MicroRNA-124 involves in ankylosing spondylitis by targeting ANTXR2

Modern Rheumatology

Volumn 25, Issue 5, 2015, Pages 784-789

  Xia, Yu ^a   Chen, Kun ^b   Zhang, Ming Hua ^c   Wang, Lai Cheng ^a   Ma, Chun Yan ^a   Lin, Yan Liang ^a   Zhao, Yue Ran ^a  

^a SHANDONG PROVINCIAL HOSPITAL AFFILIATED TO SHANDONG UNIVERSITY   (China)

^b SHANDONG UNIVERSITY   (China)

^c Shandong Medical College   (China)

Author keywords

Ankylosing Spondylitis; ANTXR2; Autophagy; JNK; MIR 124

Indexed keywords

ANTHRAX TOXIN RECEPTOR 2; MICRORNA 124; RECEPTOR; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG; ANTXR2 PROTEIN, HUMAN; DNA; MICRORNA; MIRN124 MICRORNA, HUMAN;

ADOLESCENT; ADULT; ANKYLOSING SPONDYLITIS; ARTICLE; AUTOPHAGY; BLOOD ANALYSIS; CLINICAL ARTICLE; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; DOWN REGULATION; FEMALE; FLOW CYTOMETRY; GENE OVEREXPRESSION; GENETIC ANALYSIS; GENETIC ASSOCIATION; HUMAN; HUMAN CELL; LUCIFERASE ASSAY; MALE; NUCLEAR MAGNETIC RESONANCE IMAGING; OSSIFICATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; RISK FACTOR; SACROILIITIS; TRANSIENT TRANSFECTION; UPREGULATION; WESTERN BLOTTING; BIOSYNTHESIS; CELL CULTURE; GENE EXPRESSION REGULATION; GENETICS; GENOME-WIDE ASSOCIATION STUDY; METABOLISM; SPONDYLITIS, ANKYLOSING;

ADULT; BLOTTING, WESTERN; CELLS, CULTURED; DNA; FLOW CYTOMETRY; GENE EXPRESSION REGULATION; GENOME-WIDE ASSOCIATION STUDY; HUMANS; MALE; MICRORNAS; REAL-TIME POLYMERASE CHAIN REACTION; RECEPTORS, PEPTIDE; SPONDYLITIS, ANKYLOSING; TOMOGRAPHY, X-RAY COMPUTED;

EID: 84940561535     PISSN: 14397595     EISSN: 14397609     Source Type: Journal    
DOI: 10.3109/14397595.2015.1023887     Document Type: Article

References (41)

