Combined therapies that induce senescence and stabilize p53 block melanoma growth and prompt antitumor immune responses

OncoImmunology

Volumn 4, Issue 8, 2015, Pages

  Vilgelm, Anna ^a,b   Richmond, Ann ^a,b  

^a DEPARTMENT OF VETERANS AFFAIRS   (United States)

^b VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

apoptosis; Aurora kinase; melanoma; p53; senescence

Indexed keywords

ANTINEOPLASTIC AGENT; AURORA A KINASE; AURORA KINASE INHIBITOR; CHEMOKINE; CYTOKINE; PROTEIN MDM2 ANTAGONIST; PROTEIN P53; UNCLASSIFIED DRUG;

ARTICLE; CANCER GROWTH; CARCINOGENESIS; CELL CYCLE ARREST; CELL INVASION; CELL MIGRATION; CHEMOTAXIS; DNA DAMAGE; GENE ACTIVATION; HUMAN; IMMUNE RESPONSE; IMMUNOSURVEILLANCE; MELANOMA; NONHUMAN; ONCOGENE; SENESCENCE; SURVIVAL; TUMOR MICROENVIRONMENT; TUMOR REGRESSION;

EID: 84940489454     PISSN: 21624011     EISSN: 2162402X     Source Type: Journal    
DOI: 10.1080/2162402X.2015.1009299     Document Type: Article

References (10)

1. J.S.Pawlikowski, P.D.Adams, D.M.Nelson. Senescence at a glance. J Cell Sci 2013; 126(Pt 18): 4061–7; PMID:23970414; http://dx.doi.org/10.1242/jcs.109728
2. Y.Liu, O.E.Hawkins, Y.Su, A.E.Vilgelm, T.Sobolik, Y.M.Thu, S.Kantrow, R.C.Splittgerber, S.Short, K.I.Amiri, J.A.Ecsedy, J.A.Sosman, M.C.Kelley, A.Richmond. Targeting aurora kinases limits tumour growth through DNA damage-mediated senescence and blockade of NF-kappaB impairs this drug-induced senescence. EMBO Mol Med 2013; 5(1): 149–66; PMID:23180582; http://dx.doi.org/10.1002/emmm.201201378
3. C.A.Schmitt, J.S.Fridman, M.Yang, S.Lee, E.Baranov, R.M.Hoffman, S.W.Lowe. A senescence program controlled by p53 and p16INK4a contributes to the outcome of cancer therapy. Cell 2002; 109(3): 335–46; PMID:12015983; http://dx.doi.org/10.1016/S0092-8674(02)00734-1
4. A.Ventura, D.G.Kirsch, M.E.McLaughlin, D.A.Tuveson, J.Grimm, L.Lintault, J.Newman, E.E.Reczek, R.Weissleder, T.Jacks. Restoration of p53 function leads to tumour regression in vivo. Nature 2007; 445(7128): 661–5; PMID:17251932; http://dx.doi.org/10.1038/nature05541
5. W.Xue, L.Zender, C.Miething, R.A.Dickins, E.Hernando, V.Krizhanovsky, C.Cordon-Cardo, S.W.Lowe. Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas. Nature 2007; 445(7128): 656–60; PMID:17251933; http://dx.doi.org/10.1038/nature05529
6. F.Rodier, J.Campisi. Four faces of cellular senescence. J Cell Biol 2011; 192(4): 547–56; PMID:21321098; http://dx.doi.org/10.1083/jcb.201009094
7. Q.Wang, P.C.Wu, D.Z.Dong, I.Ivanova, E.Chu, S.Zeliadt, H.Vesselle, D.Y.Wu. Polyploidy road to therapy-induced cellular senescence and escape. Int J Cancer 2013; 132(7): 1505–15; PMID:22945332; http://dx.doi.org/10.1002/ijc.27810
8. A.E.Vilgelm, J.S.Pawlikowski, Y.Liu, O.E.Hawkins, T.A.Davis, J.Smith, K.P.Weller, L.W.Horton, C.M.McClain, G.D.Ayers, et al. Mdm2 and aurora kinase a inhibitors synergize to block melanoma growth by driving apoptosis and immune clearance of tumor cells. Cancer Res 2015; 75(1): 181–93; PMID:25398437; http://dx.doi.org/10.1158/0008-5472.CAN-14-2405
9. C.M.Beausejour, A.Krtolica, F.Galimi, M.Narita, S.W.Lowe, P.Yaswen, J.Campisi. Reversal of human cellular senescence: roles of the p53 and p16 pathways. EMBO J 2003; 22(16): 4212–22; PMID:12912919; http://dx.doi.org/10.1093/emboj/cdg417
10. D.A.Oble, R.Loewe, P.Yu, M.C.Mihm, Jr. Focus on TILs: prognostic significance of tumor infiltrating lymphocytes in human melanoma. Cancer Immun 2009; 9: 3; PMID:19338264