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Volumn 39, Issue 5, 2015, Pages 299-304

Five Years of Deferasirox Therapy for Cardiac Iron in β-Thalassemia Major

Author keywords

5 years; cardiac magnetic resonance imaging (MRI) T2 ; deferasirox (DFX); ferritin; left ventricular ejection fraction (LVEF); Thalassemia major ( TM)

Indexed keywords

CREATININE; DEFERASIROX; FERRITIN; LIVER ENZYME; BENZOIC ACID DERIVATIVE; IRON; IRON CHELATING AGENT; TRIAZOLE DERIVATIVE;

EID: 84940740266     PISSN: 03630269     EISSN: 1532432X     Source Type: Journal    
DOI: 10.3109/03630269.2015.1064003     Document Type: Review
Times cited : (10)

References (34)
  • 1
    • 20844460608 scopus 로고    scopus 로고
    • Survival and complications in patients with thalassemia major treated with transfusion and deferoxamine
    • Borgna-Pignatti C, Rugolotto S, De Stefano P, et al. Survival and complications in patients with thalassemia major treated with transfusion and deferoxamine. Haematologica. 2004;89(10):1187-1193.
    • (2004) Haematologica. , vol.89 , Issue.10 , pp. 1187-1193
    • Borgna-Pignatti, C.1    Rugolotto, S.2    De Stefano, P.3
  • 2
    • 0034631379 scopus 로고    scopus 로고
    • Survival in β-thalassaemia major in the UK: Data from the UK Thalassaemia Register
    • Modell B, Khan M, Darlison M. Survival in β-thalassaemia major in the UK: Data from the UK Thalassaemia Register. Lancet. 2000;355(9220):2051-2052.
    • (2000) Lancet. , vol.355 , Issue.9220 , pp. 2051-2052
    • Modell, B.1    Khan, M.2    Darlison, M.3
  • 3
    • 0030048681 scopus 로고    scopus 로고
    • Results of long-term iron-chelating therapy
    • Gabutti V, Piga A. Results of long-term iron-chelating therapy. Acta Haematol. 1996;95(1):26-36.
    • (1996) Acta Haematol. , vol.95 , Issue.1 , pp. 26-36
    • Gabutti, V.1    Piga, A.2
  • 4
    • 0002371305 scopus 로고    scopus 로고
    • Clinical consequences of new insights in the pathophysiology of disorders of iron and heme metabolism
    • Brittenham GM, Weiss G, Brissot P, et al. Clinical consequences of new insights in the pathophysiology of disorders of iron and heme metabolism. Hematology Am Soc Hematol Educ Program. 2000:39-50.
    • (2000) Hematology Am Soc Hematol Educ Program. , pp. 39-50
    • Brittenham, G.M.1    Weiss, G.2    Brissot, P.3
  • 5
    • 0035725868 scopus 로고    scopus 로고
    • Practical management of iron overload
    • Porter JB. Practical management of iron overload. Br J Haematol. 2001;115(2):239-252.
    • (2001) Br J Haematol. , vol.115 , Issue.2 , pp. 239-252
    • Porter, J.B.1
  • 6
    • 33745551087 scopus 로고    scopus 로고
    • Low serum ferritin levels are misleading for detecting cardiac iron overload and increase the risk of cardiomyopathy in thalassemia patients. The importance of cardiac iron overload monitoring using magnetic resonance imaging T2 and T2∗
    • Kolnagou A, Economides C, Eracleous E, Kontoghiorghes GJ. Low serum ferritin levels are misleading for detecting cardiac iron overload and increase the risk of cardiomyopathy in thalassemia patients. The importance of cardiac iron overload monitoring using magnetic resonance imaging T2 and T2∗. Hemoglobin. 2006;30(2):219-227.
