메뉴 건너뛰기




Volumn 95, Issue 1, 1996, Pages 26-36

Results of Long-Term Iron-Chelating Therapy

Author keywords

Chelation; Complications; Iron overload; Survival

Indexed keywords

DEFEROXAMINE; FERRITIN; IRON;

EID: 0030048681     PISSN: 00015792     EISSN: 14219662     Source Type: Journal    
DOI: 10.1159/000203853     Document Type: Article
Times cited : (321)

References (108)
  • 1
    • 0017713378 scopus 로고
    • Total management of thalassemia
    • Modell B: Total management of thalassemia. Arch Dis Child 1977;52:489-500.
    • (1977) Arch Dis Child , vol.52 , pp. 489-500
    • Modell, B.1
  • 3
    • 0015112912 scopus 로고
    • Iron in the heart: Etiology and clinical significance
    • Buja LM. Roberts WC: Iron in the heart: Etiology and clinical significance. Am J Med 1971; 51:209-221.
    • (1971) Am J Med , vol.51 , pp. 209-221
    • Buja, L.M.1    Roberts, W.C.2
  • 4
    • 0023555692 scopus 로고
    • Management of iron overload in pediatric patients
    • Cohen A: Management of iron overload in pediatric patients. Hcmatol Oncol Clin North Am 1987;1:521-544.
    • (1987) Hcmatol Oncol Clin North Am , vol.1 , pp. 521-544
    • Cohen, A.1
  • 5
    • 0016238533 scopus 로고
    • Hepatocellular uptake of ferritin in the rat
    • Unger A, Hershko C: Hepatocellular uptake of ferritin in the rat. Br J Haematol 1974;28:169— 179.
    • (1974) Br J Haematol , vol.28
    • Unger, A.1    Hershko, C.2
  • 6
    • 0021856398 scopus 로고
    • Aruoma Ol. Baum H. Peters TJ: Formation of hydroxyl radicals in the presence of ferritin and haemosiderin
    • O’Connell MJ. Halliwell B. Moorhouse CP. Aruoma Ol. Baum H. Peters TJ: Formation of hydroxyl radicals in the presence of ferritin and haemosiderin. Biochem J 1985:229:135-139.
    • (1985) Biochem J , vol.229 , pp. 135-139
    • O’Connell, M.J.1    Halliwell, B.2    Moorhouse, C.P.3
  • 7
    • 0018164919 scopus 로고
    • Non-specific serum iron in thalassemia: An abnormal scrum iron fraction of potential toxicity
    • Hershko C. Graham G. Bates GW. Rachmilc-witz EA: Non-specific serum iron in thalassemia: An abnormal scrum iron fraction of potential toxicity. Br J Haematol 1978:40:255-263.
    • (1978) Br J Haematol , vol.40 , pp. 255-263
    • Hershko, C.1    Graham, G.2    Bates, G.W.3    Rachmilc-Witz, E.A.4
  • 8
    • 0022960016 scopus 로고
    • Nontransfer-rin-bound serum iron in thalassemia and sickle cell patients
    • Ahmed NK, Hanna M, Wang W: Nontransfer-rin-bound serum iron in thalassemia and sickle cell patients. Int J Biochem 1986:18:953-956.
    • (1986) Int J Biochem , vol.18 , pp. 953-956
    • Ahmed, N.K.1    Hanna, M.2    Wang, W.3
  • 9
    • 0025126555 scopus 로고
    • Role of free radicals and catalytic metal ions in human disease: An overview
    • Halliwell B, Gutteridge JMC: Role of free radicals and catalytic metal ions in human disease: An overview. Methods Enzymol 1990; 186:1— 85.
    • (1990) Methods Enzymol , vol.186
    • Halliwell, B.1    Gutteridge, J.2
  • 10
    • 0002750772 scopus 로고
    • Mechanisms ofiron toxicity
    • Brock JH. HallidayJW. Pip-pard MJ. Powell LW (eds), London. Saunders
    • Britton RS. Tavill AS. Bacon BR: Mechanisms ofiron toxicity: in Brock JH. HallidayJW. Pip-pard MJ. Powell LW (eds): Iron Metabolism in Health and Disease. London. Saunders. 1994. pp 311-351.
