Differential synovial Th1 cell reactivity towards Escherichia coli antigens in patients with ankylosing spondylitis and rheumatoid arthritis

Annals of the Rheumatic Diseases

Volumn 71, Issue 9, 2012, Pages 1573-1576

  Syrbe, Uta ^a   Scheer, Rebecca ^a   Wu, Peihua ^a,b   Sieper, Joachim ^a,b  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b DEUTSCHES RHEUMA FORSCHUNGSZENTRUM   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL ANTIGEN; CD40 LIGAND; ESCHERICHIA COLI PROTEIN; GAMMA INTERFERON; STAPHYLOCOCCUS ENTEROTOXIN B; VIRULENCE FACTOR;

ANKYLOSING SPONDYLITIS; ARTICLE; CD4 LYMPHOCYTE COUNT; CELL SPECIFICITY; CLINICAL ARTICLE; COMMENSAL ESCHERICHIA COLI; CONTROLLED STUDY; CYTOMEGALOVIRUS; HUMAN; HUMAN CELL; IMMUNOREACTIVITY; IMMUNOSTIMULATION; INTERFERON PRODUCTION; MOLECULAR PATHOLOGY; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; RHEUMATOID ARTHRITIS; SYNOVIAL FLUID; SYNOVIOCYTE; TH1 CELL;

ANTIGENS, BACTERIAL; ARTHRITIS, RHEUMATOID; ESCHERICHIA COLI; HUMANS; SPONDYLITIS, ANKYLOSING; SYNOVIAL MEMBRANE; TH1 CELLS;

EID: 84864872929     PISSN: 00034967     EISSN: 14682060     Source Type: Journal    
DOI: 10.1136/annrheumdis-2012-201404     Document Type: Article

References (17)

1. Mielants H, Veys EM, Cuvelier C, et al. The evolution of spondyloarthropathies in relation to gut histology. II. Histological aspects. J Rheumatol 1995;22:2273-8.
2. Mielants H, Veys EM, Cuvelier C, et al. Ileocolonoscopic findings in seronegative spondylarthropathies. Br J Rheumatol 1988;27(Suppl 2):95-105.
3. Taurog JD, Richardson JA, Croft JT, et al. The germfree state prevents development of gut and joint inflammatory disease in HLA-B27 transgenic rats. J Exp Med 1994;180:2359-64. (Pubitemid 24351619)
4. Maki-Ikola O, Nissila M, Lehtinen K, et al. IgA class serum antibodies against three different Klebsiella serotypes in ankylosing spondylitis. Br J Rheumatol 1998;37:1299-302.
5. Madhavan R, Porkodi R, Rajendran CP, et al. IgM, IgG, and IgA response to Enterobacteria in patients with ankylosing spondylitis in southern India. Ann N Y Acad Sci 2002;958:408-11. (Pubitemid 34592272)
6. Duchmann R, May E, Heike M, et al. T cell specificity and cross reactivity towards Enterobacteria, Bacteroides, Bifidobacterium, and antigens from resident intestinal flora in humans. Gut 1999;44:812-18. (Pubitemid 29244216)
7. Ergin A, Bussow K, Sieper J, et al. Homologous high-throughput expression and purification of highly conserved E coli proteins. Microb Cell Fact 2007;6:18.
8. Swidsinski A, Ladhoff A, Pernthaler A, et al. Mucosal flora in inflammatory bowel disease. Gastroenterology 2002;122:44-54. (Pubitemid 34049193)
9. Ergin A, Syrbe U, Scheer R, et al. Impaired peripheral Th1 CD4+ T cell response to Escherichia coli proteins in patients with Crohn's disease and ankylosing spondylitis. J Clin Immunol 2011;31:998-1009.
10. Frentsch M, Arbach O, Kirchhoff D, et al. Direct access to CD4+ T cells specific for defined antigens according to CD154 expression. Nat Med 2005;11:1118-24. (Pubitemid 41486836)
11. Hermann E, Sucke B, Droste U, et al. Klebsiella pneumoniae-reactive T cells in blood and synovial fluid of patients with ankylosing spondylitis. Comparison with HLA-B27+ healthy control subjects in a limiting dilution study and determination of the specificity of synovial fluid T cell clones. Arthritis Rheum 1995;38:1277-82.
12. Salmi M, Rajala P, Jalkanen S. Homing of mucosal leukocytes to joints. Distinct endothelial ligands in synovium mediate leukocyte-subtype specific adhesion. J Clin Invest 1997;99:2165-72. (Pubitemid 27203772)
13. Salmi M, Jalkanen S. Human leukocyte subpopulations from inflamed gut bind to joint vasculature using distinct sets of adhesion molecules. J Immunol 2001;166:4650-7. (Pubitemid 32233752)
14. Granfors K, Jalkanen S, von Essen R, et al. Yersinia antigens in synovial-fluid cells from patients with reactive arthritis. N Engl J Med 1989;320:216-21. (Pubitemid 19034147)
15. Rudwaleit M, Siegert S, Yin Z, et al. Low T cell production of TNFalpha and IFNgamma in ankylosing spondylitis: its relation to HLA-B27 and influence of the TNF-308 gene polymorphism. Ann Rheum Dis 2001;60:36-42. (Pubitemid 32038951)
16. Kurokawa M, Kato T, Masuko-Hongo K, et al. Characterisation of T cell clonotypes that accumulated in multiple joints of patients with rheumatoid arthritis. Ann Rheum Dis 1999;58:546-53. (Pubitemid 29409100)
17. Rittner HL, Zettl A, Jendro MC, et al. Multiple mechanisms support oligoclonal T cell expansion in rheumatoid synovitis. Mol Med 1997;3:452-65. (Pubitemid 27438769)