The type 2 cannabinoid receptor regulates susceptibility to osteoarthritis in mice

Osteoarthritis and Cartilage

Volumn 23, Issue 9, 2015, Pages 1586-1594

  Sophocleous, A ^a   Borjesson A E ^a   Salter, D M ^a   Ralston, S H ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

Cannabinoids; Cartilage; CB2; Cnr2; Mouse model; Osteoarthritis

Indexed keywords

4 [4 (1,1 DIMETHYLHEPTYL) 2,6 DIMETHOXYPHENYL] 6,6 DIMETHYLBICYCLO[3.1.1]HEPT 2 EN 2 YLMETHANOL; CANNABINOID 2 RECEPTOR; PROTEOGLYCAN; CANNABINOID; CNR2 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARTILAGE CELL; CELL CULTURE; CONTROLLED STUDY; DESTABILISATION OF THE MEDIAL MENISCUS; DISEASE PREDISPOSITION; DISEASE SEVERITY; ENZYME ACTIVATION; ENZYME REGULATION; IN VITRO STUDY; KNEE DISEASE; KNEE OSTEOARTHRITIS; MALE; MOUSE; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; AGING; AGONISTS; ANIMAL; BIOSYNTHESIS; CHONDROCYTE; DEFICIENCY; DRUG EFFECTS; KNEE MENISCUS; METABOLISM; MICRO-COMPUTED TOMOGRAPHY; OSTEOARTHRITIS; OSTEOARTHRITIS, KNEE; PHYSIOLOGY;

AGING; ANIMALS; CANNABINOIDS; CHONDROCYTES; DISEASE SUSCEPTIBILITY; MENISCI, TIBIAL; MICE; OSTEOARTHRITIS; OSTEOARTHRITIS, KNEE; PROTEOGLYCANS; RECEPTOR, CANNABINOID, CB2; X-RAY MICROTOMOGRAPHY;

EID: 84940452817     PISSN: 10634584     EISSN: 15229653     Source Type: Journal    
DOI: 10.1016/j.joca.2015.04.020     Document Type: Article

References (35)