    • (1994) Iron Metabolism in Health and Disease. , pp. 311-351
    • Britton, R.S.1    Tavill, A.S.2    Bacon, B.R.3
  • 11
    • 0018114375 scopus 로고
    • Organelle pathology in primary and secondary haemochromatosis with special reference to lysosomal changes
    • Seymour CA, Peters TJ: Organelle pathology in primary and secondary haemochromatosis with special reference to lysosomal changes. Br J Haematol 1978;40:239-253.
    • (1978) Br J Haematol , vol.40 , pp. 239-253
    • Seymour, C.A.1    Peters, T.J.2
  • 12
    • 0027323039 scopus 로고
    • Rat heart cells in culture: A model of iron toxicity and chelation
    • Link G, Hershko C: Rat heart cells in culture: A model of iron toxicity and chelation. J Lab Clin Med 1993;122:14-16.
    • (1993) J Lab Clin Med , vol.122 , pp. 14-16
    • Link, G.1    Hershko, C.2
  • 13
    • 0024536246 scopus 로고
    • Ultrastructural pathology of iron overload
    • Iancu TC: Ultrastructural pathology of iron overload. Baillieres Clin Hematol 1989:2:375— 395.
    • (1989) Baillieres Clin Hematol , vol.2
    • Iancu, T.C.1
  • 14
    • 0022656390 scopus 로고
    • Value of hepatic iron measurements in early hemochromatosis and determination of the critical iron level associated with fibrosis
    • Bassett ML, Halliday JW, Lawrie WP: Value of hepatic iron measurements in early hemochromatosis and determination of the critical iron level associated with fibrosis. Hepatologv 1986: 6:24-29.
    • (1986) Hepatologv , vol.6 , pp. 24-29
    • Bassett, M.L.1    Halliday, J.W.2    Lawrie, W.P.3
  • 15
    • 0345898226 scopus 로고
    • Relationship of hepatic iron concentration to histochemical grading and to total chelatable body iron in conditions associated with iron overload
    • Walker RJ, Miller JPG, Dymolk JW, Stillkin KB. Williams R: Relationship of hepatic iron concentration to histochemical grading and to total chelatable body iron in conditions associated with iron overload. Gut 1977;132:1011 — 1014.
    • (1977) Gut , vol.132
    • Walker, R.J.1    Miller, J.2    Dymolk, J.W.3    Stillkin, K.B.4    Williams, R.5
  • 16
    • 0027990266 scopus 로고
    • Excess iron into hepatocytes is required for activation of collagen type 1 gene during experimental siderosis
    • Gualdi R, Casalgrandi G, Montosi G, Ventura E, Pietrangelo A: Excess iron into hepatocytes is required for activation of collagen type 1 gene during experimental siderosis. Gastroenterology 1994:107:1118-1124.
    • (1994) Gastroenterology , vol.107 , pp. 1118-1124
    • Gualdi, R.1    Casalgrandi, G.2    Montosi, G.3    Ventura, E.4    Pietrangelo, A.5
  • 17
    • 0028118654 scopus 로고
    • Enhanced hepatic collagen type I mRNA expression into fat-storing cells in a rodent model of hemochromatosis
    • Pietrangelo A. Gualdi R. Casalgrandi G, Geerts A, De Bleser P, Montosi G. Ventura E: Enhanced hepatic collagen type I mRNA expression into fat-storing cells in a rodent model of hemochromatosis. Hcpatology 1994:19: 714-721.
    • (1994) Hcpatology , vol.19 , pp. 714-721
    • Pietrangelo, A.1    Gualdi, R.2    Casalgrandi, G.3    Geerts, A.4    De Bleser, P.5    Montosi, G.6    Ventura, E.7
  • 23
    • 10344238960 scopus 로고
    • Biosusceptometry -Current status of clinical diagnostics and bio-magnetic research
    • Hoke M (ed), Amsterdam, Elsevier
    • Fischer R, Heinrich HC: Biosusceptometry -Current status of clinical diagnostics and bio-magnetic research; in Hoke M (ed): Biomagnetism: Clinical Aspects. Amsterdam, Elsevier, 1992, pp 573-581.
