Effect of a 24-month physical activity intervention vs health education on cognitive outcomes in sedentary older adults: The LIFE randomized trial

JAMA - Journal of the American Medical Association

Volumn 314, Issue 8, 2015, Pages 781-790

  Sink, Kaycee M ^a   Espeland, Mark A ^a   Castro, Cynthia M ^b,s   Church, Timothy ^c,o   Cohen, Ron ^d   Dodson, John A ^e   Guralnik, Jack ^f   Hendrie, Hugh C ^g   Jennings, Janine ^h   Katula, Jeffery ^h   Lopez, Oscar L ⁱ   McDermott, Mary M ^j,k,n   Pahor, Marco ^d,u,w   Reid, Kieran F ^l   Rushing, Julia ^a   Verghese, Joe ^m   Rapp, Stephen ^a   Williamson, Jeff D ^a   Spring, Bonnie ⁿ   Hauser, Joshua ⁿ   Gulati, Martha ⁿ   Shah, Sanjiv ⁿ   Domanchuk, Kathryn ⁿ   Graff, Rex ⁿ   Kadela, Kasia ⁿ   Rego, Alvito ⁿ   Blair, Steven ^o   Myers, Valerie ^o   Monce, Ron ^o   Britt, Nathan ^o   Nauta, Melissa ^o   Parks, Ami ^o   Rodarte, Ruben ^o   Millet, Heidi ^o   Tudor Locke, Catrine ^o   Butitta, Ben ^o   Donatto, Sheletta ^o   Bonds, Denise ^p   Hadley, Evan C ^q   Patel, Kushang V ^q   Romashkan, Sergei ^q   Kaplan, Robert M ^r   King, Abby C ^s   Haskell, William L ^s   Stafford, Randall S ^s   Yank, Veronica ^s   Pruitt, Leslie A ^s   Berra, Kathy ^s   Bell, Carol ^s   Thiessen, Rosita ^s   Youngman, Kate P ^s   Virgen, Selene B ^s   Tarin, Kristina N ^s   Klaftenegger, Heather ^s   Prosak, Carolyn A ^s   Campero, Ines ^s   Garcia, Dulce M ^s   Soto, José ^s   Chio, Linda ^s   Hoskins, David ^s   Fielding, Roger ^t   Nelson, Miriam ^t   Folta, Sara ^t   Phillips, Edward ^t   Liu, Christine ^t   Cifarelli, Erica ^t   Lacasse, Paige ^t   Kirn, Dylan ^t   Pasha, Evan ^t   Ribourg, Sonnly ^t   Ruais, Karen ^t   Kim, Won ^t   Cloutier, Gregory ^t   Manini, Todd ^u,w   Anton, Stephen ^u,w   Buford, Thomas ^u,w   Nayfield, Susan ^u,w   Nocera, Joe ^u   Marsiske, Michael ^u   Sandesara, Bhanu ^u   Lee, Jocelyn ^u,w   Hiatt Jensen, Deborah ^u   Black, Mieniecia ^u   Case, Kimberly ^u   Herring, Katherine ^u   Schwier Delvisco, Amber ^u   Burk, Bill ^u   Hoover, Brian ^u   Knaggs, Jeffrey ^u   Martin, Allison ^u   Xie, Chonglun ^v   Morris, Holly ^v   Singletary, Flo ^v   Causer, Jackie ^v   Yonce, Susan ^v   Del Boccio, Christine ^v   Gay, Charles ^v   Alexander, Tangerica Peavy ^v   Leeuwenburgh, Christiaan ^w   Caudle, Connie ^w   Crump, Lauren ^w   Holmes, Latonia ^w   Lester, Ronald ^w   Lu, Ching Ju ^w   O'Mara, Ryan ^w   Pepine, Carl J ^x   Ariet, Mario ^x   Handberg, Eileen ^x   Deluca, Daniel ^x   Hill, James ^x   Guralnik, Jack M ^f   Newman, Anne B ^y   Studenski, Stephanie A ^y   Goodpaster, Bret H ^y   Glynn, Nancy W ^y   Bonk, Janet T ^y   Rush, Jennifer ^y   Kost, Piera ^y   Gerger, Allison ^y   Vincent, Pamela ^y   Davis, Latisha ^y   Newman, Mark A ^y   Grove, George ^y   Williams, Kathy ^y   Groessl, Erik J ^z   Kritchevsky, Stephen B ^h   Marsh, Anthony ^h   Brinkley, Tina ^h   Demons, Jamehl ^h   Kennedy, Kimberly ^h   Shertzer Skinner, Rachel ^h   Wrights, Abbie ^h   Fries, Rose ^h   Barr, Deborah ^h   Rapp, Stephen R ^aa   Woolard, Nancy ^aa   Wilson, Valerie K ^aa   Miller, Michael E ^ab   Ambrosius, Walter ^ab   Babcock, Don ^ab   Beavers, Daniel ^ab   Byington, Robert P ^ab   Cook, Delilah ^ab   Furberg, Curt ^ab   Goode, Candace ^ab   Griffin, Jason ^ab   Harvin, Lea ^ab   Henkin, Leora ^ab   Hepler, John ^ab   Hsu, Fang Chi ^ab   Joyce, Kathy ^ab   Lovato, Laura ^ab   Roberson, Wesley ^ab   Robertson, Julia ^ab   Rushing, Scott ^ab   Stowe, Cynthia L ^ab   Walkup, Michael P ^ab   Hire, Don ^ab   Rejeski, Jack ^ab   Brubaker, Peter H ^ab   Mihalko, Shannon ^ab   Jennings, Janine M ^ab   Lane, Kathy ^ab   Gill, Thomas M ^ac   Axtell, Robert S ^ac   Kashaf, Susan S ^ac   De Renekeire, Nathalie ^ac   McGloin, Joanne M ^ac   Mautner, Raeleen ^ac   Huie White, Sharon M ^ac   Bianco, Luann ^ac   Zocher, Janice ^ac   Shepard, Denise M ^ac   Fennelly, Barbara ^ac   Halpin, Sean ^ac   Barnett, Theresa ^ac   Wu, Karen C ^ac   Iannone, Lynne P ^ac   Bugaj, Julie A ^ac   Bailey, Christine ^ac   Chupp, Geoffrey ^ad   Flynn, Gail ^ad   Hankinson, John ^ad   Vaz Fragoso, Carlos A ^ad   more..

