Coenzyme Q10 and male infertility

Journal of Endocrinological Investigation

Volumn 32, Issue 7, 2009, Pages 626-632

  Balercia, G ^a   Mancini, A ^b   Paggi, F ^a   Tiano, L ^a   Pontecorvi, A ^b   Boscaro, M ^a   Lenzi, A ^c   Littarru, G P ^a  

^a UNIVERSITÀ POLITECNICA DELLE MARCHE   (Italy)

^b CATHOLIC UNIVERSITY   (Italy)

^c SAPIENZA UNIVERSITY OF ROME   (Italy)

Author keywords

Coenzyme Q10; Infertility; Oxidative stress; Ubiquinol

Indexed keywords

PLACEBO; RECOMBINANT FOLLITROPIN; UBIDECARENONE; DRUG DERIVATIVE; UBIQUINOL; UBIQUINONE; VITAMIN;

ASTHENOSPERMIA; CLINICAL TRIAL; DRUG ACTIVITY; HUMAN; IN VITRO STUDY; MALE INFERTILITY; REVIEW; SEMINAL PLASMA; SPERMATOZOON; SPERMATOZOON MOTILITY; ANIMAL; DOUBLE BLIND PROCEDURE; ENZYMOLOGY; MALE; METABOLISM; OXIDATION REDUCTION REACTION; PHYSIOLOGY; RANDOMIZED CONTROLLED TRIAL; SPERM;

ANIMALS; ASTHENOZOOSPERMIA; DOUBLE-BLIND METHOD; HUMANS; INFERTILITY, MALE; MALE; OXIDATION-REDUCTION; RANDOMIZED CONTROLLED TRIALS AS TOPIC; SEMEN; SPERM MOTILITY; SPERMATOZOA; UBIQUINONE; VITAMINS;

EID: 70949092044     PISSN: 03914097     EISSN: None     Source Type: Journal    
DOI: 10.1007/bf03346521     Document Type: Review

References (78)

