Genetic loci that regulate ectopic calcification in response to knee trauma in LG/J by SM/J advanced intercross mice

Journal of Orthopaedic Research

Volumn 33, Issue 10, 2015, Pages 1412-1423

  Rai, Muhammad Farooq ^a   Schmidt, Eric J ^a   Hashimoto, Shingo ^a   Cheverud, James M ^b   Sandell, Linda J ^a,c,d  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b LOYOLA UNIVERSITY CHICAGO   (United States)

^c WASHINGTON UNIVERSITY IN ST LOUIS   (United States)

^d BARNES JEWISH HOSPITAL   (United States)

Author keywords

advanced intercross line; ectopic calcification; gene expression; genetics; osteoarthritis; QTL analysis

Indexed keywords

ADAM10 ENDOPEPTIDASE; MESSENGER RNA; TISSUE INHIBITOR OF METALLOPROTEINASE; TRANSCRIPTION FACTOR T BET; TRANSIENT RECEPTOR POTENTIAL CHANNEL M3;

ADVANCED INTERCROSS LINE; ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANK GENE; ANKYLOSING SPONDYLITIS; ARTICLE; BONE METABOLISM; CALCIFICATION; COL1A2 GENE; CONTROLLED STUDY; FAM105B GENE; FUNCTIONAL ASSESSMENT; GENE; GENE EXPRESSION; GENE LOCUS; GENETIC SUSCEPTIBILITY; HOXB9 GENE; JOINT INJURY; KIF26B GENE; KNEE INJURY; KNEE MENISCUS; LARP6 GENE; LIPC GENE; MAP4K4 GENE; MICRO-COMPUTED TOMOGRAPHY; MOUSE; MYO1E GENE; NFE2L1 GENE; NONHUMAN; NPRL3 GENE; PARENT; PHENOTYPE; PON1 GENE; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; QUANTITATIVE TRAIT LOCUS; QUANTITATIVE TRAIT LOCUS MAPPING; SINGLE NUCLEOTIDE POLYMORPHISM; STAB2 GENE; SYNOVIUM; TBKBP1 GENE; TGFB2 GENE; TLE3 GENE; ANIMAL; ARTHROPATHY; CALCINOSIS; COMPARATIVE STUDY; COMPLICATION; FEMALE; GENETICS; HUMAN; MALE; PATHOLOGY;

ANIMALS; CALCINOSIS; FEMALE; GENE EXPRESSION; HUMANS; JOINT DISEASES; KNEE INJURIES; MALE; MENISCI, TIBIAL; MICE; PHENOTYPE; QUANTITATIVE TRAIT LOCI; SPONDYLITIS, ANKYLOSING; SYNOVIAL MEMBRANE;

EID: 84940459119     PISSN: 07360266     EISSN: 1554527X     Source Type: Journal    
DOI: 10.1002/jor.22944     Document Type: Article

References (53)

