A new pharmacological effect of levornidazole: Inhibition of NLRP3 inflammasome activation

Biochemical Pharmacology

Volumn 97, Issue 2, 2015, Pages 178-188

  Wang, Xingqi ^a   Wang, Shiyu ^a   Hu, Chunhui ^a   Chen, Wei ^a   Shen, Yan ^a   Wu, Xuefeng ^a   Sun, Yang ^a   Xu, Qiang ^a  

^a NANJING UNIVERSITY   (China)

Author keywords

Dextrornidazole; IL 1 ; Levornidazole; Macrophages; NLRP3 inflammasome

Indexed keywords

ADENOSINE TRIPHOSPHATE; CRYOPYRIN; DEXAMETHASONE; DEXTRAN SULFATE; DEXTRORNIDAZOLE; GAMMA INTERFERON; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INFLAMMASOME; INTERLEUKIN 18; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; INTERLEUKIN 6; LEVORNIDAZOLE; LIPOPOLYSACCHARIDE; MESSENGER RNA; METHAMPHETAMINE; NITROIMIDAZOLE DERIVATIVE; PYRROLIDINE DITHIOCARBAMATE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; URATE; CARRIER PROTEIN; CIAS1 PROTEIN, MOUSE; ORNIDAZOLE;

ANAEROBIC BACTERIUM; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COLITIS; COMPARATIVE STUDY; CONTROLLED STUDY; CYTOKINE RELEASE; DISEASE ACTIVITY; DISEASE SEVERITY; DRUG ACTIVITY; DRUG EFFECT; ENZYME LINKED IMMUNOSORBENT ASSAY; EX VIVO STUDY; FEMALE; HISTOPATHOLOGY; IN VITRO STUDY; IN VIVO STUDY; INFLAMMATION; LYMPHOCYTE PROLIFERATION; MACROPHAGE; MITOCHONDRIAL MEMBRANE POTENTIAL; MOUSE; NONHUMAN; PERITONEUM MACROPHAGE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SECRETION; SEPTIC SHOCK; SKIN ALLERGY; SURVIVAL RATE; THERAPY EFFECT; WEIGHT REDUCTION; WESTERN BLOTTING; ANALOGS AND DERIVATIVES; ANIMAL; ANTAGONISTS AND INHIBITORS; C57BL MOUSE; CELL LINE; DOSE RESPONSE; DRUG EFFECTS; HUMAN; METABOLISM;

ANIMALS; CARRIER PROTEINS; CELL LINE; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HUMANS; INFLAMMASOMES; MACROPHAGES; MICE, INBRED C57BL; ORNIDAZOLE;

EID: 84940578544     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2015.06.030     Document Type: Article

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