Mucosal glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide cell numbers in the super-obese human foregut after gastric bypass

Surgery for Obesity and Related Diseases

Volumn 11, Issue 6, 2015, Pages 1237-1246

  Nergård, Bent J ^a   Lindqvist, Andreas ^b   Gislason, Hjörtur G ^a   Groop, Leif ^b   Ekelund, Mikael ^c   Wierup, Nils ^b   Hedenbro, Jan L ^a,c  

^a Aleris Obesity Academy   (Sweden)

^b LUND UNIVERSITY DIABETES CENTRE   (Sweden)

^c LUND UNIVERSITY   (Sweden)

Author keywords

Enterohormones; Gastric bypass; GIP; GLP 1; Incretins; Superobesity

Indexed keywords

CHOLECYSTOKININ; GASTRIC INHIBITORY POLYPEPTIDE; GHRELIN; GLUCAGON LIKE PEPTIDE 1; HISTAMINE; MESSENGER RNA; NEUROTENSIN; SECRETIN; SEROTONIN; SOMATOSTATIN; BIOLOGICAL MARKER; GASTRIC INHIBITORY POLYPEPTIDE (1-42); GLUCOSE BLOOD LEVEL; PEPTIDE FRAGMENT;

ADULT; ARTICLE; BARIATRIC SURGERY; BILIOPANCREATIC BYPASS; CELL COUNT; CELL DENSITY; CELL POPULATION; CLINICAL ARTICLE; CONTROLLED STUDY; DEMOGRAPHY; ENTEROENDOCRINE CELL; FEMALE; FOREGUT; GENE EXPRESSION; HIGH VOLUME HOSPITAL; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOCOMPETENT CELL; INTESTINE ENDOSCOPY; INTESTINE MUCOSA; INTESTINE VILLUS; JEJUNUM; JEJUNUM BIOPSY; LAPAROSCOPIC ROUX EN Y GASTRIC BYPASS; LAPAROSCOPIC SURGERY; MALE; OBESITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; RANDOMIZED CONTROLLED TRIAL (TOPIC); REAL TIME POLYMERASE CHAIN REACTION; ROUX Y ANASTOMOSIS; STOMACH BYPASS; SUPER OBESITY; SURGICAL PATIENT; UNIVERSITY HOSPITAL; BODY MASS; GASTRIC BYPASS SURGERY; GLUCOSE BLOOD LEVEL; INSULIN RESISTANCE; METABOLISM; MIDDLE AGED; OBESITY, MORBID; PATHOLOGY; PHYSIOLOGY; POSTOPERATIVE PERIOD; PROGNOSIS; RANDOMIZED CONTROLLED TRIAL; STOMACH MUCOSA; YOUNG ADULT;

ADULT; BIOMARKERS; BLOOD GLUCOSE; BODY MASS INDEX; CELL COUNT; FEMALE; GASTRIC BYPASS; GASTRIC INHIBITORY POLYPEPTIDE; GASTRIC MUCOSA; GLUCAGON-LIKE PEPTIDE 1; HUMANS; INSULIN RESISTANCE; MALE; MIDDLE AGED; OBESITY, MORBID; PEPTIDE FRAGMENTS; POSTOPERATIVE PERIOD; PROGNOSIS; YOUNG ADULT;

EID: 84940783047     PISSN: 15507289     EISSN: 18787533     Source Type: Journal    
DOI: 10.1016/j.soard.2015.03.021     Document Type: Article

References (36)

