메뉴 건너뛰기




Volumn 29, Issue 9, 2015, Pages 1832-1838

BCR-ABL1 mutation development during first-line treatment with dasatinib or imatinib for chronic myeloid leukemia in chronic phase

Author keywords

[No Author keywords available]

Indexed keywords

BCR ABL PROTEIN; DASATINIB; IMATINIB; NILOTINIB;

EID: 84940797444     PISSN: 08876924     EISSN: 14765551     Source Type: Journal    
DOI: 10.1038/leu.2015.168     Document Type: Article
Times cited : (58)

References (61)
  • 1
    • 33750077276 scopus 로고    scopus 로고
    • Frequency and clinical significance of BCR-ABL mutations in patients with chronic myeloid leukemia treated with imatinib mesylate
    • Jabbour E, Kantarjian H, Jones D, Talpaz M, Bekele N, O'Brien S et al. Frequency and clinical significance of BCR-ABL mutations in patients with chronic myeloid leukemia treated with imatinib mesylate. Leukemia 2006; 20: 1767-1773.
    • (2006) Leukemia , vol.20 , pp. 1767-1773
    • Jabbour, E.1    Kantarjian, H.2    Jones, D.3    Talpaz, M.4    Bekele, N.5    O'Brien, S.6
  • 2
    • 81155123199 scopus 로고    scopus 로고
    • Sensitive detection of BCR-ABL1 mutations in patients with chronic myeloid leukemia after imatinib resistance is predictive of outcome during subsequent therapy
    • Parker WT, Lawrence RM, Ho M, Irwin DL, Scott HS, Hughes TP et al. Sensitive detection of BCR-ABL1 mutations in patients with chronic myeloid leukemia after imatinib resistance is predictive of outcome during subsequent therapy. J Clin Oncol 2011; 29: 4250-4259.
    • (2011) J Clin Oncol , vol.29 , pp. 4250-4259
    • Parker, W.T.1    Lawrence, R.M.2    Ho, M.3    Irwin, D.L.4    Scott, H.S.5    Hughes, T.P.6
  • 3
    • 73949105873 scopus 로고    scopus 로고
    • Dasatinib treatment of chronic-phase chronic myeloid leukemia: Analysis of responses according to preexisting BCR-ABL mutations
    • Müller MC, Cortes JE, Kim DW, Druker BJ, Erben P, Pasquini R et al. Dasatinib treatment of chronic-phase chronic myeloid leukemia: analysis of responses according to preexisting BCR-ABL mutations. Blood 2009; 114: 4944-4953.
    • (2009) Blood , vol.114 , pp. 4944-4953
    • Müller, M.C.1    Cortes, J.E.2    Kim, D.W.3    Druker, B.J.4    Erben, P.5    Pasquini, R.6
  • 4
    • 70249105789 scopus 로고    scopus 로고
    • Impact of baseline BCR-ABL mutations on response to nilotinib in patients with chronic myeloid leukemia in chronic phase
    • Hughes T, Saglio G, Branford S, Soverini S, Kim DW, Müller MC et al. Impact of baseline BCR-ABL mutations on response to nilotinib in patients with chronic myeloid leukemia in chronic phase. J Clin Oncol 2009; 27: 4204-4210.
    • (2009) J Clin Oncol , vol.27 , pp. 4204-4210
    • Hughes, T.1    Saglio, G.2    Branford, S.3    Soverini, S.4    Kim, D.W.5    Müller, M.C.6
  • 5
    • 77949767505 scopus 로고    scopus 로고
    • International randomized study of interferon vs STI571 (IRIS) 8-year follow up: Sustained survival and low risk for progression or events in patients with newly diagnosed chronic myeloid leukemia in chronic phase (CML-CP) treated with imatinib
    • abstract 1126
    • Deininger M, O'Brien SG, Guilhot F, Goldman JM, Hochhaus A, Hughes TP et al. International randomized study of interferon vs STI571 (IRIS) 8-year follow up: sustained survival and low risk for progression or events in patients with newly diagnosed chronic myeloid leukemia in chronic phase (CML-CP) treated with imatinib. Blood 2009; 114: abstract 1126.
    • (2009) Blood , vol.114
    • Deininger, M.1    O'Brien, S.G.2    Guilhot, F.3    Goldman, J.M.4    Hochhaus, A.5    Hughes, T.P.6
  • 6
    • 67349233062 scopus 로고    scopus 로고
    • Six-year follow-up of patients receiving imatinib for the first-line treatment of chronic myeloid leukemia
    • Hochhaus A, O'Brien SG, Guilhot F, Druker BJ, Branford S, Foroni L et al. Six-year follow-up of patients receiving imatinib for the first-line treatment of chronic myeloid leukemia. Leukemia 2009; 23: 1054-1061.