^a WAKE FOREST SCHOOL OF MEDICINE   (United States)

^b STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c Pennington Biomedical Center   (United States)

^d UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^e NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^f UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^g INDIANA UNIVERSITY   (United States)

^h WAKE FOREST UNIVERSITY   (United States)

ⁱ UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^j NORTHWESTERN UNIVERSITY   (United States)

^k JAMA   (United States)

^l TUFTS UNIVERSITY   (United States)

^m ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

ⁿ NORTHWESTERN UNIVERSITY   (United States)

^o PENNINGTON BIOMEDICAL RESEARCH CENTER   (United States)

^p NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

^q NATIONAL INSTITUTE ON AGING   (United States)

^r NATIONAL INSTITUTES OF HEALTH   (United States)

^s STANFORD UNIVERSITY   (United States)

^t TUFTS UNIVERSITY   (United States)

^u UNIVERSITY OF FLORIDA   (United States)

^v Brooks Center for Rehabilitation Studies   (United States)

^w Administrative Coordinating Center   (United States)

^x Electrocardiogram Reading Center   (United States)

^y UNIVERSITY OF PITTSBURGH   (United States)

^z UNIVERSITY OF CALIFORNIA   (United States)

^aa University of Pittsburgh ^*  (United States)

^ab Infinity Pharmaceuticals   (United States)

^ac YALE UNIVERSITY   (United States)

^ad Spirometry Reading Center   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

AGED; ARTICLE; COGNITION; DEMENTIA; EDUCATION PROGRAM; ETHNICITY; EXECUTIVE FUNCTION; EXERCISE INTENSITY; FEMALE; HEALTH EDUCATION; HUMAN; MAJOR CLINICAL STUDY; MALE; MILD COGNITIVE IMPAIRMENT; PHYSICAL ACTIVITY; PHYSICAL PERFORMANCE; PRIORITY JOURNAL; RATING SCALE; RISK REDUCTION; SCORING SYSTEM; SEDENTARY LIFESTYLE; SELF REPORT; VERY ELDERLY; AGE; ARM; CLINICAL TRIAL; CONTROLLED STUDY; HEALTH PROMOTION; KINESIOTHERAPY; MULTICENTER STUDY; PROCEDURES; RANDOMIZED CONTROLLED TRIAL; RESISTANCE TRAINING; STRETCHING EXERCISE; TREATMENT OUTCOME; WALKING;