1. L. Sjöström Bariatric surgery and reduction in morbidity and mortality: experiences from the SOS study Int J Obes (Lond) 32 Suppl 7 2008 S93 S97
2. L. Sjöström Review of the key results from the Swedish Obese Subjects (SOS) trial - a prospective controlled intervention study of bariatric surgery J Intern Med 273 3 2013 219 234
3. J. Karlsson, L. Sjostrom, and M. Sullivan Swedish obese subjects (SOS) - an intervention study of obesity. Two-year follow-up of health-related quality of life (HRQL) and eating behavior after gastric surgery for severe obesity Int J Obes Relat Metab Disord 22 2 1998 113 126
4. N.V. Christou, D. Look, and L.D. Maclean Weight gain after short- and long-limb gastric bypass in patients followed for longer than 10 years Ann Surg 244 5 2006 734 740
5. B.J. Nergaard, B.G. Leifsson, J. Hedenbro, and H. Gislason Gastric bypass with long alimentary limb or long pancreato-biliary limb - long-term results on weight loss, resolution of co-morbidities and metabolic parameters Obes Surg 24 10 2014 1595 1602
6. Brolin RE, LaMarca LB, Kenler HA, Cody RP. Malabsorptive gastric bypass in patients with superobesity. J Gastrointest Surg 2002;6(2):195-203; discussion 4-5.
7. G. Bottcher, K. Sjolund, E. Ekblad, R. Håkanson, T.W. Schwartz, and F. Sundler Coexistence of peptide YY and glicentin immunoreactivity in endocrine cells of the gut Regul Pept 8 4 1984 261 266
8. S.H. Jacobsen, S.C. Olesen, C. Dirksen, and et al. Changes in gastrointestinal hormone responses, insulin sensitivity, and beta-cell function within 2 weeks after gastric bypass in non-diabetic subjects Obes Surg 22 7 2012 1084 1096
9. R.S. Rao, and S. Kini GIP and bariatric surgery Obes Surg 21 2 2011 244 252
10. H. Ashrafian, T. Athanasiou, J.V. Li, and et al. Diabetes resolution and hyperinsulinaemia after metabolic Roux-en-Y gastric bypass Obes Rev 12 5 2011 e257 e272
11. L.L. Baggio, and D.J. Drucker Biology of incretins: GLP-1 and GIP Gastroenterology 132 6 2007 2131 2157
12. R. Kohli, K.D. Setchell, M. Kirby, and et al. A surgical model in male obese rats uncovers protective effects of bile acids post-bariatric surgery Endocrinology 154 7 2013 2341 2351
13. D.J. Pournaras, C. Glicksman, R.P. Vincent, S. Kuganolipava, J. Alaghband-Zadeh, D. Mahon, and et al. The role of bile after Roux-en-Y gastric bypass in promoting weight loss and improving glycaemic control Endocrinology 153 8 2012 3613 3619
14. T.E. Sweeney, and J.M. Morton The human gut microbiome: a review of the effect of obesity and surgically induced weight loss JAMA Surg 148 2013 563 569
15. A. Lindqvist, P. Spégel, M. Ekelund, and et al. Gastric bypass improves β-cell function and increases beta-cell mass in a porcine model Diabetes 63 5 2014 1665 1671
16. C.W. le Roux, C. Borg, K. Wallis, and et al. Gut hypertrophy after gastric bypass is associated with increased glucagon-like peptide 2 and intestinal crypt cell proliferation Ann Surg 252 1 2010 50 56
17. M.B. Mumphrey, L.M. Patterson, H. Zheng, and H.R. Berthoud Roux-en-Y gastric bypass surgery increases number but not density of CCK-, GLP-1-, 5-HT-, and neurotensin-expressing enteroendocrine cells in rats Neurogastroenterol Motil 25 1 2013 e70 e79
18. C.F. Hansen, M. Bueter, N. Theis, and et al. Hypertrophy dependent doubling of L-cells in Roux-en-Y gastric bypass operated rats PLoS One 8 6 2013 e65696