    • (2009) Leukemia , vol.23 , pp. 1054-1061
    • Hochhaus, A.1    O'Brien, S.G.2    Guilhot, F.3    Druker, B.J.4    Branford, S.5    Foroni, L.6
  • 7
    • 0001686739 scopus 로고    scopus 로고
    • Multiple BCR-ABL kinase domain mutations confer polyclonal resistance to the tyrosine kinase inhibitor imatinib (STI571) in chronic phase and blast crisis chronic myeloid leukemia
    • Shah NP, Nicoll JM, Nagar B, Gorre ME, Paquette RL, Kuriyan J et al. Multiple BCR-ABL kinase domain mutations confer polyclonal resistance to the tyrosine kinase inhibitor imatinib (STI571) in chronic phase and blast crisis chronic myeloid leukemia. Cancer Cell 2002; 2: 117-125.
    • (2002) Cancer Cell , vol.2 , pp. 117-125
    • Shah, N.P.1    Nicoll, J.M.2    Nagar, B.3    Gorre, M.E.4    Paquette, R.L.5    Kuriyan, J.6
  • 8
    • 10744232328 scopus 로고    scopus 로고
    • Detection of BCR-ABL mutations in patients with CML treated with imatinib is virtually always accompanied by clinical resistance, and mutations in the ATP phosphate-binding loop (P-loop) are associated with a poor prognosis
    • Branford S, Rudzki Z, Walsh S, Parkinson I, Grigg A, Szer J et al. Detection of BCR-ABL mutations in patients with CML treated with imatinib is virtually always accompanied by clinical resistance, and mutations in the ATP phosphate-binding loop (P-loop) are associated with a poor prognosis. Blood 2003; 102: 276-283.
    • (2003) Blood , vol.102 , pp. 276-283
    • Branford, S.1    Rudzki, Z.2    Walsh, S.3    Parkinson, I.4    Grigg, A.5    Szer, J.6
  • 9
    • 23044458596 scopus 로고    scopus 로고
    • ABL mutations in late chronic phase chronic myeloid leukemia patients with up-front cytogenetic resistance to imatinib are associated with a greater likelihood of progression to blast crisis and shorter survival: A study by the GIMEMA Working Party on Chronic Myeloid Leukemia
    • Soverini S, Martinelli G, Rosti G, Bassi S, Amabile M, Poerio A et al. ABL mutations in late chronic phase chronic myeloid leukemia patients with up-front cytogenetic resistance to imatinib are associated with a greater likelihood of progression to blast crisis and shorter survival: a study by the GIMEMA Working Party on Chronic Myeloid Leukemia. J Clin Oncol 2005; 23: 4100-4109.
    • (2005) J Clin Oncol , vol.23 , pp. 4100-4109
    • Soverini, S.1    Martinelli, G.2    Rosti, G.3    Bassi, S.4    Amabile, M.5    Poerio, A.6
  • 10
    • 49149111543 scopus 로고    scopus 로고
    • Imatinib for newly diagnosed patients with chronic myeloid leukemia: Incidence of sustained responses in an intention-to-treat analysis
    • de Lavallade H, Apperley JF, Khorashad JS, Milojkovic D, Reid AG, Bua M et al. Imatinib for newly diagnosed patients with chronic myeloid leukemia: incidence of sustained responses in an intention-to-treat analysis. J Clin Oncol 2008; 26: 3358-3363.
    • (2008) J Clin Oncol , vol.26 , pp. 3358-3363
    • De Lavallade, H.1    Apperley, J.F.2    Khorashad, J.S.3    Milojkovic, D.4    Reid, A.G.5    Bua, M.6
  • 11
    • 33846228789 scopus 로고    scopus 로고
    • Contribution of ABL kinase domain mutations to imatinib resistance in different subsets of Philadelphia-positive patients: By the GIMEMA Working Party on Chronic Myeloid Leukemia
    • Soverini S, Colarossi S, Gnani A, Rosti G, Castagnetti F, Poerio A et al. Contribution of ABL kinase domain mutations to imatinib resistance in different subsets of Philadelphia-positive patients: by the GIMEMA Working Party on Chronic Myeloid Leukemia. Clin Cancer Res 2006; 12: 7374-7379.
