A randomized trial of nebulized 3% hypertonic saline with salbutamol in the treatment of acute bronchiolitis in hospitalized infants

Pediatric Pulmonology

Volumn 51, Issue 4, 2016, Pages 418-425

  Flores, Pedro ^a   Mendes, Ana Luisa ^a   Neto, Ana S ^a  

^a CUF Descobertas Hospital   (Portugal)

Author keywords

asthma early wheeze; evidence based medicine outcomes; Pneumonia; TB; viral

Indexed keywords

SALBUTAMOL; SODIUM CHLORIDE; BRONCHODILATING AGENT;

AGITATION; APNEA; ARTICLE; BEHAVIOR DISORDER; BRONCHOSPASM; CONTROLLED STUDY; COUGHING; CYANOSIS; DISEASE SEVERITY; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG SAFETY; FEMALE; HUMAN; INFANT; LENGTH OF STAY; MAJOR CLINICAL STUDY; MALE; OXYGEN SUPPLY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RHINORRHEA; RISK ASSESSMENT; TACHYCARDIA; TREATMENT OUTCOME; VIRAL BRONCHIOLITIS; VOMITING; BRONCHIOLITIS; CHILD HEALTH; COUGH; HOSPITALIZED CHILD; INHALATIONAL DRUG ADMINISTRATION; NEBULIZER; NEWBORN; PATHOPHYSIOLOGY; PORTUGAL; SEVERITY OF ILLNESS INDEX;

ADMINISTRATION, INHALATION; ALBUTEROL; BRONCHIOLITIS; BRONCHODILATOR AGENTS; CHILD, HOSPITALIZED; COUGH; DOUBLE-BLIND METHOD; FEMALE; HUMANS; INFANT; INFANT HEALTH; INFANT, NEWBORN; LENGTH OF STAY; MALE; NEBULIZERS AND VAPORIZERS; PORTUGAL; SALINE SOLUTION, HYPERTONIC; SEVERITY OF ILLNESS INDEX; TREATMENT OUTCOME;

EID: 84940878064     PISSN: 87556863     EISSN: 10990496     Source Type: Journal    
DOI: 10.1002/ppul.23306     Document Type: Article

References (30)

