Behavioral effects of neurofeedback in adolescents with ADHD: a randomized controlled trial

European Child and Adolescent Psychiatry

Volumn 24, Issue 9, 2015, Pages 1035-1048

  Bink, Marleen ^a,b   van Nieuwenhuizen, Chijs ^a,c   Popma, Arne ^d   Bongers, Ilja L ^c   van Boxtel, Geert J M ^e  

^a TILBURG UNIVERSITY   (Netherlands)

^b VU UNIVERSITY AMSTERDAM   (Netherlands)

^c GGzE Foundation for Mental Health Care Eindhoven en de Kempen   (Netherlands)

^d VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^e TILBURG UNIVERSITY   (Netherlands)

Author keywords

ADHD; Neurofeedback; RCT; Theta SMR training

Indexed keywords

ADOLESCENT; ARTICLE; ARTIFACT; ATTENTION DEFICIT DISORDER; AUTISM; BEHAVIOR CHANGE; CHILD BEHAVIOR CHECKLIST; CONTROLLED STUDY; DSM-IV-TR; ELECTROENCEPHALOGRAM; FEMALE; GLOBAL ASSESSMENT OF FUNCTIONING; HUMAN; HUMAN EXPERIMENT; INTELLIGENCE QUOTIENT; MALE; MULTICENTER STUDY; MUSCLE TONE; NEUROFEEDBACK; RANDOMIZED CONTROLLED TRIAL; SEX DIFFERENCE; SLEEP PATTERN; ADULT; ATTENTION DEFICIT DISORDER WITH HYPERACTIVITY; CHILD; PROCEDURES; TREATMENT OUTCOME;

ADOLESCENT; ADULT; ATTENTION DEFICIT DISORDER WITH HYPERACTIVITY; CHILD; FEMALE; HUMANS; MALE; NEUROFEEDBACK; TREATMENT OUTCOME;

EID: 84940723804     PISSN: 10188827     EISSN: 1435165X     Source Type: Journal    
DOI: 10.1007/s00787-014-0655-3     Document Type: Article

References (64)

