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Volumn 30, Issue 1, 2015, Pages 64-72

Levodopa therapy for Parkinson's disease: Pharmacokinetics and pharmacodynamics

Author keywords

Carbidopa; Levodopa; Parkinson's disease; Pharmacodynamics; Pharmacokinetics

Indexed keywords

DOPAMINE; LEVODOPA; ANTIPARKINSON AGENT;

EID: 84940452643     PISSN: 08853185     EISSN: 15318257     Source Type: Journal    
DOI: 10.1002/mds.26082     Document Type: Review
Times cited : (267)

References (78)
  • 1
    • 0014208039 scopus 로고
    • Aromatic amino acids and modification of parkinsonism
    • Cotzias GC, Van Woert MH, Schiffer LM. Aromatic amino acids and modification of parkinsonism. N Engl J Med 1967;276:374-379.
    • (1967) N Engl J Med , vol.276 , pp. 374-379
    • Cotzias, G.C.1    Van Woert, M.H.2    Schiffer, L.M.3
  • 2
    • 0014673226 scopus 로고
    • Modification of Parkinsonism: chronic treatment with l-dopa
    • Cotzias GC, Papavasiliou PS, Gellene R. Modification of Parkinsonism: chronic treatment with l-dopa. N Engl J Med 1969;280:337-345.
    • (1969) N Engl J Med , vol.280 , pp. 337-345
    • Cotzias, G.C.1    Papavasiliou, P.S.2    Gellene, R.3
  • 3
    • 4644314827 scopus 로고    scopus 로고
    • Levodopa in the treatment of Parkinson's disease: the second consensus meeting
    • Olanow CW, Agid Y, Mizuno Y, et al. Levodopa in the treatment of Parkinson's disease: the second consensus meeting. Mov Disord 2004;19:997-1005.
    • (2004) Mov Disord , vol.19 , pp. 997-1005
    • Olanow, C.W.1    Agid, Y.2    Mizuno, Y.3
  • 4
    • 0000428532 scopus 로고
    • 3,4-Dihydroxyphenylalanine and 5-hydroxytryptophan as reserpine antagonists
    • Carlsson A, Lindqvist M, Magnusson T. 3, 4-Dihydroxyphenylalanine and 5-hydroxytryptophan as reserpine antagonists. Nature 1957:180:1200.
    • (1957) Nature , vol.180 , pp. 1200
    • Carlsson, A.1    Lindqvist, M.2    Magnusson, T.3
  • 5
    • 79960696174 scopus 로고    scopus 로고
    • A brief history of levodopa
    • Hornykiewicz O. A brief history of levodopa. J Neurol 2010;257(Suppl 2):S249-S252.
    • (2010) J Neurol , vol.257 , pp. S249-S252
    • Hornykiewicz, O.1
  • 6
    • 0010684051 scopus 로고
    • The effects of intravenous injection of L-dopa upon blood pressure
    • Oster KA, Sorkin SZ. The effects of intravenous injection of L-dopa upon blood pressure. Proc Soc Exp Biol Med 1942;51:67-71.
    • (1942) Proc Soc Exp Biol Med , vol.51 , pp. 67-71
    • Oster, K.A.1    Sorkin, S.Z.2
  • 7
    • 0342595134 scopus 로고
    • Über das sympathetikomimetische pressorische Prinzip des Hirns ("Urosympathin")
    • Holtz P, Credner K, Kroneberg G. Über das sympathetikomimetische pressorische Prinzip des Hirns ("Urosympathin"). Arch Exp Path Pharmak 1947;204:28-243.
    • (1947) Arch Exp Path Pharmak , vol.204 , pp. 28-243
    • Holtz, P.1    Credner, K.2    Kroneberg, G.3
  • 8
    • 0009648487 scopus 로고
    • The pharmacology of levodopa in treatment of Parkinson disease: an update. In: Calne DB, ed. Drugs for the Treatment of Parkinson's Disease
    • Berlin: Springer-Verlag
    • LeWitt PA. The pharmacology of levodopa in treatment of Parkinson disease: an update. In: Calne DB, ed. Drugs for the Treatment of Parkinson's Disease. Handbook of Experimental Pharmacology, vol 88. Berlin: Springer-Verlag; 1989:325-384.