1. Everard M,. Respiratory syncytial virus bronchiolitis and pneumonia. In: Paediatric respiratory medicine, 2nd edition. St Louis: Mosby; 2009. pp 491-500.
2. Franco J, Costa C, Queiroz AM, Alves AD, Virella D, Jorge A,. Estimativa da eficiência do uso de palivizumab na prevenção de hospitalizações por infecção por vírus sincicial respiratório numa coorte de prematuros. Acta Pediatr Port 2006; 1: 15-22.
3. Grewal S, Ali S, McConnell DW, Vandermeer B, Klassen TP,. A randomized trial of nebulized 3% hypertonic saline with epinephrine in the treatment of acute bronchiolitis in the emergency department. Arch Pediatr Adolesc Med 2009; 163: 1007-1012.
4. De Brasi D, Pannuti F, Antonelli F, de Seta F, Siani P, de Seta L,. Therapeutic approach to bronchiolitis: why pediatricians continue to overprescribe drugs?. Ital J Pediatr 2010; 36-43.
5. González de Diosa J, Ochoa Sangrador C,. y Grupo Investigador del Proyecto aBREVIADo (BRonquiolitis-Estudio de Variabilidad, Idoneidad y ADecuación). Estudio de variabilidad en el abordaje de la bronquiolitis aguda en España en relación con la edad de los pacientes. An Pediatr (Barc) 2010; 72: 4-18.
6. Gouveia R, Saianda A, Vieira M, Mendes L, Nunes T, Lobo L, Bandeira T,. Bronquiolite aguda: poucas indicações para a utilização de exames complementares de diagnóstico. Acta Pediatr Port 2010; 41: 69-74.
7. Hervás D, Reina J, Yañez A, Figuerola J, Hervás JA,. Epidemiology of hospitalization for acute bronchiolitis in children: differences between RSV and non-RSV bronchiolitis. Eur J Clin Microbiol Infect Dis 2012; 31: 1975-1981.
8. García-Marcos L, Valverde-Molina J, Pavlovic-Nesic S, Claret-Teruel G, Peñalba-Citores AC, Nehme-Álvarez D, Korta-Murua J, Sánchez-Etxaniz J, Alonso-Salas MT, Campos-Calleja C, et al., Pediatricians' attitudes and costs of bronchiolitis in the emergency department: a prospective multicentre study. Pediatr Pulmonol 2014; 49: 1011-1019.
9. Ralston SL, Lieberthal AS, Meissner HC, Alverson BK, Baley JE, Gadomski AM, Johnson DW, Light MJ, Maraqa NF, Mendonza EA, et al., Clinical practice guideline: the diagnosis, management, and prevention of bronchiolitis. Pediatrics 2014; 134: e1474-e1502.
10. Zhang L, Mendoza-Sassi RA, Wainwright C, Klassen TP,. Nebulised hypertonic saline solution for acute bronchiolitis in infants. Cochrane Database Syst Rev 2013; 7: CD006458.
11. Teunissen J, Hochs AHJ, Vaessen-Verberne A, Boehmer AL, Smeets CC, Brackel H, van Gent R, Wesseling J, Logtens-Stevens D, de Moor R, et al., The effect of 3% and 6% hypertonic saline in viral bronchiolitis: a randomised controlled trial. ERJ 2014; 44: 913-921.
12. Everard ML, Hind D, Ugonna K, Freeman J, Bradburn M, Cooper CL, Cross E, Maguire C, Cantrill H, Alexander J, et al., SABRE: a multicentre randomised control trial of nebulised hypertonic saline in infants hospitalised with acute bronchiolitis. Thorax 2014; 69: 1105-1112.
13. Wu S, Baker C, Lang ME, Schrager SM, Liley FF, Papa C, Mira V, Balkian A, Mason WH,. Nebulized hypertonic saline for bronchiolitis: a randomized clinical trial. JAMA Pediatr 2014; 168: 657-663.
14. Mandelberg A, Tal G, Witzling M, Someck E, Houri S, Balin A, Priel IE,. Nebulized 3% hypertonic saline solution treatment in hospitalized infants with viral bronchiolitis. Chest 2003; 123: 481-487.
15. Luo Z, Liu E, Luo J, Li S, Zeng F, Yang X, Fu Z,. Nebulized hypertonic saline/salbutamol solution treatment in hospitalized children with mild to moderate bronchiolitis. Pediatr Int 2010; 52: 199-202.
16. Sarrell EM, Tal G, Witzling M, Someck E, Houri S, Cohen HA, Mandelberg A,. Nebulized 3% hypertonic saline solution treatment in ambulatory children with viral bronchiolitis decreases symptoms. Chest 2002; 122: 2015-2020.
17. Anil AB, Anil M, Saglam AB, Cetin N, Bal A, Aksu N,. High volume normal saline alone is as effective as nebulized salbutamol-normal saline, epinephrine-normal saline, and 3% saline in mild bronchiolitis. Pediatr Pulmonol 2010; 45: 41-47.
18. Tal G, Cesar K, Oron A, Houri S, Ballin A, Mandelberg A,. Hypertonic saline/epinephrine treatment in hospitalized infants with viral bronchiolitis reduces hospitalization stay: 2 years experience. Isr Med Assoc J 2006; 8: 169-173.
19. Kuzik BA, Al-Qadhi SA, Kent S, Flavin MP, Hopman W, Hotte S, Gander S,. Nebulized hypertonic saline in the treatment of viral bronchiolitis in infants. J Pediatr 2007; 151: 266-270.
20. Luo Z, Fu Z, Liu E, Xu X, Fu X, Peng D, Liu Y, Li S, Zeng F, Yang X,. Nebulized hypertonic saline treatment in hospitalized children with moderate to severe viral bronchiolitis. Clinical Microbiology and Infection 2011; 17: 1829-1833.
21. Del Giudice MM, Saitta F, Leonardi S, Capasso M, Niglio B, Chinellato I, Decimo F, Maiello N, Capristo C, Perrone L, et al., Effectiveness of nebulized hypertonic saline and epinephrine in hospitalized infants with bronchiolitis. Int J Immunopathol Pharmacol 2012; 25: 485-491.
22. Scottish Intercollegiate Guidelines Network SIGN. Bronchiolitis in children-a national clinical guideline 2006. http://www.sign.ac.uk/pdf/sign91.pdf (accessed 1 Dez 2014).
23. Bush A,. Acute bronchiolits. BMJ 2007; 335: 1037-1041.
24. Ipek IO, Yalcin EU, Sezer RG, Bozaykut A,. The efficacy of nebulized salbutamol, hypertonic saline and salbutamol/hypertonic saline combination in moderate bronchiolitis. Pulm Pharmacol Ther 2011; 24: 633-637.
25. Wang EE, Milner R, Allen U, Maj H,. Bronchodilators for treatment of mild bronchiolitis: a factorial randomised trial. Arch Dis Child 1992; 67: 289-293.
26. Jacobs JD, Foster M, Wan J, Pershad J,. 7% Hypertonic saline in acute bronchiolitis: a randomized controlled trial. Pediatrics 2014; 133: e8-e13.
27. Florin TA, Byczkowski T, Ruddy RM, Zorc JJ, Test M, Shah SS,. Utilization of nebulized 3% saline in infants hospitalized with bronchiolitis. J Pediatr 2015; 166: 1168-1174.
28. Kuzik BA, Flavin MP, Kent S, Zielinski D, Kwan CW, Adeleye A, Vegsund BC, Rossi C,. Effect of inhaled hypertonic saline on hospital admission rate in children with viral bronchiolitis: a randomized trial. CJEM 2010; 12: 477-484.
29. Al-Ansari K, Sakran M, Davidson BL, El-Sayyed R, Mahjoub H, Ibrahim K,. Nebulized 5% or 3% hypertonic or 0.9% saline for treating acute bronchiolitis in infants. J Pediatr 2010; 157: 630-634.
30. Florin TA, Shaw KN, Kittick M, Yakscoe S, Zorc JJ,. Nebulized hypertonic saline for bronchiolitis in the emergency department: a randomized clinical trial. JAMA Pediatr 2014; 168: 664-670.