    • (2006) Clin Cancer Res , vol.12 , pp. 7374-7379
    • Soverini, S.1    Colarossi, S.2    Gnani, A.3    Rosti, G.4    Castagnetti, F.5    Poerio, A.6
  • 12
    • 80051573352 scopus 로고    scopus 로고
    • BCR-ABL kinase domain mutation analysis in chronic myeloid leukemia patients treated with tyrosine kinase inhibitors: Recommendations from an expert panel on behalf of European LeukemiaNet
    • Soverini S, Hochhaus A, Nicolini FE, Gruber F, Lange T, Saglio G et al. BCR-ABL kinase domain mutation analysis in chronic myeloid leukemia patients treated with tyrosine kinase inhibitors: recommendations from an expert panel on behalf of European LeukemiaNet. Blood 2011; 118: 1208-1215.
    • (2011) Blood , vol.118 , pp. 1208-1215
    • Soverini, S.1    Hochhaus, A.2    Nicolini, F.E.3    Gruber, F.4    Lange, T.5    Saglio, G.6
  • 14
    • 80055070888 scopus 로고    scopus 로고
    • Safety and efficacy of bosutinib (SKI-606) in chronic phase Philadelphia chromosome-positive chronic myeloid leukemia patients with resistance or intolerance to imatinib
    • Cortes JE, Kantarjian HM, Brümmendorf TH, Kim DW, Turkina AG, Shen ZX et al. Safety and efficacy of bosutinib (SKI-606) in chronic phase Philadelphia chromosome-positive chronic myeloid leukemia patients with resistance or intolerance to imatinib. Blood 2011; 118: 4567-4576.
    • (2011) Blood , vol.118 , pp. 4567-4576
    • Cortes, J.E.1    Kantarjian, H.M.2    Brümmendorf, T.H.3    Kim, D.W.4    Turkina, A.G.5    Shen, Z.X.6
  • 16
    • 58549088155 scopus 로고    scopus 로고
    • Activity of bosutinib, dasatinib, and nilotinib against 18 imatinib-resistant BCR/ABL mutants
    • Redaelli S, Piazza R, Rostagno R, Magistroni V, Perini P, Marega M et al. Activity of bosutinib, dasatinib, and nilotinib against 18 imatinib-resistant BCR/ABL mutants. J Clin Oncol 2009; 27: 469-471.
    • (2009) J Clin Oncol , vol.27 , pp. 469-471
    • Redaelli, S.1    Piazza, R.2    Rostagno, R.3    Magistroni, V.4    Perini, P.5    Marega, M.6
  • 20
    • 0008348082 scopus 로고    scopus 로고
    • last accessed 5 February 2015
    • European Medicines Agency. European public assessment reports for Sprycel. http://www.ema.europa.eu/ema/index.jsp?curl=pages/medicines/human/medicines/ 000709/human-med-001062.jsp&murl =menus/medicines/medicines.jsp&mid = WC0b01ac058001d125 (last accessed 5 February 2015).
    • European Public Assessment Reports for Sprycel
    • European Medicines Agency1
  • 22
    • 84867395848 scopus 로고    scopus 로고
    • Nilotinib vs imatinib in patients with newly diagnosed Philadelphia chromosome-positive chronic myeloid leukemia in chronic phase: ENESTnd 3-year follow-up
    • Larson RA, Hochhaus A, Hughes TP, Clark RE, Etienne G, Kim DW et al. Nilotinib vs imatinib in patients with newly diagnosed Philadelphia chromosome-positive chronic myeloid leukemia in chronic phase: ENESTnd 3-year follow-up. Leukemia 2012; 26: 2197-2203.
    • (2012) Leukemia , vol.26 , pp. 2197-2203
    • Larson, R.A.1    Hochhaus, A.2    Hughes, T.P.3    Clark, R.E.4    Etienne, G.5    Kim, D.W.6
  • 23
    • 84893136765 scopus 로고    scopus 로고
    • Early response with dasatinib or imatinib in chronic myeloid leukemia: 3-year follow-up from a randomized phase 3 trial (DASISION)
    • Jabbour E, Kantarjian HM, Saglio G, Steegmann JL, Shah NP, Boqué C et al. Early response with dasatinib or imatinib in chronic myeloid leukemia: 3-year follow-up from a randomized phase 3 trial (DASISION). Blood 2014; 123: 494-500.
    • (2014) Blood , vol.123 , pp. 494-500
    • Jabbour, E.1    Kantarjian, H.M.2    Saglio, G.3    Steegmann, J.L.4    Shah, N.P.5    Boqué, C.6
  • 24
    • 84863011486 scopus 로고    scopus 로고
    • Dasatinib or imatinib in newly diagnosed chronic-phase chronic myeloid leukemia: 2-year follow-up from a randomized phase 3 trial (DASISION)
    • Kantarjian HM, Shah NP, Cortes JE, Baccarani M, Agarwal MB, Undurraga MS et al. Dasatinib or imatinib in newly diagnosed chronic-phase chronic myeloid leukemia: 2-year follow-up from a randomized phase 3 trial (DASISION). Blood 2012; 119: 1123-1129.
