Kinetochore-localized PP1-Sds22 couples chromosome segregation to polar relaxation

Nature

Volumn 524, Issue 7566, 2015, Pages 489-492

  Rodrigues, Nelio T L ^a   Lekomtsev, Sergey ^a   Jananji, Silvana ^b   Kriston Vizi, Janos ^a   Hickson, Gilles R X ^b,c   Baum, Buzz ^a,d  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY OF MONTREAL   (Canada)

^c UNIVERSITÉ DE MONTRÉAL   (Canada)

^d INSTITUT CURIE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CELL PROTEIN; EZRIN; MOESIN; PHOSPHATASE; PP1 PHOSPHATASE; RADIXIN; SDS22 PHOSPHATASE; UNCLASSIFIED DRUG; ACTIN; ACTIN BINDING PROTEIN; CHROMATIN; CYTOSKELETON PROTEIN; MEMBRANE PROTEIN; PHOSPHOPROTEIN PHOSPHATASE 1; PPP1R7 PROTEIN, HUMAN;

ANATOMY; CELL ORGANELLE; CELLS AND CELL COMPONENTS; CHEMICAL REACTION; CHROMOSOME; CYTOLOGY; FLY; HOMINID; POLARIZATION; PROTEIN;

ANAPHASE; ARTICLE; ASTRAL MICROTUBULE; CELL ELONGATION; CELL POLARITY; CELL PROLIFERATION; CENTROMERE; CHROMOSOME ARM; CHROMOSOME SEGREGATION; CONTROLLED STUDY; DROSOPHILA; ENZYME INACTIVATION; HUMAN; HUMAN CELL; MITOSIS; NONHUMAN; POLAR BODY; PRIORITY JOURNAL; PROMETAPHASE; PROTEIN DEPHOSPHORYLATION; RNA INTERFERENCE; SIGNAL TRANSDUCTION; ANIMAL; CENTROSOME; CHROMATIN; CYTOLOGY; DROSOPHILA MELANOGASTER; ENZYMOLOGY; FEMALE; GENETICS; MALE; METABOLISM; MICROTUBULE; PHOSPHORYLATION;

ACTINS; ANAPHASE; ANIMALS; CELL POLARITY; CENTROSOME; CHROMATIN; CHROMOSOME SEGREGATION; CYTOSKELETAL PROTEINS; DROSOPHILA MELANOGASTER; FEMALE; HUMANS; KINETOCHORES; MALE; MEMBRANE PROTEINS; MICROFILAMENT PROTEINS; MICROTUBULES; PHOSPHORYLATION; PROTEIN PHOSPHATASE 1; SIGNAL TRANSDUCTION;

EID: 84940482672     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature14496     Document Type: Article

References (35)