1. American Psychiatric Association (2000) Diagnostic and statistical manual of mental disorders. Fourth edition, text revision edn. American Psychiatric Association, Washington, DC
2. Willcutt EG (2012) The prevalence of DSM-IV attention-deficit/hyperactivity disorder: a meta-analytic review. Neurotherapeutics 9(3):490–499. doi:10.1007/s13311-012-0135-8
3. Barkley RA (2006) Comorbid disorders, social and family adjustment, and subtyping. In: Barkley RA (ed) Attention-deficit hyperactivity disorder: a handbook for diagnosis and treatment. The Guilford Press, New York, pp 184–218
4. Larson K, Russ SA, Kahn RS, Halfon N (2011) Patterns of comorbidity, functioning, and service use for US children with ADHD, 2007. Pediatrics 127(3):462–470. doi:10.1542/peds.2010-0165
5. Lee DO, Ousley OY (2006) Attention-deficit hyperactivity disorder symptoms in a clinic sample of children and adolescents with pervasive developmental disorders. J Child Adolesc Psychopharmacol 16(6):737–746. doi:10.1089/cap.2006.16.737
6. Simonoff E, Pickles A, Charman T, Chandler S, Loucas T, Baird G (2008) Psychiatric disorders in children with autism spectrum disorders: prevalence, comorbidity, and associated factors in a population-derived sample. J Am Acad Child Adolesc Psychiatry 47(8):921–929. doi:10.1097/CHI.0b013e318179964f
7. Gjevik E, Eldevik S, Fjaeran-Granum T, Sponheim E (2011) Kiddie-SADS reveals high rates of DSM-IV disorders in children and adolescents with autism spectrum disorders. J Autism Dev Disord 41(6):761–769. doi:10.1007/s10803-010-1095-7
8. Wolraich M, Brown L, Brown RT, DuPaul G, Earls M, Feldman HM, Ganiats TG, Kaplanek B, Meyer B, Perrin J, Pierce K, Reiff M, Stein MT, Visser S (2011) ADHD: clinical practice guideline for the diagnosis, evaluation, and treatment of attention-deficit/hyperactivity disorder in children and adolescents. Pediatrics 128(5):1007–1022. doi:10.1542/peds.2011-2654
9. Faraone SV, Buitelaar J (2010) Comparing the efficacy of stimulants for ADHD in children and adolescents using meta-analysis. Eur Child Adolesc Psychiatry 19(4):353–364. doi:10.1007/s00787-009-0054-3
10. Greenhill LL, Swanson JM, Vitiello B, Davies M, Clevenger W, Wu M, Arnold LE, Abikoff HB, Bukstein OG, Conners CK, Elliott GR, Hechtman L, Hinshaw SP, Hoza B, Jensen PS, Kraemer HC, March JS, Newcorn JH, Severe JB, Wells K, Wigal T (2001) Impairment and deportment responses to different methylphenidate doses in children with ADHD: the MTA titration trial. J Am Acad Child Adolesc Psychiatry 40(2):180–187. doi:10.1097/00004583-200102000-00012
11. Research Units on Pediatric Psychopharmacology Autism Network (2005) Randomized, controlled, crossover trial of methylphenidate in pervasive developmental disorders with hyperactivity. Arch Gen Psychiatry 62(11):1266–1274. doi:10.1001/archpsyc.62.11.1266
12. Graham J, Coghill D (2008) Adverse effects of pharmacotherapies for attention-deficit hyperactivity disorder: epidemiology, prevention and management. CNS Drugs 22(3):213–237
13. Lofthouse N, Arnold LE, Hersch S, Hurt E, DeBeus R (2012) A review of neurofeedback treatment for pediatric ADHD. J Atten Disord 16(5):351–372. doi:10.1177/1087054711427530
14. Gevensleben H, Rothenberger A, Moll GH, Heinrich H (2012) Neurofeedback in children with ADHD: validation and challenges. Expert Rev Neurother 12(4):447–460. doi:10.1586/ern.12.22
15. Moriyama TS, Polanczyk G, Caye A, Banaschewski T, Brandeis D, Rohde LA (2012) Evidence-based information on the clinical use of neurofeedback for ADHD. Neurotherapeutics 9(3):588–598. doi:10.1007/s13311-012-0136-7
16. Holtmann M, Steiner S, Hohmann S, Poustka L, Banaschewski T, Bolte S (2011) Neurofeedback in autism spectrum disorders. Dev Med Child Neurol 53(11):986–993. doi:10.1111/j.1469-8749.2011.04043.x
17. Snyder SM, Hall JR (2006) A meta-analysis of quantitative EEG power associated with attention-deficit hyperactivity disorder. J Clin Neurophysiol 23(5):440–455. doi:10.1097/01.wnp.0000221363.12503.78
18. Banaschewski T, Brandeis D (2007) Annotation: what electrical brain activity tells us about brain function that other techniques cannot tell us—a child psychiatric perspective. J Child Psychol Psychiatry 48(5):415–435
19. Sterman MB, Wyrwicka W (1967) EEG correlates of sleep: evidence for seperate forbrain substrates. Brain Res 6:143–163
20. Sterman MB, Wyrwicka W, Roth S (1969) Electrophysiological correlates and neural substrates of alimentary behavior in the cat. Ann N Y Acad Sci 157:723–739
21. Lubar JF, Shouse MN (1976) EEG and behavioral changes in a hyperkinetic child concurrent with training of the sensorimotor rhythm (SMR): a preliminary report. Biofeedback Self-Regul 1(3):293–306