    • (2012) Blood , vol.119 , pp. 1123-1129
    • Kantarjian, H.M.1    Shah, N.P.2    Cortes, J.E.3    Baccarani, M.4    Agarwal, M.B.5    Undurraga, M.S.6
  • 25
    • 80052383499 scopus 로고    scopus 로고
    • Nilotinib versus imatinib for the treatment of patients with newly diagnosed chronic phase, Philadelphia chromosome-positive, chronic myeloid leukaemia: 24-month minimum follow-up of the phase 3 randomised ENESTnd trial
    • Kantarjian HM, Hochhaus A, Saglio G, De Souza C, Flinn IW, Stenke L et al. Nilotinib versus imatinib for the treatment of patients with newly diagnosed chronic phase, Philadelphia chromosome-positive, chronic myeloid leukaemia: 24-month minimum follow-up of the phase 3 randomised ENESTnd trial. Lancet Oncol 2011; 12: 841-851.
    • (2011) Lancet Oncol , vol.12 , pp. 841-851
    • Kantarjian, H.M.1    Hochhaus, A.2    Saglio, G.3    De Souza, C.4    Flinn, I.W.5    Stenke, L.6
  • 26
    • 80053414182 scopus 로고    scopus 로고
    • published erratum appears in
    • [published erratum appears in Lancet Oncol 2011; 12: 989].
    • (2011) Lancet Oncol , vol.12 , pp. 989
  • 27
    • 84879710913 scopus 로고    scopus 로고
    • Nilotinib is associated with a reduced incidence of BCR-ABL mutations vs imatinib in patients with newly diagnosed chronic myeloid leukemia in chronic phase
    • Hochhaus A, Saglio G, Larson RA, Kim DW, Etienne G, Rosti G et al. Nilotinib is associated with a reduced incidence of BCR-ABL mutations vs imatinib in patients with newly diagnosed chronic myeloid leukemia in chronic phase. Blood 2013; 121: 3703-3708.
    • (2013) Blood , vol.121 , pp. 3703-3708
    • Hochhaus, A.1    Saglio, G.2    Larson, R.A.3    Kim, D.W.4    Etienne, G.5    Rosti, G.6
  • 28
    • 77953725855 scopus 로고    scopus 로고
    • Dasatinib versus imatinib in newly diagnosed chronic-phase chronic myeloid leukemia
    • Kantarjian H, Shah NP, Hochhaus A, Cortes J, Shah S, Ayala M et al. Dasatinib versus imatinib in newly diagnosed chronic-phase chronic myeloid leukemia. N Engl J Med 2010; 362: 2260-2270.
    • (2010) N Engl J Med , vol.362 , pp. 2260-2270
    • Kantarjian, H.1    Shah, N.P.2    Hochhaus, A.3    Cortes, J.4    Shah, S.5    Ayala, M.6
  • 29
    • 33747154547 scopus 로고    scopus 로고
    • Evolving concepts in the management of chronic myeloid leukemia: Recommendations from an expert panel on behalf of the European LeukemiaNet
    • Baccarani M, Saglio G, Goldman J, Hochhaus A, Simonsson B, Appelbaum F et al. Evolving concepts in the management of chronic myeloid leukemia: recommendations from an expert panel on behalf of the European LeukemiaNet. Blood 2006; 108: 1809-1820.
    • (2006) Blood , vol.108 , pp. 1809-1820
    • Baccarani, M.1    Saglio, G.2    Goldman, J.3    Hochhaus, A.4    Simonsson, B.5    Appelbaum, F.6
  • 30
    • 33745603988 scopus 로고    scopus 로고
    • Monitoring CML patients responding to treatment with tyrosine kinase inhibitors: Review and recommendations for harmonizing current methodology for detecting BCR-ABL transcripts and kinase domain mutations and for expressing results
    • Hughes T, Deininger M, Hochhaus A, Branford S, Radich J, Kaeda J et al. Monitoring CML patients responding to treatment with tyrosine kinase inhibitors: review and recommendations for harmonizing current methodology for detecting BCR-ABL transcripts and kinase domain mutations and for expressing results. Blood 2006; 108: 28-37.