    • (1992) Biomagnetism: Clinical Aspects. , pp. 573-581
    • Fischer, R.1    Heinrich, H.C.2
  • 25
    • 0018757587 scopus 로고
    • Correlation between computed tomographic values and liver iron content in thalassemia major with iron overload
    • Houang MTW, Arozena X. Skalicka A, Huehns ER. Shaw DG: Correlation between computed tomographic values and liver iron content in thalassemia major with iron overload. Lancet 1979:i: 1322— 1323.
    • (1979) Lancet , vol.1
    • Houang, M.1    Arozena, X.2    Skalicka, A.3    Huehns, E.R.4    Shaw, D.G.5
  • 26
    • 0024601819 scopus 로고
    • Computed tomography scanning of the liver to determine efficacy ofiron chelation therapy in thalassemia major
    • Olivieri NF, Grisaru D, Daneman A. Martin DJ, Rose V, Freedman MH: Computed tomography scanning of the liver to determine efficacy ofiron chelation therapy in thalassemia major. J Pediatr 1989; 114:427-430.
    • (1989) J Pediatr , vol.114 , pp. 427-430
    • Olivieri, N.F.1    Grisaru, D.2    Daneman, A.3    Martin, D.J.4    Rose, V.5    Freedman, M.H.6
  • 28
    • 0025230594 scopus 로고
    • Non-invasivc quantification of liver iron-overload by magnetic resonance imaging
    • Kaltwasser J P, Gottschalk R, Schalk KP. Hartl W: Non-invasivc quantification of liver iron-overload by magnetic resonance imaging. Br J Haematol 1990:74:360-363.
    • (1990) Br J Haematol , vol.74 , pp. 360-363
    • Kaltwasser, J.P.1    Gottschalk, R.2    Schalk, K.P.3    Hartl, W.4
  • 30
    • 13344296323 scopus 로고
    • Magnetic resonance imaging (MRI) of the iron loaded anterior pituitary gland in thalassemia major: Correlation of signal intensity, T2 relaxation and hormonal status
    • Olivieri NF, Kucharzyck W, Liu P: Magnetic resonance imaging (MRI) of the iron loaded anterior pituitary gland in thalassemia major: Correlation of signal intensity, T2 relaxation and hormonal status. Blood 1990:76 (suppl 1): 278a.
    • (1990) Blood , vol.76 , pp. 278a
    • Olivieri, N.F.1    Kucharzyck, W.2    Liu, P.3
  • 32
    • 0025970809 scopus 로고
    • Transfusion requirements and effects in patients with thalassemia major: Cooleycare Programme
    • Rcbulla P, Modell B: Transfusion requirements and effects in patients with thalassemia major: Cooleycare Programme. Lancet 1991: 337:277-280.
    • (1991) Lancet , vol.337 , pp. 277-280
    • Rcbulla, P.1    Modell, B.2
  • 33
    • 0025569760 scopus 로고
    • Current therapy for thalassemia in Italy
    • Gabutti V: Current therapy for thalassemia in Italy. Ann NY Acad Sci 1990;612:268-274.
    • (1990) Ann NY Acad Sci , vol.612 , pp. 268-274
    • Gabutti, V.1
  • 35
    • 0024566311 scopus 로고
    • Myocardial iron grading by endomyocardial biopsy: A clinico-pathologic study on iron overloaded patients
    • Barosi G, Arbustini E, Gavazzi A, Grasso M. Pucci A: Myocardial iron grading by endomyocardial biopsy: A clinico-pathologic study on iron overloaded patients. Eur J Haematol 1989;42:382-388.