    • (2006) Hemoglobin. , vol.30 , Issue.2 , pp. 219-227
    • Kolnagou, A.1    Economides, C.2    Eracleous, E.3    Kontoghiorghes, G.J.4
  • 7
    • 27644539382 scopus 로고    scopus 로고
    • Intracellular labile iron pools as direct targets of iron chelators: A fluorescence study of chelator action in living cells
    • Glickstein H, El RB, Shvartsman M, Cabantchik ZI. Intracellular labile iron pools as direct targets of iron chelators: A fluorescence study of chelator action in living cells. Blood. 2005;106(9):3242-3250.
    • (2005) Blood. , vol.106 , Issue.9 , pp. 3242-3250
    • Glickstein, H.1    El, R.B.2    Shvartsman, M.3    Cabantchik, Z.I.4
  • 8
    • 33750001927 scopus 로고    scopus 로고
    • Action of chelators in iron-loaded cardiac cells: Accessibility to intracellular labile iron and functional consequences
    • Glickstein H, El RB, Link G, et al. Action of chelators in iron-loaded cardiac cells: Accessibility to intracellular labile iron and functional consequences. Blood. 2006;108(9):3195-3203.
    • (2006) Blood. , vol.108 , Issue.9 , pp. 3195-3203
    • Glickstein, H.1    El, R.B.2    Link, G.3
  • 9
    • 18044399191 scopus 로고    scopus 로고
    • Cardiovascular T2-star (T2∗) magnetic resonance for the early diagnosis of myocardial iron overload
    • Anderson LJ, Holden S, Davis B, et al. Cardiovascular T2-star (T2∗) magnetic resonance for the early diagnosis of myocardial iron overload. Eur Heart J. 2001;22(23):2171-2179.
    • (2001) Eur Heart J. , vol.22 , Issue.23 , pp. 2171-2179
    • Anderson, L.J.1    Holden, S.2    Davis, B.3
  • 10
    • 29744440418 scopus 로고    scopus 로고
    • T2∗ magnetic resonance and myocardial iron in thalassemia
    • Pennell DJ. T2∗ magnetic resonance and myocardial iron in thalassemia. Ann N Y Acad Sci. 2005;1054:373-378.
    • (2005) Ann N Y Acad Sci. , vol.1054 , pp. 373-378
    • Pennell, D.J.1
  • 11
    • 57349095277 scopus 로고    scopus 로고
    • Improved survival of thalassaemia major in the UK and relation to T2∗ cardiovascular magnetic resonance
    • Modell B, Khan M, Darlison M, et al. Improved survival of thalassaemia major in the UK and relation to T2∗ cardiovascular magnetic resonance. J Cardiovasc Magn Reson. 2008;10:42. doi: 10.1186/1532-429X-10-42.
    • (2008) J Cardiovasc Magn Reson. , vol.10 , pp. 42
    • Modell, B.1    Khan, M.2    Darlison, M.3
  • 12
    • 0028059813 scopus 로고
    • Efficacy of deferoxamine in preventing complications of iron overload in patients with thalassemia major
    • Brittenham GM, Griffith PM, Nienhuis AW, et al. Efficacy of deferoxamine in preventing complications of iron overload in patients with thalassemia major. N Engl J Med. 1994;331(9):567-573.
    • (1994) N Engl J Med. , vol.331 , Issue.9 , pp. 567-573
    • Brittenham, G.M.1    Griffith, P.M.2    Nienhuis, A.W.3
  • 13
    • 84893438907 scopus 로고    scopus 로고
    • Desferrioxamine mesylate for managing transfusional iron overload in people with transfusion-dependent thalassaemia
    • Fisher SA, Brunskill SJ, Doree C, et al. Desferrioxamine mesylate for managing transfusional iron overload in people with transfusion-dependent thalassaemia. Cochrane Database Syst Rev. 2013;8:CD004450.
    • (2013) Cochrane Database Syst Rev. , vol.8
    • Fisher, S.A.1    Brunskill, S.J.2    Doree, C.3
  • 15
    • 44049102508 scopus 로고    scopus 로고
    • Combined chelation therapy in thalassemia major for the treatment of severe myocardial siderosis with left ventricular dysfunction
    • Tanner MA, Galanello R, Dessi C, et al. Combined chelation therapy in thalassemia major for the treatment of severe myocardial siderosis with left ventricular dysfunction. J Cardiovasc Magn Reson. 2008;10:12. doi: 10.1002/14651858.CD004839.pub3.