    • (1989) Handbook of Experimental Pharmacology, vol 88 , pp. 325-384
    • LeWitt, P.A.1
  • 9
    • 58149130627 scopus 로고
    • How does L-dopa work?
    • In Barbeau A, McDowell FH, eds. . Philadelphia: FA Davis
    • Hornykiewicz O. How does L-dopa work? In Barbeau A, McDowell FH, eds. L-dopa and Parkinsonism. Philadelphia: FA Davis; 1970:393-399.
    • (1970) L-dopa and Parkinsonism , pp. 393-399
    • Hornykiewicz, O.1
  • 10
    • 84901411897 scopus 로고    scopus 로고
    • Effects of noradrenergic denervation by anti-DBH-saporin on behavioral responsivity to L-DOPA in the hemi-parkinsonian rat
    • Ostock CY, Lindenbach D, Goldenberg AA, Kampton E, Bishop C. Effects of noradrenergic denervation by anti-DBH-saporin on behavioral responsivity to L-DOPA in the hemi-parkinsonian rat. Behav Brain Res 2014;270:75-85.
    • (2014) Behav Brain Res , vol.270 , pp. 75-85
    • Ostock, C.Y.1    Lindenbach, D.2    Goldenberg, A.A.3    Kampton, E.4    Bishop, C.5
  • 11
    • 34250025128 scopus 로고    scopus 로고
    • Norepinephrine: the redheaded stepchild of Parkinson's disease
    • Rommelfanger KS, Weinshenker D. Norepinephrine: the redheaded stepchild of Parkinson's disease. Biochem Pharmacol 2007;74:177-190.
    • (2007) Biochem Pharmacol , vol.74 , pp. 177-190
    • Rommelfanger, K.S.1    Weinshenker, D.2
  • 12
    • 0021920211 scopus 로고
    • Partial lesions of the nigrostriatal pathway in the rat: acceleration of transmitter synthesis and release of surviving dopaminergic neurones by drugs
    • Hefti F, Enz A, Melamed E. Partial lesions of the nigrostriatal pathway in the rat: acceleration of transmitter synthesis and release of surviving dopaminergic neurones by drugs. Neuropharmacology 1985;24:19-23.
    • (1985) Neuropharmacology , vol.24 , pp. 19-23
    • Hefti, F.1    Enz, A.2    Melamed, E.3
  • 13
    • 12244301573 scopus 로고    scopus 로고
    • L-3,4-Dihydroxyphenylalanine as a neurotransmitter candidate in the central nervous system
    • Misu Y, Kitahama K, Goshima U. L-3, 4-Dihydroxyphenylalanine as a neurotransmitter candidate in the central nervous system. Pharmacol Ther 2003;97:117-137.
    • (2003) Pharmacol Ther , vol.97 , pp. 117-137
    • Misu, Y.1    Kitahama, K.2    Goshima, U.3
  • 14
    • 58149137635 scopus 로고    scopus 로고
    • DOPA as a neurotransmitter candidate
    • In: Misu Y, Goshima Y, eds. . Boca Raton, FL: CRC Press
    • Misu Y, Goshima Y. DOPA as a neurotransmitter candidate. In: Misu Y, Goshima Y, eds. Neurobiology of DOPA as a Neurotransmitter. Boca Raton, FL: CRC Press; 2006:23-34.
    • (2006) Neurobiology of DOPA as a Neurotransmitter , pp. 23-34
    • Misu, Y.1    Goshima, Y.2
  • 15
    • 80053576374 scopus 로고    scopus 로고
    • L-Dihydroxyphenylalanine modulates the steady-state expression of mouse striatal tyrosine hydroxylase, aromatic L-amino acid decarboxylase, dopamine and its metabolites in an MPTP mouse model of Parkinson's disease
    • King JM, Muthian G, Mackey V, Smith M, Charlton C. L-Dihydroxyphenylalanine modulates the steady-state expression of mouse striatal tyrosine hydroxylase, aromatic L-amino acid decarboxylase, dopamine and its metabolites in an MPTP mouse model of Parkinson's disease. Life Sci 2011;89:638-643.