    • (1989) Eur J Haematol , vol.42 , pp. 382-388
    • Barosi, G.1    Arbustini, E.2    Gavazzi, A.3    Grasso, M.4    Pucci, A.5
  • 37
    • 0025878026 scopus 로고
    • Prolonged survival in patients with beta-thalassemia major treated with deferoxamine
    • Ehlers KH, Giardina PJ, Lesser ML, Engle MA, Hilgartner MW: Prolonged survival in patients with beta-thalassemia major treated with deferoxamine. J Pediatr 1991;118:540-545.
    • (1991) J Pediatr , vol.118 , pp. 540-545
    • Ehlers, K.H.1    Giardina, P.J.2    Lesser, M.L.3    Engle, M.A.4    Hilgartner, M.W.5
  • 40
    • 0018814356 scopus 로고
    • Longitudinal study of cardiac function in thalassemia major
    • Ehlers KH, Levin AR, Markenson AL: Longitudinal study of cardiac function in thalassemia major. Ann NY Acad Sci 1980:344:397-404.
    • (1980) Ann NY Acad Sci , vol.344 , pp. 397-404
    • Ehlers, K.H.1    Levin, A.R.2    Markenson, A.L.3
  • 44
    • 0007452972 scopus 로고
    • Prevalence of endocrine complications in patients with p-thalassemia major: An Italian multicenter study
    • Pintor C. Muller EE. Loche S, New MI (eds), Berlin, Springer
    • De Sanctis V. Pintor C. Aliquò, MC: Prevalence of endocrine complications in patients with p-thalassemia major: An Italian multicenter study; in Pintor C. Muller EE. Loche S, New MI (eds): Advances in Pediatric Endocrinology. Berlin, Springer. 1992, pp 127-133.
    • (1992) Advances in Pediatric Endocrinology , pp. 127-133
    • De Sanctis, V.1    Pintor, C.2    Aliquò, M.C.3
  • 45
    • 0024542279 scopus 로고
    • Results of long-term subcutaneous desferrioxamine therapy
    • Hoffbrand AV, Wonke B: Results of long-term subcutaneous desferrioxamine therapy. Bail-lieres Clin Hematol 1989:2:345-362.
    • (1989) Bail-Lieres Clin Hematol , vol.2 , pp. 345-362
    • Hoffbrand, A.V.1    Wonke, B.2
  • 49
    • 33845382806 scopus 로고
    • Nonparametric estimation from incomplete observation
    • Kaplan EL, Meier P: Nonparametric estimation from incomplete observation. J Am Stat Assoc 1958;53:457-481.
    • (1958) J am Stat Assoc , vol.53 , pp. 457-481
    • Kaplan, E.L.1    Meier, P.2
  • 50
    • 13344266128 scopus 로고
    • Long term results of standard management in thalassemia (Abstract). 5th Int Conf Thalassaemias and the Haemoglobinopathies
    • Gabutti V, Piga A, Sacchetti L, Prioro M, Scagni P: Long term results of standard management in thalassemia (abstract). 5th Int Conf Thalassaemias and the Haemoglobinopathies, Nicosia, 1993, p 90.
    • (1993) Nicosia , pp. 90
    • Gabutti, V.1    Piga, A.2    Sacchetti, L.3    Prioro, M.4    Scagni, P.5
  • 54
    • 0023726904 scopus 로고
    • Hypothalamic pituitary gonadal axis in thalassemic patients with secondary amenorrhea
    • De Sanctis V. Vullo C, Katz M. Wonke B, Hoffbrand V, Bagni B: Hypothalamic pituitary gonadal axis in thalassemic patients with secondary amenorrhea. Obstet Gynecol 1988:72: 643-647.
    • (1988) Obstet Gynecol , vol.72 , pp. 643-647
    • De Sanctis, V.1    Vullo, C.2    Katz, M.3    Wonke, B.4    Hoffbrand, V.5    Bagni, B.6
  • 55
    • 7444249085 scopus 로고
    • The biochemistry of dcsferrioxam-ine and its relation to iron metabolism
    • Keberle H: The biochemistry of dcsferrioxam-ine and its relation to iron metabolism. Ann NY Acad Sci 1964:119:758-768.
