Postmortem findings in cloned and transgenic piglets dead before weaning

Theriogenology

Volumn 84, Issue 6, 2015, Pages 1014-1023

  Schmidt, M ^a   Winther, K D ^b   Secher, J O ^a   Callesen, H ^c  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b Danish Agriculture and Food Council   (Denmark)

^c AARHUS UNIVERSITY   (Denmark)

Author keywords

Autopsy; Malformation; Porcine; SCNT; Three breeds

Indexed keywords

PIERIS BRASSICAE; SUIDAE; SUS;

ANIMAL; AUTOPSY; CONGENITAL MALFORMATION; EMBRYO TRANSFER; GENETICS; MULTIPLE MALFORMATION SYNDROME; PATHOLOGY; PIG; RETROSPECTIVE STUDY; STILLBIRTH; TRANSGENIC ANIMAL; VETERINARY;

ABNORMALITIES, MULTIPLE; ANIMALS; ANIMALS, GENETICALLY MODIFIED; AUTOPSY; EMBRYO TRANSFER; RETROSPECTIVE STUDIES; STILLBIRTH; SWINE;

EID: 84940467203     PISSN: 0093691X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.theriogenology.2015.05.037     Document Type: Article

References (63)

1. Estrada J., Sommer J., Collins B., Mir B., Martin A., York A., et al. Swine generated by somatic cell nuclear transfer have increased incidence of intrauterine growth restriction (IUGR). Cloning Stem Cells 2007, 9:229-236.
2. Park M.R., Cho S.K., Park J.Y., Lee S.Y., Choi Y.J., Kwon D.N., et al. Detection of rare Leydig cell hypoplasia in somatic cell cloned male piglets. Zygote 2004, 12:305-313.
3. Carter D.B., Lai L., Park K.W., Samuel M., Lattimer J.C., Jordan K.R., et al. Phenotyping of transgenic cloned piglets. Cloning Stem Cells 2002, 2002:131-145.
4. Umeyama K., Watanabe M., Saito H., Kurome M., Tohi S., Matsunari H., et al. Dominant-negative mutant hepatocyte nuclear factor 1alpha induces diabetes in transgenic-cloned pigs. Transgenic Res 2009, 18:697-706.
5. Hu K., Kong Q.F., Zhao Z.F., Lu X.F., Liu B.F., Li Y.F., et al. Assessment of reproduction and growth performance of offspring derived from somatic cell cloned pigs. Anim Sci J 2012, 83:639-643.
6. Schmidt M., Winter K.D., Dantzer V., Li J., Kragh P.M., Du Y., et al. Maternal endometrial oedema may increase perinatal mortality of cloned and transgenic piglets. Reprod Fertil Dev 2011, 2011:645-653.
7. Whyte J.J., Samuel M., Mahan E., Padilla J., Simmons G.H., Arce-Esquivel A.A., et al. Vascular endothelium-specific overexpression of human catalase in cloned pigs. Transgenic Res 2011, 20:989-1001.
8. Kurome M., Geistlinger L.F., Kessler B.F., Zakhartchenko V.F., Klymiuk N.F., Wuensch A.F., et al. Factors influencing the efficiency of generating genetically engineered pigs by nuclear transfer: multi-factorial analysis of a large data set. BMC Biotechnol 2013, 13:43.
9. Schmidt M., Winther K.D., Callesen H. Lifetime mortality of cloned piglets. Reprod Fertil Dev 2013, 12:2013. Ref Type: Generic.
10. Lee S.Y., Park J.Y., Choi Y.J., Cho S.K., Ahn J.D., Kwon D.N., et al. Comparative proteomic analysis associated with term placental insufficiency in cloned pig. Proteomics 2007, 7:1303-1315.
11. Chae J.I., Lee K.S., Kim D.J., Han Y.M., Lee D.S., Lee K.K., et al. Abnormal gene expression in extraembryonic tissue from cloned porcine embryos. Theriogenology 2009, 71:323-333.
12. Whitworth K.M., Spate L.D., Li R., Rieke A., Sutovsky P., Green J.A., et al. Activation method does not alter abnormal placental gene expression and development in cloned pigs. Mol Reprod Dev 2010, 2010:1016-1030.
