Clinical correlation of peripheral CD4+-cell sub-sets, their imbalance and Parkinson's disease

Molecular Medicine Reports

Volumn 12, Issue 4, 2015, Pages 6105-6111

  Chen, Yuhua ^a   Qi, Benquan ^a   Xu, Wenfang ^a   Ma, Bo ^a   Li, Li ^a   Chen, Qiming ^a   Qian, Weidong ^a   Liu, Xiaolin ^a   Qu, Hongdang ^a  

^a BENGBU MEDICAL COLLEGE   (China)

Author keywords

CD4+ T cells; Parkinson's disease; T helper type 1 2 cell balance; T helper type 17 T regulatory cell balance

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 17; INTERLEUKIN 4;

ADULT; ARTICLE; AUTOANALYSIS; CD4+ T LYMPHOCYTE; CELLULAR IMMUNITY; COMPARATIVE STUDY; CONTROLLED STUDY; DISEASE SEVERITY; FEMALE; FLOW CYTOMETRY; HEMATOLOGY; HUMAN; HUMAN CELL; IMMUNOPATHOGENESIS; IMMUNOSTIMULATION; LEUKOCYTE COUNT; LYMPHOCYTE COUNT; LYMPHOCYTE DIFFERENTIATION; MAJOR CLINICAL STUDY; MALE; MOTOR PERFORMANCE; NEUTROPHIL COUNT; PARKINSON DISEASE; QUANTITATIVE ANALYSIS; REGULATORY T LYMPHOCYTE; T LYMPHOCYTE SUBPOPULATION; TH1 CELL; TH1 TH2 BALANCE; TH17 CELL; TH17 REGULATORY T LYMPHOCYTE CELL BALANCE; TH2 CELL; UNIFIED PARKINSON DISEASE RATING SCALE; AGED; CASE CONTROL STUDY; IMMUNOLOGY; MIDDLE AGED; PATHOPHYSIOLOGY;

ADULT; AGED; CASE-CONTROL STUDIES; CD4-POSITIVE T-LYMPHOCYTES; FEMALE; HUMANS; MALE; MIDDLE AGED; PARKINSON DISEASE; T-LYMPHOCYTES, REGULATORY; TH1-TH2 BALANCE; TH17 CELLS;

EID: 84940549571     PISSN: 17912997     EISSN: 17913004     Source Type: Journal    
DOI: 10.3892/mmr.2015.4136     Document Type: Article

References (42)

