Whole genome sequencing shows a low proportion of tuberculosis disease is attributable to known close contacts in rural Malawi

PLoS ONE

Volumn 10, Issue 7, 2015, Pages

  Glynn, Judith R ^a   Guerra Assunção, José Afonso ^a   Houben, Rein M G J ^a   Sichali, Lifted ^b   Mzembe, Themba ^b   Mwaungulu, Lorrain K ^b   Mwaungulu, J Nimrod ^b   McNerney, Ruth ^a   Khan, Palwasha ^a   Parkhill, Julian ^c   Crampin, Amelia C ^a,b   Clark, Taane G ^a  

^a LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

^b KARONGA PREVENTION STUDY   (Malawi)

^c WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ISONIAZID; BACTERIAL DNA;

ADULT; AGE; ALLELE; ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL STRAIN; BACTERIUM CULTURE; CLOSE CONTACT; CONTROLLED STUDY; DISEASE TRANSMISSION; FEMALE; GENE SEQUENCE; GENOTYPE; HEALTH STATUS; HETEROZYGOSITY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; INFECTION RISK; LINEAR REGRESSION ANALYSIS; MAJOR CLINICAL STUDY; MALAWI; MALE; NONHUMAN; PATHOPHYSIOLOGY; RURAL POPULATION; SINGLE NUCLEOTIDE POLYMORPHISM; SMEAR; SPUTUM ANALYSIS; TUBERCULOSIS; WHOLE GENOME SEQUENCING; BACTERIUM IDENTIFICATION; CHILD; CONTACT EXAMINATION; DNA SEQUENCE; GENETICS; INCIDENCE; ISOLATION AND PURIFICATION; MICROSCOPY; MIDDLE AGED; MYCOBACTERIUM TUBERCULOSIS; STATISTICS AND NUMERICAL DATA; TIME FACTOR; TRANSMISSION; TUBERCULOSIS, PULMONARY;

ADULT; BACTERIAL TYPING TECHNIQUES; CHILD; CONTACT TRACING; DNA, BACTERIAL; FEMALE; HUMANS; INCIDENCE; MALAWI; MALE; MICROSCOPY; MIDDLE AGED; MYCOBACTERIUM TUBERCULOSIS; POLYMORPHISM, SINGLE NUCLEOTIDE; RURAL POPULATION; SEQUENCE ANALYSIS, DNA; TIME FACTORS; TUBERCULOSIS, PULMONARY;

EID: 84940784745     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0132840     Document Type: Article

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