    • (2011) Life Sci , vol.89 , pp. 638-643
    • King, J.M.1    Muthian, G.2    Mackey, V.3    Smith, M.4    Charlton, C.5
  • 16
    • 0028988351 scopus 로고
    • Iron-mediated oxidation of 3,4-dihydroxyphenylalanine to an excitotoxin
    • Newcomer TA, Rosenberg PA, Aizenman E. Iron-mediated oxidation of 3, 4-dihydroxyphenylalanine to an excitotoxin. J Neurochem 1995;64:1742-1748.
    • (1995) J Neurochem , vol.64 , pp. 1742-1748
    • Newcomer, T.A.1    Rosenberg, P.A.2    Aizenman, E.3
  • 17
    • 84881368865 scopus 로고    scopus 로고
    • Dual effects of L-DOPA on nigral dopaminergic neurons
    • Guatteo E, Yee A, McKearney J, et al. Dual effects of L-DOPA on nigral dopaminergic neurons. Exp Neurol 2013;247:582-594.
    • (2013) Exp Neurol , vol.247 , pp. 582-594
    • Guatteo, E.1    Yee, A.2    McKearney, J.3
  • 18
    • 84892480344 scopus 로고    scopus 로고
    • 5-S-cysteinyldopamine neurotoxicity: influence on the expression of α-synuclein and ERp57 in cellular and animal models of Parkinson's disease
    • Aureli C, Cassano T, Masci A, et al. 5-S-cysteinyldopamine neurotoxicity: influence on the expression of α-synuclein and ERp57 in cellular and animal models of Parkinson's disease. J Neurosci Res 2014;92:347-358.
    • (2014) J Neurosci Res , vol.92 , pp. 347-358
    • Aureli, C.1    Cassano, T.2    Masci, A.3
  • 20
    • 0022556678 scopus 로고
    • Inhibition of L-[18F]fluorodopa uptake into human brain by amino acids demonstrated by positron emission tomography
    • Leenders KL, Poewe WH, Palmer AJ, Brenton DP, Frackowiak RS. Inhibition of L-[18F]fluorodopa uptake into human brain by amino acids demonstrated by positron emission tomography. Ann Neurol 1986;20:258-262.
    • (1986) Ann Neurol , vol.20 , pp. 258-262
    • Leenders, K.L.1    Poewe, W.H.2    Palmer, A.J.3    Brenton, D.P.4    Frackowiak, R.S.5
  • 21
    • 38949133757 scopus 로고    scopus 로고
    • The role of 3-O-methyldopa in the side effects of L-DOPA
    • Lee ES, Chen H, King J, Charlton C. The role of 3-O-methyldopa in the side effects of L-DOPA. Neurochem Res 2008;33:401-411.
    • (2008) Neurochem Res , vol.33 , pp. 401-411
    • Lee, E.S.1    Chen, H.2    King, J.3    Charlton, C.4
  • 22
    • 78649384409 scopus 로고    scopus 로고
    • Problems with the present inhibitors and a relevance of new and improved COMT inhibitors in Parkinson's disease
    • Kaakkola S. Problems with the present inhibitors and a relevance of new and improved COMT inhibitors in Parkinson's disease. Int Rev Neurobiol 2010;95:207-225.
    • (2010) Int Rev Neurobiol , vol.95 , pp. 207-225
    • Kaakkola, S.1
  • 23
    • 0022230744 scopus 로고
    • Effect of carbidopa on pharmacokinetics of intravenously administered levodopa: implications for mechanism of action of carbidopa in the treatment of Parkinsonism
    • Nutt JG, Woodward WR, Anderson JL. Effect of carbidopa on pharmacokinetics of intravenously administered levodopa: implications for mechanism of action of carbidopa in the treatment of Parkinsonism. Ann Neurol 1985;13:537-544.