    • (1964) Ann NY Acad Sci , vol.119 , pp. 758-768
    • Keberle, H.1
  • 56
    • 0019990842 scopus 로고
    • Hepato-cyte iron kinetics in the rat explored with an iron chelator
    • Pippard MJ, Johnson DK, Finch CA: Hepato-cyte iron kinetics in the rat explored with an iron chelator. Br J Haematol 1982:52:211 —224.
    • (1982) Br J Haematol , vol.52
    • Pippard, M.J.1    Johnson, D.K.2    Finch, C.A.3
  • 57
    • 0024521376 scopus 로고
    • Desferrioxamine-induccd iron excretion in humans
    • Pippard MJ: Desferrioxamine-induccd iron excretion in humans. Baillieres Clin Hematol 1989;2:323-343.
    • (1989) Baillieres Clin Hematol , vol.2 , pp. 323-343
    • Pippard, M.J.1
  • 58
    • 0017883237 scopus 로고
    • Determinants of fecal and urinary' iron excretion in desferrioxamine-treated rats
    • Hershko C: Determinants of fecal and urinary' iron excretion in desferrioxamine-treated rats. Blood 1978:51:415-423.
    • (1978) Blood , vol.51 , pp. 415-423
    • Hershko, C.1
  • 59
    • 0018777993 scopus 로고
    • Studies in desferrioxamine and fer-rioxaminc metabolism in normal and iron-loaded subjects
    • Summers MR, Jacobs A, Tudway D, Perera P, Ricketts C: Studies in desferrioxamine and fer-rioxaminc metabolism in normal and iron-loaded subjects. Br J Haematol 1979:42:547— 555.
    • (1979) Br J Haematol , vol.42
    • Summers, M.R.1    Jacobs, A.2    Tudway, D.3    Perera, P.4    Ricketts, C.5
  • 60
    • 0017077213 scopus 로고
    • Reassessment of the use of desferrioxamine B in iron overload
    • Propper RD, Shuring SB, Nathan DG: Reassessment of the use of desferrioxamine B in iron overload. N Engl J Med 1976:294:1421— 1423.
    • (1976) N Engl J Med , vol.294
    • Propper, R.D.1    Shuring, S.B.2    Nathan, D.G.3
  • 61
    • 0016138724 scopus 로고
    • Long-term desferrioxamine therapy in thalassemia
    • Modell CB. Beck J: Long-term desferrioxamine therapy in thalassemia. Ann NY Acad Sci 1974;232:201-210.
    • (1974) Ann NY Acad Sci , vol.232 , pp. 201-210
    • Modell, C.B.1    Beck, J.2
  • 62
    • 0025108768 scopus 로고
    • Treatment of Cooley’s anemia
    • Fosburg MT. Nathan DG: Treatment of Cooley’s anemia. Blood 1990;76:435-444.
    • (1990) Blood , vol.76 , pp. 435-444
    • Fosburg, M.T.1    Nathan, D.G.2
  • 63
    • 0015947937 scopus 로고
    • Long-term chelation in thalassaemia major: Effect on liver iron concentration, liver histology and clinical progress
    • Barry M, Flynn DM, Letsky EA, Risdon RA: Long-term chelation in thalassaemia major: Effect on liver iron concentration, liver histology and clinical progress. BrMcdJ 1974:i: 16—21.
    • (1974) Brmcdj , vol.1 , pp. 16-21
    • Barry, M.1    Flynn, D.M.2    Letsky, E.A.3    Risdon, R.A.4
  • 65
    • 0019839707 scopus 로고
    • Response to long-term deferoxamine therapy in thalassemia
    • Cohen A, Martin M, Schwartz E: Response to long-term deferoxamine therapy in thalassemia. J Pediatr 1981:99:689-694.
    • (1981) J Pediatr , vol.99 , pp. 689-694
    • Cohen, A.1    Martin, M.2    Schwartz, E.3
  • 67
    • 0028434335 scopus 로고
    • Thalassemia major in Connecticut: A 20-year study of changing age distribution and survival
    • Pearson HA. Rink L. Guiliotis DK: Thalassemia major in Connecticut: A 20-year study of changing age distribution and survival. Conn Med 1994;58:259-260.