22. Loo SK, Makeig S (2012) Clinical utility of EEG in attention-deficit/hyperactivity disorder: a research update. Neurotherapeutics 9(3):569–587. doi:10.1007/s13311-012-0131-z
23. Arns M, de Ridder S, Strehl U, Breteler M, Coenen A (2009) Efficacy of neurofeedback treatment in ADHD: the effects on inattention, impulsivity and hyperactivity: a meta-analysis. Clin EEG Neurosci 40(3):180–189
24. Sonuga-Barke EJ, Brandeis D, Cortese S, Daley D, Ferrin M, Holtmann M, Stevenson J, Danckaerts M, van der Oord S, Dopfner M, Dittmann RW, Simonoff E, Zuddas A, Banaschewski T, Buitelaar J, Coghill D, Hollis C, Konofal E, Lecendreux M, Wong IC, Sergeant J (2013) Nonpharmacological interventions for ADHD: systematic review and meta-analyses of randomized controlled trials of dietary and psychological treatments. Am J Psychiatry. doi:10.1176/appi.ajp.2012.12070991
25. Wechsler D (1991) Wechsler intelligence scale for children, 3rd edn. TX: The Psychological Corporation, San Antonio
26. Wechsler D (1997) Wechsler adult intelligence scale, 3rd edn. The Psychological Corporation, San Antonio
27. Kooij JJS (2002) ADHD bij volwassenen. Inleiding bij diagnostiek en behandeling [ADHD in adults. Introduction to diagnosis and treatment (in Dutch, 1st. ed.)]. 1st edn. Swets & Zeitlinger, Lisse
28. Sheehan DV, Lecrubier Y, Sheehan KH, Janavs J, Weiller E, Keskiner A, Schinka J, Knapp E, Sheehan MF, Dunbar GC (1997) The validity of the mini international neuropsychiatric interview (MINI) according to the SCID-P and its reliability. Eur Psychiatry 12(5):232–241
29. Sheehan DV, Lecrubier Y, Sheehan KH, Amorim P, Janavs J, Weiller E, Hergueta T, Baker R, Dunbar GC (1998) The mini-international neuropsychiatric interview (MINI): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. J Clin Psychiatry 59(20):22–33; quiz 34–57
30. Hermens DF, Kohn MR, Clarke SD, Gordon E, Williams LM (2005) Sex differences in adolescent ADHD: findings from concurrent EEG and EDA. Clin Neurophysiol 116(6):1455–1463. doi:10.1016/j.clinph.2005.02.012
31. Hermens DF, Williams LM, Lazzaro I, Whitmont S, Melkonian D, Gordon E (2004) Sex differences in adult ADHD: a double dissociation in brain activity and autonomic arousal. Biol Psychol 66(3):221–233. doi:10.1016/j.biopsycho.2003.10.006
32. Bink M, van Nieuwenhuizen C, Popma A, Bongers IL, van Boxtel GJM (2014) Neurocognitive effects of neurofeedback in adolescents with ADHD: an RCT. J Clin Psychiatry 75(5):535–542. doi:10.4088/JCP.13m08590
33. Dallal GE (2007) Randomization plan generator; first generator. http://www.randomization.com
34. Faul F, Erdefelder E, Lang AG, Buchner A (2007) G*power 3: a flexible statistical power analysis program for the social, behavioral and biomedical sciences. Behav Res Methods 39(2):175–191
35. Schulz KF, Altman DG, Moher D (2010) CONSORT 2010 Statement: updated guidelines for reporting parallel group randomised trials. BMC Med 8:18. doi:10.1186/1741-7015-8-18
36. Vink M, Van Wamel A (2007) Landelijk basisprogramma ADHD bij kinderen en jeugdigen [Dutch basic ADHD program for children and adolescents (in Dutch)]. Trimbos-instituut, Netherlands Institute of Mental Health and Addiction, Utrecht
37. Lubar JF (2003) Neurofeedback for the management of attention deficit disorders. In: Schwartz MS, Andrasik F (eds) Biofeedback a practitioner’s guide, 3rd edn. The Guilford Press, New York, pp 409–437
38. Lubar JO, Lubar JF (1984) Electroencephalographic biofeedback of SMR and beta for treatment of attention deficit disorders in a clinical setting. Biofeedback Self-Regul 9(1):1–23
39. Fuchs T, Birbaumer N, Lutzenberger W, Gruzelier JH, Kaiser J (2003) Neurofeedback treatment for attention-deficit/hyperactivity disorder in children: a comparison with methylphenidate. Appl Psychophysiol Biofeedback 28(1):1–12
40. Braininquiry PET EEG 2.0 duo channel bipolar system
41. EEGer Spectrum Systems EEGer neurofeedback software. 4.2.1.S edn
42. Kooij JJS, Buitelaar JK, van den Oord EJ, Furer JW, Rijnders CA, Hodiamont PP (2005) Internal and external validity of attention-deficit hyperactivity disorder in a population-based sample of adults. Psychol Med 35(6):817–827
43. Kooij JJS, Boonstra AM, Swinkels SHN, Bekker EM, Noord Id, Buitelaar JK (2008) Reliability, validity, and utility of instruments for self-report and informant report concerning symptoms of ADHD in adult patients. J Atten Disord 11(4):445–458. doi:10.1177/1087054707299367
44. DuPaul GJ, Anastopoulos AD, Power TJ, Reid R, Ikeda MJ, McGoey KE (1998) Parent ratings of attention-deficit/hyperactivity disorder symptoms: factor structure and normative data. J Psychopathol Behav Assess 20(1):83–102
45. Achenbach TM (1991) Integrative guide for the 1991 CBCL/4-18, YSR and TRF profiles. University of Vermont Department of Psychiatry, Burlington