    • (1985) Ann Neurol , vol.13 , pp. 537-544
    • Nutt, J.G.1    Woodward, W.R.2    Anderson, J.L.3
  • 25
    • 0021361984 scopus 로고
    • L-dopa decarboxylation in chronically treated patients
    • Ward CD, Trombley IK, Calne DB, Kopin IJ. L-dopa decarboxylation in chronically treated patients. Neurology 1984;34:198-201.
    • (1984) Neurology , vol.34 , pp. 198-201
    • Ward, C.D.1    Trombley, I.K.2    Calne, D.B.3    Kopin, I.J.4
  • 26
    • 0030749473 scopus 로고    scopus 로고
    • Pharmacodynamics of benserazide assessed by its effects on endogenous and exogenous levodopa pharmacokinetics
    • Dingemanse J, Kleinbloesem CH, Zürcher G, et al. Pharmacodynamics of benserazide assessed by its effects on endogenous and exogenous levodopa pharmacokinetics. Br J Clin Pharmacol 1997;44:41-48.
    • (1997) Br J Clin Pharmacol , vol.44 , pp. 41-48
    • Dingemanse, J.1    Kleinbloesem, C.H.2    Zürcher, G.3
  • 27
    • 0033601926 scopus 로고    scopus 로고
    • Role of serotonergic neurons in L-DOPA-derived extracellular dopamine in the striatum of 6-OHDA-lesioned rats
    • Tanaka H, Kannari K, Maeda T, et al. Role of serotonergic neurons in L-DOPA-derived extracellular dopamine in the striatum of 6-OHDA-lesioned rats. Neuroreport 1999;10:631-634.
    • (1999) Neuroreport , vol.10 , pp. 631-634
    • Tanaka, H.1    Kannari, K.2    Maeda, T.3
  • 28
    • 0019422869 scopus 로고
    • The site of dopamine formation in rat striatum after L-dopa administration
    • Hefti F, Melamed E, Wurtman RJ. The site of dopamine formation in rat striatum after L-dopa administration. J Pharmacol Exp Ther 1981;217:189-197.
    • (1981) J Pharmacol Exp Ther , vol.217 , pp. 189-197
    • Hefti, F.1    Melamed, E.2    Wurtman, R.J.3
  • 29
    • 44949222522 scopus 로고    scopus 로고
    • Results from a phase I safety trial of hAADC gene therapy for Parkinson disease
    • Eberling JL, Jagust WJ, Christine CW, et al. Results from a phase I safety trial of hAADC gene therapy for Parkinson disease. Neurology 2008;70:1980-1983.
    • (2008) Neurology , vol.70 , pp. 1980-1983
    • Eberling, J.L.1    Jagust, W.J.2    Christine, C.W.3
  • 30
    • 84860130544 scopus 로고    scopus 로고
    • Long-term evaluation of a phase 1 study of AADC gene therapy for Parkinson's disease
    • Mittermeyer G, Christine CW, Rosenbluth KH, et al. Long-term evaluation of a phase 1 study of AADC gene therapy for Parkinson's disease. Hum Gene Ther 2012;23:377-381.
    • (2012) Hum Gene Ther , vol.23 , pp. 377-381
    • Mittermeyer, G.1    Christine, C.W.2    Rosenbluth, K.H.3
  • 31
    • 84897076939 scopus 로고    scopus 로고
    • Long-term safety and tolerability of ProSavin, a lentiviral vector-based gene therapy for Parkinson's disease: a dose escalation, open-label, phase 1/2 trial
    • Palfi S, Gurruchaga JM, Ralph GS, et al. Long-term safety and tolerability of ProSavin, a lentiviral vector-based gene therapy for Parkinson's disease: a dose escalation, open-label, phase 1/2 trial. Lancet Neurol 2014;383:1138-1146.
    • (2014) Lancet Neurol , vol.383 , pp. 1138-1146
    • Palfi, S.1    Gurruchaga, J.M.2    Ralph, G.S.3
  • 32
    • 65349157665 scopus 로고    scopus 로고
    • MAO-B inhibitor know-how: back to the pharm
    • LeWitt PA. MAO-B inhibitor know-how: back to the pharm. Neurology 2009;72:152-157.
