Dynamics of adaptive and innate immunity inpatients treated during primary human immunodeficiency virus infection: Results from Maraviroc in HIV Acute Infection (MAIN) randomized clinical trial

Clinical Microbiology and Infection

Volumn 21, Issue 9, 2015, Pages 876.e1-876.e4

  Ripa, M ^a,b   Pogliaghi, M ^a,b   Chiappetta, S ^a,b   Galli, L ^b   Pensieroso, S ^b   Cavarelli, M ^b   Scarlatti, G ^b   De Biasi, S ^c   Cossarizza, A ^c   De Battista, D ^b   Malnati, M ^b   Lazzarin, A ^a,b   Nozza, S ^b   Tambussi, G ^b  

^a VITA SALUTE SAN RAFFAELE UNIVERSITY   (Italy)

^b SAN RAFFAELE HOSPITAL   (Italy)

^c UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

Author keywords

B cells; Dendritic cells; Immune activation; Natural killer cells; Primary human immunodeficiency virus type 1 infection

Indexed keywords

CD16 ANTIGEN; CD4 ANTIGEN; CD56 ANTIGEN; CD8 ANTIGEN; MARAVIROC; PROTEINASE INHIBITOR; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; CYCLOHEXANE DERIVATIVE; TRIAZOLE DERIVATIVE;

ADAPTIVE IMMUNITY; ADULT; ARTICLE; B LYMPHOCYTE; BONE MARROW CELL; CD4 CD8 RATIO; CD8+ T LYMPHOCYTE; CELL COUNT; CLINICAL ARTICLE; CONTROLLED STUDY; DENDRITIC CELL; FEMALE; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; INNATE IMMUNITY; MALE; NATURAL KILLER CELL; PERIPHERAL BLOOD MONONUCLEAR CELL; PLASMACYTOID DENDRITIC CELL; PRIMARY INFECTION; PRIORITY JOURNAL; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; T LYMPHOCYTE ACTIVATION; HIV INFECTIONS; HUMAN IMMUNODEFICIENCY VIRUS; IMMUNOLOGY; LYMPHOCYTE SUBPOPULATION; PROCEDURES;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1;

ADAPTIVE IMMUNITY; ADULT; ANTI-HIV AGENTS; ANTIRETROVIRAL THERAPY, HIGHLY ACTIVE; CYCLOHEXANES; DENDRITIC CELLS; FEMALE; HIV; HIV INFECTIONS; HUMANS; IMMUNITY, INNATE; LYMPHOCYTE SUBSETS; MALE; PROSPECTIVE STUDIES; TRIAZOLES;

EID: 84940614591     PISSN: 1198743X     EISSN: 14690691     Source Type: Journal    
DOI: 10.1016/j.cmi.2015.05.007     Document Type: Article

References (16)

1. Cohen M.S., Shaw G.M., McMichael A.J., Haynes B.F. Acute HIV-1 infection. NEngl J Med 2011, 364:1943-1954.
2. + T cells in multiple tissues during acute SIV infection. Nature 2005, 434(7037):1093-1097.
3. Streeck H., Jessen H., Alter G., et al. Immunological and virological impact of highly active antiretroviral therapy initiated during acute HIV-1 infection. JInfect Dis 2006, 194:734-739.
4. ++ T cells and viraemia in response to quadruple highly active antiretroviral therapy in primary HIV infection. AIDS 2002, 16:589-596.
5. Moir S., Fauci A.S. Bcells in HIV infection and disease. Nat Rev Immunol 2009, 9:235-245.
6. Moir S., Fauci A.S. Insights into B cells and HIV-specific B-cell responses in HIV-infected individuals. Immunol Rev 2013, 254:207-224.
7. Amu S., Ruffin N., Rethi B., Chiodi F. Impairment of B-cell functions during HIV-1 infection. AIDS 2013, 27:2323-2334.
8. Moir S., Ho J., Malaspina A., Wang W., et al. Evidence for HIV-associated B cell exhaustion in a dysfunctional memory B cell compartment in HIV-infected viremic individuals. JExp Med 2008, 205:1797-1805.
9. Alter G., Teigen N., Davis B.T., et al. Sequential deregulation of NK cell subset distribution and function starting in acute HIV-1 infection. Blood 2005, 106:3366-3369.
10. + natural killer (NK) cells: a highly dysfunctional NK subset expanded in HIV-infected viremic individuals. Proc Natl Acad Sci USA 2005, 102:2886-2891.
11. Huang J., Yang Y., Al-Mozaini M., et al. Dendritic cell dysfunction during primary HIV-1 infection. JInfect Dis 2011, 204:1557-1562.
12. Robbins G.K., Spritzler J.G., Chan E.S., et al. Incomplete reconstitution of T cell subsets on combination antiretroviral therapy in the AIDS Clinical Trials Group protocol 384. Clin Infect Dis 2009, 1(48):350-361.
13. Titanji K., Chiodi F., Bellocco R., et al. Primary HIV-1 infection sets the stage for important B lymphocyte dysfunctions. AIDS 2005, 19:1947-1955.
14. Moir S., Buckner C.M., Ho J., et al. Bcells in early and chronic HIV infection: evidence for preservation of immune function associated with early initiation of antiretroviral therapy. Blood 2010, 116:5571-5579.
15. Pensieroso S., Galli L., Nozza S., et al. B-cell subsetalterations and correlated factors in HIV-1 infection. AIDS 2013, 27:1209-1217.
16. Manches O., Frleta D., Bhardwaj N. Dendritic cells in progression and pathology of HIV infection. Trends Immunol 2013, doi:pii:S1471-4906(13) 00156-7.