1. Dorsey ER, Constantinescu R, Thompson J P, et al: Projected number of people with Parkinson's disease in the most populous nations, 2005 through 2030. Neurology 68: 384-386, 2007.
2. Mori F, Nishie M, Kakita A, Yoshimoto M, Takahashi H and Wakabayashi K: Relationship among alpha-synuclein accumulation, dopamine synthesis, and neurodegeneration in Parkinson disease substantia nigra. J Neuropathol Exp Neurol 65: 808-815, 2006.
3. Croisier E, Moran LB, Dexter DT, Pearce RK and Graeber MB: Microglial infammation in the parkinsonian substantia nigra: Relationship to alphaa-synuclein deposition. J Neuroinfammation 2: 14, 2005.
4. Stevens CH, Rowe D, Morel-Kopp MC, Orr C, Russell T, Ranola M, Ward C and Halliday GM: Reduced T helper and B lymphocytes in Parkinson's disease. J Neuroimmunol 252: 95-99, 2012.
5. Umemura A, Oeda T, Tomita S, Hayashi R, Kohsaka M, Park K, Sugiyama H and Sawada H: Delirium and high Fever are associated with subacute motor deterioration in Parkinson disease: A nested case-control study. PLOS One 9: e94944, 2014.
6. Noelker C, Morel L, Osterloh A, Alvarez-Fischer D, Lescot T, Breloer M, Gold M, Oertel WH, Henze C, Michel PP, et al: Heat shock protein 60: An endogenous inducer of dopaminergic cell death in Parkinson disease. J Neuroinfammation 11: 86, 2014.
7. More SV, Kumar H, Kim IS, Song SY and Choi DK: Cellular and molecular mediators of neuroinfammation in the pathogenesis of Parkinson's disease. Mediators Infamm 2013: 952375, 2013.
8. Bakay RA, Boyer K L, Freed CR and Ansari AA: Immunological responses to injury and grafting in the central nervous system of nonhuman primates. Cell Transplant 7: 109-120, 1998.
9. Luk KC, Kehm VM, Zhang B, O'Brien P, Trojanowski JQ and Lee VM: Intracerebral inoculation of pathological α-synuclein initiates a rapidly progressive neurodegenerative α-synucleinopathy in mice. J Exp Med 209: 975-986, 2012.
10. Maetzler W, Apel A, Langkamp M, Deuschle C, Dilger SS, Stirnkorb JG, Schulte C, Schleicher E, Gasser T and Berg D: Comparable autoantibody serum levels against amyloid-and infammation-associated proteins in Parkinson's disease patients and controls. PLOS One 9: e88604, 2014.
11. Hamza TH, Zabetian CP, Tenesa A, Laederach A, Montimurro J, Yearout D, Kay DM, Doheny KF, Paschall J, Pugh E, et al: Common genetic variation in the HLA region is associated with late-onset sporadic Parkinson's disease. Nat Genet 42: 781-785, 2010.
12. Melief J, Koning N, Schuurman KG, Van De Garde MD, Smolders J, Hoek RM, Van Eijk M, Hamann J and Huitinga I: Phenotyping primary human microglia: Tight regulation of LPS responsiveness. Glia 60: 1506-1517, 2012.
13. Shannon KM, Keshavarzian A, Dodiya HB, Jakate S and Kordower JH: Is alpha-synuclein in the colon a biomarker for premotor Parkinson's disease? Evidence from 3 cases. Mov Disord 27: 716-719, 2012.
14. Hirsch EC and Hunot S: Neuroinflammation in Parkinson's disease: A target for neuroprotection? Lancet Neurol 8: 382-397, 2009.
15. Brochard V, Combadière B, Prigent A, Laouar Y, Perrin A, Beray-Berthat V, Bonduelle O, Alvarez-Fischer D, Callebert J, Launay JM, et al: Infltration of CD4+lymphocytes into the brain contributes to neurodegeneration in a mouse model of Parkinson disease. J Clin Invest 119: 182-192, 2009.
16. González H, Contreras F, Prado C, Elgueta D, Franz D, Bernales S and Pacheco R: Dopamine receptor D3 expressed on CD4+ T cells favors neurodegeneration of dopaminergic neurons during Parkinson's disease. J Immunol 190: 5048-5056, 2013.
17. Zhou L, Chong MM and Littman DR: Plasticity of CD4+ T cell lineage differentiation. Immunity 30: 646-655, 2009.
18. Wan YY: Multi-tasking of helper T cells. Immunology 130: 166-171, 2010.
19. Mu L, Sun B, Kong Q, Wang J, Wang G, Zhang S, Wang D, Liu Y, Liu Y, An H, et al: Disequilibrium of T helper type 1, 2 and 17 cells and regulatory T cells during the development of experimental autoimmune myasthenia gravis. Immunology 128: e826-e8362009.
20. Nie K, Zhang Y, Gan R, Wang L, Zhao J, Huang Z, Tang H and Wang L. Polymorphisms in immune/inflammatory cytokine genes are related to Parkinson's disease with cognitive impair ment in the han Chinese population. Neurosci Lett 541: 111-115, 2013.
21. Sanchez-Guajardo V, Annibali A, Jensen PH and Romero-Ramos M: α-Synuclein vaccination prevents the accumulation of parkinson disease-like pathologic inclusions in striatum in association with regulatory T cell recruitment in a rat model. J Neuropathol Exp Neurol 72: 624-645, 2013.
