIABETES MELLITUS; HEPATOMEGALY; INDIA; LIVER CIRRHOSIS; MIDDLE AGED; NON-ALCOHOLIC FATTY LIVER DISEASE; VERY ELDERLY; YOUNG ADULT;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; BLOOD GLUCOSE; CHOLELITHIASIS; DIABETES MELLITUS; FEMALE; HEPATOMEGALY; HUMANS; INDIA; INSULIN; INSULIN RESISTANCE; LIVER CIRRHOSIS; MALE; MIDDLE AGED; NON-ALCOHOLIC FATTY LIVER DISEASE; OBESITY; RETROSPECTIVE STUDIES; TRANSAMINASES; TRIGLYCERIDES; YOUNG ADULT;

EID: 84940892609     PISSN: 22107401     EISSN: 2210741X     Source Type: Journal    
DOI: 10.1016/j.clinre.2014.08.014     Document Type: Article

References (37)

1. Bedogni G., Miglioli L., Masutti F., Tiribelli C., Marchesini G., Bellentani S. Prevalence of and risk factors for nonalcoholic fatty liver disease: the Dionysos nutrition and liver study. Hepatology 2005, 42:44-52.
2. Bugianesi E., Leone N., Vanni E., et al. Expanding the natural history of nonalcoholic steatohepatitis: from cryptogenic cirrhosis to hepatocellular carcinoma. Gastroenterology 2002, 123:134-140.
3. Caldwell S.H., Crespo D. The spectrum expanded: cryptogenic cirrhosis and the natural history of non-alcoholic fatty liver disease. J Hepatol 2004, 40:578-584.
4. Browning J.D., Szczepaniak L.S., Dobbins R., et al. Prevalence of hepatic steatosis in an urban population in the United States: impact of ethnicity. Hepatology 2004, 40:1387-1395.
5. Chitturi S., Farrell G.C., George J. Non-alcoholic steatohepatitis in the Asia-Pacific region: future shock. J Gastroenterol Hepatol 2004, 19:368-374.
6. Amarapurkar D., Kamani P., Patel N., et al. Prevalence of non-alcoholic fatty liver disease: population based study. Ann Hepatol 2007, 6:161-163.
7. Singh S.P., Nayak S., Swain M., et al. Prevalence of nonalcoholic fatty liver disease in coastal eastern India: a preliminary ultrasonographic survey. Trop Gastroenterol 2004, 25:76-79.
8. Singh S.P., Panda C.R., Dash B.K., et al. Prevalence of fatty liver in fatal traffic casualties in coastal Orissa. J Gastroenterol Hepatol 2004, 19:A838.
9. Misra A., Khurana L. Obesity and the metabolic syndrome in developing countries. J Clin Endocrinol Metab 2008, 93(11 Suppl1):S9-S30.
10. Gupta R., Sarna M., Thanvi J., et al. Prevalence of coronary heart disease and risk factors in an urban Indian population: Jaipur Heart Watch-2. Indian Heart J 2002, 54:59-66.
11. Gupta R., Misra A. Type 2 diabetes in India: regional disparities. Br J Diabetes Vasc Dis 2007, 7:12-16.
12. Das S., Singh S.P., Parida P.K., Mallik R.N. Non-alcoholic fatty liver disease in subjects with type 2 diabetes mellitus and non-diabetics with special references to insulin resistance and hepatic histopathological changes. Diabetes Metab Syndr Clin Res Rev 2010, 4:226-229.
13. American Diabetes Association Diagnosis and classification of diabetes mellitus. Diabetes Care 2006, 29:S43-S48.
14. Executive summary of the third report of the National Cholesterol Education Program (NCEP) Expert Panel On Detection, Evaluation And Treatment Of High Blood Cholesterol In Adults (adult treatment panel III). J Am Med Assoc 2001, 285:2486-2497.
15. Vikram N.K., Misra A., Dwivedi M., et al. Correlations of C-reactive protein levels with anthropometric profile, percentage of body fat and lipids in healthy adolescent and young adults in urban North India. Atherosclerosis 2003, 168:305-313.
16. Madan K., Batra Y., Gupta S.D., et al. Non-alcoholic fatty liver disease may not be a severe disease at presentation among Asian Indians. World J Gastroenterol 2006, 12:3400-3405.
17. Matthews D.R., Hosker J.P., Rudenski A.S., Naylor B.A., Treacher D.F., Turner R.C. Homeostasis model assessment: insulin resistance and Beta cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985, 28:412-419.