1. Crotty JM, Monu JU, Pope TL, Jr., 1996. Synovial osteochondromatosis. Radiol Clin North Am 34: 327-342.
2. Barwell R,. 1876. Clinical lectures on movable bodies in joints. Br Med J 1: 184-185.
3. Felson DT, Anderson JJ, Naimark A, et al., 1989. The prevalence of chondrocalcinosis in the elderly and its association with knee osteoarthritis: the Framingham Study. J Rheumatol 16: 1241-1245.
4. Wilkins E, Dieppe P, Maddison P, et al., 1983. Osteoarthritis and articular chondrocalcinosis in the elderly. Ann Rheum Dis 42: 280-284.
5. Steitz SA, Speer MY, McKee MD, et al., 2002. Osteopontin inhibits mineral deposition and promotes regression of ectopic calcification. Am J Pathol 161: 2035-2046.
6. Ji Y, Christopherson GT, Kluk MW, et al., 2011. Heterotopic ossification following musculoskeletal trauma: modeling stem and progenitor cells in their microenvironment. Adv Exp Med Biol 720: 39-50.
7. Ciancio G, Bortoluzzi A, Govoni M,. 2011. Epidemiology of gout and chondrocalcinosis. Reumatismo 63: 207-220.
8. Moochhala SH,. 2012. Extracellular pyrophosphate in the kidney: how does it get there and what does it do? Nephron Physiology 120: 33-38.
9. Li Q, Uitto J,. 2013. Mineralization/anti-mineralization networks in the skin and vascular connective tissues. Am J Pathol 183: 10-18.
10. Richtsmeier JT, Flaherty K,. 2013. Hand in glove: brain and skull in development and dysmorphogenesis. Acta neuropathologica 125: 469-489.
11. Hughes AE, McGibbon D, Woodward E, et al., 1995. Localisation of a gene for chondrocalcinosis to chromosome 5p. Hum Mol Genet 4: 1225-1228.
12. Baldwin CT, Farrer LA, Adair R, et al., 1995. Linkage of early-onset osteoarthritis and chondrocalcinosis to human chromosome 8q. Am J Hum Genet 56: 692-697.
13. Rodriguez-Valverde V, Zuniga M, Casanueva B, et al., 1988. Hereditary articular chondrocalcinosis. Clinical and genetic features in 13 pedigrees. Am J Med 84: 101-106.
14. Pendleton A, Johnson MD, Hughes A, et al., 2002. Mutations in ANKH cause chondrocalcinosis. Am J Hum Genet 71: 933-940.
15. Balsa A, Martin-Mola E, Gonzalez T, et al., 1990. Familial articular chondrocalcinosis in Spain. Ann Rheum Dis 49: 531-535.
16. Hrbek T, de Brito RA, Wang B, et al., 2006. Genetic characterization of a new set of recombinant inbred lines (LGXSM) formed from the inter-cross of SM/J and LG/J inbred mouse strains. Mamm Genome 17: 417-429.
17. Cheverud JM, Routman EJ, Duarte FA, et al., 1996. Quantitative trait loci for murine growth. Genetics 142: 1305-1319.
18. Cheverud JM, Lawson HA, Fawcett GL, et al., 2011. Diet-dependent genetic and genomic imprinting effects on obesity in mice. Obesity (Silver Spring) 19: 160-170.
19. Cheverud JM, Lawson HA, Bouckaert K, et al., 2014. Fine-mapping quantitative trait loci affecting murine external ear tissue regeneration in the LG/J by SM/J advanced intercross line. Heredity (Edinb) 112: 508-518.
20. Hashimoto S, Rai MF, Janiszak KL, et al., 2012. Cartilage and bone changes during development of post-traumatic osteoarthritis in selected LGXSM recombinant inbred mice. Osteoarthritis Cartilage 20: 562-571.
21. Glasson SS, Blanchet TJ, Morris EA,. 2007. The surgical destabilization of the medial meniscus (DMM) model of osteoarthritis in the 129/SvEv mouse. Osteoarthritis Cartilage 15: 1061-1069.
22. Rai MF, Hashimoto S, Johnson EE, et al., 2012. Heritability of articular cartilage regeneration and its association with ear wound healing in mice. Arthritis Rheum 64: 2300-2310.
23. Lawson HA, Cady JE, Partridge C, et al., 2011. Genetic effects at pleiotropic loci are context-dependent with consequences for the maintenance of genetic variation in populations. PLoS Genet 7: e1002256.
24. Williams AL, Housman DE, Rinard MC, et al., 2010. Rapid haplotype inference for nuclear families. Genome Biol 11: R108.
25. Haley CS, Knott SA,. 1992. A simple regression method for mapping quantitative trait loci in line crosses using flanking markers. Heredity (Edinb) 69: 315-324.
26. Kumar P, Henikoff S, Ng PC,. 2009. Predicting the effects of coding non-synonymous variants on protein function using the SIFT algorithm. Nature protocols 4: 1073-1081.
27. Adzhubei IA, Schmidt S, Peshkin L, et al., 2010. A method and server for predicting damaging missense mutations. Nat Methods 7: 248-249.
28. Chun S, Fay JC,. 2009. Identification of deleterious mutations within three human genomes. Genome Res 19: 1553-1561.