    • (1994) Conn Med , vol.58 , pp. 259-260
    • Pearson, H.A.1    Rink, L.2    Guiliotis, D.K.3
  • 68
    • 0002777462 scopus 로고
    • Iron chelation therapy in the treatment of iron overload
    • Bergeron RJ. Brittenham GM (eds), Boca Raton. CRC
    • Pippard MJ: Iron chelation therapy in the treatment of iron overload; in Bergeron RJ. Brittenham GM (eds): The Development of Iron Chelators for Clinical Use. Boca Raton. CRC. 1994. pp 57-74.
    • (1994) The Development of Iron Chelators for Clinical Use , pp. 57-74
    • Pippard, M.J.1
  • 71
    • 0021225166 scopus 로고
    • Depiction of excessive liver iron stores with desferrioxam-ine
    • Cohen A, Martin M, Schwartz E: Depiction of excessive liver iron stores with desferrioxam-ine. Br J Haematol 1984;58:369-373.
    • (1984) Br J Haematol , vol.58 , pp. 369-373
    • Cohen, A.1    Martin, M.2    Schwartz, E.3
  • 75
    • 0023621784 scopus 로고
    • Serial studies of auditory neurotoxicity in patients receiving deferoxamine therapy
    • Gallant T, Bovden MH, Gallant LA. Carley H, Freedman MH: Serial studies of auditory neurotoxicity in patients receiving deferoxamine therapy. Am J Med 1987;83:1085-1090.
    • (1987) Am J Med , vol.83 , pp. 1085-1090
    • Gallant, T.1    Bovden, M.H.2    Gallant, L.A.3    Carley, H.4    Freedman, M.H.5
  • 79
    • 0021707996 scopus 로고
    • Ocular changes in patients undergoing longterm desferrioxamine treatment
    • Arden GB, Wonke B, Kennedy C, Huehns ER: Ocular changes in patients undergoing longterm desferrioxamine treatment. Br J Ophthalmol 1984;68:873-877.
    • (1984) Br J Ophthalmol , vol.68 , pp. 873-877
    • Arden, G.B.1    Wonke, B.2    Kennedy, C.3    Huehns, E.R.4
  • 80
    • 0021289327 scopus 로고
    • Desferrioxamine induced toxic retinal pigmentary degeneration and presumed optic neuropathy
    • Lakhanpal V, Schocket SS, Jiji R: Desferrioxamine induced toxic retinal pigmentary degeneration and presumed optic neuropathy. Ophthalmology 1984;91:443-451.
    • (1984) Ophthalmology , vol.91 , pp. 443-451
    • Lakhanpal, V.1    Schocket, S.S.2    Jiji, R.3
  • 83
    • 0025344815 scopus 로고
    • Pulmonary syndrome in patients with thalassemia major receiving intravenous deferoxamine infusions
    • Freedman MH, Grisaru D, Olivieri N, Mac-Lusky I, Thomer PS: Pulmonary syndrome in patients with thalassemia major receiving intravenous deferoxamine infusions. Am J Dis Child 1990;144:565-569.
    • (1990) Am J Dis Child , vol.144 , pp. 565-569
    • Freedman, M.H.1    Grisaru, D.2    Olivieri, N.3    Mac-Lusky, I.4    Thomer, P.S.5
  • 84
    • 0024310392 scopus 로고
    • Desferrioxamine ototoxicity: Evaluation of risk factors in thalassaemic patients and guidelines for safe dosage
    • Porter JB, Jaswon MB, Huehns ER, East CA, Hazell JW: Desferrioxamine ototoxicity: Evaluation of risk factors in thalassaemic patients and guidelines for safe dosage. Br J Haematol 1989:73:403-409.