    • (2009) Neurology , vol.72 , pp. 152-157
    • LeWitt, P.A.1
  • 33
    • 33344469306 scopus 로고    scopus 로고
    • Pharmacokinetic optimisation in the treatment of Parkinson's disease: an update
    • Nyholm D. Pharmacokinetic optimisation in the treatment of Parkinson's disease: an update. Clin Pharmacokinet 2006;45:109-136.
    • (2006) Clin Pharmacokinet , vol.45 , pp. 109-136
    • Nyholm, D.1
  • 34
    • 69549103564 scopus 로고    scopus 로고
    • Pharmacokinetic-pharmacodynamic crossover comparison of two levodopa extension strategies
    • LeWitt PA, Jennings D, Lyons KE, et al. Pharmacokinetic-pharmacodynamic crossover comparison of two levodopa extension strategies. Mov Disord 2009;24:1319-1324.
    • (2009) Mov Disord , vol.24 , pp. 1319-1324
    • LeWitt, P.A.1    Jennings, D.2    Lyons, K.E.3
  • 35
    • 0022657221 scopus 로고
    • Episodic unresponsiveness to single doses of L-dopa in parkinsonian fluctuators
    • Melamed E, Bitton V, Zelig O. Episodic unresponsiveness to single doses of L-dopa in parkinsonian fluctuators. Neurology 1986;36:100-103.
    • (1986) Neurology , vol.36 , pp. 100-103
    • Melamed, E.1    Bitton, V.2    Zelig, O.3
  • 36
    • 0024804838 scopus 로고
    • Pharmacokinetics and bioavailability of Sinemet CR: a summary of human studies
    • Yeh YC, August TF, Bush DF, et al. Pharmacokinetics and bioavailability of Sinemet CR: a summary of human studies. Neurology 1989;39(11 Suppl 2):25-38.
    • (1989) Neurology , vol.39 , Issue.11 , pp. 25-38
    • Yeh, Y.C.1    August, T.F.2    Bush, D.F.3
  • 37
    • 0025000599 scopus 로고
    • Pharmokinetics and effects of levodopa in advanced Parkinson's disease
    • Bredberg E, Tedroff J, Aquilonius SM, et al. Pharmokinetics and effects of levodopa in advanced Parkinson's disease. Eur J Clin Pharmacol 1990;39:385-389.
    • (1990) Eur J Clin Pharmacol , vol.39 , pp. 385-389
    • Bredberg, E.1    Tedroff, J.2    Aquilonius, S.M.3
  • 38
    • 0024829604 scopus 로고
    • Controlled release carbidopa/levodopa (Sinemet 50/200 CR-4). Clinical, pharmacokinetic, and pharmacodynamic studies
    • LeWitt PA, Nelson MV, Berchou RC, et al. Controlled release carbidopa/levodopa (Sinemet 50/200 CR-4). Clinical, pharmacokinetic, and pharmacodynamic studies. Neurology 1989;39(11 Suppl 2):45-53.
    • (1989) Neurology , vol.39 , Issue.11 , pp. 45-53
    • LeWitt, P.A.1    Nelson, M.V.2    Berchou, R.C.3
  • 39
    • 0024847369 scopus 로고
    • A pharmacokinetic and pharmacodynamic comparison of Sinemet CR (50/200) and standard Sinemet (25/100)
    • Cedarbaum JM, Kutt H, McDowell FH. A pharmacokinetic and pharmacodynamic comparison of Sinemet CR (50/200) and standard Sinemet (25/100). Neurology 1989;39(11 Suppl 2):38-44.
    • (1989) Neurology , vol.39 , Issue.11 , pp. 38-44
    • Cedarbaum, J.M.1    Kutt, H.2    McDowell, F.H.3
  • 40
    • 84902959484 scopus 로고    scopus 로고
    • Population pharmacokinetics of levodopa in subjects with advanced Parkinson's disease: levodopa-carbidopa intestinal gel infusion vs. oral tablets
    • Othman AA, Dutta S. Population pharmacokinetics of levodopa in subjects with advanced Parkinson's disease: levodopa-carbidopa intestinal gel infusion vs. oral tablets. Br J Clin Pharmacol 2014;78:94-105.