13. Park J.Y., Kim J.H., Choi Y.J., Hwang K.C., Cho S.K., Park H.H., et al. Comparative proteomic analysis of malformed umbilical cords from somatic cell nuclear transfer-derived piglets: implications for early postnatal death. BMC Genomics 2009, 10:511.
14. Ka H., Seo H., Kim M., Moon S., Kim H., Lee C.K. Gene expression profiling of the uterus with embryos cloned by somatic cell nuclear transfer on day 30 of pregnancy. Anim Reprod Sci 2008, 108:79-91.
15. Kim J.H., Park J.Y., Park M.R., Hwang K.C., Park K.K., Park C., et al. Developmental arrest of SCNT-derived fetuses by disruption of the developing endometrial gland as a result of impaired trophoblast migration and invasiveness. Dev Dyn 2011, 240:627-639.
16. Kim M., Seo H.F., Choi Y.F., Hwang W.F., Lee C.K., Ka H. Aberrant expression of retinol-binding protein, osteopontin and fibroblast growth factor 7 in the porcine uterine endometrium of pregnant recipients carrying embryos produced by somatic cell nuclear transfer. Anim Reprod Sci 2009, 112:172-181.
17. Liu H., Li Y.F., Wei Q.F., Liu C.F., Bolund L.F., Vajta G.F., et al. Development of transgenic minipigs with expression of antimorphic human cryptochrome 1. PLoS One 2013, 8:e76098.
18. Gao F., Luo Y., Li S., Li J., Lin L., Nielsen A.L., et al. Comparison of gene expression and genome-wide DNA methylation profiling between phenotypically normal cloned pigs and conventionally bred controls. PLoS One 2011, 2011:e25901.
19. Park J., Marjani S.L., Lai L., Samuel M., Wax D., Davis S.R., et al. Altered gene expression profiles in the brain, kidney, and lung of deceased neonatal cloned pigs. Cell Reprogram 2010, 12:589-597.
20. Park J., Lai L., Samuel M., Wax D., Bruno R.S., French R., et al. Altered gene expression profiles in the brain, kidney, and lung of one-month-old cloned pigs. Cell Reprogram 2011, 13:215-223.
21. Tian X.C., Park J.F., Bruno R.F., French R.F., Jiang L.F., Prather R.S. Altered gene expression in cloned piglets. Reprod Fertil Dev 2009, 21:60-66.
22. Li G.F., Jia Q.F., Zhao J.F., Li X.F., Yu M.F., Samuel M.S., et al. Dysregulation of genome-wide gene expression and DNA methylation in abnormal cloned piglets. BMC Genomics 2014, 15:811.
23. Jiang L., Lai L.F., Samuel M.F., Prather R.S., Yang X., Yang X.F., et al. Expression of X-linked genes in deceased neonates and surviving cloned female piglets. Mol Reprod Dev 2008, 75:265-273.
24. Vajta G., Zhang Y., Machaty Z. Somatic cell nuclear transfer in pigs: recent achievements and future possibilities. Reprod Fertil Dev 2007, 19:403-423.
25. Cho S.K., Kim J.H., Park J.Y., Choi Y.J., Bang J.I., Hwang K.C., et al. Serial cloning of pigs by somatic cell nuclear transfer: restoration of phenotypic normality during serial cloning. Dev Dyn 2007, 236:3369-3382.
26. Leuchs S., Saalfrank A.F., Merkl C.F., Flisikowska T.F., Edlinger M.F., Durkovic M.F., et al. Inactivation and inducible oncogenic mutation of p53 in gene targeted pigs. PLoS One 2012, 7:e43323.
27. Park J.Y., Park M.R., Hwang K.C., Chung J.S., Bui H.T., Kim T., et al. Comparative gene expression analysis of somatic cell nuclear transfer-derived cloned pigs with normal and abnormal umbilical cords. Biol Reprod 2011, 84:189-199.