    • (1989) Br J Haematol , vol.73 , pp. 403-409
    • Porter, J.B.1    Jaswon, M.B.2    Huehns, E.R.3    East, C.A.4    Hazell, J.W.5
  • 86
    • 0022637891 scopus 로고
    • Fran-combe WH: Yersinia sepsis in patients with iron overload treated with deferoxamine
    • Gallant T, Freedman MH, Vellcnd H, Fran-combe WH: Yersinia sepsis in patients with iron overload treated with deferoxamine. N Engl J Med 1986;314:1643.
    • (1986) N Engl J Med , vol.314 , pp. 1643
    • Gallant, T.1    Freedman, M.H.2    Vellcnd, H.3
  • 87
    • 0025186342 scopus 로고
    • High incidence of cardiomyopathy in beta-thaias-saemia patients receiving regular transfusion and iron chelation: Reversal by intensified chelation
    • Aldouri MA, Wonke B, Hoffbrand AV, Flynn DM, Ward SE. Agnew JE, Hilson AJ: High incidence of cardiomyopathy in beta-thaias-saemia patients receiving regular transfusion and iron chelation: Reversal by intensified chelation. Acta Haematol 1990;84:113-117.
    • (1990) Acta Haematol , vol.84 , pp. 113-117
    • Aldouri, M.A.1    Wonke, B.2    Hoffbrand, A.V.3    Flynn, D.M.4    Ward, S.E.5    Agnew, J.E.6    Hilson, A.J.7
  • 88
    • 0020501909 scopus 로고
    • Early left ventricular dysfunction and chelation therapy in thalassaemia major
    • Freeman AP, Giles RW, Berdoukas VA: Early left ventricular dysfunction and chelation therapy in thalassaemia major. Ann Intern Med 1983;99:450-454.
    • (1983) Ann Intern Med , vol.99 , pp. 450-454
    • Freeman, A.P.1    Giles, R.W.2    Berdoukas, V.A.3
  • 91
    • 13344265068 scopus 로고
    • A short guide to the management of thalassemia
    • Sirchia G, Zanella A (eds), Milan, Centro Trasfusionale Ospedale Maggiore Policlinico
    • Cao A, Gabutti V. Masera G. Modell B, Sirchia G: A short guide to the management of thalassemia; in Sirchia G, Zanella A (eds): Thalassaemia Today: The Mediterranean Experience. Milan, Centro Trasfusionale Ospedale Maggiore Policlinico, 1987, pp 635-670.
    • (1987) Thalassaemia Today: The Mediterranean Experience. , pp. 635-670
    • Cao, A.1    Gabutti, V.2    Masera, G.3    Modell, B.4    Sirchia, G.5
  • 92
    • 13344271742 scopus 로고
    • Computhal: A computerized clinical record for thalassemia
    • Rebulla P. Fessas PH (eds)Thalassemia 1990. Milan, Centro Trasfusionale Ospedale Maggiore Policlinico
    • Piga A: Computhal: A computerized clinical record for thalassemia; in Rebulla P. Fessas PH (eds): Thalassemia 1990. Milan, Centro Trasfusionale Ospedale Maggiore Policlinico, 1991, pp 139-151.
    • (1991) , pp. 139-151
    • Piga, A.1
  • 93
    • 0028560319 scopus 로고
    • Clinical manifestations and therapy of transfusional haemo-siderosis
    • Gabutti V, Borgna Pignatti C: Clinical manifestations and therapy of transfusional haemo-siderosis. Baillieres Clin Haematol 1994;7: 919-940.
    • (1994) Baillieres Clin Haematol , vol.7 , pp. 919-940
    • Gabutti, V.1    Borgna Pignatti, C.2
  • 94
    • 0018757633 scopus 로고
    • Improvement in iron status and liver function in patients with transfusional iron overload with long-term subcutaneous desferrioxamine
    • Hoffbrand AV, Gorman A, Laulicht M, Garidi M, Economidou J, Georgipoulou P, Hussain MAM, Flynn DM: Improvement in iron status and liver function in patients with transfusional iron overload with long-term subcutaneous desferrioxamine. Lancet 1979;i:947—949.
