ProteoPlex: Stability optimization of macromolecular complexes by sparse-matrix screening of chemical space

Nature Methods

Volumn 12, Issue 9, 2015, Pages 859-865

  Chari, Ashwin ^a   Haselbach, David ^a   Kirves, Jan Martin ^a   Ohmer, Juergen ^b   Paknia, Elham ^b   Fischer, Niels ^a   Ganichkin, Oleg ^c   Möller, Vanessa ^d   J Frye, Jeremiah ^e   Petzold, Georg ^f   Jarvis, Marc ^f   Tietzel, Michael ^g   Grimm, Clemens ^b   Peters, Jan Michael ^f   Schulman, Brenda A ^e   Tittmann, Kai ^g   Markl, Jürgen ^d   Fischer, Utz ^b   Stark, Holger ^a  

^a MAX PLANCK INSTITUTE FOR BIOPHYSICAL CHEMISTRY   (Germany)

^b UNIVERSITY OF WÜRZBURG   (Germany)

^c FREIE UNIVERSITÄT BERLIN   (Germany)

^d JOHANNES GUTENBERG UNIVERSITY   (Germany)

^e ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^f RESEARCH INSTITUTE OF MOLECULAR PATHOLOGY   (Austria)

^g UNIVERSITY OF GÖTTINGEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BUFFER; MULTIPROTEIN COMPLEX; PROTEIN BINDING;

ARTICLE; CRYOELECTRON MICROSCOPY; CRYSTALLIZATION; IN VITRO STUDY; MACROMOLECULAR COMPLEX; MACROMOLECULE; MOLECULAR STABILITY; NONHUMAN; PH; PRIORITY JOURNAL; PROTEIN QUATERNARY STRUCTURE; SCREENING; SPARSE MATRIX SCREENING; TEMPERATURE DEPENDENCE; TRANSMISSION ELECTRON MICROSCOPY; X RAY CRYSTALLOGRAPHY; ALGORITHM; BINDING SITE; CHEMICAL MODEL; CHEMICAL STRUCTURE; CHEMISTRY; COMPUTER PROGRAM; COMPUTER SIMULATION; PROTEIN CONFORMATION; PROTEIN FOLDING; ULTRASTRUCTURE;

ALGORITHMS; BINDING SITES; COMPUTER SIMULATION; CRYSTALLIZATION; MODELS, CHEMICAL; MODELS, MOLECULAR; MULTIPROTEIN COMPLEXES; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN FOLDING; SOFTWARE;

EID: 84940608127     PISSN: 15487091     EISSN: 15487105     Source Type: Journal    
DOI: 10.1038/nmeth.3493     Document Type: Article

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