18. Bonora E., Targher G., Alberiche M., et al. Homeostasis model assessment closely mirrors the glucose clamp technique in the assessment of insulin sensitivity. Diabetes Care 2000, 23:57-63.
19. Das S., Bhoi S.K., Baliarsinha A.K., Baig M.A.A. Autoimmunity, insulin resistance and β cell function in subjects with low body weight, type 2 diabetes mellitus: metabolic syndrome and related disorder. Metab Syndr Relat Disord 2007, 5:136-141.
20. Das S., Misra B., Roul L., Minz N.T., Pattnaik M., Baig M.A. Insulin resistance and beta cell function as prognostic indicator in multi-organ dysfunction syndrome. Metab Syndr Relat Disord 2009, 7:47-51.
21. Gore R.M. Diffuse liver disease. Textbook of gastrointestinal radiology 1994, 1968-2017. WB. Saunders, Philadelphia. R.M. Gore, M.S. Levine, I. Laufer (Eds.).
22. Kleiner D.E., Brunt E.M., Van Natta M., et al. Design and validation of a histological scoring system for nonalcoholic fatty liver disease. Hepatology 2005, 41:1313-1321.
23. Omiya K., Akashi Y.J., Kida K., et al. An impaired pancreatic beta cell function attenuates the exercise training effects in phase 2 cardiac rehabilitation. Eur J Cardiovasc Prev Rehabil 2011, 18(Suppl 1):S46.
24. Ruhl C.E., Everhart J.E. Determinants of the association of overweight and elevated serum alanine aminotransferase activity in the United States. Gastroenterology 2003, 124:71-79.
25. Amarapurkar D., Patel N. Prevalence of clinical spectrum and natural history of nonalcoholic steatohepatitis with normal alanine aminotransferase values. Trop Gastroenterol 2004, 25:130-134.
26. Marchesini G., Bugianesi E., Forlani G., et al. Nonalcoholic fatty liver, steatohepatitis, and the metabolic syndrome. Hepatology 2003, 37:917-923.
27. Kotronen A., Westerbacka J., Bergholm R., Pietilainen K.H., Yki-Järvinen H. Liver fat in the metabolic syndrome. J Clin Endocrinol Metab 2007, 92:3490-3497.
28. Bugianesi E., Gastaldelli A., Vanni E., et al. Insulin resistance in non-diabetic patients with non-alcoholic fatty liver disease: sites and mechanisms. Diabetologia 2005, 48:634-642.
29. Kotronen A., Westerbacka J., Bergholm R., Pietiläinen K.H., Yki-Järvinen H. Nonalcoholic steatohepatitis: summary of AASLD single topic conference. Hepatology 2003, 37:1202-1219.
30. Grove J., Daly A.K., Bassendine M.F., Day C.P. Association of a tumor necrosis factor promoter polymorphism with susceptibility to alcoholic steatohepatitis. Hepatology 1997, 26:143-146.
31. Kumar R., Prakash S., Chhabra S., et al. Association of pro-inflammatory cytokines, adipokines & oxidative stress with insulin resistance & non-alcoholic fatty liver disease. Indian J Med Res 2012, 136:229-236.
32. O'Brien R.M., Granner D.K. Regulation of gene expression by insulin. Biochem J 1991, 278:609-619.
33. Das S., Baliarsinha A.K. Lipids and lipoprotein cholesterol in diabetes mellitus-Indian scene. Lipid India 1997, II:7-11.
34. Schwarz J.-M., Linfoot P., Dare D., Aghajanian K. Hepatic de novo lipogenesis in normoinsulinemic and hyperinsulinemic subjects consuming high-fat, low-carbohydrate and low-fat, high-carbohydrate isoenergetic diets. Am J Clin Nutr 2003, 77:43-50.
35. Unger R.H., Grundy S. Hyperglycaemia as an inducer as well as a consequence of impaired islet cell function and insulin resistance: implications for the management of diabetes. Diabetologia 1985, 28:119-121.
36. Compare D., Coccoli P., Rocco A., Nardone O.M., Maria De S., Carteni M., et al. Gut-liver axis: the impact of gut microbiota on non-alcoholic fatty liver disease. Nutr Metab Cardiovasc Dis 2012, 22:471-476.
37. Polyzos S.A., Kountouras J., Papatheodorou A., et al. Helicobacter pylori infection in patients with nonalcoholic fatty liver disease. Metabolism 2013, 62:121-126.