    • (1979) Lancet , vol.1 , pp. 947-949
    • Hoffbrand, A.V.1    Gorman, A.2    Laulicht, M.3    Garidi, M.4    Economidou, J.5    Georgipoulou, P.6    Hussain, M.7    Flynn, D.M.8
  • 97
    • 0020282963 scopus 로고
    • Subcutaneous desferrioxamine: The effect of three years treatment on liver iron, serum ferritin anc comments for echocardiography
    • Flynn DM, Hoffbrand AV, Politis D: Subcutaneous desferrioxamine: The effect of three years treatment on liver iron, serum ferritin anc comments for echocardiography. Birth Defects 1982:18:347-353.
    • (1982) Birth Defects , vol.18 , pp. 347-353
    • Flynn, D.M.1    Hoffbrand, A.V.2    Politis, D.3
  • 99
    • 85025577840 scopus 로고
    • Evaluation at autopsy of iron overload in different tissues in thalassemia major (Abstract) Proc Int Symp Bone Marrow Transplantation and Related Problems
    • Sep
    • Forni M, Morra I, Sandri A, Sacchetti L, Piga A, Gabutti V: Evaluation at autopsy of iron overload in different tissues in thalassemia major (abstract) Proc Int Symp Bone Marrow Transplantation and Related Problems. Urbino, Sep 1988.
    • (1988) Urbino
    • Forni1    Morra, M.I.2    Sandri, A.3    Sacchetti, L.4    Piga, A.5    Gabutti, V.6
  • 101
    • 13344254934 scopus 로고
    • Psychology of thethalassemic patient and his family
    • Sirchia G, Zanella A (eds), Milan. Centro Trasfusionale Ospedale Maggiore Policlinico
    • Massaglia P. Carpignano M: Psychology of thethalassemic patient and his family; in Sirchia G, Zanella A (eds): Thalassaemia Today: The Mediterranean Experience. Milan. Centro Trasfusionale Ospedale Maggiore Policlinico. 1987, pp 69-79.
    • (1987) Thalassaemia Today: The Mediterranean Experience. , pp. 69-79
    • Massaglia, P.1    Carpignano, M.2
  • 103
    • 0025569575 scopus 로고
    • Family reactions and relationships in thalassemia
    • Tsiantis J: Family reactions and relationships in thalassemia. Ann NY Acad Sci 1990;612: 451-461.
    • (1990) Ann NY Acad Sci , vol.612 , pp. 451-461
    • Tsiantis, J.1
  • 106
    • 0024355371 scopus 로고
    • Rapid removal of excessive iron with daily, high-dose intravenous chelation therapy
    • Cohen A. Mizanin J. Schwartz E: Rapid removal of excessive iron with daily, high-dose intravenous chelation therapy. J Pediatr 1989;115:151-155.
    • (1989) J Pediatr , vol.115 , pp. 151-155
    • Cohen, A.1    Mizanin, J.2    Schwartz, E.3
  • 107
    • 0026686492 scopus 로고
    • Reduction in tissue iron stores with a new regimen of continuous ambulatory' intravenous deferoxamine
    • Olivieri NF, Berriman AM, Tyler BJ, Davis SA, Francombe WH, Liu PP: Reduction in tissue iron stores with a new regimen of continuous ambulatory' intravenous deferoxamine. Am J Hematol 1992;41:61-63.
    • (1992) Am J Hematol , vol.41 , pp. 61-63
    • Olivieri, N.F.1    Berriman, A.M.2    Tyler, B.J.3    Davis, S.A.4    Francombe, W.H.5    Liu, P.P.6
  • 108
    • 85025569358 scopus 로고
    • Deferoxamine chelation by intravenous implantable systems (Abstract)
    • 3rd Symp on the Development of Iron Chelators for Clinical Use
    • Piga A. Lanza C, Sacchetti L, Lcrro P: Deferoxamine chelation by intravenous implantable systems (abstract). 3rd Symp on the Development of Iron Chelators for Clinical Use, Gainesville, 1992.
    • (1992) Gainesville
    • Piga, A.1    Lanza, C.2    Sacchetti, L.3    Lcrro, P.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.