Effect of ubiquinol therapy on sperm parameters and serum testosterone levels in oligoasthenozoospermic infertile men

Journal of Clinical and Diagnostic Research

Volumn 9, Issue 9, 2015, Pages

  Thakur, Amar Singh ^a   Littattarru, Gian Paolo ^b   Funahashi, Iwao ^c   Painkara, Umeshwar Singh ^d   Dange, Narendra Shriram ^e   Chauhan, Prabha ^e  

^a Department of Biochemistry GMC Jagdalpur(CG)   (India)

^b UNIVERSITÀ POLITECNICA DELLE MARCHE   (Italy)

^c KANEKA CORPORATION   (Japan)

^d Department of Medicine Government Medical College   (India)

^e Department of Biochemistry GMC(CG)   (India)

Author keywords

Anitoxidant; Male infertility; Seminal plasma

Indexed keywords

UBIQUINOL CYTOCHROME C REDUCTASE;

ADULT; ARTICLE; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; MAJOR CLINICAL STUDY; MALE; MALE INFERTILITY; OLIGOSPERMIA; SEMEN ANALYSIS; SPERMATOZOON COUNT; SPERMATOZOON MOTILITY; SPERMATOZOON TAIL; TESTOSTERONE BLOOD LEVEL; TREATMENT RESPONSE;

EID: 84940706235     PISSN: 2249782X     EISSN: 0973709X     Source Type: Journal    
DOI: 10.7860/JCDR/2015/13617.6424     Document Type: Article

References (19)

1. Balercia G, Mancini A, Paggi F, Tiano L, Pontecorvi A, Boscaro M, et al. Coenzyme Q 10 & male infertility. J Endcrinol Invest. 2009; 32(7): 626-32.
2. Afarwal A, Saleh RA, et al. Role of oxidants in male infertility: rationale, significance and treatment. Urol clin N Am. 2002; 29: 817-27.
3. Sindair S et al. Male infertility: Nutritionla and environmental considerations. Altern Med Rev. 2000; 5(1): 28-38.
4. Sharma RK, et al. Role of reactive oxyen species in male infertility (Clinical review). From the Andrology Research & Clinical laboratories, Dept. of Urology, The Cleveland foundation, Cleveland, Ohio. Urology. 1996; 48(6): 835-50.
5. Agarwal A, Sushil A, et al. Prevention of Oxidative Stress Injury to Sperm. Journal of Andrology. 2005; 26(6): 654-60.
6. Agarwal A, Sekhon LH, et al. The role of antioxidant therapy in the treatment of male infertility. Human Fertility. 2010; 13(4): 217-25.
7. Martin-Du Pan RC, Sakkas D. Are antioxidants useful in the treatment of male infertility? Hum Reprod. 1998; 13: 2984-85.
8. Suleiman SA, Ali ME, Zaki ZMS, et al. Lipid peroxidation and human sperm motility: protective role of vitamin E. J Androl. 1996; 17: 530-37.
9. Abel BJ, Carswell G, Elton R, et al. Randomized trial of clomiphene citrate treatment and vitamin C for male infertility. Br J Urol. 1982; 54: 780-84.
10. Moilanen J, Hovatta O. Excretion of alpha-tocopherol into human seminal plasma after oral administration. Andrologia. 1995; 27: 133-36.
11. Comhaire FH, Christophe AB, Zalata AA, et al. The effects of combined conventional treatment, oral antioxidants and essential fatty acids on sperm biology in subfertile men. Prostaglandins Leukot Essent Fatty Acids. 2000; 63: 159-65.
12. Balericia G, Mosca F, Boscara M, Mancini A, Ricciardo-lamonica G, Littarru G, et al. Coenzyme Q (10) supllementation in infertile men with idiopathic asthenozoospermia: an open, uncontrolled pilot study. Fertil Steril. 2004; 81(1): 93-98.
13. Gaby AR, et at. The role of coenzyme Q 10 in clinical medicine. Part II. Cardiovascular disease, hypertension, Diabetes Mellitus and infertility. Alternative Medicine review. 1996; 1(3): 168-75.
14. Tietz NW. Text book of Clinical Guide to Laboratory Tests, Third Edition, p578-580. W. B. Saunders Company; Philadelphia, 1995.
15. WHO. Laboratory manual for the examination and processing of human semen. 5th edition: chapter-2; pp. 10 -102
16. Safarinejad MR, et al. Efficiency of coenzyme Q 10 on semen parameters, sperm function and reproductive hormones in infertile men. The Journal of Urology. 2009; 182: 237-48.
17. Schachter MB, 1996. Available from. http: //www. mbschachter. com/coenzyme q10. htm
18. Thakur AS, Littaru GP, Moesgaard S, Dan Sindberg C, Khan Y, Singh CM, et al. Hematological parameters and RBC TBARS level of Q 10 supllemented tribal sickle cell patients: A hospital based study. Ind J Clin Biochem. 2012; pp. 1-4, doi: 10. 1007/s12291-012-0277-79.
19. Littarru GP, Tiano L, et al. Clinical aspects of coenzyme Q 10: An update. Nutrition. 2010; 26: 250-54.