MicroRNA let-7c-5p protects against cerebral ischemia injury via mechanisms involving the inhibition of microglia activation

Brain, Behavior, and Immunity

Volumn 49, Issue , 2015, Pages 75-85

  Ni, Jingshu ^a   Wang, Xiaoyu ^a   Chen, Shuangshuang ^a   Liu, Huihui ^c   Wang, Yun ^a   Xu, Xingshun ^b,c   Cheng, Jian ^b,c   Jia, Jia ^a   Zhen, Xuechu ^a  

^a MEDICAL COLLEGE OF SOOCHOW UNIVERSITY   (China)

^b SOOCHOW UNIVERSITY   (China)

^c THE SECOND AFFILIATED HOSPITAL OF SOOCHOW UNIVERSITY   (China)

Author keywords

Ischemic stroke; Let 7c 5p; Microglia; MicroRNA

Indexed keywords

CASPASE 3; LET 7C 5P; MESSENGER RNA; MICRORNA; UNCLASSIFIED DRUG; 3' UNTRANSLATED REGION; AUTACOID;

3' UNTRANSLATED REGION; ADULT; AGED; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BRAIN CORTEX; BRAIN INFARCTION; BRAIN INFARCTION SIZE; BRAIN INJURY; BRAIN ISCHEMIA; CASPASE 3 GENE; CELL ACTIVATION; CLINICAL ARTICLE; CORPUS STRIATUM; EXPERIMENTAL STROKE; GENE EXPRESSION REGULATION; GENE OVEREXPRESSION; HISTOPATHOLOGY; HUMAN; MALE; MICROGLIA; MOUSE; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; TREATMENT OUTCOME; ANIMAL; BLOOD; CEREBROVASCULAR ACCIDENT; DISEASE MODEL; ENCEPHALITIS; METABOLISM; MIDDLE AGED;

3' UNTRANSLATED REGIONS; AGED; ANIMALS; BRAIN ISCHEMIA; CASPASE 3; CEREBRAL CORTEX; CORPUS STRIATUM; DISEASE MODELS, ANIMAL; ENCEPHALITIS; HUMANS; INFLAMMATION MEDIATORS; MALE; MICE; MICROGLIA; MICRORNAS; MIDDLE AGED; STROKE;

EID: 84940576141     PISSN: 08891591     EISSN: 10902139     Source Type: Journal    
DOI: 10.1016/j.bbi.2015.04.014     Document Type: Article

References (32)