1. Green, R. A., Paluch, E. & Oegema, K. Cytokinesis in animal cells. Annu. Rev. Cell Dev. Biol. 28, 29-58 (2012).
2. Kunda, P. et al. PP1-mediatedmoesin dephosphorylation couples polar relaxation to mitotic exit. Curr. Biol. 22, 231-236 (2012).
3. Roubinet, C. et al. Molecular networks linked by Moesin drive remodeling of the cell cortex during mitosis. J. Cell Biol. 195, 99-112 (2011).
4. Matthews, H. K. et al. Changes in Ect2 localization couple actomyosin-dependent cell shape changes to mitotic progression. Dev. Cell 23, 371-383 (2012).
5. Sedzinski, J. et al. Polar actomyosin contractility destabilizes the position of the cytokinetic furrow. Nature 476, 462-466 (2011).
6. Roegiers, F., Younger-Shepherd, S., Jan, L. Y. & Jan, Y. N. Two types of asymmetric divisions in the Drosophila sensory organ precursor cell lineage. Nature Cell Biol. 3, 58-67 (2001).
7. Georgiou, M. & Baum, B. Polarity proteins and Rho GTPases cooperate to spatially organise epithelial actin-based protrusions. J. Cell Sci. 123, 1089-1098 (2010).
8. Hickson, G. R., Echard, A. & O'Farrell, P. H. Rho-kinase controls cell shape changes during cytokinesis. Curr. Biol. 16, 359-370 (2006).
9. Mishima, M., Kaitna, S. & Glotzer, M. Central spindle assembly and cytokinesis require a kinesin-like protein/RhoGAP complex with microtubule bundling activity. Dev. Cell 2, 41-54 (2002).
10. Lekomtsev, S. et al. Centralspindlin links the mitotic spindle to the plasma membrane during cytokinesis. Nature 492, 276-279 (2012).
11. Tse, Y. C., Piekny, A. & Glotzer, M. Anillin promotes astral microtubule-directed cortical myosin polarization. Mol. Biol. Cell 22, 3165-3175 (2011).
12. Fededa, J. P. & Gerlich, D. W. Molecular control of animal cell cytokinesis. Nature Cell Biol. 14, 440-447 (2012).
13. Murthy, K. & Wadsworth, P. Dual role for microtubules in regulating cortical contractility during cytokinesis. J. Cell Sci. 121, 2350-2359 (2008).
14. Werner, M., Munro, E. & Glotzer, M. Astral signals spatially bias cortical myosin recruitment to break symmetry and promote cytokinesis. Curr. Biol. 17, 1286-1297 (2007).
15. Blachon, S. et al. Drosophila asterless and vertebrate Cep152 Are orthologs essential for centriole duplication. Genetics 180, 2081-2094 (2008).
16. Hu, C. K., Coughlin, M., Field, C. M. & Mitchison, T. J. Cell polarization during monopolar cytokinesis. J. Cell Biol. 181, 195-202 (2008).
17. Lancaster, O. M. et al. Mitotic rounding alters cell geometry to ensure efficient bipolar spindle formation. Dev. Cell 25, 270-283 (2013).
18. Zhang, D. & Nicklas, R. B. 'Anaphase' and cytokinesis in the absence of chromosomes. Nature 382, 466-468 (1996).
19. Lesage, B., Qian, J. & Bollen, M. Spindle checkpoint silencing: PP1 tips the balance. Curr. Biol. 21, R898-R903 (2011).
20. Posch, M. et al. Sds22 regulates aurora B activity and microtubule-kinetochore interactions at mitosis. J. Cell Biol. 191, 61-74 (2010).
21. Wurzenberger, C. et al. Sds22 and Repo-Man stabilize chromosome segregation by counteracting Aurora B on anaphase kinetochores. J. Cell Biol. 198, 173-183 (2012).
22. Qian, J., Lesage, B., Beullens, M., Van Eynde, A. & Bollen, M. PP1/Repo-man dephosphorylates mitotic histone H3 at T3 and regulates chromosomal aurora B targeting. Curr. Biol. 21, 766-773 (2011).
23. Liu, D. et al. Regulated targeting of protein phosphatase 1 to the outer kinetochore by KNL1 opposes Aurora B kinase. J. Cell Biol. 188, 809-820 (2010).
24. Kennedy, M. J. et al. Rapid blue-light-mediated induction of protein interactions in living cells. Nature Methods 7, 973-975 (2010).
25. Turlier, H., Audoly, B., Prost, J. & Joanny, J. F. Furrow constriction in animal cell cytokinesis. Biophys. J. 106, 114-123 (2014).
26. Kiyomitsu, T. & Cheeseman, I. M. Cortical dynein and asymmetric membrane elongation coordinately position the spindle in anaphase. Cell 154, 391-402 (2013).
27. Dehapiot, B. & Halet, G. Ran GTPase promotes oocyte polarization by regulating ERM (Ezrin/Radixin/Moesin) inactivation. Cell Cycle 12, 1672-1678 (2013).
28. Edwards, K. A., Demsky, M., Montague, R. A., Weymouth, N. & Kiehart, D. P. GFPmoesin illuminates actin cytoskeleton dynamics in living tissue and demonstrates cell shape changes during morphogenesis in Drosophila. Dev. Biol. 191, 103-117 (1997).
29. Mummery-Widmer, J. L. et al. Genome-wide analysis of Notch signalling in Drosophila by transgenic RNAi. Nature 458, 987-992 (2009).
30. Matsumoto, K., Toh-e, A. & Oshima, Y. Genetic control of galactokinase synthesis in Saccharomyces cerevisiae: evidence for constitutive expression of the positive regulatory gene gal4. J. Bacteriol. 134, 446-457 (1978).
31. Jeong, J. Y. et al. One-step sequence- and ligation-independent cloning as a rapid and versatile cloning method for functional genomics studies. Appl. Environ. Microbiol. 78, 5440-5443 (2012).
32. Hickson, G. R. & O'Farrell, P. H. Rho-dependent control of anillin behavior during cytokinesis. J. Cell Biol. 180, 285-294 (2008).
33. Théry, M. et al. The extracellular matrix guides the orientation of the cell division axis. Nature Cell Biol. 7, 947-953 (2005).
34. Lénárt, P. et al. The small-molecule inhibitor BI 2536 reveals novel insights into mitotic roles of polo-like kinase 1. Curr. Biol. 17, 304-315 (2007).
35. Liu, T., Sims, D. & Baum, B. Parallel RNAi screens across different cell lines identify genericandcell type-specific regulators of actin organizationand cellmorphology. Genome Biol. 10, R26 (2009).