1. Iwasaki A, Gagnon C. Formation of reactive oxygen species in spermatozoa of infertile men. Fertil Steril 1992, 47: 409-411
2. MacLeod J. The role of oxygen in the metabolism and motility of human spermatozoa. Am J Physiol 1943, 138: 512-518
3. Aitken RJ, Krausz C. Oxidative stress, DNA damage and the Y chromosome. Reproduction 2001, 122: 497-506.
4. Agarwal A, Saleh RA. Role of oxidants in male infertility: rationale, significance and treatment. Urol Clin N Am 2002, 29: 817-827 (Pubitemid 36015326)
5. Jones R, Mann T, Sherins R. Peroxidative breakdown of phospholipids in human spermatozoa, spermicidal properties of fatty acid peroxides, and protective action of seminal plasma. Fertil Steril 1979, 31: 531-537 (Pubitemid 9150061)
6. Aitken RJ, Clarkson JS, Fishel S. Generation of reactive oxygen species, lipid peroxidation, and human sperm function. Biol Reprod 1989, 41: 183-197 (Pubitemid 19246344)
7. Sharma RK, Agarwal A. Role of reactive oxygen species in male infertility. Urology 1996, 48: 835-850 (Pubitemid 26427090)
8. Alvarez JG, Touchstone JC, Blasco L, Storey BT. Spontaneous lipid peroxidation and production of hydrogen peroxide and superoxide in human spermatozoa: superoxide dismutase as major enzyme protectant against oxygen toxicity. J Androl 1987, 8: 338-348
9. Aitken RJ. Molecular mechanisms regulating sperm function. Mol Hum Reprod 1997, 3: 169-173 (Pubitemid 127509474)
10. Halliwell B. Free radicals, antioxidants, and human disease: curiosity, cause, or consequence? Lancet 1994, 344: 721-724
11. Cummins JM, Jequier AM, Kan R. Molecular biology of human male infertility: links with aging, mitochondrial genetics, and oxidative stress? Mol Reprod Dev 1994, 37: 345-362
12. Geva E, Lessino JB, Lerner-Geva L, Amit A. Free radicals, antioxidants and human spermatozoa: clinical implications. Hum Reprod 1998, 13: 1422-1424 (Pubitemid 28310466)
13. Wolf DE, Hagopian SS, Lewis RG, Voglmayr JK, Fairbanks G. Lateral regionalization and diffusion of a maturation-dependent antigen in the ram sperm plasma membrane. J Cell Biol 1996, 102: 1826-1831
14. Myles DG, Primakoff P. Localized surface antigens of guinea pig sperm migrate to new regions prior to fertilization. J Cell Biol 1984, 99: 1634-1641 (Pubitemid 15223599)
15. Gaunt SJ, Brown CR, Jones R. Identification of mobile and fixed antigens on the plasma membrane of rat spermatozoa using monoclonal antibodies. Exp Cell Res 1983, 144: 275-284
16. Hall JC, Hadley J, Doman T. Correlation between changes in rat sperm membrane lipids, protein, and the membrane physical state during epididymal maturation. J Androl 1991, 12: 76-87.
17. Lenzi A, Gandini L, Picardo M. A rationale for glutathione therapy. Hum Reprod 1998, 13: 1419-1422
18. Wolff H, Politch JA, Martinez A, Haimovici F, Hill JA, Anderson DJ. Leukocytospermia is associated with poor semen quality. Fertil Steril 1990, 53: 528-536 (Pubitemid 20093619)
19. Johnson L, Varner DD. Effect of daily spermtozoan production but not age on transit time of spermatozoa through the human epididymis. Biol Reprod 1988, 39: 812-817 (Pubitemid 18279149)
20. Ford WCL, Whittington K. Antioxidant treatment for male subfertility: a promise that remains unfulfilled. Hum Reprod 1998, 13: 1416-1419 (Pubitemid 28310464)
21. Sakkas D, Mariethoz E, St.John JC. Abnormal sperm parameters in humans are indicative of an abortive apoptotic mechanism linked to the Fas-mediated pathway. Exp Cell Res 1999, 251: 350-355 (Pubitemid 29431872)
22. Irvine DS, Twigg J, Gordon E, Fulton N, Milne P, Aitken RJ. DNA integrity in human spermatozoa: relationship with semen quality. J Androl 2000, 21: 33-44. (Pubitemid 30069079)
23. Donnelly ET, O'Connell M, McClure N, Lewis SE. Differences in nuclear DNA fragmentation and mitochondrial integrity of semen and prepared human spermatozoa. Hum Reprod 2000, 15: 1552-1561 (Pubitemid 30741929)
24. Russell LD. Editorial: The perils of sperm release - 'let my children go'. Int J Androl 1991, 14: 307-311
25. Huszar G, Vigue L. Correlation between the rate of lipid peroxidation and cellular maturity as measured by creatine kinase activity in human spermatozoa. J Androl 1994, 15: 71-77 (Pubitemid 24061788)
26. Zalata A, Hafez T, Comhaire F. Evaluation of the role of reactive oxygen species in male infertility. Hum Reprod 1995, 10: 1444-1451