1. Pertwee R.G., Howlett A.C., Abood M.E., Alexander S.P., Di Marzo V, Elphick M.R., et al. International Union of Basic and Clinical Pharmacology. LXXIX. Cannabinoid receptors and their ligands: beyond CB(1) and CB(2). Pharmacol Rev 2010, 62:588-631.
2. Idris A.I., Ralston S.H. Cannabinoids and bone: friend or foe?. Calcif Tissue Int 2010, 87:285-297.
3. Idris A.I., 't Hof R.J., Greig I.R., Ridge S.A., Baker D., Ross R.A., et al. Regulation of bone mass, bone loss and osteoclast activity by cannabinoid receptors. Nat Med 2005, 11:774-779.
4. Idris A.I., Sophocleous A., Landao-Bassonga E., Canals M., Milligan G., Baker D., et al. Cannabinoid receptor type 1 protects against age-related osteoporosis by regulating osteoblast and adipocyte differentiation in marrow stromal cells. Cell Metab 2009, 10:139-147.
5. Tam J., Ofek O., Fride E., Ledent C., Gabet Y., Muller R., et al. Involvement of neuronal cannabinoid receptor CB1 in regulation of bone mass and bone remodeling. Mol Pharmacol 2006, 70:786-792.
6. Ofek O., Karsak M., Leclerc N., Fogel M., Frenkel B., Wright K., et al. Peripheral cannabinoid receptor, CB2, regulates bone mass. Proc Natl Acad Sci USA 2006, 103:696-701.
7. Sophocleous A., Landao-Bassonga E., van't Hof R.J., Idris A.I., Ralston S.H. The type 2 cannabinoid receptor regulates bone mass and ovariectomy-induced bone loss by affecting osteoblast differentiation and bone formation. Endocrinology 2011, 152:2141-2149.
8. Malfait A.M., Gallily R., Sumariwalla P.F., Malik A.S., Andreakos E., Mechoulam R., et al. The nonpsychoactive cannabis constituent cannabidiol is an oral anti-arthritic therapeutic in murine collagen-induced arthritis. Proc Natl Acad Sci USA 2000, 97:9561-9566.
9. Sumariwalla P.F., Gallily R., Tchilibon S., Fride E., Mechoulam R., Feldmann M. A novel synthetic, nonpsychoactive cannabinoid acid (HU-320) with antiinflammatory properties in murine collagen-induced arthritis. Arthritis Rheum 2004, 50:985-998.
10. Mbvundula E.C., Bunning R.A., Rainsford K.D. Arthritis and cannabinoids: HU-210 and Win-55,212-2 prevent IL-1alpha-induced matrix degradation in bovine articular chondrocytes in-vitro. J Pharm Pharmacol 2006, 58:351-358.
11. Richardson D., Pearson R.G., Kurian N., Latif M.L., Garle M.J., Barrett D.A., et al. Characterisation of the cannabinoid receptor system in synovial tissue and fluid in patients with osteoarthritis and rheumatoid arthritis. Arthritis Res Ther 2008, 10:R43.
12. Dequeker J., Luyten F.P. The history of osteoarthritis-osteoarthrosis. Ann Rheum Dis 2008, 67:5-10.
13. Burr D.B., Gallant M.A. Bone remodelling in osteoarthritis. Nat Rev Rheumatol 2012, 8:665-673.
14. Buckley N.E., McCoy K.L., Mezey E., Bonner T., Zimmer A., Felder C.C., et al. Immunomodulation by cannabinoids is absent in mice deficient for the cannabinoid CB(2) receptor. Eur J Pharmacol 2000, 396:141-149.
15. Buckley N.E. The peripheral cannabinoid receptor knockout mice: an update. Br J Pharmacol 2008, 153:309-318.
16. Glasson S.S., Blanchet T.J., Morris E.A. The surgical destabilization of the medial meniscus (DMM) model of osteoarthritis in the 129/SvEv mouse. Osteoarthritis Cartilage 2007, 15:1061-1069.
17. Inglis J.J., McNamee K.E., Chia S.L., Essex D., Feldmann M., Williams R.O., et al. Regulation of pain sensitivity in experimental osteoarthritis by the endogenous peripheral opioid system. Arthritis Rheum 2008, 58:3110-3119.
18. Hanus L., Breuer A., Tchilibon S., Shiloah S., Goldenberg D., Horowitz M., et al. HU-308: a specific agonist for CB(2), a peripheral cannabinoid receptor. Proc Natl Acad Sci USA 1999, 96:14228-14233.
19. Glasson S.S., Chambers M.G., van den Berg W.B., Little C.B. The OARSI histopathology initiative - recommendations for histological assessments of osteoarthritis in the mouse. Osteoarthritis Cartilage 2010, 18(Suppl 3):S17-S23.
20. Salvat C., Pigenet A., Humbert L., Berenbaum F., Thirion S. Immature murine articular chondrocytes in primary culture: a new tool for investigating cartilage. Osteoarthritis Cartilage 2005, 13:243-249.
21. Ahmed S.A., Gogal R.M., Walsh J.E. A new rapid and simple non-radioactive assay to monitor and determine the proliferation of lymphocytes: an alternative to [3H]thymidine incorporation assay. J Immunol Methods 1994, 170:211-224.
22. Adolphe M., Thenet-Gauci S., Demignot S. Chondrocyte culture: a target system to evaluate pharmacotoxicological effects of crugs. In Vitro Methods in Pharmaceutical Research 1997, 182-199. J.C. Catell, M.J. Gomez-Lechon (Eds.).
23. Review Manager (RevMan) [Computer Program]. Version 5.3. Copenhagen: The Nordic Cochrane Centre, The Cochrane Collaboration; 2014.
24. Landis J.R., Koch G.G. The measurement of observer agreement for categorical data. Biometrics 1977, 33:159-174.
25. Dunn S.L., Wilkinson J.M., Crawford A., Le Maitre C.L., Bunning R.A. Cannabinoids: novel therapies for arthritis?. Future Med Chem 2012, 4:713-725.
26. Gui H., Liu X., Wang Z.W., He D.Y., Su D.F., Dai S.M. Expression of cannabinoid receptor 2 and its inhibitory effects on synovial fibroblasts in rheumatoid arthritis. Rheumatology (Oxford) 2014, 53:802-809.
27. Idris A.I., Sophocleous A., Landao-Bassonga E., van't Hof R.J., Ralston S.H. Regulation of bone mass, osteoclast function, and ovariectomy-induced bone loss by the type 2 cannabinoid receptor. Endocrinology 2008, 149:5619-5626.
28. Tam J., Trembovler V., Di Marzo V., Petrosino S., Leo G., Alexandrovich A., et al. The cannabinoid CB1 receptor regulates bone formation by modulating adrenergic signaling. FASEB J 2008, 22:285-294.
29. Glasson S.S. In vivo osteoarthritis target validation utilizing genetically-modified mice. Curr Drug Targets 2007, 8:367-376.
30. Kim B.J., Choi B.H., Jin L.H., Park S.R., Min B.-H. Comparison between subchondral bone change and cartilage degeneration in collagenase- and DMM-induced osteoarthritis (OA) models in mice. Tissue Eng Regen Med 2013, 10:211-217.
31. Burston J.J., Sagar D.R., Shao P., Bai M., King E., Brailsford L., et al. Cannabinoid CB2 receptors regulate central sensitization and pain responses associated with osteoarthritis of the knee joint. PLoS One 2013, 8:e80440.
32. La Porta C., Bura S.A., Aracil-Fernandez A., Manzanares J., Maldonado R. Role of CB1 and CB2 cannabinoid receptors in the development of joint pain induced by monosodium iodoacetate. Pain 2013, 154:160-174.
33. Yao B.B., Hsieh G.C., Frost J.M., Fan Y., Garrison T.R., Daza A.V., et al. In vitro and in vivo characterization of A-796260: a selective cannabinoid CB(2) receptor agonist exhibiting analgesic activity in rodent pain models. Br J Pharmacol 2008, 153:390-401.
34. Sophocleous A., Sims A.H., Idris A.I., Ralston S.H. Modulation of strain-specific differences in gene expression by cannabinoid type 2 receptor deficiency. Calcif Tissue Int 2014, 94:423-432.
35. The Cochrane Collaboration [updated March 2011]. In: Higgins JPT, Green S, Eds. Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 2011. Available from: www.cochrane-handbook.org.