29. Rai MF, Schmidt EJ, McAlinden A, et al., 2013. Molecular insight into the association between cartilage regeneration and ear wound healing in genetic mouse models: targeting new genes in regeneration. G3 3: 1881-1891.
30. Ronchetti I, Boraldi F, Annovi G, et al., 2013. Fibroblast involvement in soft connective tissue calcification. Front Genet 4: 22.
31. Collett GD, Canfield AE,. 2005. Angiogenesis and pericytes in the initiation of ectopic calcification. Circ Res 96: 930-938.
32. Piovesan EJ, Young Blood MR, Kowacs PA, et al., 2007. Prevalence of migraine in Noonan syndrome. Cephalalgia 27: 330-335.
33. Neame RL, Carr AJ, Muir K, et al., 2003. UK community prevalence of knee chondrocalcinosis: evidence that correlation with osteoarthritis is through a shared association with osteophyte. Ann Rheum Dis 62: 513-518.
34. Kokabu S, Nguyen T, Ohte S, et al., 2013. TLE3, transducing-like enhancer of split 3, suppresses osteoblast differentiation of bone marrow stromal cells. Biochem Biophys Res Commun 438: 205-210.
35. Filvaroff E, Erlebacher A, Ye J, et al., 1999. Inhibition of TGF-beta receptor signaling in osteoblasts leads to decreased bone remodeling and increased trabecular bone mass. Development 126: 4267-4279.
36. Yamada Y, Ando F, Shimokata H,. 2007. Association of candidate gene polymorphisms with bone mineral density in community-dwelling Japanese women and men. Int J Mol Med 19: 791-801.
37. Kim J, Xing W, Wergedal J, et al., 2010. Targeted disruption of nuclear factor erythroid-derived 2-like 1 in osteoblasts reduces bone size and bone formation in mice. Physiol Genomics 40: 100-110.
38. Gurley KA, Reimer RJ, Kingsley DM,. 2006. Biochemical and genetic analysis of ANK in arthritis and bone disease. Am J Hum Genet 79: 1017-1029.
39. Pimentel-Santos FM, Ligeiro D, Matos M, et al., 2012. ANKH and susceptibility to and severity of ankylosing spondylitis. J Rheumatol 39: 131-134.
40. Australo-Anglo-American Spondyloarthritis Consortium, Reveille JD, Sims AM, et al., 2010. Genome-wide association study of ankylosing spondylitis identifies non-MHC susceptibility loci. Nat Genet 42: 123-127.
41. Li G, Han N, Li Z, et al., 2013. Identification of transcription regulatory relationships in rheumatoid arthritis and osteoarthritis. Clin Rheumatol 32: 609-615.
42. Simsa-Maziel S, Zaretsky J, Reich A, et al., 2013. IL-1RI participates in normal growth plate development and bone modeling. Am J Physiol Endocrinol Metab 305: E15-E21.
43. Sokolowska M, Chen LY, Eberlein M, et al., 2014. Low molecular weight hyaluronan activates cytosolic phospholipase A2alpha and eicosanoid production in monocytes and macrophages. J Biol Chem 289: 4470-4488.
44. Kondo Y, Iizuka M, Wakamatsu E, et al., 2012. Overexpression of T-bet gene regulates murine autoimmune arthritis. Arthritis Rheum 64: 162-172.
45. Aouadi M, Tesz GJ, Nicoloro SM, et al., 2009. Orally delivered siRNA targeting macrophage Map4k4 suppresses systemic inflammation. Nature 458: 1180-1184.
46. Rouault K, Scotet V, Autret S, et al., 2009. Do HOXB9 and COL1A1 genes play a role in congenital dislocation of the hip? Study in a Caucasian population. Osteoarthritis Cartilage 17: 1099-1105.
47. Blackstock CD, Higashi Y, Sukhanov S, et al., 2014. Insulin-like growth factor-1 increases synthesis of collagen type I via induction of the mRNA-binding protein LARP6 expression and binding to the 5' stem-loop of COL1a1 and COL1a2 mRNA. J Biol Chem 289: 7264-7274.
48. Schlondorff J, Blobel CP,. 1999. Metalloprotease-disintegrins: modular proteins capable of promoting cell-cell interactions and triggering signals by protein-ectodomain shedding. J Cell Sci 112: 3603-3617.
49. Jackson MT, Moradi B, Smith MM, et al., 2014. Matrix metalloproteinase (MMP)-2, MMP-9 and MMP-13 are activated by Activated Protein C (APC) in human osteoarthritic cartilage chondrocytes. Arthritis Rheum 66: 1525-1536.
50. Gill SE, Gharib SA, Bench EM, et al., 2013. Tissue inhibitor of metalloproteinases-3 moderates the proinflammatory status of macrophages. Am J Respir Cell Mol Biol 49: 768-777.
51. Ciurtin C, Majeed Y, Naylor J, et al., 2010. TRPM3 channel stimulated by pregnenolone sulphate in synovial fibroblasts and negatively coupled to hyaluronan. BMC Musculoskelet Disord 11: 111.
52. Jaeger K, Selent C, Jaehme W, et al., 2008. The genetics of osteoarthritis in STR/ort mice. Osteoarthritis Cartilage 16: 607-614.
53. Ramos YF, Bos SD, van der Breggen R, et al., 2014. A gain of function mutation in TNFRSF11B encoding osteoprotegrin causes osteoarthritis with chondocalcinosis. Ann Rheum Dis doi: 10.1136/annrheumdis-2