    • (2006) Blood , vol.108 , pp. 28-37
    • Hughes, T.1    Deininger, M.2    Hochhaus, A.3    Branford, S.4    Radich, J.5    Kaeda, J.6
  • 32
    • 84881298446 scopus 로고    scopus 로고
    • European LeukemiaNet recommendations for the management of chronic myeloid leukemia: 2013
    • Baccarani M, Deininger MW, Rosti G, Hochhaus A, Soverini S, Apperley JF et al. European LeukemiaNet recommendations for the management of chronic myeloid leukemia: 2013. Blood 2013; 122: 872-884.
    • (2013) Blood , vol.122 , pp. 872-884
    • Baccarani, M.1    Deininger, M.W.2    Rosti, G.3    Hochhaus, A.4    Soverini, S.5    Apperley, J.F.6
  • 33
    • 21144451094 scopus 로고    scopus 로고
    • In vitro activity of Bcr-Abl inhibitors AMN107 and BMS-354825 against clinically relevant imatinib-resistant Abl kinase domain mutants
    • O'Hare T, Walters DK, Stoffregen EP, Jia T, Manley PW, Mestan J et al. In vitro activity of Bcr-Abl inhibitors AMN107 and BMS-354825 against clinically relevant imatinib-resistant Abl kinase domain mutants. Cancer Res 2005; 65: 4500-4505.
    • (2005) Cancer Res , vol.65 , pp. 4500-4505
    • O'Hare, T.1    Walters, D.K.2    Stoffregen, E.P.3    Jia, T.4    Manley, P.W.5    Mestan, J.6
  • 34
    • 33749325184 scopus 로고    scopus 로고
    • Comparison of imatinib mesylate, dasatinib (BMS-354825), and nilotinib (AMN107) in an N-ethyl-N-nitrosourea (ENU)-based mutagenesis screen: High efficacy of drug combinations
    • Bradeen HA, Eide CA, O'Hare T, Johnson KJ, Willis SG, Lee FY et al. Comparison of imatinib mesylate, dasatinib (BMS-354825), and nilotinib (AMN107) in an N-ethyl-N-nitrosourea (ENU)-based mutagenesis screen: high efficacy of drug combinations. Blood 2006; 108: 2332-2338.
    • (2006) Blood , vol.108 , pp. 2332-2338
    • Bradeen, H.A.1    Eide, C.A.2    O'Hare, T.3    Johnson, K.J.4    Willis, S.G.5    Lee, F.Y.6
  • 35
    • 37049003546 scopus 로고    scopus 로고
    • Dynamics of BCRABL kinase domain mutations in chronic myeloid leukemia after sequential treatment with multiple tyrosine kinase inhibitors
    • Cortes J, Jabbour E, Kantarjian H, Yin CC, Shan J, O'Brien S et al. Dynamics of BCRABL kinase domain mutations in chronic myeloid leukemia after sequential treatment with multiple tyrosine kinase inhibitors. Blood 2007; 110: 4005-4011.
    • (2007) Blood , vol.110 , pp. 4005-4011
    • Cortes, J.1    Jabbour, E.2    Kantarjian, H.3    Yin, C.C.4    Shan, J.5    O'Brien, S.6
  • 36
    • 34848911943 scopus 로고    scopus 로고
    • Sequential ABL kinase inhibitor therapy selects for compound drug-resistant BCR-ABL mutations with altered oncogenic potency
    • Shah NP, Skaggs BJ, Branford S, Hughes TP, Nicoll JM, Paquette RL et al. Sequential ABL kinase inhibitor therapy selects for compound drug-resistant BCR-ABL mutations with altered oncogenic potency. J Clin Invest 2007; 117: 2562-2569.
    • (2007) J Clin Invest , vol.117 , pp. 2562-2569
    • Shah, N.P.1    Skaggs, B.J.2    Branford, S.3    Hughes, T.P.4    Nicoll, J.M.5    Paquette, R.L.6
  • 37
    • 70349254450 scopus 로고    scopus 로고
    • Philadelphia-positive patients who already harbor imatinib-resistant Bcr-Abl kinase domain mutations have a higher likelihood of developing additional mutations associated with resistance to second-or third-line tyrosine kinase inhibitors
    • Soverini S, Gnani A, Colarossi S, Castagnetti F, Abruzzese E, Paolini S et al. Philadelphia-positive patients who already harbor imatinib-resistant Bcr-Abl kinase domain mutations have a higher likelihood of developing additional mutations associated with resistance to second-or third-line tyrosine kinase inhibitors. Blood 2009; 114: 2168-2171.