    • (2008) J Cardiovasc Magn Reson. , vol.10 , pp. 12
    • Tanner, M.A.1    Galanello, R.2    Dessi, C.3
  • 16
    • 34247103036 scopus 로고    scopus 로고
    • A randomized, placebo-controlled, double-blind trial of the effect of combined therapy with deferoxamine and deferiprone on myocardial iron in thalassemia major using cardiovascular magnetic resonance
    • Tanner MA, Galanello R, Dessi C, et al. A randomized, placebo-controlled, double-blind trial of the effect of combined therapy with deferoxamine and deferiprone on myocardial iron in thalassemia major using cardiovascular magnetic resonance. Circulation. 2007;115(14):1876-1884.
    • (2007) Circulation. , vol.115 , Issue.14 , pp. 1876-1884
    • Tanner, M.A.1    Galanello, R.2    Dessi, C.3
  • 17
    • 34547824328 scopus 로고    scopus 로고
    • Prospective evaluation of patient-reported outcomes during treatment with deferasirox or deferoxamine for iron overload in patients with β-thalassemia
    • Cappellini MD, Bejaoui M, Agaoglu L, et al. Prospective evaluation of patient-reported outcomes during treatment with deferasirox or deferoxamine for iron overload in patients with β-thalassemia. Clin Ther. 2007;29(5):909-917.
    • (2007) Clin Ther. , vol.29 , Issue.5 , pp. 909-917
    • Cappellini, M.D.1    Bejaoui, M.2    Agaoglu, L.3
  • 18
    • 52249085605 scopus 로고    scopus 로고
    • Long-term experience with deferasirox (ICL670), a once-daily oral iron chelator, in the treatment of transfusional iron overload
    • Cappellini MD, Taher MD. Long-term experience with deferasirox (ICL670), a once-daily oral iron chelator, in the treatment of transfusional iron overload. Expert Opin Pharmacother. 2008;9(13):2391-2402.
    • (2008) Expert Opin Pharmacother. , vol.9 , Issue.13 , pp. 2391-2402
    • Cappellini, M.D.1    Taher, M.D.2
  • 19
    • 84901430700 scopus 로고    scopus 로고
    • Compliance and satisfaction with deferasirox (Exjade®) compared with deferoxamine in patients with transfusion-dependent β-thalassemia
    • Haghpanah S, Zarei T, Zahedi Z, Karimi M. Compliance and satisfaction with deferasirox (Exjade®) compared with deferoxamine in patients with transfusion-dependent β-thalassemia. Hematology. 2014;19(4):187-191.
    • (2014) Hematology. , vol.19 , Issue.4 , pp. 187-191
    • Haghpanah, S.1    Zarei, T.2    Zahedi, Z.3    Karimi, M.4
  • 20
    • 33745774771 scopus 로고    scopus 로고
    • Randomized phase II trial of deferasirox (Exjade, ICL670), a once-daily, orally-administered iron chelator, in comparison to deferoxamine in thalassemia patients with transfusional iron overload
    • Piga A, Galanello R, Forni GL, et al. Randomized phase II trial of deferasirox (Exjade, ICL670), a once-daily, orally-administered iron chelator, in comparison to deferoxamine in thalassemia patients with transfusional iron overload. Haematologica. 2006;91(7):873-880.
    • (2006) Haematologica. , vol.91 , Issue.7 , pp. 873-880
    • Piga, A.1    Galanello, R.2    Forni, G.L.3
  • 21
    • 10744230223 scopus 로고    scopus 로고
    • Effectiveness and safety of ICL670 in iron-loaded patients with thalassaemia: A randomised, double-blind, placebo-controlled, dose-escalation trial
    • Nisbet-Brown E, Olivieri NF, Giardina PJ, et al. Effectiveness and safety of ICL670 in iron-loaded patients with thalassaemia: A randomised, double-blind, placebo-controlled, dose-escalation trial. Lancet. 2003;361(9369):1597-1602.