AGE FACTORS; AGED; AGED, 80 AND OVER; DEMENTIA; EXECUTIVE FUNCTION; EXERCISE THERAPY; FEMALE; HEALTH EDUCATION; HEALTH PROMOTION; HUMANS; MALE; MILD COGNITIVE IMPAIRMENT; MUSCLE STRETCHING EXERCISES; RESISTANCE TRAINING; SEDENTARY LIFESTYLE; TREATMENT OUTCOME; UPPER EXTREMITY; WALKING;

EID: 84940530815     PISSN: 00987484     EISSN: 15383598     Source Type: Journal    
DOI: 10.1001/jama.2015.9617     Document Type: Article

References (40)

1. Burdette JH, Laurienti PJ, Espeland MA, et al. Using network science to evaluate exercise-associated brain changes in older adults. Front Aging Neurosci. 2010;2:23.
2. Colcombe SJ, Erickson KI, Scalf PE, et al. Aerobic exercise training increases brain volume in aging humans. J Gerontol A Biol Sci Med Sci. 2006;61(11): 1166-1170.
3. Erickson KI, Leckie RL,Weinstein AM. Physical activity, fitness, and gray matter volume. Neurobiol Aging. 2014;35(suppl 2):S20-S28.
4. Coelho FG, Gobbi S, Andreatto CA, et al. Physical exercise modulates peripheral levels of brain-derived neurotrophic factor (BDNF). Arch Gerontol Geriatr. 2013;56(1):10-15.
5. Erickson KI, Gildengers AG, Butters MA. Physical activity and brain plasticity in late adulthood. Dialogues Clin Neurosci. 2013;15(1):99-108.
6. Adlard PA, Perreau VM, Pop V, Cotman CW. Voluntary exercise decreases amyloid load in a transgenic model of Alzheimer's disease. J Neurosci. 2005;25(17):4217-4221.
7. Snowden M, Steinman L, Mochan K, et al. Effect of exercise on cognitive performance in community-dwelling older adults. J AmGeriatr Soc. 2011;59(4):704-716.
8. Denkinger MD, Nikolaus T, Denkinger C, Lukas A. Physical activity for the prevention of cognitive decline. Z Gerontol Geriatr. 2012;45(1):11-16.
9. Smith PJ, Blumenthal JA, Hoffman BM, et al. Aerobic exercise and neurocognitive performance. Psychosom Med. 2010;72(3):239-252.
10. Barnes DE, Santos-ModesittW, Poelke G, et al. The Mental Activity and eXercise (MAX) trial. JAMA Intern Med. 2013;173(9):797-804.
11. Legault C, Jennings JM, Katula JA, et al. Designing clinical trials for assessing the effects of cognitive training and physical activity interventions on cognitive outcomes. BMC Geriatr. 2011;11:27.
12. Lautenschlager NT, Cox KL, Flicker L, et al. Effect of physical activity on cognitive function in older adults at risk for Alzheimer disease: a randomized trial. JAMA. 2008;300(9):1027-1037.
13. Williamson JD, Espeland M, Kritchevsky SB, et al. Changes in cognitive function in a randomized trial of physical activity. J Gerontol A Biol Sci Med Sci. 2009;64(6):688-694.
14. Pahor M, Guralnik JM, AmbrosiusWT, et al. Effect of structured physical activity on prevention of major mobility disability in older adults. JAMA. 2014;311(23):2387-2396.
15. Fielding RA, RejeskiWJ, Blair S, et al. The Lifestyle Interventions and Independence for Elders study. J Gerontol A Biol Sci Med Sci. 2011;66(11): 1226-1237.
16. Guralnik JM, Ferrucci L, Simonsick EM, et al. Lower-extremity function in persons over the age of 70 years as a predictor of subsequent disability. N Engl J Med. 1995;332(9):556-561.
17. Teng EL, Chui HC. The Modified Mini-Mental State (3MS) examination. J Clin Psychiatry. 1987;48 (8):314-318.