    • (2009) Blood , vol.114 , pp. 2168-2171
    • Soverini, S.1    Gnani, A.2    Colarossi, S.3    Castagnetti, F.4    Abruzzese, E.5    Paolini, S.6
  • 38
    • 58149380741 scopus 로고    scopus 로고
    • Characteristics and outcome of chronic myeloid leukemia patients with F317L BCR-ABL kinase domain mutation after therapy with tyrosine kinase inhibitors
    • Jabbour E, Kantarjian HM, Jones D, Reddy N, O'Brien S, Garcia-Manero G et al. Characteristics and outcome of chronic myeloid leukemia patients with F317L BCR-ABL kinase domain mutation after therapy with tyrosine kinase inhibitors. Blood 2008; 112: 4839-4842.
    • (2008) Blood , vol.112 , pp. 4839-4842
    • Jabbour, E.1    Kantarjian, H.M.2    Jones, D.3    Reddy, N.4    O'Brien, S.5    Garcia-Manero, G.6
  • 39
    • 41349085814 scopus 로고    scopus 로고
    • In vivo kinetics of kinase domain mutations in CML patients treated with dasatinib after failing imatinib
    • Khorashad JS, Milojkovic D, Mehta P, Anand M, Ghorashian S, Reid AG et al. In vivo kinetics of kinase domain mutations in CML patients treated with dasatinib after failing imatinib. Blood 2008; 111: 2378-2381.
    • (2008) Blood , vol.111 , pp. 2378-2381
    • Khorashad, J.S.1    Milojkovic, D.2    Mehta, P.3    Anand, M.4    Ghorashian, S.5    Reid, A.G.6
  • 40
    • 84871400814 scopus 로고    scopus 로고
    • Patients with chronic myeloid leukemia in chronic phase carrying more than one BCR-ABL kinase domain mutation exhibit poorer response rates and outcomes to second-line dasatinib compared to those with no or only one BCR-ABL mutation
    • abstract 2297
    • Quintás-Cardama A, Kantarjian H, Shah NP, Schiffer CA, le Coutre P, Saglio G et al. Patients with chronic myeloid leukemia in chronic phase carrying more than one BCR-ABL kinase domain mutation exhibit poorer response rates and outcomes to second-line dasatinib compared to those with no or only one BCR-ABL mutation. Blood 2010; 116: abstract 2297.
    • (2010) Blood , vol.116
    • Quintás-Cardama, A.1    Kantarjian, H.2    Shah, N.P.3    Schiffer, C.A.4    Le Coutre, P.5    Saglio, G.6
  • 41
    • 84858042055 scopus 로고    scopus 로고
    • Poor response to second-line kinase inhibitors in chronic myeloid leukemia patients with multiple low-level mutations, irrespective of their resistance profile
    • Parker WT, Ho M, Scott HS, Hughes TP, Branford S. Poor response to second-line kinase inhibitors in chronic myeloid leukemia patients with multiple low-level mutations, irrespective of their resistance profile. Blood 2012; 119: 2234-2238.
    • (2012) Blood , vol.119 , pp. 2234-2238
    • Parker, W.T.1    Ho, M.2    Scott, H.S.3    Hughes, T.P.4    Branford, S.5
  • 43
    • 35448967331 scopus 로고    scopus 로고
    • Part I: Mechanisms of resistance to imatinib in chronic myeloid leukaemia
    • Apperley JF. Part I: mechanisms of resistance to imatinib in chronic myeloid leukaemia. Lancet Oncol 2007; 8: 1018-1029.
    • (2007) Lancet Oncol , vol.8 , pp. 1018-1029
    • Apperley, J.F.1
  • 47
    • 33746934638 scopus 로고    scopus 로고
    • Kinase domain mutants of Bcr-Abl exhibit altered transformation potency, kinase activity, and substrate utilization, irrespective of sensitivity to imatinib
    • Griswold IJ, MacPartlin M, Bumm T, Goss VL, O'Hare T, Lee KA et al. Kinase domain mutants of Bcr-Abl exhibit altered transformation potency, kinase activity, and substrate utilization, irrespective of sensitivity to imatinib. Mol Cell Biol 2006; 26: 6082-6093.
    • (2006) Mol Cell Biol , vol.26 , pp. 6082-6093
    • Griswold, I.J.1    MacPartlin, M.2    Bumm, T.3    Goss, V.L.4    O'Hare, T.5    Lee, K.A.6
  • 48
    • 76249090055 scopus 로고    scopus 로고
    • Selecting optimal second-line tyrosine kinase inhibitor therapy for chronic myeloid leukemia patients after imatinib failure: Does the BCR-ABL mutation status really matter?
