Arsenite Binds to the RING Finger Domains of RNF20-RNF40 Histone E3 Ubiquitin Ligase and Inhibits DNA Double-Strand Break Repair

Journal of the American Chemical Society

Volumn 136, Issue 37, 2014, Pages 12884-12887

  Zhang, Fan ^a   Paramasivam, Manikandan ^b   Cai, Qian ^a   Dai, Xiaoxia ^a   Wang, Pengcheng ^a   Lin, Krystal ^b   Song, Jikui ^b   Seidman, Michael M ^b   Wang, Yinsheng ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b NATIONAL INSTITUTE ON AGING   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; ARSENIC; CELL CULTURE; CELLS; CYTOLOGY; DNA; ENZYMES; REPAIR;

CARCINOGENIC EFFECTS; CHROMATIN FIBERS; CYSTEINE RESIDUES; DNA DOUBLE STRAND BREAKS; E3 UBIQUITIN LIGASES; ENVIRONMENTAL CONTAMINANT; MOLECULAR MECHANISM; UBIQUITIN LIGASES;

PROTEINS;

ARSENIC TRIOXIDE; BRCA1 PROTEIN; CYSTEINE; HETERODIMER; HISTONE H2B; RAD51 PROTEIN; RNF20 HETERODIMER; RNF40 HETERODIMER; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG; ZINOSTATIN; ARSENOUS ACID DERIVATIVE; CARCINOGEN; HISTONE; RNF20 PROTEIN, HUMAN; RNF40 PROTEIN, HUMAN; UBIQUITIN PROTEIN LIGASE;

ARTICLE; CARCINOGENIC ACTIVITY; CONTROLLED STUDY; DNA END JOINING REPAIR; DOUBLE STRANDED DNA BREAK; FLOW CYTOMETRY; HISTONE UBIQUITINATION; HUMAN; HUMAN CELL; IN VITRO STUDY; IONIZING RADIATION; REAL TIME POLYMERASE CHAIN REACTION; RING FINGER MOTIF; CELL LINE; CHEMISTRY; DRUG EFFECTS; METABOLISM; UBIQUITINATION;

ARSENITES; CARCINOGENS; CELL LINE; DNA BREAKS, DOUBLE-STRANDED; HISTONES; HUMANS; RING FINGER DOMAINS; UBIQUITIN-PROTEIN LIGASES; UBIQUITINATION;

EID: 84940667985     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja507863d     Document Type: Article

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