Hypermethylation of FOXD3 suppresses cell proliferation, invasion and metastasis in hepatocellular carcinoma

Experimental and Molecular Pathology

Volumn 99, Issue 2, 2015, Pages 374-382

  He, Guoyang ^a,b   Hu, Shuiwang ^a   Zhang, Dan ^a   Wu, Pingxiang ^a   Zhu, Xiaohui ^a   Xin, Sainan ^a   Lu, Guifeng ^a   Ding, Yanqing ^a   Liang, Li ^a  

^a SOUTHERN MEDICAL UNIVERSITY   (China)

^b XINXIANG MEDICAL UNIVERSITY   (China)

Author keywords

FOXD3; Hepatocellular carcinoma; Invasion; Metastasis; Methylation

Indexed keywords

FORKHEAD BOX D3; FORKHEAD TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; FOXD3 PROTEIN, HUMAN; MESSENGER RNA; TUMOR MARKER;

ADULT; AGED; ARTICLE; CANCER GROWTH; CELL DIFFERENTIATION; CELL INVASION; CELL MIGRATION; CELL PROLIFERATION; CONTROLLED STUDY; DNA METHYLATION; DOWN REGULATION; ENZYME INHIBITION; ENZYME REPRESSION; EPITHELIAL MESENCHYMAL TRANSITION; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; LIVER CARCINOGENESIS; LIVER CELL CARCINOMA; MAJOR CLINICAL STUDY; MALE; METASTASIS; PROMOTER REGION; TUMOR GROWTH; ANIMAL; APOPTOSIS; CANCER STAGING; CELL MOTION; DRUG SCREENING; ENZYME IMMUNOASSAY; FLUORESCENT ANTIBODY TECHNIQUE; FOLLOW UP; GENE EXPRESSION REGULATION; GENETICS; LIVER TUMOR; METABOLISM; MIDDLE AGED; MORTALITY; MOUSE; NUDE MOUSE; PATHOLOGY; PROGNOSIS; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SECONDARY; SURVIVAL RATE; TUMOR CELL CULTURE; TUMOR INVASION; VERY ELDERLY; WESTERN BLOTTING;

ADULT; AGED; AGED, 80 AND OVER; ANIMALS; APOPTOSIS; BIOMARKERS, TUMOR; BLOTTING, WESTERN; CARCINOMA, HEPATOCELLULAR; CELL MOVEMENT; CELL PROLIFERATION; DNA METHYLATION; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE; FOLLOW-UP STUDIES; FORKHEAD TRANSCRIPTION FACTORS; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; IMMUNOENZYME TECHNIQUES; LIVER NEOPLASMS; MALE; MICE; MICE, NUDE; MIDDLE AGED; NEOPLASM INVASIVENESS; NEOPLASM STAGING; PROGNOSIS; PROMOTER REGIONS, GENETIC; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SURVIVAL RATE; TUMOR CELLS, CULTURED; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84940738945     PISSN: 00144800     EISSN: 10960945     Source Type: Journal    
DOI: 10.1016/j.yexmp.2015.06.017     Document Type: Article

References (22)

1. Abel E.V., Aplin A.E. FOXD3 is a mutant B-RAF-regulated inhibitor of G(1)-S progression in melanoma cells. Cancer Res. 2010, 70:2891-2900.
2. Abel E.V., et al. Melanoma adapts to RAF/MEK inhibitors through FOXD3-mediated upregulation of ERBB3. J. Clin. Invest. 2013, 123:2155-2168.
3. Bernardo G.M., et al. FOXA1 represses the molecular phenotype of basal breast cancer cells. Oncogene 2013, 32:554-563.
4. WHO Classification of Tumours of the Digestive System 2010, F.T. Bosman, R. Hruban, N. Theise (Eds.).
5. Cao J., et al. PLZF mediates the PTEN/AKT/FOXO3a signaling in suppression of prostate tumorigenesis. PLoS One 2013, 8:e77922.
6. Cheng A.S., et al. Helicobacter pylori causes epigenetic dysregulation of FOXD3 to promote gastric carcinogenesis. Gastroenterology 2013, 144:122-133. (e9).
7. Chu T.L., et al. FoxD3 deficiency promotes breast cancer progression by induction of epithelial-mesenchymal transition. Biochem. Biophys. Res. Commun. 2014, 446:580-584.
8. El-Serag H.B., et al. Diagnosis and treatment of hepatocellular carcinoma. Gastroenterology 2008, 134:1752-1763.
9. Katiyar P., Aplin A.E. FOXD3 regulates migration properties and Rnd3 expression in melanoma cells. Mol. Cancer Res. 2011, 9:545-552.
10. Li D., et al. FOXD3 is a novel tumor suppressor that affects growth, invasion, metastasis and angiogenesis of neuroblastoma. Oncotarget 2013, 4:2021-2044.
11. Ling N., et al. microRNA-155 regulates cell proliferation and invasion by targeting FOXO3a in glioma. Oncol. Rep. 2013, 30:2111-2118.
12. Liu L.L., et al. FoxD3-regulated microRNA-137 suppresses tumour growth and metastasis in human hepatocellular carcinoma by targeting AKT2. Oncotarget 2014, 5:5113-5124.
13. Lo P.K., et al. Epigenetic inactivation of the potential tumor suppressor gene FOXF1 in breast cancer. Cancer Res. 2010, 70:6047-6058.
14. Natsuizaka M., et al. Clinical features of hepatocellular carcinoma with extrahepatic metastases. J. Gastroenterol. Hepatol. 2005, 20:1781-1787.
15. Pan G., Thomson J.A. Nanog and transcriptional networks in embryonic stem cell pluripotency. Cell Res. 2007, 17:42-49.
16. Pan G., et al. A negative feedback loop of transcription factors that controls stem cell pluripotency and self-renewal. FASEB J. 2006, 20:1730-1732.
17. Plank J.L., et al. Transcriptional targets of Foxd3 in murine ES cells. Stem Cell Res. 2014, 12:233-240.
18. Plouhinec J.L., et al. Pax3 and Zic1 trigger the early neural crest gene regulatory network by the direct activation of multiple key neural crest specifiers. Dev. Biol. 2014, 386:461-472.
19. Schmid C.A., Muller A. FoxD3 is a novel, epigenetically regulated tumor suppressor in gastric carcinogenesis. Gastroenterology 2013, 144:22-25.
20. Teng L., et al. Requirement for Foxd3 in the maintenance of neural crest progenitors. Development 2008, 135:1615-1624.
21. Wang F., et al. FBX8 acts as an invasion and metastasis suppressor and correlates with poor survival in hepatocellular carcinoma. PLoS One 2013, 8:e65495.
22. Yamazaki Y., et al. Gradual DNA demethylation of the Oct4 promoter in cloned mouse embryos. Mol. Reprod. Dev. 2006, 73:180-188.