    • Branford S, Melo JV, Hughes TP. Selecting optimal second-line tyrosine kinase inhibitor therapy for chronic myeloid leukemia patients after imatinib failure: does the BCR-ABL mutation status really matter? Blood 2009; 114: 5426-5435.
    • (2009) Blood , vol.114 , pp. 5426-5435
    • Branford, S.1    Melo, J.V.2    Hughes, T.P.3
  • 49
    • 40849105148 scopus 로고    scopus 로고
    • Dynamics of BCR-ABL mutated clones prior to hematologic or cytogenetic resistance to imatinib
    • Ernst T, Erben P, Müller MC, Paschka P, Schenk T, Hoffmann J et al. Dynamics of BCR-ABL mutated clones prior to hematologic or cytogenetic resistance to imatinib. Haematologica 2008; 93: 186-192.
    • (2008) Haematologica , vol.93 , pp. 186-192
    • Ernst, T.1    Erben, P.2    Müller, M.C.3    Paschka, P.4    Schenk, T.5    Hoffmann, J.6
  • 50
    • 70349245253 scopus 로고    scopus 로고
    • Long-term outcome of patients with chronic myeloid leukemia treated with secondgeneration tyrosine kinase inhibitors after imatinib failure is predicted by the in vitro sensitivity of BCR-ABL kinase domain mutations
    • Jabbour E, Jones D, Kantarjian HM, O'Brien S, Tam C, Koller C et al. Long-term outcome of patients with chronic myeloid leukemia treated with secondgeneration tyrosine kinase inhibitors after imatinib failure is predicted by the in vitro sensitivity of BCR-ABL kinase domain mutations. Blood 2009; 114: 2037-2043.
    • (2009) Blood , vol.114 , pp. 2037-2043
    • Jabbour, E.1    Jones, D.2    Kantarjian, H.M.3    O'Brien, S.4    Tam, C.5    Koller, C.6
  • 51
    • 77953275532 scopus 로고    scopus 로고
    • Dynamic change of T315I BCR-ABL kinase domain mutation in Korean chronic myeloid leukaemia patients during treatment with Abl tyrosine kinase inhibitors
    • Kim WS, Kim D, Kim DW, Kweon IY, Kim SH, Goh HG et al. Dynamic change of T315I BCR-ABL kinase domain mutation in Korean chronic myeloid leukaemia patients during treatment with Abl tyrosine kinase inhibitors. Hematol Oncol 2010; 28: 82-88.
    • (2010) Hematol Oncol , vol.28 , pp. 82-88
    • Kim, W.S.1    Kim, D.2    Kim, D.W.3    Kweon, I.Y.4    Kim, S.H.5    Goh, H.G.6
  • 52
    • 84875868687 scopus 로고    scopus 로고
    • Coexisting with clonal evolution and BCR-ABL mutant in CML patients treated with second-generation tyrosine kinase inhibitors predict the discrepancy of in vitro drug sensitivity
    • Ahn JS, Kim YK, Lee SR, Yu L, Yang DH, Cho SH et al. Coexisting with clonal evolution and BCR-ABL mutant in CML patients treated with second-generation tyrosine kinase inhibitors predict the discrepancy of in vitro drug sensitivity. Cancer Res Treat 2010; 42: 37-41.
    • (2010) Cancer Res Treat , vol.42 , pp. 37-41
    • Ahn, J.S.1    Kim, Y.K.2    Lee, S.R.3    Yu, L.4    Yang, D.H.5    Cho, S.H.6
  • 53
    • 79957876935 scopus 로고    scopus 로고
    • Analysis of molecular data and the emergence of mutations for chronicphase chronic myelogenous leukemia (CML-CP) patients treated with dasatinib after imatinib failure
    • abstract 3282
    • Branford S, Hochhaus A, Mueller M, Bahceci E, Ploughman L, Mukhopadhyay J et al. Analysis of molecular data and the emergence of mutations for chronicphase chronic myelogenous leukemia (CML-CP) patients treated with dasatinib after imatinib failure. Blood 2009; 114: abstract 3282.
    • (2009) Blood , vol.114
    • Branford, S.1    Hochhaus, A.2    Mueller, M.3    Bahceci, E.4    Ploughman, L.5    Mukhopadhyay, J.6
  • 54
    • 84856708602 scopus 로고    scopus 로고
    • Dynamics of the emergence of dasatinib and nilotinib resistance in imatinib-resistant CML patients
    • Gruber FX, Ernst T, Porkka K, Engh RA, Mikkola I, Maier J et al. Dynamics of the emergence of dasatinib and nilotinib resistance in imatinib-resistant CML patients. Leukemia 2012; 26: 172-177.