1. Banerjee S., Xie N., Cui H., Tan Z., Yang S., Icyuz M., Abraham E., Liu G. MicroRNA let-7c regulates macrophage polarization. J. Immunol. 2013, 190:6542-6549.
2. Bjorner S., Fitzpatrick P.A., Li Y., Allred C., Howell A., Ringberg A., Olsson H., Miller C.J., Axelson H., Landberg G. Epithelial and stromal microRNA signatures of columnar cell hyperplasia linking Let-7c to precancerous and cancerous breast cancer cell proliferation. PLoS One 2014, 9:e105099.
3. Boland K., Flanagan L., Prehn J.H. Paracrine control of tissue regeneration and cell proliferation by Caspase-3. Cell Death Dis. 2013, 4:e725.
4. Burguillos M.A., Deierborg T., Kavanagh E., Persson A., Hajji N., Garcia-Quintanilla A., Cano J., Brundin P., Englund E., Venero J.L., Joseph B. Caspase signalling controls microglia activation and neurotoxicity. Nature 2011, 472:319-324.
5. Ceulemans A.G., Zgavc T., Kooijman R., Hachimi-Idrissi S., Sarre S., Michotte Y. The dual role of the neuroinflammatory response after ischemic stroke: modulatory effects of hypothermia. J. Neuroinflammation 2010, 7.
6. Dawson D.A., Hallenbeck J.M. Acute focal ischemia-induced alterations in MAP2 immunostaining: description of temporal changes and utilization as a marker for volumetric assessment of acute brain injury. J. Cereb. Blood Flow Metab. 1996, 16:170-174.
7. Denes A., Vidyasagar R., Feng J., Narvainen J., McColl B.W., Kauppinen R.A., Allan S.M. Proliferating resident microglia after focal cerebral ischaemia in mice. J. Cereb. Blood Flow Metab. 2007, 27:1941-1953.
8. Eacker S.M., Dawson T.M., Dawson V.L. Understanding microRNAs in neurodegeneration. Nat. Rev. Neurosci. 2009, 10:837-841.
9. Fricker M., Vilalta A., Tolkovsky A.M., Brown G.C. Caspase inhibitors protect neurons by enabling selective necroptosis of inflamed microglia. J. Biol. Chem. 2013, 288:9145-9152.
10. Goldstein L.B., Adams R., Becker K., Furberg C.D., Gorelick P.B., Hademenos G., Hill M., Howard G., Howard V.J., Jacobs B., Levine S.R., Mosca L., Sacco R.L., Sherman D.G., Wolf P.A., del Zoppo G.J. Primary prevention of ischemic stroke: a statement for healthcare professionals from the Stroke Council of the American Heart Association. Stroke 2001, 32:280-299.
11. Hu X.M., Li P.Y., Guo Y.L., Wang H.Y., Leak R.K., Chen S.E., Gao Y.Q., Chen J. Microglia/macrophage polarization dynamics reveal novel mechanism of injury expansion after focal cerebral ischemia. Stroke 2012, 43:3063-U3474.
12. Jin Q., Cheng J., Liu Y., Wu J., Wang X.Y., Wei S.W., Zhou X.M., Qin Z.H., Jia J., Zhen X.C. Improvement of functional recovery by chronic metformin treatment is associated with enhanced alternative activation of microglia/macrophages and increased angiogenesis and neurogenesis following experimental stroke. Brain Behav. Immun. 2014, 40:131-142.
13. Kim S.J., Li J.R. Caspase blockade induces RIP3-mediated programmed necrosis in Toll-like receptor-activated microglia. Cell Death Dis. 2013, 4.
14. Kim M.J., Cho J.H., Cho J.H., Park J.H., Ahn J.H., Tae H.J., Cho G.S., Yan B.C., Hwang I.K., Lee C.H., Bae E.J., Won M.H., Lee J.C. Impact of hyperthermia before and during ischemia-reperfusion on neuronal damage and gliosis in the gerbil hippocampus induced by transient cerebral ischemia. J. Neurol. Sci. 2015, 348:101-110.
15. Lagos-Quintana M., Rauhut R., Yalcin A., Meyer J., Lendeckel W., Tuschl T. Identification of tissue-specific microRNAs from mouse. Curr. Biol. 2002, 12:735-739.
16. Li J., Zhang S.Y., Lu M.R., Chen Z.B., Chen C., Han L.J., Zhang M.J., Xu Y. Hydroxysafflor yellow A suppresses inflammatory responses of BV2 microglia after oxygen-glucose deprivation. Neurosci. Lett. 2013, 535:51-56.
17. McColl B.W., Allan S.M., Rothwell N.J. Systemic infection, inflammation and acute ischemic stroke. Neuroscience 2009, 158:1049-1061.
18. Olde Loohuis N.F., Kos A., Martens G.J., Van Bokhoven H., Nadif Kasri N., Aschrafi A. MicroRNA networks direct neuronal development and plasticity. Cell. Mol. Life Sci. 2012, 69:89-102.
19. Pan J., Palmateer J., Schallert T., Hart M., Pandya A., Vandenbark A.A., Offner H., Hurn P.D. Novel humanized recombinant T cell receptor ligands protect the female brain after experimental stroke. Transl. Stroke Res. 2014, 5:577-585.
20. Pena-Philippides J.C., Yang Y., Bragina O., Hagberg S., Nemoto E., Roitbak T. Effect of pulsed electromagnetic field (PEMF) on infarct size and inflammation after cerebral ischemia in mice. Transl. Stroke Res. 2014, 5:491-500.
21. Rougvie A.E. Control of developmental timing in animals. Nat. Rev. Genet. 2001, 2:690-701.
22. Seifert H.A., Pennypacker K.R. Molecular and cellular immune responses to ischemic brain injury. Transl. Stroke Res. 2014, 5:543-553.
23. Sorensen S.S., Nygaard A.B., Nielsen M.Y., Jensen K., Christensen T. MiRNA expression profiles in cerebrospinal fluid and blood of patients with acute ischemic stroke. Transl. Stroke Res. 2014, 5:711-718.
24. Tan K.S., Armugam A., Sepramaniam S., Lim K.Y., Setyowati K.D., Wang C.W., Jeyaseelan K. Expression profile of MicroRNAs in young stroke patients. PLoS One 2009, 4:e7689.
25. Tan M.S., Yu J.T., Jiang T., Zhu X.C., Guan H.S., Tan L. IL12/23 p40 inhibition ameliorates Alzheimer's disease-associated neuropathology and spatial memory in SAMP8 mice. J. Alzheimer's Dis. 2014, 38:633-646.
26. Tao L., Zhang F., Hao L., Wu J., Jia J., Liu J.Y., Zheng L.T., Zhen X. 1-O-tigloyl-1-O-deacetyl-nimbolinin B inhibits LPS-stimulated inflammatory responses by suppressing NF-kappaB and JNK activation in microglia cells. J. Pharm. Sci. 2014, 125:364-374.
27. Taylor R.A., Sansing L.H. Microglial responses after ischemic stroke and intracerebral hemorrhage. Clin. Dev. Immunol. 2013.
28. Wang C.X., Shuaib A. Involvement of inflammatory cytokines in central nervous system injury. Prog. Neurobiol. 2002, 67:161-172.
29. Xu Z., Wu J., Zheng J., Ma H., Zhang H., Zhen X., Zheng L.T., Zhang X. Design, synthesis and evaluation of a series of non-steroidal anti-inflammatory drug conjugates as novel neuroinflammatory inhibitors. Int. Immunopharmacol. 2015, 25:528-537.
30. Yilmaz G., Granger D.N. Cell adhesion molecules and ischemic stroke. Neurol. Res. 2008, 30:783-793.
31. Zhan M., Qu Q., Wang G., Zhou H. Let-7c sensitizes acquired cisplatin-resistant A549 cells by targeting ABCC2 and Bcl-XL. Pharmazie 2013, 68:955-961.
32. Zhang W., Liu H., Liu W., Liu Y., Xu J. Polycomb-mediated loss of microRNA let-7c determines inflammatory macrophage polarization via PAK1-dependent NF-kappaB pathway. Cell Death Differ. 2015, 22:287-297.