Antiepileptic drug use during pregnancy: Perinatal outcomes

Seizure

Volumn 20, Issue 9, 2011, Pages 667-672

  Kulaga, Sophie ^a,b   Sheehy, Odile ^b   Zargarzadeh, Amir H ^a,c   Moussally, Krystel ^b   Bérard, Anick ^a,b  

^a UNIVERSITÉ DE MONTRÉAL   (Canada)

^b UNIVERSITY OF MONTREAL   (Canada)

^c WESTERN UNIVERSITY OF HEALTH SCIENCES   (United States)

Author keywords

Antiepileptic drugs; Discontinuation; Monotherapy; Polytherapy; Pregnancy; Quebec Pregnancy Registry

Indexed keywords

CARBAMAZEPINE; CLOBAZAM; VALPROIC ACID;

ABORTION; ADULT; ARTICLE; CONGENITAL MALFORMATION; CONTROLLED STUDY; DRUG USE; EPILEPSY; FEMALE; HUMAN; LIVE BIRTH; LOW BIRTH WEIGHT; MAJOR CLINICAL STUDY; MATERNAL AGE; MONOTHERAPY; PREGNANCY OUTCOME; PREMATURITY; PRENATAL DRUG EXPOSURE; PRIORITY JOURNAL; REGISTER; RISK ASSESSMENT; SMALL FOR DATE INFANT; SPONTANEOUS ABORTION; STILLBIRTH; THERAPY; TREATMENT WITHDRAWAL;

ABNORMALITIES, DRUG-INDUCED; ADOLESCENT; ADULT; ANTICONVULSANTS; CARBAMAZEPINE; COHORT STUDIES; DRUG THERAPY, COMBINATION; EPILEPSY; FEMALE; HUMANS; INFANT, NEWBORN; MIDDLE AGED; PREGNANCY; PREGNANCY OUTCOME; PRENATAL EXPOSURE DELAYED EFFECTS; QUEBEC; REGISTRIES; VALPROIC ACID; YOUNG ADULT;

EID: 80053576080     PISSN: 10591311     EISSN: 15322688     Source Type: Journal    
DOI: 10.1016/j.seizure.2011.06.012     Document Type: Article

References (38)

