Perinatal outcomes from the use of antiepileptic drugs during pregnancy: A case-control study

Journal of Maternal-Fetal and Neonatal Medicine

Volumn 28, Issue 12, 2015, Pages 1445-1450

  Barroso, Frederico Vitório Lopes ^a,b   Araujo, Edward ^a   Guazelli, Cristina Aparecida Falbo ^a   Santana, Eduardo Felix Martins ^a   Rolo, Liliam Cristine ^a   Martins, Marília Da Glória ^b   Moron, Antonio Fernandes ^a  

^a FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

^b FEDERAL UNIVERSITY OF MARANHÃO   (Brazil)

Author keywords

Antiepileptic drug; epilepsy; perinatal outcome; pregnancy

Indexed keywords

ANTICONVULSIVE AGENT; CARBAMAZEPINE; DIAZEPAM; HYDANTOIN; PHENOBARBITAL; VALPROIC ACID;

ADULT; APGAR SCORE; ARTICLE; CASE CONTROL STUDY; CHILDBIRTH; COMBINATION CHEMOTHERAPY; CONGENITAL MALFORMATION; CONTROLLED STUDY; DELIVERY; DRUG USE; EPILEPSY; FEMALE; GESTATIONAL AGE; HUMAN; LONGITUDINAL STUDY; LOW BIRTH WEIGHT; MAJOR CLINICAL STUDY; MALE; MONOTHERAPY; NEWBORN; NEWBORN HEMORRHAGIC DISEASE; NEWBORN MORTALITY; PERINATAL MORBIDITY; PERINATAL PERIOD; PREGNANCY OUTCOME; PREMATURITY; PRENATAL DRUG EXPOSURE; PRIORITY JOURNAL; RETROSPECTIVE STUDY; STILLBIRTH; COMPLICATION; CONGENITAL ABNORMALITIES; HEMORRHAGIC DISORDERS; INFANT; INFANT MORTALITY; PREGNANCY; PREGNANCY COMPLICATIONS;

ADULT; ANTICONVULSANTS; APGAR SCORE; CASE-CONTROL STUDIES; CONGENITAL ABNORMALITIES; EPILEPSY; FEMALE; GESTATIONAL AGE; HEMORRHAGIC DISORDERS; HUMANS; INFANT; INFANT MORTALITY; INFANT, NEWBORN; LONGITUDINAL STUDIES; PHENOBARBITAL; PREGNANCY; PREGNANCY COMPLICATIONS; PREGNANCY OUTCOME; RETROSPECTIVE STUDIES;

EID: 84940764976     PISSN: 14767058     EISSN: 14764954     Source Type: Journal    
DOI: 10.3109/14767058.2014.955006     Document Type: Article

References (29)

1. Kulaga S, Sheehy O, Zargarzadeh AH, et al. Antiepileptic drug use during pregnancy: perinatal outcomes. Seizure 2011;20:667-72.
2. Fisher RS, van Emde Boas W, Blume W, et al. Epileptic seizures and epilepsy: definitions proposed by the International League Against Epilepsy (ILAE) and the International Bureau for Epilepsy (IBE). Epilepsia 2005;46:470-2.
3. Tomson T, Battino D. Teratogenic effects of antiepileptic drugs. Lancet Neurol 2012;11:803-13.
4. Dominguez M, Díaz-Obregón MC, Bhathal H, Santiago R. [Epilepsy and pregnancy]. Rev Neurol 2001;33:1179-85.
5. Hart LA, Sibai BM. Seizures in pregnancy: epilepsy, eclampsia, and stroke. Semin Perinatol 2013;37:207-24.
6. Wide K, Winbladh B, Tomson T, Kallen B. Body dimensions of infants exposed to antiepileptic drugs in utero: observations spanning 25 years. Epilepsia 2000;41:854-61.
7. Frey L, Hauser WA. Epidemiology of neural tube defects. Epilepsia 2003;44:4-13.
8. Williams J, Myson V, Steward S, et al. Self-discontinuation of antiepileptic medication in pregnancy: detection by hair analysis. Epilepsia 2002;43:824-31.
9. Briggs GG, Freeman RK, Yaffe SJ. Drugs in pregnancy and lactation. Philadephia, PA: Lippincott, Williams & Wilkins; 2002.
10. Capurro H, Konichezky S, Fonseca D, Caldeyro-Barcia R. A simplified method for diagnosis of gestational age in the newborn infant. J Pediatr 1978;93:120-2.
11. Ballard JL, Novak KK, Driver M. New Ballard Score. J Pediatric 1991;119:417-21.
12. Alexander GR, Himes JH, Kaufman RB, et al. A United States national reference for fetal growth. Obstet Gynecol 1996;87:163-8.
13. Perucca E. Current trends in antiepileptic drug therapy. Epilepsia 2003;4:41-7.
14. Lorenzato RZ, Cavalli RC, Duarte G, et al. [Epilepsy and pregnancy: evolution and repercussions]. Rev Bras Ginecol Obstet 2002;24:521-6.
15. Katz JM, Devinsky O. Primary generalized epilepsy: a risk factor for seizures in labor and delivery? Seizure 2003;12:217-19.
16. Battino D. Assessment of teratogenic risk. Epilepsy Res 2001;45:171-3.
17. Wide K, Winbladh B, Kallen B. Major malformations in infants exposed to antiepileptic drugs in utero, with emphasis on carbamazepine and valproic acid: a nation-wide, population-based register study. Acta Paediatr 2004;93:174-6.
18. Perucca E. Birth defects after prenatal exposure to antiepileptic drugs. Lancet Neurol 2005;4:781-6.
19. Kaplan PW. Reproductive health effects and teratogenicity of antiepileptic drugs. Neurology 2004;63:S13-23.
20. Katz O, Wiznitzer A, Levy A, Sheiner E. Pregnancy and perinatal outcome in epileptic women: a population-based study. J Mater Fetal Neonatal Med 2006;1:21-5.
21. Al Bunyan M, Zainab A-T. Outcome of pregnancies in epileptic women: a study in Saudi Arabia. Seizure 1999;8:26-9.
22. Yerby MS, Kaplan P, Tran T. Risks and management of pregnancy in women with epilepsy. Cleve Clin J Med 2004;2:S25-37.
23. Richmond JR, Krishnamoorthy P, Andermann E, Benjamin A. Epilepsy and pregnancy: an obstetric perspective. Am J Obstet Gynecol 2004;190:371-9.
24. Morrow J, Russell A, Guthrie E, et al. Malformation risks of antiepileptic drugs in pregnancy: a prospective study from the UK Epilepsy and Pregnancy Register. J Neurol Neurosurg Psychiatry 2006;77:193-8.
25. Canger R, Battino D, Canevini MP, et al. Malformations in offspring of women with epilepsy: a prospective study. Epilepsia 1999;40:1231-6.
26. Trousdale RT. Fetal hydantoin syndrome: an unusual cause of hip dysplasia. Orthopedics 1998;21:210-12.
27. Duncan S, Mercho S, Lopes-Cendes I, et al. Repeated neural tube defects and valproate monotherapy suggest a pharmacogenetic abnormality. Epilepsia 2001;42:750-3.
28. Wide K, Winbladh B, Kallen B. Major malformations in infants exposed to antiepileptic drugs in utero, with emphasis on carbamazepine and valproic acid: a nation-wide, population-based register study. Acta Paediatr 2004;93:174-6.
29. Nulman I, Laslo D, Koren G. Treatment of epilepsy in pregnancy. Drugs 1999;57:535-44.