1. Brown M A, Kennedy L G, MacGregor A J, Darke C, Duncan E, Shatford JL, et al. Susceptibility to ankylosing spondylitis in twins: the role of genes, HLA, and the environment. Arthritis Rheum. 1997; 40(10): 1823-8.
2. Lin Z, Bei JX, Shen M, Li Q, Liao Z, Zhang Y, et al. A genome-wide association study in Han Chinese identifies new susceptibility loci for ankylosing spondylitis. Nat Genet. 2012; 44(1): 73-7.
3. Brown M A, Pile K D, Kennedy L G, Calin A, Darke C, Bell J, e t a l. H LAclass I associations of ankylosing spondylitis in the white population in the United Kingdom. Ann Rheum Dis. 1996; 55(4): 268-70.
4. Reveille JD, Sims AM, Danoy P, Evans DM, Leo P, Pointon JJ, et al. Genome-wide association study of ankylosing spondylitis identifies non-MHC susceptibility loci. Nat Genet. 2010; 42(2): 123-7.
5. Haroon N, Tsui F W, Uchanska-Ziegler B, Ziegler A, Inman R D. Endoplasmic reticulum aminopeptidase 1 (ERAP1) exhibits functionally significant interaction with HLA-B27 and relates to subtype specificity in ankylosing spondylitis. Ann Rheum Dis. 2012; 71(4): 589-95.
6. Wong RH, Wei JC, Huang CH, Lee HS, Chiou SY, Lin SH, et al. Association of IL-12B genetic polymorphism with the susceptibility and disease severity of ankylosing spondylitis. J Rheumatol. 2012; 39(1): 135-40.
7. Rahman P, Inman RD, Gladman DD, Reeve JP, Peddle L, Maksymowych WP. Association of interleukin-23 receptor variants with ankylosing spondylitis. Arthritis Rheum. 2008; 58(4): 1020-5.
8. Pearce E L, Mullen A C, Martins G A, Krawczyk C M, Hutchins AS, Zediak VP, et al. Control of effector CD8 + T cell function by the transcription factor Eomesodermin. Science. 2003; 302(5647): 1041-3.
9. Xiao S, Su DM, Manley NR. Atypical memory phenotype T cells with low homeostatic potential and impaired TCR signaling and regulatory T cell function in Foxn1Delta/Delta mutant mice. J Immunol. 2007; 179(12): 8153-63.
10. R eeves C V, Dufraine J, Young J A, Kitajewski J. Anthrax toxin receptor 2 is expressed in murine and tumor vasculature and functions in endothelial proliferation and morphogenesis. Oncogene. 2010; 29(6): 789-801.
11. Hanks S, Adams S, Douglas J, Arbour L, Atherton DJ, Balci S, et al. Mutations in the gene encoding capillary morphogenesis protein 2 cause juvenile hyaline fibromatosis and infantile systemic hyalinosis. Am J Hum Genet. 2003; 73(4): 791-800.
12. Ha SD, Ham B, Mogridge J, Saftig P, Lin S, Kim SO. Cathepsin B-mediated autophagy flux facilitates the anthrax toxin receptor 2-mediated delivery of anthrax lethal factor into the cytoplasm. J Biol Chem. 2010; 285(3): 2120-9.
13. Deuquet J, Lausch E, Superti-Furga A, v an der Goot F G. The dark sides of capillary morphogenesis gene 2. EMBO J. 2012; 31(1): 3-13.
14. Tsui F W, Tsui H W, Akram A, Haroon N, Inman R D. The genetic basis of ankylosing spondylitis: new insights into disease pathogenesis. Appl Clin Genet. 2014; 7: 105-15.
15. Kenna T J, Davidson S I, Duan R, Bradbury L A, McFarlane J, Smith M, et al. Enrichment of circulating interleukin-17-secreting interleukin-23 receptor-positive gamma/delta Tcells in patients with active ankylosing spondylitis. Arthritis Rheum. 2012; 64(5): 1420-9.
16. Shen H, Goodall J C, Hill Gaston J S. Frequency and phenotype of peripheral blood Th17 cells in ankylosing spondylitis and rheumatoid arthritis. Arthritis Rheum. 2009; 60(6): 1647-56.
17. Xueyi L, Lina C, Zhenbiao W, Qing H, Qiang L, Zhu P. Levels of circulating Th17 cells and regulatory T cells in ankylosing spondylitis patients with an inadequate response to anti-TNF-alpha therapy. J Clin Immunol. 2013; 33(1): 151-61.
18. Bidad K, Salehi E, Jamshidi A, Saboor-Yaraghi A A, Oraei M, Meysamie A, et al. Effect of all-transretinoic acid on Th17 and T regulatory cell subsets in patients with ankylosing spondylitis. J Rheumatol. 2013; 40(4): 476-83.
19. Brown M A. Genetics and the pathogenesis of ankylosing spondylitis. Curr Opin Rheumatol. 2009; 21(4): 318-23.
20. Shan S, Dang J, Li J, Yang Z, Zhao H, Xin Q, et al. ETS1 variants confer susceptibility to ankylosing spondylitis in Han Chinese. Arthritis Res Ther. 2014; 16(2): R87.