27. Parinaud J, Le Lannou D, Vieitez G, Griveau JF, Milhet P, Richoilley G. Enhancement of motility by treating spermatozoa with an antioxidant solution (Sperm-Fit) following ejaculation. Hum Reprod 1997, 12: 2434-2436 (Pubitemid 27522203)
28. Babior BM, Cumutte JT, McMurrich BJ. The particulate superoxide-forming system in human neutrophils. Properties of the system and further evidence supporting its participation in the respiratory burst. J Clin Invest 1976, 58: 989-996
29. Aitken RJ, Buckingham D, West K, Wu FC, Zikopoulous K, Richardson DW. Differential contribution of leukocytes and spermatozoa to the generation of reactive oxygen species in the ejaculates of oligozoospermic patients and fertile donors. J Reprod Fertil 1992, 94: 451-462
30. Griveau JF, Dumont E, Renard P, Callegari JP, Le Lannou D. Reactive oxygen species, lipid peroxidation and enzymatic defence systems in human spematozoa. J Reprod Fertil 1995, 103: 17-26.
31. Aitken RJ, West K, Buckingham D. Leukocytic infiltration into the human ejaculate and its association with semen quality, oxidative stress, and sperm function. J Androl 1994, 15: 343-352 (Pubitemid 24256649)
32. Aitken RJ, Buckingham DW, Brindle J, Gomez E, Baker HW, Irvine DS. Analysis of sperm movement in relation to the oxidative stress created by leukocytes in washed sperm preparation and seminal plasma. Hum Reprod 1995, 10: 2061-2071
33. Wolff H. The biologic significance of white blood-cells in semen. Fertil Steril 1995, 63: 1143-1157
34. Zini A, De Lamirande E, Gagnon C. Reactive oxygen species in semen of infertile patients: levels of superoxide dismutase- and catalase-like activities in seminal plasma and spermatozoa. Int J Androl 1993, 16: 183-188 (Pubitemid 23241013)
35. Smith R, Vantman D, Ponce J, Escobar J, Lissi E. Total antioxidant capacity of human seminal plasma. Hum Reprod 1996, 11: 1655-1660 (Pubitemid 26318905)
36. Lewis SE, Boyle PM, McKinney KA, Young IS, Thompson W. Total antioxidant capacity of seminal plasma is different in fertile and infertile men. Fertil Steril 1995, 64: 868-870
37. Sharma RK, Pasqualotto FF, Nelson DR, Thomas AJ Jr, Agarwal A. The reactive species-total antioxidant capacity score is a new measure of oxidative stress to predict male infertility. Hum Reprod 1999, 14: 2801-2807 (Pubitemid 29520697)
38. Pasqualotto FF, Sharma RK, Kobayashi H, Nelson DR, Thomas AJ Jr, Agarwal A. Oxidative stress in normospermic men undergoing infertility evaluation. J Androl 2001, 22: 316-322 (Pubitemid 32174193)
39. Hendin BN, Kolettis PN, Sharma RK, Thomas AJ Jr, Agarwal A. Varicocele is associated with elevated spermatozoal reactive oxygen species production and diminished seminal plasma antioxidant capacity. J Urol 1999, 161: 1831-1834 (Pubitemid 29420743)
40. Aksoy H, Aksoy Y, Ozbey I, Altuntas I, Akcay F. The relationship between varicocele and semen nitric oxide concentrations. Urol Res 2000, 28: 357-359 (Pubitemid 32039603)
41. Saleh RA, Agarwal A, Sharma RK, Nelson DR, Thomas AJ. Effect of cigarette smoking on levels of seminal oxidative stress in infertile men: a prospective study. Fertil Steril 2002, 78: 491-499 (Pubitemid 35041578)
42. Pasqualotto FF, Sharma RK, Potts JM, Nelson DR, Thomas AJ, Agarwal A. Seminal oxidative stress in patients with chronic prostatitis. Urology 2000, 55: 881-885 (Pubitemid 30330792)
43. Depuydt CE, Bosmans E, Zalata A, Schoonjans F, Comhaire F. The relation between reactive oxygen species and cytokines in andrological patients with or without male accessory gland infection. J Androl 1996, 17: 699-707. (Pubitemid 27014436)
44. Pasqualotto FF, Sharma RK, Nelson DR, Thomas AJ, Agarwal A. Relationship between oxidative stress, semen characteristics, and clinical diagnosis in men undergoing infertility investigation. Fertil Steril 2000, 73: 459-464 (Pubitemid 30109638)
45. Zini A, O'Bryan M, Schlegel PN. Nitric oxide synthase activity in human seminal plasma. Urology 2001, 58: 85-89 (Pubitemid 32633941)
46. Huang C, Li J, Zheng R, Cui K. Hydrogen peroxide-induced apoptosis in human hepatoma cells is mediated by CD95(APO-1/Fas) receptor/ligand system and may involve activation of wild-type p53. Mol Biol Rep 2000, 27: 1-11.
47. Sayers TJ, Brooks AD, Seki N, et al. T cell lysis of murine renal cancer: multiple signalling pathways for cell death via Fas. J Leukoc Biol 2000, 68: 81-86 (Pubitemid 30679739)
48. Mancini A, Meucci E, Bianchi A, Milardi D, De Marinis L, Littarru G. Antioxidant systems in human seminal plasma: physiopathological meaning and new perspectives. In: Panglossi HV ed. "Antioxidants: New Research", New York: Nova Pub. 2006, 131-147