46. Baron-Cohen S, Hoekstra RA, Knickmeyer R, Wheelwright S (2006) The autism-spectrum quotient (AQ)—adolescent version. J Autism Dev Disord 36(3):343–350. doi:10.1007/s10803-006-0073-6
47. Duric NS, Assmus J, Gundersen D, Elgen IB (2012) Neurofeedback for the treatment of children and adolescents with ADHD: a randomized and controlled clinical trial using parental reports. BMC Psychiatry 12:107. doi:10.1186/1471-244X-12-107
48. van Dongen-Boomsma M, Vollebregt MA, Slaats-Willemse D, Buitelaar JK (2013) A randomized placebo-controlled trial of electroencephalographic (EEG) neurofeedback in children with attention-deficit/hyperactivity disorder. J Clin Psychiatry 74(8):821–827. doi:10.4088/JCP.12m08321
49. Arnold LE, Lofthouse N, Hersch S, Pan X, Hurt E, Bates B, Kassouf K, Moone S, Grantier C (2013) EEG neurofeedback for ADHD: double-blind sham-controlled randomized pilot feasibility trial. J Atten Disord 17(5):410–419. doi:10.1177/1087054712446173
50. Perreau-Linck E, Lessard N, Levesque J, Beauregard M (2010) Effects of neurofeedback training on inhibitory capacities in ADHD children: a single-blind, randomized, placebo-controlled study. J Neurother 14:229–242. doi:10.1080/10874208.2010.501514
51. Vollebregt MA, van Dongen-Boomsma M, Buitelaar JK, Slaats-Willemse D (2013) Does EEG-neurofeedback improve neurocognitive functioning in children with attention-deficit/hyperactivity disorder? A systematic review and a double-blind placebo-controlled study. J Child Psychol Psychiatry. doi:10.1111/jcpp.12143
52. Monastra VJ, Monastra DM, George S (2002) The effects of stimulant therapy, EEG biofeedback, and parenting style on the primary symptoms of attention-deficit/hyperactivity disorder. Appl Psychophysiol Biofeedback 27(4):231–249
53. Meisel V, Servera M, Garcia-Banda G, Cardo E, Moreno I (2013) Neurofeedback and standard pharmacological intervention in ADHD: a randomized controlled trial with six-month follow-up. Biol Psychol 94(1):12–21. doi:10.1016/j.biopsycho.2013.04.015
54. Ogrim G, Hestad KA (2013) Effects of neurofeedback versus stimulant medication in attention-deficit/hyperactivity disorder: a randomized pilot study. J Child Adolesc Psychopharmacol 23(7):448–457. doi:10.1089/cap.2012.0090
55. Greenhill LL, Pliszka S, Dulcan MK, Bernet W, Arnold V, Beitchman J, Benson RS, Bukstein O, Bukstein O, Kinlan J, McClellan J, Rue D, Shaw JA, Stock S, American Academy of C, Adolescent P (2002) Practice parameter for the use of stimulant medications in the treatment of children, adolescents, and adults. J Am Acad Child Adolesc Psychiatry 41(2 Suppl):26S–49S
56. Rapport MD, Denney C (1997) Titrating methylphenidate in children with attention-deficit/hyperactivity disorder: is body mass predictive of clinical response? J Am Acad Child Adolesc Psychiatry 36(4):523–530. doi:10.1097/00004583-199704000-00015
57. Arns M, Kenemans JL (2012) Neurofeedback in ADHD and insomnia: vigilance stabilization through sleep spindles and circadian networks. Neurosci Biobehav Rev. doi:10.1016/j.neubiorev.2012.10.006
58. Holtmann M, Sonuga-Barke E, Cortese S, Brandeis D (2014) Neurofeedback for ADHD: a review of current evidence. Child Adolesc Psychiatr Clin N Am 23(4):789–806. doi:10.1016/j.chc.2014.05.006
59. Liechti MD, Valko L, Muller UC, Dohnert M, Drechsler R, Steinhausen HC, Brandeis D (2013) Diagnostic value of resting electroencephalogram in attention-deficit/hyperactivity disorder across the lifespan. Brain Topogr 26(1):135–151. doi:10.1007/s10548-012-0258-6
60. Poil SS, Bollmann S, Ghisleni C, O’Gorman RL, Klaver P, Ball J, Eich-Hochli D, Brandeis D, Michels L (2014) Age dependent electroencephalographic changes in attention-deficit/hyperactivity disorder (ADHD). Clin Neurophysiol. doi:10.1016/j.clinph.2013.12.118
61. Birbaumer N, Elbert T, Canavan AG, Rockstroh B (1990) Slow potentials of the cerebral cortex and behavior. Physiol Rev 70(1):1–41
62. Doehnert M, Brandeis D, Schneider G, Drechsler R, Steinhausen HC (2013) A neurophysiological marker of impaired preparation in an 11-year follow-up study of attention-deficit/hyperactivity disorder (ADHD). J Child Psychol Psychiatry 54(3):260–270. doi:10.1111/j.1469-7610.2012.02572.x
63. Drechsler R, Straub M, Doehnert M, Heinrich H, Steinhausen HC, Brandeis D (2007) 1Controlled evaluation of a neurofeedback training of slow cortical potentials in children with attention deficit/hyperactivity disorder (ADHD). Behav Brain Funct: BBF 3:35. doi:10.1186/1744-9081-3-35
64. Strehl U, Leins U, Goth G, Klinger C, Hinterberger T, Birbaumer N (2006) Self-regulation of slow cortical potentials: a new treatment for children with attention-deficit/hyperactivity disorder. Pediatrics 118(5):e1530–e1540. doi:10.1542/peds.2005-2478