19. C.B. Chan, A.M. Buchan, K.A. Green, and R.A. Pederson The effect of jejunoileal bypass (JIB) in the obese Zucker rat on a sub-group of enteroendocrine cells Int J Obes 11 3 1987 285 293
20. H. Mendieta-Zerón, A. Larrad-Jiménez, M.A. Burrell, and et al. Biliopancreatic diversion induces villi elongation and cholecystokinin and ghrelin increase Diabetes Metab Syndr 5 2 2011 66 70
21. L. Ockander, J.L. Hedenbro, J.F. Rehfeld, and K. Sjolund Jejunoileal bypass changes the duodenal cholecystokinin and somatostatin cell density Obes Surg 13 4 2003 584 590
22. E. Aghajani, H.J. Jacobsen, B.J. Nergaard, J.L. Hedenbro, B.G. Leifson, and H. Gislason Internal hernia after gastric bypass: a new and simplified technique for laparoscopic primary closure of the mesenteric defects J Gastrointest Surg 16 3 2012 641 645
23. K. Landerholm, S.E. Falkmer, J. Jarhult, F. Sundler, and N. Wierup Cocaine- and amphetamine-regulated transcript in neuroendocrine tumors Neuroendocrinology 94 3 2011 228 236
24. N. Wierup, M. Björkqvist, B. Weström, S. Pierzynowski, F. Sundler, and K. Sjölund Ghrelin and motilin are cosecreted from a prominent endocrine cell population in the small intestine J Clin Endocrinol Metab 92 9 2007 3573 3581
25. K. Sjölund, S. Fasth, R. Ekman, and et al. Neuropeptides in idiopathic chronic constipation (slow transit constipation) Neurogastroenterol Motil 9 3 1997 143 150
26. H. Buchwald, R. Estok, K. Fahrbach, and et al. Weight and type 2 diabetes after bariatric surgery: systematic review and meta-analysis Am J Med 122 3 2009 248 256 e5
27. L. Sjöstrom, M. Peltonen, P. Jacobson, and et al. Association of bariatric surgery with long-term remission of type 2 diabetes and with microvascular and macrovascular complications JAMA 311 22 2014 2297 2304
28. J.J. Holst Enteroendocrine secretion of gut hormones in diabetes, obesity and after bariatric surgery Curr Opin Pharmacol 13 6 2013 983 988
29. M. Salehi, and D.A. D'Alessio Effects of glucagon like peptide-1 to mediate glycemic effects of weight loss surgery Rev Endocr Metab Disord 15 2014 171 179
30. M.A. Valencia-Sanchez, J. Liu, G.J. Hannon, and R. Parker Control of translation and mRNA degradation by miRNAs and siRNAs Genes Dev 20 5 2006 515 524
31. A. Lindqvist, P. Spégel, M. Ekelund, and et al. Effects of ingestion routes on hormonal and metabolic profiles in gastric-bypassed humans J Clin Endocrinol Metab 98 5 2013 E856 E861
32. B. Laferrère, S. Heshka, K. Wang, and et al. Incretin levels and effect are markedly enhanced 1 month after Roux-en-Y gastric bypass surgery in obese patients with type 2 diabetes Diabetes Care 30 7 2007 1709 1716
33. B. Laferrère, J. Teixeira, J. McGinty, and et al. Effect of weight loss by gastric bypass surgery versus hypocaloric diet on glucose and incretin levels in patients with type 2 diabetes J Clin Endocrinol Metab 93 7 2008 2479 2485
34. N. Wierup, A. Lindqvist, P. Spégel, L. Groop, J. Hedenbro, and M. Ekelund Short- and long-term hormonal and metabolic consequences of reversing gastric bypass to normal anatomy in a type 2 diabetes patient Obes Surg 25 1 2015 180 185
35. E. Spak, P. Björklund, H.F. Helander, and et al. Changes in the mucosa of the Roux-limb after gastric bypass surgery Histopathology 57 5 2010 680 688
36. P. Barrett, R.C. Hobbs, P.J. Coates, R.A. Risdon, N.A. Wright, and P.A. Hall Endocrine cells of the human gastrointestinal tract have no proliferative capacity Histochem J 27 6 1995 482 486