    • (2012) Leukemia , vol.26 , pp. 172-177
    • Gruber, F.X.1    Ernst, T.2    Porkka, K.3    Engh, R.A.4    Mikkola, I.5    Maier, J.6
  • 56
    • 70350507997 scopus 로고    scopus 로고
    • AP24534, a pan-BCR-ABL inhibitor for chronic myeloid leukemia, potently inhibits the T315I mutant and overcomes mutation-based resistance
    • O'Hare T, Shakespeare WC, Zhu X, Eide CA, Rivera VM, Wang F et al. AP24534, a pan-BCR-ABL inhibitor for chronic myeloid leukemia, potently inhibits the T315I mutant and overcomes mutation-based resistance. Cancer Cell 2009; 16: 401-412.
    • (2009) Cancer Cell , vol.16 , pp. 401-412
    • O'Hare, T.1    Shakespeare, W.C.2    Zhu, X.3    Eide, C.A.4    Rivera, V.M.5    Wang, F.6
  • 57
    • 84940789223 scopus 로고    scopus 로고
    • Potential economic consequences of genetic mutations and restricted acccess to tyrosine kinase inhibitor treatments among patients with chronic myelogenous leukemia in the USA
    • abstract 2645
    • Jabbour EJ, Makenbaeva D, Lingohr-Smith M, Lin J. Potential economic consequences of genetic mutations and restricted acccess to tyrosine kinase inhibitor treatments among patients with chronic myelogenous leukemia in the USA. Blood 2014; 124: abstract 2645.
    • (2014) Blood , vol.124
    • Jabbour, E.J.1    Makenbaeva, D.2    Lingohr-Smith, M.3    Lin, J.4
  • 58
    • 84873648419 scopus 로고    scopus 로고
    • Sensitive detection of pre-existing BCR-ABL kinase domain mutations in CD34+ cells of newly diagnosed chronic-phase chronic myeloid leukemia patients is associated with imatinib resistance: Implications in the post-imatinib era
    • Iqbal Z, Aleem A, Iqbal M, Naqvi MI, Gill A, Taj AS et al. Sensitive detection of pre-existing BCR-ABL kinase domain mutations in CD34+ cells of newly diagnosed chronic-phase chronic myeloid leukemia patients is associated with imatinib resistance: implications in the post-imatinib era. PLoS One 2013; 8: e55717.
    • (2013) PLoS One , vol.8
    • Iqbal, Z.1    Aleem, A.2    Iqbal, M.3    Naqvi, M.I.4    Gill, A.5    Taj, A.S.6
  • 59
    • 84877082097 scopus 로고    scopus 로고
    • The quantitative level of T315I mutated BCR-ABL predicts for major molecular response to secondline nilotinib or dasatinib treatment in patients with chronic myeloid leukemia
    • Lange T, Ernst T, Gruber FX, Maier J, Cross M, Müller MC et al. The quantitative level of T315I mutated BCR-ABL predicts for major molecular response to secondline nilotinib or dasatinib treatment in patients with chronic myeloid leukemia. Haematologica 2013; 98: 714-717.
    • (2013) Haematologica , vol.98 , pp. 714-717
    • Lange, T.1    Ernst, T.2    Gruber, F.X.3    Maier, J.4    Cross, M.5    Müller, M.C.6
  • 60
    • 24744443720 scopus 로고    scopus 로고
    • High-sensitivity detection of BCR-ABL kinase domain mutations in imatinib-naive patients: Correlation with clonal cytogenetic evolution but not response to therapy
    • Willis SG, Lange T, Demehri S, Otto S, Crossman L, Niederwieser D et al. High-sensitivity detection of BCR-ABL kinase domain mutations in imatinib-naive patients: correlation with clonal cytogenetic evolution but not response to therapy. Blood 2005; 106: 2128-2137.
    • (2005) Blood , vol.106 , pp. 2128-2137
    • Willis, S.G.1    Lange, T.2    Demehri, S.3    Otto, S.4    Crossman, L.5    Niederwieser, D.6
  • 61
    • 77957196195 scopus 로고    scopus 로고
    • Properties of CD34+ CML stem/progenitor cells that correlate with different clinical responses to imatinib mesylate
    • Jiang X, Forrest D, Nicolini F, Turhan A, Guilhot J, Yip C et al. Properties of CD34+ CML stem/progenitor cells that correlate with different clinical responses to imatinib mesylate. Blood 2010; 116: 2112-2121.
    • (2010) Blood , vol.116 , pp. 2112-2121
    • Jiang, X.1    Forrest, D.2    Nicolini, F.3    Turhan, A.4    Guilhot, J.5    Yip, C.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.