    • (2003) Lancet. , vol.361 , Issue.9369 , pp. 1597-1602
    • Nisbet-Brown, E.1    Olivieri, N.F.2    Giardina, P.J.3
  • 22
    • 34250360747 scopus 로고    scopus 로고
    • Comparison of twice-daily vs once-daily deferasirox dosing in a gerbil model of iron cardiomyopathy
    • Otto-Duessel M, Aguilar M, Nick H, et al. Comparison of twice-daily vs once-daily deferasirox dosing in a gerbil model of iron cardiomyopathy. Exp Hematol. 2007;35(7):1069-1073.
    • (2007) Exp Hematol. , vol.35 , Issue.7 , pp. 1069-1073
    • Otto-Duessel, M.1    Aguilar, M.2    Nick, H.3
  • 23
    • 77953779950 scopus 로고    scopus 로고
    • The effect of deferasirox on cardiac iron in thalassemia major: Impact of total body iron stores
    • Wood JC, Kang BP, Thompson A, et al. The effect of deferasirox on cardiac iron in thalassemia major: Impact of total body iron stores. Blood. 2010;116(4):537-543.
    • (2010) Blood. , vol.116 , Issue.4 , pp. 537-543
    • Wood, J.C.1    Kang, B.P.2    Thompson, A.3
  • 24
    • 84862141974 scopus 로고    scopus 로고
    • Deferasirox for up to 3 years leads to continued improvement of myocardial T2∗ in patients with β-thalassemia major
    • Pennell DJ, Porter JB, Cappellini MD, et al. Deferasirox for up to 3 years leads to continued improvement of myocardial T2∗ in patients with β-thalassemia major. Haematologica. 2012;97(6):842-848.
    • (2012) Haematologica. , vol.97 , Issue.6 , pp. 842-848
    • Pennell, D.J.1    Porter, J.B.2    Cappellini, M.D.3
  • 25
    • 84937511547 scopus 로고    scopus 로고
    • A 5-year follow-up in deferasirox treatment: Improvement of cardiac and hepatic iron overload and amelioration in cardiac function in thalassemia major patients
    • Cassinerio E, Roghi A, Orofino N, et al. A 5-year follow-up in deferasirox treatment: Improvement of cardiac and hepatic iron overload and amelioration in cardiac function in thalassemia major patients. Ann Hematol. 2015;94(6):939-945.
    • (2015) Ann Hematol. , vol.94 , Issue.6 , pp. 939-945
    • Cassinerio, E.1    Roghi, A.2    Orofino, N.3
  • 26
    • 1442307460 scopus 로고    scopus 로고
    • Myocardial iron loading in transfusion-dependent thalassemia and sickle cell disease
    • Wood JC, Tyszka JM, Carson S, et al. Myocardial iron loading in transfusion-dependent thalassemia and sickle cell disease. Blood. 2004;103(5):1934-1936.
    • (2004) Blood. , vol.103 , Issue.5 , pp. 1934-1936
    • Wood, J.C.1    Tyszka, J.M.2    Carson, S.3
  • 27
    • 72449177984 scopus 로고    scopus 로고
    • Cardiac T2∗ magnetic resonance for prediction of cardiac complications in thalassemia major
    • Kirk P, Roughton M, Porter JB, et al. Cardiac T2∗ magnetic resonance for prediction of cardiac complications in thalassemia major. Circulation. 2009;120(20):1961-1968.
    • (2009) Circulation. , vol.120 , Issue.20 , pp. 1961-1968
    • Kirk, P.1    Roughton, M.2    Porter, J.B.3
  • 28
    • 84907927202 scopus 로고    scopus 로고
    • Randomized controlled trials of iron chelators for the treatment of cardiac siderosis in thalassaemia major
    • eCollection 2014
    • Baksi AJ, Pennell DJ. Randomized controlled trials of iron chelators for the treatment of cardiac siderosis in thalassaemia major. Front Pharmacol. 2014;5:217. doi: 10.3389/fphar.2014.00217. eCollection 2014.