22. Saunders JA, Estes KA, Kosloski LM, Allen HE, Dempsey KM, Torres-Russotto DR, Meza JL, Santamaria PM, Bertoni JM, Murman DL, et al: CD4+ regulatory and effector/memory T cell subsets profile motor dysfunction in Parkinson's disease. J Neuroimmune Pharmacol 7: 927-738, 2012.
23. Niwa F, Kuriyama N, Nakagawa M and Imanishi J: Effects of peripheral lymphocyte subpopulations and the clinical correlation with Parkinson's disease. Geriatr Gerontol Int 12: 102-107, 2012.
24. Fazekas de St Groth B, Zhu E, Asad S and Lee L: Flow cyto-metric detection of human regulatory T cells. Methods Mol Biol 707: 263-279, 2011.
25. McClymont SA, Putnam AL, Lee MR, Esensten JH, Liu W, Hulme MA, Hoffmüller U, Baron U, Olek S, Bluestone JA, et al: Plasticity of human regulatory T cells in healthy subjects and patients with type 1 diabetes. J Immunol 186: 3918-3926, 2011.
26. Pott Godoy MC, Ferrari CC and Pitossi FJ: Nigral neurode-generation triggered by striatal AdIL-1 administration can be exacerbated by systemic IL-1 expression. J Neuroimmunol 222: 29-39, 2010.
27. Hasegawa Y, Inagaki T, Sawada M and Suzumura A: Impaired cytokine production by peripheral blood mononuclear cells and monocytes/macrophages in Parkinson's disease. Acta Neurol Scand 101: 159-164, 2000.
28. Brodacki B, Staszewski J, Toczyłowska B, Kozłowska E, Drela N, Chalimoniuk M and Stepien A: Serum interleukin (IL-2, IL-10, IL-6, IL-4), TNF alpha and INF gamma concentrations are elevated in patients with atypical and idiopathic parkinsonism. Neurosci Lett 441: 158-162, 2008.
29. Reale M, Iarlori C, Thomas A, Gambi D, Perfetti B, Di Nicola M and Onofrj M: Peripheral cytokines profile in Parkinson's disease. Brain Behav Immun 23: 55-63, 2009.
30. Mu L, Sun B, Kong Q, Wang J, Wang G, Zhang S, Wang D, Liu Y, Liu Y, An H, et al: Disequilibrium of T helper type 1, 2 and 17 cells and regulatory T cells during the development of experimental autoimmune myasthenia gravis. Immunology 128 (1 Suppl): e826-e836, 2009.
31. Hawkins R D, Larjo A, Tripathi SK, Wagner U, Luu Y, Lönnberg T, Raghav SK, Lee LK, Lund R, Ren B, Lähdesmäki H and Lahesmaa R: Global chromatin state analysis reveals lineage-specific enhancers during the initiation of human T helper 1 and T helper 2 cell polarization. Immunity 38: 1271-1284, 2013.
32. Olson NC, Sallam R, Doyle MF, Tracy RP and Huber SA: T helper cell polarization in healthy people: Implications for cardiovascular disease. J Cardiovasc Transl Res 6: 772-786, 2013.
33. Wan YY and Flavell RA: How diverse-CD4 effector T cells and their functions. J Mol Cell Biol 1: 20-36, 2009.
34. Homey B: After TH1/TH2 now comes Treg/TH17: Signifcance of T helper cells in immune response organization. Hautarzt 57: 730-732, 2006 (In German).
35. Sakaguchi S, Ono M, Setoguchi R, Yagi H, Hori S, Fehervari Z, Shimizu J, Takahashi T and Nomura T: Foxp3+ CD25+ CD4+ natural regulatory T cells in dominant self-tolerance and autoimmune disease. Immunol Rev 212: 8-27, 2006.
36. Chen Z, Lin F, Gao Y, Li Z, Zhang J, Xing Y, Deng Z, Yao Z, Tsun A and Li B: FOXP3 and RORγt: Transcriptional regulation of Treg and Th17. Int Immunopharmacol 11: 536-542, 2011.
37. Charles PD, Esper GJ and Davis TL: A definition of "on": Patient diaries compared to the UPDRS. Parkinsonism Relat Disord 5: 99-101, 1999.
38. Longhi M, Ricciardi G, Tommasi G, Nicolato A, Foroni R, Betrolasi L, Beltramello A, Moretto G, Tinazzi M and Gerosa M: The role of 3T magnetic resonance imaging for targeting the human subthalamic nucleus in deep brain stimulation for Parkinson Disease. J Neurol Surg A Cent Eur Neurosurg 76: 181-189, 2015.
39. Braak H, Sastre M, Bohl JR, de Vos RA and Del Tredici K: Parkinson's disease: Lesions in dorsal horn layer I, involvement of parasympathetic and sympathetic pre-and postganglionic neurons. Acta Neuropathol 113: 421-429, 2007.
40. Chen Y, Yu M, Liu X, Qu H, Chen Q, Qian W, Wei D, Xu W, Ma B and Wu W: Clinical characteristics and peripheral T cell subsets in Parkinson's disease patients with constipation. Int J Clin Exp Pathol 8: 2495-2504, 2015.
41. Reynolds AD, Stone DK, Hutter JA, Benner EJ, Mosley RL, Gendelman HE: Regulatory T cells attenuate Th17 cell-mediated nigrostriatal dopaminergic neurodegeneration in a model of Parkinson's disease. J Immunol 184: 22612271.
42. Appel SH: CD4+ T cells mediate cytotoxicity in neurodegen-erative diseases. J Clin Invest 119: 1315, 2009.