Measures of kidney function by minimally invasive techniques correlate with histological glomerular damage in SCID mice with adriamycin-induced nephropathy

Scientific Reports

Volumn 5, Issue , 2015, Pages

  Scarfe, Lauren ^a   Rak Raszewska, Aleksandra ^a,e   Geraci, Stefania ^a   Darssan, Darsy ^a   Sharkey, Jack ^a   Huang, Jiaguo ^b   Burton, Neal C ^c   Mason, David ^a   Ranjzad, Parisa ^d   Kenny, Simon ^a   Gretz, Norbert ^b   Lévy, Raphaël ^a   Park, B Kevin ^a   García Fiñana, Marta ^a   Woolf, Adrian S ^d   Murray, Patricia ^a   Wilm, Bettina ^a  

^a UNIVERSITY OF LIVERPOOL   (United Kingdom)

^b UNIVERSITY OF HEIDELBERG   (Germany)

^c ITHERA MEDICAL GMBH   (Germany)

^d UNIVERSITY OF MANCHESTER   (United Kingdom)

^e UNIVERSITY OF OULU   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; DOXORUBICIN; FLUORESCEIN DERIVATIVE; FLUORESCEIN-ISOTHIOCYANATE SINISTRIN; INDOLE DERIVATIVE; OLIGOSACCHARIDE;

ALBUMINURIA; ANIMAL; BAGG ALBINO MOUSE; BODY WEIGHT; CHEMICALLY INDUCED; COMPLICATION; FEMALE; GLOMERULUS; HALF LIFE TIME; KIDNEY DISEASE; KIDNEY FUNCTION TEST; KINETICS; METABOLISM; NEPHROLOGY; PATHOLOGY; PATHOPHYSIOLOGY; PHOTOACOUSTICS; PROCEDURES; SCID MOUSE; STATISTICAL MODEL;

ALBUMINURIA; ANIMALS; BIOMARKERS; BODY WEIGHT; DOXORUBICIN; FEMALE; FLUORESCEINS; HALF-LIFE; INDOLES; KIDNEY DISEASES; KIDNEY FUNCTION TESTS; KIDNEY GLOMERULUS; KINETICS; MICE, INBRED BALB C; MICE, SCID; MODELS, STATISTICAL; NEPHROLOGY; OLIGOSACCHARIDES; PHOTOACOUSTIC TECHNIQUES;

EID: 84940872234     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep13601     Document Type: Article

References (46)