    • (2014) Front Pharmacol , vol.5 , pp. 217
    • Baksi, A.J.1    Pennell, D.J.2
  • 29
    • 84897504545 scopus 로고    scopus 로고
    • A 1-year randomized controlled trial of deferasirox vs deferoxamine for myocardial iron removal in β-thalassemia major (CORDELIA)
    • Pennell DJ, Porter JB, Piga A, et al. A 1-year randomized controlled trial of deferasirox vs deferoxamine for myocardial iron removal in β-thalassemia major (CORDELIA). Blood. 2014;123(10):1447-1454.
    • (2014) Blood. , vol.123 , Issue.10 , pp. 1447-1454
    • Pennell, D.J.1    Porter, J.B.2    Piga, A.3
  • 30
    • 84940782881 scopus 로고    scopus 로고
    • Efficacy and safety of a novel combination of two oral chelators deferasirox/deferiprone over deferoxamine/deferiprone in severely iron-overloaded young βthalassemia major patients
    • Jan 20 [Epub ahead of print]
    • Elalfy MS, Adly AM, Wali Y, et al. Efficacy and safety of a novel combination of two oral chelators deferasirox/deferiprone over deferoxamine/deferiprone in severely iron-overloaded young βthalassemia major patients. Eur J Haematol. 2015 Jan 20. doi: 10.1111/ejh.12507. [Epub ahead of print].
    • (2015) Eur J Haematol.
    • Elalfy, M.S.1    Adly, A.M.2    Wali, Y.3
  • 31
    • 84921325842 scopus 로고    scopus 로고
    • Sustained improvements in myocardial T2∗ over 2 years in severely iron-overloaded patients with β thalassemia major treated with deferasirox or deferoxamine
    • Pennell DJ, Porter JB, Piga A, et al. Sustained improvements in myocardial T2∗ over 2 years in severely iron-overloaded patients with β thalassemia major treated with deferasirox or deferoxamine. Am J Hematol. 2015;90(2):91-96.
    • (2015) Am J Hematol. , vol.90 , Issue.2 , pp. 91-96
    • Pennell, D.J.1    Porter, J.B.2    Piga, A.3
  • 32
    • 77649296214 scopus 로고    scopus 로고
    • Deferasirox (Exjade) significantly improves cardiac T2∗ in heavily iron-overloaded patients with β-thalassemia major
    • Pathare A, Taher A, Daar S. Deferasirox (Exjade) significantly improves cardiac T2∗ in heavily iron-overloaded patients with β-thalassemia major. Ann Hematol. 2010;89(4):405-409.
    • (2010) Ann Hematol. , vol.89 , Issue.4 , pp. 405-409
    • Pathare, A.1    Taher, A.2    Daar, S.3
  • 33
    • 77950617863 scopus 로고    scopus 로고
    • Efficacy of deferasirox in reducing and preventing cardiac iron overload in β-thalassemia
    • Pennell DJ, Porter JB, Cappellini MD, et al. Efficacy of deferasirox in reducing and preventing cardiac iron overload in β-thalassemia. Blood. 2010;115(12):2364-2371.
    • (2010) Blood. , vol.115 , Issue.12 , pp. 2364-2371
    • Pennell, D.J.1    Porter, J.B.2    Cappellini, M.D.3
  • 34
    • 70449403619 scopus 로고    scopus 로고
    • Efficacy and safety of deferasirox doses of >30 mg/kg per d in patients with transfusion-dependent anaemia and iron overload
    • Taher A, Cappellini MD, Vichinsky E, et al. Efficacy and safety of deferasirox doses of >30 mg/kg per d in patients with transfusion-dependent anaemia and iron overload. Br J Haematol. 2009;147(5):752-759.
    • (2009) Br J Haematol. , vol.147 , Issue.5 , pp. 752-759
    • Taher, A.1    Cappellini, M.D.2    Vichinsky, E.3


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