21. Syrbe U, Scheer R, Wu P, Sieper J. Differential synovial Th1 cell reactivity towards Escherichia coli antigens in patients with ankylosing spondylitis and rheumatoid arthritis. Ann Rheum Dis. 2012; 71(9): 1573-6.
22. Banks DJ, Barnajian M, Maldonado-Arocho FJ, Sanchez AM, Bradley KA. Anthrax toxin receptor 2 mediates Bacillus anthracis killing of macrophages following spore challenge. Cell Microbiol. 2005; 7(8): 1173-85.
23. Lai NS, Yu HC, Chen HC, Yu CL, Huang HB, Lu MC. Aberrant expression of microRNAs in T cells from patients with ankylosing spondylitis contributes to the immunopathogenesis. Clin Exp Immunol. 2013; 173(1): 47-57.
24. Ma C, Li Y, Li M, Deng G, Wu X, Zeng J, et al. microRNA-124 negatively regulates TLR signaling in alveolar macrophages in response to mycobacterial infection. Mol Immunol. 2014; 62(1): 150-8.
25. v an der Linden S, Valkenburg H A, Cats A. Evaluation of diagnostic criteria for ankylosing spondylitis. A proposal for modification of the New York criteria. Arthritis Rheum. 1984; 27(4): 361-8.
26. Reeves CV, Wang X, Charles-Horvath PC, Vink JY, Borisenko VY, Young JA, et al. Anthrax toxin receptor 2 functions in ECM homeostasis of the murine reproductive tract and promotes MMP activity. PLoS One. 2012; 7(4): e34862.
27. Zou J, Xu L, Ju Y, Zhang P, Wang Y, Zhang B. Cholesterol depletion induces ANTXR2-dependent activation of MMP-2 via ERK1/2 phosphorylation in neuroglioma U251 cell. Biochem Biophys Res Commun. 2014; 452(1): 186-90.
28. Wei W, Lu Q, Chaudry G J, Leppla S H, Cohen S N. The LDL receptorrelated protein LRP6 mediates internalization and lethality of anthrax toxin. Cell. 2006; 124(6): 1141-54.
29. Corr M. Wnt signaling in ankylosing spondylitis. Clin Rheumatol. 2014; 33(6): 759-62.
30. Karaderi T, Keidel S M, Pointon J J, Appleton L H, Brown M A, Evans DM, et al. Ankylosing spondylitis is associated with the anthrax toxin receptor 2 gene (ANTXR2). Ann Rheum Dis. 2014; 73(11): 2054-8.
31. Hou C, Zhu M, Sun M, Lin Y. MicroRNA let-7i induced autophagy to protect T cell from apoptosis by targeting IGF1R. Biochem Biophys Res Commun. 2014; 453(4): 728-34.
32. Wei J, Wang F, Kong LY, Xu S, Doucette T, Ferguson SD, et al. miR-124 inhibits STAT3 signaling to enhance T cell-mediated immune clearance of glioma. Cancer Res. 2013; 73(13): 3913-26.
33. Yang S, Liu X, Li X, Sun S, Sun F, Fan B, et al. MicroRNA-124 reduces caveolar density by targeting caveolin-1 in porcine kidney epithelial PK15 cells. Mol Cell Biochem. 2013; 384(1-2): 213-9.
34. Jiang S, Li C, McRae G, Lykken E, Sevilla J, Liu SQ, et al. MeCP2 reinforces STAT3 signaling and the generation of effector CD4 + T cells by promoting miR-124-mediated suppression of SOCS5. Sci Signal. 2014; 7(316): ra25.
35. Ponomarev E D, Veremeyko T, Barteneva N, Krichevsky A M, Weiner HL. MicroRNA-124 promotes microglia quiescence and suppresses EAE by deactivating macrophages via the C/EBP-alpha-PU.1 pathway. Nat Med. 2011; 17(1): 64-70.
36. Nakamachi Y, Ohnuma K, Uto K, Noguchi Y, Saegusa J, Kawano S. MicroRNA-124 inhibits the progression of adjuvant-induced arthritis in rats. Ann Rheum Dis. 2015.
37. Vreugdenhil E, Verissimo CS, Mariman R, Kamphorst JT, Barbosa JS, Zweers T, et al. MicroRNA 18 and 124a down-regulate the glucocorticoid receptor: implications for glucocorticoid responsiveness in the brain. Endocrinology. 2009; 150(5): 2220-8.
38. Lorin S, Pierron G, Ryan K M, Codogno P, Djavaheri-Mergny M. Evidence for the interplay between JNK and p53-DRAM signalling pathways in the regulation of autophagy. Autophagy. 2010; 6(1): 153-4.
39. Choi AM, Ryter SW and Levine B. Autophagy in human health and disease. N Engl J Med. 2013; 368(7): 1845-6.
40. Mizushima N, Levine B, Cuervo AM, Klionsky DJ. Autophagy fights disease through cellular self-digestion. Nature. 2008; 451(7182): 1069-75.
41. Ciccia F, Accardo-Palumbo A, Rizzo A, Guggino G, Raimondo S, Giardina A, et al. Evidence that autophagy, but not the unfolded protein response, regulates the expression of IL-23 in the gut of patients with ankylosing spondylitis and subclinical gut inflammation. Ann Rheum Dis. 2014; 73(8): 1566-74.