49. Dallner G, Stocker R. Coenzyme Q10. Encyclopedia of Dietary Supplements 2005, 121-131
50. Groneberg DA, Kindermann B, Althammer M, et al. Coenzyme Q10 affects expression of genes involved in cell signalling, metabolism and transport in human CaCo-2 cells. Int J Biochem Cell Biol 2005, 37: 1208-1218 (Pubitemid 40381197)
51. Fawcett DW. The mammalian spermatozoon. Dev Biol 1975, 44: 394-436.
52. Kalen A, Appelkvist EL, Chojnacki T, Dallner G. Nonaprenyl-4- hydroxybenzoate transferase, an enzyme involved in ubiquinone biosynthesis in endoplasmic reticulum-Golgi system of rat liver. J Biol Chem 1990, 265: 1158-1164 (Pubitemid 20048912)
53. 10 concentrations in normal and pathological human seminal fluid. J Androl 1994, 15: 591-594
54. th ed. Cambridge: Cambridge University Press, 1999.
55. Hirsh AV, Cameron KM, Tyler JP, Simpson J, Pryor JP. The Doppler assessment of varicoceles and internal spermatic vein reflux in infertile men. Br J Urol 1980, 52: 50-56
56. 10: another biochemical alteration linked to infertility in varicocele patients?. Metabolism 2003, 52: 402-406 (Pubitemid 36773259)
57. Angelitti AG, Colacicco L, Callà C, Arizzi M, Lippa S. Coenzyme Q: potentially useful index of bioenergetic and oxidative status of spermatozoa. Clin Chem 1995, 41: 217-219
58. 10 levels in human seminal fluid: diagnostic and clinical implications. Mol Aspects Med 1994, 15 (Suppl): s249-55.
59. 10 levels. In: Folkers K, Littarru GP, Yamagami T (eds). Biomedical and clinical aspects of Coenzyme Q. Amsterdam: Elsevier 1991, 167-178
60. Mancini A, Conte G, Milardi D, De Marinis L, Littarru G. Relationship between sperm cell ubiquinone and seminal parameters in subjects with and without varicocele. Andrologie 1998, 30: 1-4. (Pubitemid 28175461)
61. 10 in varicocele patients. Horm Metab Res 2005, 37: 428-432 (Pubitemid 41081223)
62. Meucci E, Milardi D, Mordente A, et al. Total antioxidant capacity in patients with varicocele. Fertil Steril 2003, 79 (Suppl 3): 1577-1583
63. 10 association, Los Angeles 2005, 64-65
64. Alleva R, Scaramucci A, Mantero F, Bompadre S, Leoni L, Littarru G. The protective role of ubiquinol-10 against formation of lipid hydroperoxides in human seminal fluid. Mol Aspects Med (Suppl 1) 1997, 18: 221-228 (Pubitemid 127673480)
65. 10 results in increased levels of ubiquinol-10 within circulating lipoproteins and increased resistance of human low-density lipoprotein to the initiation of lipid peroxidation. Biochim Biophys Acta 1992, 1126: 247-254
66. 10 levels in idiopathic and varicocele-associated asthenozoospermia. Andrologia 2002, 34: 107-111 (Pubitemid 34429518)
67. 10: an update. Curr Opin Clin Nutr Metab Care 2005, 8: 641-646
68. nd International Symposium on Reproductive Medicine, Fiuggi. Rome: Acta Medica, Edizioni e Congressi 1988, 71.
69. 10). J Endocrinol Invest 1990, 13: S1, 88.
70. 10 on sperm motility and function. Molec Aspects Med 1997, 18 (Suppl): S213-9.
71. Balercia G, Mantero F, Armeni T, Principato G, Regoli F. Total oxyradical scavenging capacity toward different reactive species in seminal plasma and sperm cells. Clin Chem Lab Med 2003, 41: 13-19 (Pubitemid 36285379)
72. Balercia G, Mosca F, Mantero F, et al. Coenzyme Q(10) supplementation in infertile men with idiopathic asthenozoospermia: an open, uncontrolled pilot study. Fertil Steril 2004, 81: 93-98
73. Balercia G, Moretti S, Vignini A, et al. Role of nitric oxide concentrations on human sperm motility. J Androl 2004, 25: 245-249 (Pubitemid 38240666)
74. Frei B, Yamamoto Y, Niclas D, Ames BN. Evaluation of an isoluminol chemiluminescence assay for detection of hydroperoxides in human blood plasma. Annal Biochem 1998, 175: 120-130
75. 10. Mol Aspects Med 1997, 8 (Suppl): S145-51.
76. 10 treatment in infertile male with idiopathic asthenozoospermia. A placebo-controlled, double blind randomized trial. Fertil Steril 2009, 91: 1785-1792
77. Fato R, Cavazzoni M, Castelluccio C, Parenti Castelli G, Lenaz G. Steady-state kinetics of ubiquinol-cytochrome c reductase in bovine heart submitochondrial particles: diffusional effects. Biochem J 1993, 290: 225-236 (Pubitemid 23081223)
78. Kelso KA, Redpath A, Noble RC, Speake BK. Lipid and antioxidant changes in spermatozoa and seminal plasma throughout the reproductive period of bulls. J Reprod Fertil 1997, 109: 1-6. (Pubitemid 27089477)