1. Bussolati, B. et al. Isolation of renal progenitor cells from adult human kidney. Am. J. Pathol. 166, 545-555, doi: 10.1016/s0002-9440(10)62276-6 (2005).
2. Harari-Steinberg, O. et al. Identification of human nephron progenitors capable of generation of kidney structures and functional repair of chronic renal disease. EMBO Mol. Med. 5, 1556-1568, doi: 10.1002/emmm.201201584 (2013).
3. Lu, J. et al. Discrete functions of M2a and M2c macrophage subsets determine their relative efficacy in treating chronic kidney disease. Kidney international 84, 745-755, doi: 10.1038/ki.2013.135 (2013).
4. Ronconi, E. et al. Regeneration of glomerular podocytes by human renal progenitors. J. Am. Soc. Nephrol. 20, 322-332, doi: 10.1681/asn.2008070709 (2009).
5. Kitiyakara, C., Eggers, P. & Kopp, J. B. Twenty-one-year trend in ESRD due to focal segmental glomerulosclerosis in the United States. American journal of kidney diseases: the official journal of the National Kidney Foundation 44, 815-825 (2004).
6. Korbet, S. M. Treatment of primary FSGS in adults. Journal of the American Society of Nephrology: JASN 23, 1769-1776, doi: 10.1681/ASN.2012040389 (2012).
7. Jeansson, M., Bjorck, K., Tenstad, O. & Haraldsson, B. Adriamycin alters glomerular endothelium to induce proteinuria. J. Am. Soc. Nephrol. 20, 114-122, doi: 10.1681/asn.2007111205 (2009).
8. Lee, V. W. & Harris, D. C. Adriamycin nephropathy: a model of focal segmental glomerulosclerosis. Nephrology (Carlton, Vic.) 16, 30-38, doi: 10.1111/j.1440-1797.2010.01383.x (2011).
9. Lee, V. W. et al. Adriamycin nephropathy in severe combined immunodeficient (SCID) mice. Nephrol. Dial. Transplant 21, 3293-3298, doi: 10.1093/ndt/gfl413 (2006).
10. Schock-Kusch, D. et al. Transcutaneous assessment of renal function in conscious rats with a device for measuring FITC-sinistrin disappearance curves. Kidney Int. 79, 1254-1258 (2011).
11. Schreiber, A. et al. Transcutaneous measurement of renal function in conscious mice. Am. J. Physiol. Renal Physiol 303, F783-788 (2012).
12. Fusellier, M. et al. Influence of three anesthetic protocols on glomerular filtration rate in dogs. Am. J. Vet. Res. 68, 807-811, doi: 10.2460/ajvr.68.8.807 (2007).
13. Mazze, R. I., Cousins, M. J. & Barr, G. A. Renal effects and metabolism of isoflurane in man. Anesthesiology 40, 536-542 (1974).
14. Taruttis, A., Morscher, S., Burton, N. C., Razansky, D. & Ntziachristos, V. Fast multispectral optoacoustic tomography (MSOT) for dynamic imaging of pharmacokinetics and biodistribution in multiple organs. PLoS ONE 7, doi: 10.1371 (2012).
15. Ntziachristos, V. Going deeper than microscopy: The optical imaging frontier in biology. Nat. Methods 7, 603-614 (2010).
16. Wang, L. V. & Hu, S. Photoacoustic Tomography: In Vivo Imaging from Organelles to Organs. Science 335, 1458-1462 (2012).
17. Lasagni, L. et al. Notch activation differentially regulates renal progenitors proliferation and differentiation toward the podocyte lineage in glomerular disorders. Stem cells (Dayton, Ohio) 28, 1674-1685, doi: 10.1002/stem.492 (2010).
18. Schock-Kusch, D. et al. Transcutaneous measurement of glomerular filtration rate using FITC-sinistrin in rats. Nephrol. Dial. Transplant. 24, 2997-3001, doi: 10.1093/ndt/gfp225 (2009).
19. Wang, Y., Wang, Y. P., Tay, Y. C. & Harris, D. C. Progressive adriamycin nephropathy in mice: sequence of histologic and immunohistochemical events. Kidney Int. 58, 1797-1804, doi: 10.1046/j.1523-1755.2000.00342.x (2000).
20. Cowley, A. W., Jr. et al. Progression of glomerular filtration rate reduction determined in conscious dahl salt-sensitive hypertensive rats. Hypertension 62, 85-90, doi: 10.1161/hypertensionaha.113.01194 (2013).
21. Schock-Kusch, D. et al. Reliability of transcutaneous measurement of renal function in various strains of conscious mice. PLoS ONE 8, 1254-1258 (2013).
22. Zöllner, F. G. et al. Simultaneous measurement of kidney function by dynamic contrast enhanced MRI and FITC-sinistrin clearance in rats at 3 tesla: Initial results. PLoS ONE 8, doi: 10.1371 (2013).
23. Ellery, S., Cai, X., Walker, D., Dickinson, H. & Kett, M. M. Transcutaneous Measurement of Glomerular Filtration Rate in Small Rodents; Through the Skin for the Win? Nephrology (Carlton, Vic.) doi: 10.1111/nep.12363 (2014).
24. Bonventre, J. V., Vaidya, V. S., Schmouder, R., Feig, P. & Dieterle, F. Next-generation biomarkers for detecting kidney toxicity. Nature biotechnology 28, 436-440, doi: 10.1038/nbt0510-436 (2010).