18. RejeskiWJ, Fielding RA, Blair SN, et al. The Lifestyle Interventions and Independence for Elders (LIFE) pilot study. Contemp Clin Trials. 2005;26(2): 141-154.
19. Stewart AL, Verboncoeur CJ, McLellan BY, et al. Physical activity outcomes of CHAMPS II. J Gerontol A Biol Sci Med Sci. 2001;56(8):M465-M470.
20. Sink KM, Espeland MA, Rushing J, et al. The LIFE cognition study. Clin Interv Aging. 2014;9: 1425-1436.
21. Wechsler D.WAIS-III Manual. New York, NY: Psychological Corp; 1997.
22. Brandt J, Benedict RHB. Hopkins Verbal Learning Test-Revised: Professional Manual. Lutz, FL: Psychological Assessment Resources Inc; 2001.
23. Kaplan E, Goodglass H,Weintraub S. The Boston Naming Test. 2nd ed. Philadelphia, PA; Lea & Febiger; 1983.
24. Reitan R. Trail Making Test: Manual for Administration and Scoring. Tucson, AZ: Neuropsychological Laboratory; 1992.
25. Kirchner WK. Age differences in short-term retention of rapidly changing information. J Exp Psychol. 1958;55(4):352-358.
26. Eriksen B, Eriksen CW. Effects of noise letters upon the identificaiton of a target letter in a nonsearch task. Percept Psychophys. 1974;16:143-149.
27. Rogers R, Monsell S. Costs of a predictable switch between simple cognitive tasks. J Exp Psychol Gen. 1995;124:207-231.
28. Weissman MM, Sholomskas D, Pottenger M, et al. Assessing depressive symptoms in five psychiatric populations. Am J Epidemiol. 1977;106 (3):203-214.
29. Pfeffer RI, Kurosaki TT, Harrah CH Jr, et al. Measurement of functional activities in older adults in the community. J Gerontol. 1982;37(3):323-329.
30. AlbertMS, DeKosky ST, Dickson D, et al. The diagnosis ofmild cognitive impairment due to Alzheimer's disease. Alzheimers Dement. 2011;7(3): 270-279.
31. McKhann GM, Knopman DS, Chertkow H, et al. The diagnosis of dementia due to Alzheimer's disease. Alzheimers Dement. 2011;7(3):263-269.
32. Yuan Y. Multiple imputation using SAS software. J Stat Softw. 2011;45:1-25.
33. Espeland MA, Rapp SR, Bray GA, et al. Long-term impact of behavioral weight loss intervention on cognitive function. J Gerontol A Biol Sci Med Sci. 2014;69(9):1101-1108.
34. Ngandu T, Lehtisalo J, Solomon A, et al. A 2 year multidomain intervention of diet, exercise, cognitive training, and vascular risk monitoring versus control to prevent cognitive decline in at-risk elderly people (FINGER). Lancet. 2015;385(9984): 2255-2263.
35. Robertson DA, Savva GM, Coen RF, Kenny RA. Cognitive function in the prefrailty and frailty syndrome. J AmGeriatr Soc. 2014;62(11):2118-2124.
36. Mielke MM, Roberts RO, Savica R, et al. Assessing the temporal relationship between cognition and gait. J Gerontol A Biol Sci Med Sci. 2013;68(8):929-937.
37. Stern Y. Cognitive reserve in ageing and Alzheimer's disease. Lancet Neurol. 2012;11(11): 1006-1012.
38. Verghese J, Lipton RB, Katz MJ, et al. Leisure activities and the risk of dementia in the elderly. N Engl J Med. 2003;348(25):2508-2516.
39. Etnier JL, Nowell PM, Landers DM, Sibley BA. Ameta-regression to examine the relationship between aerobic fitness and cognitive performance. Brain Res Rev. 2006;52(1):119-130.
40. Colcombe S, Kramer AF. Fitness effects on the cognitive function of older adults. Psychol Sci. 2003;14(2):125-130.