28. Jakobsen J.E., Li J., Kragh P.M., Moldt B., Lin L., Liu Y., et al. Pig transgenesis by Sleeping Beauty DNA transposition. Transgenic Res 2011, 20:533-545.
29. Kragh P.M., Nielsen A.L., Li J., Du Y., Lin L., Schmidt M., et al. Hemizygous minipigs produced by random gene insertion and handmade cloning express the Alzheimer's disease-causing dominant mutation APPsw. Transgenic Res 2009, 18:545-558.
30. Al-Mashhadi R.H., Sorensen C.B., Kragh P.M., Christoffersen C., Mortensen M.B., Tolbod L.P., et al. Familial hypercholesterolemia and atherosclerosis in cloned minipigs created by DNA transposition of a human PCSK9 gain-of-function mutant. Sci Transl Med 2013, 5:166ra1.
31. Callesen H., Liu Y.F., Pedersen H.S., Li R., Schmidt M. Increasing efficiency in production of cloned piglets. Cell Reprogram 2014, 16:407-410.
32. Du Y., Kragh P.M., Zhang Y., Li J., Schmidt M., Bogh I.B., et al. Piglets born from handmade cloning, an innovative cloning method without micromanipulation. Theriogenology 2007, 68:1104-1110.
33. Yoshioka K., Suzuki C.F., Tanaka A.F., Anas I.M., Iwamura S. Birth of piglets derived from porcine zygotes cultured in a chemically defined medium. Biol Reprod 2002, 66:112-119.
34. Berggren K, Jensen M. The incidence of external and visceral congenital malformations in the Göttingen mini pig 2008. Veterinary Thesis, University of Copenhagen.
35. Wise L.D., Beck S.L., Beltrame D.F., Beyer B.K., Chahoud I.F., Clark R.L., et al. Terminology of developmental abnormalities in common laboratory mammals (version 1). Teratology 1997, 55:249-292.
36. Makris S.L., Solomon H.M., Clark R., Shiota K., Barbellion S., Buschmann J., et al. Terminology of developmental abnormalities in common laboratory mammals (version 2). Reprod Toxicol 2009, 2009:371-434.
37. Vallet J.L., Miles J.R., Brown-Brandl T.M., Nienaber J.A. Proportion of the litter farrowed, litter size, and progesterone and estradiol effects on piglet birth intervals and stillbirths. Anim Reprod Sci 2010, 119:68-75.
38. van Dijk A.J., van Rens B.T., van der Lende T.F., Taverne M.A. Factors affecting duration of the expulsive stage of parturition and piglet birth intervals in sows with uncomplicated, spontaneous farrowings. Theriogenology 2005, 64:1573-1590.
39. Vanderhaeghe C., Dewulf J.F., De Vliegher S., Papadopoulos G.A., de Kruif A.F., Maes D. Longitudinal field study to assess sow level risk factors associated with stillborn piglets. Anim Reprod Sci 2010, 120:78-83.
40. Vanderhaeghe C., Dewulf J.F., de Kruif A.F., Maes D. Non-infectious factors associated with stillbirth in pigs: a review. Anim Reprod Sci 2013, 139:76-88.
41. Rootwelt V., Reksen O.F., Farstad W.F., Framstad T. Postpartum deaths: piglet, placental, and umbilical characteristics. J Anim Sci 2013, 91:2647-2656.
42. Leenhouwers J.I., Wissink P.F., van der Lende T.F., Paridaans H.F., Knol E.F. Stillbirth in the pig in relation to genetic merit for farrowing survival. J Anim Sci 2003, 81:2419-2424.
43. Vinther J. Landsgennemsnit for produktivitet i svineproduktionen 2014, Ref Type: Internet Communication; SEGES Landbrugsinfo.
