Traumatic brain injury results in rapid pericyte loss followed by reactive pericytosis in the cerebral cortex

Scientific Reports

Volumn 5, Issue , 2015, Pages

  Zehendner, Christoph M ^a,b   Sebastiani, Anne ^a   Hugonnet, André ^a   Bischoff, Florian ^b   Luhmann, Heiko J ^a   Thal, Serge C ^a  

^a JOHANNES GUTENBERG UNIVERSITY   (Germany)

^b GOETHE UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

PLATELET DERIVED GROWTH FACTOR BETA RECEPTOR;

ANIMAL; BRAIN CORTEX; BRAIN INJURY; C57BL MOUSE; METABOLISM; MOUSE; PATHOLOGY; PERICYTE;

ANIMALS; BRAIN INJURIES; CEREBRAL CORTEX; MICE; MICE, INBRED C57BL; PERICYTES; RECEPTOR, PLATELET-DERIVED GROWTH FACTOR BETA;

EID: 84940874500     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep13497     Document Type: Article

References (32)

1. Chintalgattu, V. et al. Coronary Microvascular Pericytes Are the Cellular Target of Sunitinib Malate-Induced Cardiotoxicity. Sci. Transl. Med. 5, 18769-18769 (2013).
2. Winkler, E. A., Bell, R. D., Zlokovic, B. V. Central nervous system pericytes in health and disease. Nat. Neurosci. 14, 1398-1405 (2011).
3. Cheng, L. et al. Glioblastoma Stem Cells Generate Vascular Pericytes to Support Vessel Function and Tumor Growth. Cell 153, 139-152 (2013).
4. Zlokovic, B. V. The blood-brain barrier in health and chronic neurodegenerative disorders. Neuron 57, 178-201 (2008).
5. Armulik, A. et al. Pericytes regulate the blood-brain barrier. Nature 468, 557-561 (2010).
6. Bell, R. D. et al. Pericytes control key neurovascular functions and neuronal phenotype in the adult brain and during brain aging. Neuron 68, 409-427 (2010).
7. Lindahl, P. Pericyte Loss and Microaneurysm Formation in PDGF-B-Deficient Mice. Science 277, 242-245 (1997).
8. Hall, C. N. et al. Capillary pericytes regulate cerebral blood flow in health and disease. Nature 508, 55-60 (2014).
9. Peppiatt, C. M., Howarth, C., Mobbs, P., Attwell, D. Bidirectional control of CNS capillary diameter by pericytes. Nature 443, 700-704 (2006).
10. Yemisci, M. et al. Pericyte contraction induced by oxidative-nitrative stress impairs capillary reflow despite successful opening of an occluded cerebral artery. Nat. Med. 15, 1031-1037 (2009).
11. Zehendner, C. M., Wedler, H. E., Luhmann, H. J. A novel in vitro model to study pericytes in the neurovascular unit of the developing cortex. PloS One 8, e81637 (2013).
12. Chen, Y.-T. et al. Platelet-derived growth factor receptor signaling activates pericyte-myofibroblast transition in obstructive and post-ischemic kidney fibrosis. Kidney Int. 80, 1170-1181 (2011).
13. Goritz, C. et al. A Pericyte Origin of Spinal Cord Scar Tissue. Science 333, 238-242 (2011).
14. Birbrair, A. et al. Type-1 pericytes participate in fibrous tissue deposition in aged skeletal muscle. AJP Cell Physiol. 305, C1098-C1113 (2013).
15. Karow, M. Mountaineering pericytes-A universal key to tissue repair? BioEssays News Rev. Mol. Cell. Dev. Biol. (2013) doi: 10.1002/bies.201300055
16. Karow, M. et al. Reprogramming of Pericyte-Derived Cells of the Adult Human Brain into Induced Neuronal Cells. Cell Stem Cell 11, 471-476 (2012).
17. Fernández-Klett, F. et al. Early loss of pericytes and perivascular stromal cell-induced scar formation after stroke. J. Cereb. Blood Flow Metab. 33, 428-439 (2012).
18. Shen, J. et al. PDGFR-? as a positive regulator of tissue repair in a mouse model of focal cerebral ischemia. J. Cereb. Blood Flow Metab. 32, 353-367 (2011).
19. Winkler, E. A., Bell, R. D., Zlokovic, B. V. Pericyte-specific expression of PDGF beta receptor in mouse models with normal and deficient PDGF beta receptor signaling. Mol. Neurodegener 5, 32 (2010).
20. Thal, S. C. et al. Volatile Anesthetics Influence Blood-Brain Barrier Integrity by Modulation of Tight Junction Protein Expression in Traumatic Brain Injury. PLoS ONE 7, e50752 (2012).
21. Thal, S. C. et al. Inhibition of proteasomal glucocorticoid receptor degradation restores dexamethasone-mediated stabilization of the blood-brain barrier after traumatic brain injury. Crit. Care Med. 41, 1305-1315 (2013).
22. Timaru-Kast, R., Herbig, E. L., Luh, C., Engelhard, K., Thal, S. C. Influence of age on cerebral housekeeping gene expression for normalization of quantitative PCR after acute brain injury in mice. J. Neurotrauma (2015). doi: 10.1089/neu.2014.3784
23. D'Agostino, R. B., Pearson, E. S. Testing for Departures From Normality. 44, 316-321 (1990).
24. Campbell, M. et al. Targeted suppression of claudin-5 decreases cerebral oedema and improves cognitive outcome following traumatic brain injury. Nat. Commun. 3, 849 (2012).
25. Fernández-Klett, F. et al. Early loss of pericytes and perivascular stromal cell-induced scar formation after stroke. J. Cereb. Blood Flow Metab. 33, 428-439 (2012).
26. Sixt, M. et al. Endothelial cell laminin isoforms, laminins 8 and 10, play decisive roles in T cell recruitment across the blood-brain barrier in experimental autoimmune encephalomyelitis. J. Cell Biol. 153, 933-946 (2001).
27. Krueger, M., Bechmann, I. CNS pericytes: concepts, misconceptions, and a way out. Glia 58, 1-10 (2010).
28. Armulik, A., Genové, G., Betsholtz, C. Pericytes: Developmental, Physiological, and Pathological Perspectives, Problems, and Promises. Dev. Cell 21, 193-215 (2011).
29. Sofroniew, M. V. Molecular dissection of reactive astrogliosis and glial scar formation. Trends Neurosci. 32, 638-647 (2009).
30. Chen, X.-H., Iwata, A., Nonaka, M., Browne, K. D., Smith, D. H. Neurogenesis and glial proliferation persist for at least one year in the subventricular zone following brain trauma in rats. J. Neurotrauma 20, 623-631 (2003).
31. Winkler, E. A., Sengillo, J. D., Bell, R. D., Wang, J., Zlokovic, B. V. Blood-spinal cord barrier pericyte reductions contribute to increased capillary permeability. J. Cereb. Blood Flow Metab. 32, 1841-1852 (2012).
32. Dore-Duffy, P. et al. Pericyte migration from the vascular wall in response to traumatic brain injury. Microvasc. Res. 60, 55-69 (2000).