1. I. Borthen, M.G. Eide, G. Veiby, A.K. Daltveit, and N.E. Gilhus Complications during pregnancy in women with epilepsy: population-based cohort study BJOG 116 2009 1736 1742
2. K. Brosh, I. Matok, E. Sheiner, G. Koren, A. Wiznitzer, and R. Gorodischer Teratogenic determinants of first-trimester exposure to antiepileptic medications J Popul Ther Clin Pharmacol 18 2011 e89 e98 [Epub March 21, 2011]
3. S. Fried, E. Kozer, I. Nulman, T.R. Einarson, and G. Koren Malformation rates in children of women with untreated epilepsy: a meta-analysis Drug Saf 27 2004 197 202 (Pubitemid 38315328)
4. M. Artama, A. Auvinen, T. Raudaskoski, I. Isojarvi, and J. Isojarvi Antiepileptic drug use of women with epilepsy and congenital malformations in offspring Neurology 64 2005 1874 1878 (Pubitemid 40800700)
5. L.B. Holmes, E.A. Harvey, B.A. Coull, K.B. Huntington, and S. Khoshbin The teratogenicity of anticonvulsant drugs N Engl J Med 344 2001 1132 1138 (Pubitemid 32285234)
6. J. Morrow, A. Russell, E. Guthrie, L. Parsons, I. Robertson, and R. Waddell Malformation risks of antiepileptic drugs in pregnancy: a prospective study from the UK Epilepsy and Pregnancy Register J Neurol Neurosurg Psychiatry 77 2006 193 198 (Pubitemid 43220841)
7. N. Adab, U. Kini, J. Vinten, J. Ayres, G. Baker, and J. Clayton-Smith The longer term outcome of children born to mothers with epilepsy J Neurol Neurosurg Psychiatry 75 2004 1575 1583 (Pubitemid 39430610)
8. K.J. Meador Neurodevelopmental effects of antiepileptic drugs Curr Neurol Neurosci Rep 2 2002 373 378
9. G. Montouris Importance of monotherapy in women across the reproductive cycle Neurology 69 2007 S10 S16
10. P.B. Pennell The importance of monotherapy in pregnancy Neurology 60 2003 S31 S38
11. F.M. Martinez, M.P. Pena, I. Pérez Lopez-Fraile, M.D. Castro Vilanova, S.A. Escartin, and M.M. Martin Malformations and fetal death in the Spanish antiepileptic drug and pregnancy registry: results at 6 years Neurologia 24 2009 360 365
12. S. Eisenschenk Treatment with oxcarbazepine during pregnancy Neurologist 12 2006 249 254 (Pubitemid 44440019)
13. R. Kretz, I. Coban, V. Gaus, and B. Schmitz EURAP: the European Registry of Antiepileptic Drugs and Pregnancy Nervenarzt 77 2006 722 728 (Pubitemid 44124115)
14. G. Montouris Safety of the newer antiepileptic drug oxcarbazepine during pregnancy Curr Med Res Opin 21 2005 693 701 (Pubitemid 40695290)
15. J. Wilby, A. Kainth, N. Hawkins, D. Epstein, H. McIntosh, and C. McDaid Clinical effectiveness, tolerability and cost-effectiveness of newer drugs for epilepsy in adults: a systematic review and economic evaluation Health Technol Assess 9 2005 1 4
16. K.J. Meador, G.A. Baker, N. Browning, J. Clayton-Smith, D.T. Combs-Cantrell, and M. Cohen Cognitive function at 3 years of age after fetal exposure to antiepileptic drugs N Engl J Med 360 2009 1597 1605
17. K. Wide, B. Winbladh, and B. Kallen Major malformations in infants exposed to antiepileptic drugs in utero, with emphasis on carbamazepine and valproic acid: a nation-wide, population-based register study Acta Paediatr 93 2004 174 176 (Pubitemid 38230710)
18. D.F. Wyszynski, M. Nambisan, T. Surve, R.M. Alsdorf, C.R. Smith, and L.B. Holmes Increased rate of major malformations in offspring exposed to valproate during pregnancy Neurology 64 2005 961 965 (Pubitemid 40388443)
19. H.R. Nakhai-Pour, P. Broy, and A. Berard Use of antidepressants during pregnancy and the risk of spontaneous abortion CMAJ 182 2010 1031 1037
20. Régie de l'assurance maladie du Québec Statistiques Annuelles 2009-2010 2010 Gouvernement du Québec
21. S. Kulaga, A.H. Zargarzadeh, and A. Berard Prescriptions filled during pregnancy for drugs with the potential of fetal harm BJOG 116 2009 1788 1795
22. Eurap Study Group Utilization of antiepileptic drugs during pregnancy: comparative patterns in 38 countries based on data from the EURAP registry Epilepsia 50 2009 2305 2309
23. E. Ramos, M. St-Andre, E. Rey, D. Oraichi, and A. Berard Duration of antidepressant use during pregnancy and risk of major congenital malformations Br J Psychiatry 92 2008 344 350 (Pubitemid 351692378)
24. R. Tamblyn, G. Lavoie, L. Petrella, and J. Monette The use of prescription claims databases in pharmacoepidemiological research: the accuracy and comprehensiveness of the prescription claims database in Quebec J Clin Epidemiol 48 1995 999 1009
25. A.R. Levy, N.E. Mayo, and G. Grimard Rates of transcervical and pertrochanteric hip fractures in the province of Quebec Canada, 1981-1992 Am J Epidemiol 142 1995 428 436
26. A. Vilain, S. Otis, A. Forget, and L. Blais Agreement between administrative databases and medical charts for pregnancy-related variables among asthmatic women Pharmacoepidemiol Drug Saf 17 2008 345 353 (Pubitemid 351566350)
27. A. Berard, and A. Lacasse Validity of perinatal pharmacoepidemiologic studies using data from the RAMQ administrative database Can J Clin Pharmacol 16 2009 e360 e369
28. L. Blais, F.Z. Kettani, N. Elftouh, and A. Forget Effect of maternal asthma on the risk of specific congenital malformations: a population-based cohort study Birth Defects Res A: Clin Mol Teratol 88 2010 216 222
29. M.S. Kramer, R.W. Platt, S.W. Wen, K.S. Joseph, A. Allen, and M. Abrahamowicz A new and improved population-based Canadian reference for birth weight for gestational age Pediatrics 108 2001 E35
30. K.J. Meador, P.B. Pennell, C.L. Harden, J.C. Gordon, T. Tomson, and P.W. Kaplan Pregnancy registries in epilepsy: a consensus statement on health outcomes Neurology 71 2008 1109 1117
31. R.L. Bromley, G. Mawer, J. Love, J. Kelly, L. Purdy, and L. McEwan Early cognitive development in children born to women with epilepsy: a prospective report Epilepsia 2010
32. S. Duncan Teratogenesis of sodium valproate Curr Opin Neurol 20 2007 175 180 (Pubitemid 46411503)
33. P. Genton, F. Semah, and E. Trinka Valproic acid in epilepsy: pregnancy-related issues Drug Saf 29 2006 1 21 (Pubitemid 43213892)
34. National Institute of Neurological Disorders Seizures and epilepsy: hope through research 2004
35. C. Aaron Seizure disorders in pregnancy eMed J 2011
36. S. Kulaga, and A. Berard Congenital malformations: agreement between diagnostic codes in an administrative database and mothers' reports J Obstet Gynaecol Can 32 2010 549 554
37. N.F. Moran, K. Poole, G. Bell, J. Solomon, S. Kendall, and M. McCarthy Epilepsy in the United Kingdom: seizure frequency and severity, anti-epileptic drug utilization and impact on life in 1652 people with epilepsy Seizure 13 2004 425 433 (Pubitemid 39022849)
38. D.C. Heaney, B.K. MacDonald, A. Everitt, S. Stevenson, G.S. Leonardi, and P. Wilkinson Socioeconomic variation in incidence of epilepsy: prospective community based study in South East England BMJ 325 2002 1013 1016 (Pubitemid 35305153)