44. Bille N., Nielsen N.C. Congenital malformations in pigs in a post mortem material. Nord Vet Med 1977, 1977:128-136.
45. Partlow G.D., Fisher K.R., Page P.D., MacMillan K., Walker A.F. Prevalence and types of birth defects in Ontario swine determined by mail survey. Can J Vet Res 1993, 1993:67-73.
46. Shobhamani B., Ravi A. Congenital abnormalities in piglets. Indian Vet J 2002, 79:358-360. Ref Type: Generic.
47. Mulley R.C., Edwards M.J. Prevalence of congenital abnormalities in pigs. Aust Vet J 1984, 1984:116-120.
48. Hsu F.S., Du S.J. Congenital heart diseases in swine. Vet Pathol 1982, 1982:676-686.
49. Selby L.A., Edmonds L.D., Parke D.W., Stewart R.W., Marienfeld C.J., Heidlage W.F. Use of mailed questionnaire data in a study of swine congenital malformations. Can J Comp Med 1973, 1973:413-417.
50. Liang C., Chu R., Chen W.W.C., Liu R. Congenital abnormalities in piglets from a purebred swine herd. J Chin Soc Vet 1995, 21:183-195.
51. Thaller G., Dempfle L.F., Hoeschele I. Investigation of the inheritance of birth defects in swine by complex segregation analysis. J Anim Breed Genet 1996, 113:77-92.
52. Haubitz M., Neuenschwander S., Vogeli P. Porcine arthrogryposis multiplex congenita (AMC): new diagnostic test and narrowed candidate region. Mol Cell Probes 2012, 2012:248-252.
53. Holyoake P.K., Stevenson J., Moran C., Stokes R., Kirk E.P., Sugo E., et al. The occurrence of congenital heart defects in an inbred herd of pigs in Australia. Aust Vet J 2006, 2006:129-133.
54. Philbey A.W., Ross A.D., Kirkland P.D., Love R.J. Skeletal and neurological malformations in pigs congenitally infected with Menangle virus. Aust Vet J 2007, 2007:134-140.
55. Whittington R.J., Unger D.B., Wilson J.M. Multiple congenital malformations of the face, nervous system and musculoskeletal system of pigs. Aust Vet J 1986, 1986:48-50.
56. Martin M., Adams C., Wiseman B. Pre-weaning performance and health of pigs born to cloned (fetal cell derived) swine versus non-cloned swine. Theriogenology 2004, 2004:113-122.
57. Simianer H., Kohn F. Genetic management of the Gottingen minipig population. J Pharmacol Toxicol Methods 2010, 62:221-226.
58. Ho S.Y., Thompson R.P., Gibbs S.R., Swindle M.M., Anderson R.H. Ventricular septal defects in a family of Yucatan miniature pigs. Int J Cardiol 1991, 1991:419-425.
59. Johnson T.B., Fyfe D.A., Thompson R.P., Kline C.H., Swindle M.M., Anderson R.H. Echocardiographic and anatomic correlation of ventricular septal defect morphology in newborn Yucatan pigs. Am Heart J 1993, 125:1067-1072.
60. Park M.R., Cho S.K., Lee S.Y., Choi Y.J., Park J.Y., Kwon D.N., et al. A rare and often unrecognized cerebromeningitis and hemodynamic disorder: a major cause of sudden death in somatic cell cloned piglets. Proteomics 2005, 5:1928-1939.
61. Wakayama T.F., Yanagimachi R. Cloning of male mice from adult tail-tip cells. Nat Genet 1999, 22:127-128.
62. Hosseinia S.M., Moulavi F., Foruzanfar M., Hajian M., Abedi P., Rezazade-Valojerdi M., et al. Effect of donor cell type and gender on the efficiency of in vitro sheep somatic cell cloning. Small Rumin Res 2008, 78:162-168.
63. Koo O.J., Park H.J., Kwon D.K., Kang J.T., Jang G., Lee B.C. Effect of recipient breed on delivery rate of cloned miniature pig. Zygote 2009, 17:203-207.