25. Dieterle, F. et al. Urinary clusterin, cystatin C, beta2-microglobulin and total protein as markers to detect drug-induced kidney injury. Nature biotechnology 28, 463-469, doi: 10.1038/nbt.1622 (2010).
26. Deman, A. et al. Altered antioxidant defence in a mouse adriamycin model of glomerulosclerosis. Nephrology, dialysis, transplantation: official publication of the European Dialysis and Transplant Association-European Renal Association 16, 147-150 (2001).
27. Zhang, J. et al. Sex-related differences in mast cell activity and doxorubicin toxicity: a study in spontaneously hypertensive rats. Toxicologic pathology 42, 361-375, doi: 10.1177/0192623313482778 (2014).
28. Lee, V. W. et al. Adriamycin nephropathy in severe combined immunodeficient (SCID) mice. Nephrology, dialysis, transplantation: official publication of the European Dialysis and Transplant Association-European Renal Association 21, 3293-3298, doi: 10.1093/ndt/gfl413 (2006).
29. Tan, R. J., Zhou, L., Zhou, D., Lin, L. & Liu, Y. Endothelin receptor a blockade is an ineffective treatment for adriamycin nephropathy. PLoS One 8, e79963, doi: 10.1371/journal.pone.0079963 (2013).
30. Yasuda, K. et al. Adriamycin nephropathy: a failure of endothelial progenitor cell-induced repair. The American journal of pathology 176, 1685-1695, doi: 10.2353/ajpath.2010.091071 (2010).
31. Endre, Z. H., Pickering, J. W. & Walker, R. J. Clearance and beyond: the complementary roles of GFR measurement and injury biomarkers in acute kidney injury (AKI). Am J Physiol Renal Physiol 301, F697-707, doi: 10.1152/ajprenal.00448.2010 (2011).
32. Murray, P. T. et al. Potential use of biomarkers in acute kidney injury: report and summary of recommendations from the 10th Acute Dialysis Quality Initiative consensus conference. Kidney international 85, 513-521, doi: 10.1038/ki.2013.374 (2014).
33. Harrison, T., Paproski, R. J. & Zemp, R. J. in SPIE BiOS. 82230S-82230S-82237 (International Society for Optics and Photonics).
34. Laufer, J. et al. In vivo photoacoustic imaging of mouse embryos. Journal of biomedical optics 17, 061220, doi: 10.1117/1. JBO.17.6.061220 (2012).
35. Nam, S. Y., Ricles, L. M., Suggs, L. J. & Emelianov, S. Y. In vivo ultrasound and photoacoustic monitoring of mesenchymal stem cells labeled with gold nanotracers. PLoS One 7, e37267, doi: 10.1371/journal.pone.0037267 (2012).
36. Dean-Ben, X. L., Buehler, A., Razansky, D. & Ntziachristos, V. Estimation of optoacoustic contrast agent concentration with self-calibration blind logarithmic unmixing. Physics in medicine and biology 59, 4785-4797, doi: 10.1088/0031-9155/59/17/4785 (2014).
37. Deliolanis, N. C. et al. Deep-tissue reporter-gene imaging with fluorescence and optoacoustic tomography: a performance overview. Molecular imaging and biology: MIB: the official publication of the Academy of Molecular Imaging 16, 652-660, doi: 10.1007/s11307-014-0728-1 (2014).
38. Buehler, A. et al. High resolution tumor targeting in living mice by means of multispectral optoacoustic tomography. EJNMMI Res 2, 14 (2012).
39. Jokerst, J. V., Thangaraj, M., Kempen, P. J., Sinclair, R. & Gambhir, S. S. Photoacoustic imaging of mesenchymal stem cells in living mice via silica-coated gold nanorods. ACS nano 6, 5920-5930 (2012).
40. Xiang, L., Ahmad, M., Hu, X., Cheng, Z. & Xing, L. Label-free photoacoustic cell-tracking in real-time. X Acoust. Imaging Sens 1, 18-22 (2014).
41. Zhang, X. et al. Resolvin D1 protects podocytes in adriamycin-induced nephropathy through modulation of 14-3-3beta acetylation. PLoS One 8, e67471, doi: 10.1371/journal.pone.0067471 (2013).
42. Kairaitis, L. K., Wang, Y., Gassmann, M., Tay, Y. C. & Harris, D. C. HIF-1alpha expression follows microvascular loss in advanced murine adriamycin nephrosis. Am J Physiol Renal Physiol 288, F198-206, doi: 10.1152/ajprenal.00244.2003 (2005).
43. Egger, C. et al. Adriamycin-induced nephropathy in rats: functional and cellular effects characterized by MRI. J. Magn. Reson. Imaging, doi: 10.1002/jmri.24603 (2014).
44. Preibisch, S., Saalfeld, S. & Tomancak, P. Globally optimal stitching of tiled 3D microscopic image acquisitions. Bioinformatics 25, 1463-1465, doi: 10.1093/bioinformatics/btp184 (2009).
45. Licha, K. et al. Hydrophilic cyanine dyes as contrast agents for near-infrared tumor imaging: synthesis, photophysical properties and spectroscopic in vivo characterization. Photochem. Photobiol. 72, 392-398 (2000).
46. Hamann, F. M. et al. Controlled modulation of serum protein binding and biodistribution of asymmetric cyanine dyes by variation of the number of sulfonate groups. Mol. Imaging 10, 258-269, doi: 10.2310/7290.2011.00005 (2011).