Body dimensions of infants exposed to antiepileptic drugs in utero: Observations spanning 25 years

Epilepsia

Volumn 41, Issue 7, 2000, Pages 854-861

  Wide, K ^c   Winbladh, B ^a,c   Tomson, T ^b,c   Kallen B ^c  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^b UNIVERSITY OF LUND   (Sweden)

^c SACHS CHILDREN S HOSPITAL   (Sweden)

Author keywords

Antiepileptics; Body dimensions; Carbamazepine; Fetal growth; Pregnancy

Indexed keywords

ANTICONVULSIVE AGENT; CARBAMAZEPINE; CLONAZEPAM; LAMOTRIGINE; PHENOBARBITAL; PHENYTOIN; PRIMIDONE;

ARTICLE; BIRTH WEIGHT; BODY HEIGHT; EPILEPSY; FEMALE; FETUS GROWTH; HEAD CIRCUMFERENCE; HUMAN; INFANT; INFANT DISEASE; MAJOR CLINICAL STUDY; MALE; PRENATAL DRUG EXPOSURE; PRIORITY JOURNAL;

EID: 0033922409     PISSN: 00139580     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1528-1157.2000.tb00253.x     Document Type: Article

References (23)

1. Bossi L. Fetal effects of anticonvulsants. In: Morselli PL, Pippenger CE, Penry JK, eds. Antiepileptic Drug Therapy in Pediatrics. New York: Raven Press, 1983:37-64.
2. Hanson JW, Myrainthopoulos NC, Sedgewick Harvey MA. Smith DW. Risks to the offspring of women treated with hydantoin anticonvulsants, with emphasis on the fetal hydantoin syndrome. Pediatrics 1976;89:662-8.
3. Hiilesmaa VK, Teramo K, Granström M-L, Bardy AH. Fetal head growth retardation associated with maternal antiepileptic drugs. Lancet 1981;July 25:165-7.
4. Battino D, Granata T, Binelli S, et al. Intrauterine growth in the offspring of epileptic mothers. Acta Neurol Scand 1992;86:555-7.
5. Steegers-Theunissen R, Renier W, Borm G, et al. Factors influencing the risk of abnormal pregnancy outcome in epileptic women: a multi-centre prospective study. Epilepsy Res 1994;18: 261-9.
6. Bertollini R. Källén B, Mastroiacovo P. Robert E. Anticonvulsant drugs in monotherapy: effects on the fetus. Eur J Epidemiol 1987; 3:164-71.
7. Mastroiacovo P, Bertollini R, Licata D, et al. Fetal growth in the offspring of epileptic women: results of an Italian multicentric cohort study. Acta Neurol Scand 1988;78:110-4.
8. Källén B. A register study of maternal epilepsy and delivery outcome with special reference to drug use. Acta Neurol Scand 1986; 73:253-9.
9. Källén B. Maternal carbamazepine and infant spina bifida. Reprod Toxicol 1994;8:203-5.
10. Wide K, Winbladh B, Tomson T, Sars-Zimmer K, Berggren E. Psychomotor development and minor anomalies in children exposed to antiepileptic drugs in utero: a prospective population based case-control study. Dev Med Child Neurol 2000;42:87-92.
11. Tomson T, Lindbom U, Ekqvist B, Sundqvist A. Epilepsy and pregnancy: a prospective study of seizure control in relation to free and total plasma concentrations of carbamazepine and phenytoin. Epilepsia 1994;35:122-30.
12. Gaily E. Kantola-Sorsa E, Granström M-L. Specific cognitive dysfunction in children with epileptic mothers. Dev Med Child Neurol 1990;32:403-14.
13. Dunsky LV, Finnell LV. Parental epilepsy, anticonvulsant drugs, and reproductive outcome: epidemiological and experimental findings spanning three decades, 2 Human studies. Reprod Toxicol 1991;5:301-35.
14. Cnattinigius S, Ericsson A, Gunnarskog J, Källén B. A quality study of medical birth registry. Scand J Soc Med 1990;18:143-8.
15. Källén B. Delivery outcome after the use of acid-suppressing drugs in early pregnancy with special reference to omeprazole. Br J Obstet Gynaecol 1998;105:877-81.
16. Källén B. A birth weight for gestational age standard based on data in the Swedish Medical Birth Registry, 1985-1989. Eur J Epidemiol 1995;11:601-6.
17. Mantel N, Haenszel W. Statistical aspects of the analysis of data from retrospective studies of disease. J Nail Cancer Inst 1959;22: 719-48.
18. Miettinen OS. Simple interval estimation of risk ratio. Am J Epidemiol 1974;100:515-6.
19. Armitage P. Test for linear trend in proportions and frequencies. Biometrica 1955;11:375-86.
20. Battino D, Kaneko S, Andermann E, et al. Intrauterine growth in the offspring of epileptic women: a prospective multicenter study. Epilepsy Res 1999;36:53-60.
21. Robert E, Källén B. In utero exposure to carbamazepine: effects on the fetus. Issues Rev Teratol 1994;7:37-55.
22. Hiilesmaa VK, Teramo K, Granström M-L. Fetal head growth retardation associated with maternal antiepileptic drugs. Lancet 1981;July 25(8239):165-7.
23. Gaily E, Granström M-L, Hiilesmaa V, Bardy A. Head circumference in children of epileptic mothers: contributions of drug exposure and genetic background. Epilepsy Res 1990;3:217-22.