    • (2014) Br J Clin Pharmacol , vol.78 , pp. 94-105
    • Othman, A.A.1    Dutta, S.2
  • 41
    • 0029764853 scopus 로고    scopus 로고
    • Population pharmacokinetics of oral levodopa in parkinsonian patients
    • Triggs EJ, Charles BG, Contin M, et al. Population pharmacokinetics of oral levodopa in parkinsonian patients. Eur J Clin Pharmacol 1996;51:59-67.
    • (1996) Eur J Clin Pharmacol , vol.51 , pp. 59-67
    • Triggs, E.J.1    Charles, B.G.2    Contin, M.3
  • 42
    • 0034126571 scopus 로고    scopus 로고
    • Population pharmacokinetics of levodopa in patients with Parkinson's disease treated with tolcapone
    • Jorga K, Banken L, Fotteler B, Snell JL, Steimer JL. Population pharmacokinetics of levodopa in patients with Parkinson's disease treated with tolcapone. Clin Pharmacol Ther 2000;67:610-620.
    • (2000) Clin Pharmacol Ther , vol.67 , pp. 610-620
    • Jorga, K.1    Banken, L.2    Fotteler, B.3    Snell, J.L.4    Steimer, J.L.5
  • 43
    • 28444454886 scopus 로고    scopus 로고
    • Importance of within subject variation in levodopa pharmacokinetics: a 4 year cohort study in Parkinson's disease
    • Chan PLS, Nutt JG, Holford NHG. Importance of within subject variation in levodopa pharmacokinetics: a 4 year cohort study in Parkinson's disease. J Pharmacokin Pharmacodynam 2005;32:307-331.
    • (2005) J Pharmacokin Pharmacodynam , vol.32 , pp. 307-331
    • Chan, P.L.S.1    Nutt, J.G.2    Holford, N.H.G.3
  • 44
    • 0036264465 scopus 로고    scopus 로고
    • Evolution of the response to levodopa during the first four years of therapy
    • Nutt JG, Carter JH, Lea ES, Sexton GJ. Evolution of the response to levodopa during the first four years of therapy. Ann Neurol 2002;51:686-693.
    • (2002) Ann Neurol , vol.51 , pp. 686-693
    • Nutt, J.G.1    Carter, J.H.2    Lea, E.S.3    Sexton, G.J.4
  • 45
    • 0027477017 scopus 로고
    • Pharmacodynamic modeling of oral levodopa: clinical application in Parkinson's disease
    • Contin M, Riva R, Martinelli P, et al. Pharmacodynamic modeling of oral levodopa: clinical application in Parkinson's disease. Neurology 1993;43:367-371.
    • (1993) Neurology , vol.43 , pp. 367-371
    • Contin, M.1    Riva, R.2    Martinelli, P.3
  • 46
    • 0037076466 scopus 로고    scopus 로고
    • Gender and pramipexole effects on levodopa pharmacokinetics and pharmacodynamics
    • Kompoliti K, Adler CH, Raman R, et al. Gender and pramipexole effects on levodopa pharmacokinetics and pharmacodynamics. Neurology 2002;58:1418-1422.
    • (2002) Neurology , vol.58 , pp. 1418-1422
    • Kompoliti, K.1    Adler, C.H.2    Raman, R.3
  • 47
    • 0026609580 scopus 로고
    • Gastrointestinal dysfunction in Parkinson's disease: frequency and pathophysiology
    • Edwards LL, Quigley EM, Pfeiffer RF. Gastrointestinal dysfunction in Parkinson's disease: frequency and pathophysiology. Neurology 1992;42:726-732.
    • (1992) Neurology , vol.42 , pp. 726-732
    • Edwards, L.L.1    Quigley, E.M.2    Pfeiffer, R.F.3
  • 48
    • 0035526250 scopus 로고    scopus 로고
    • Gastric emptying time and gastric motility in patients with Parkinson's disease
    • Hardoff R, Sula M, Tamir A, et al. Gastric emptying time and gastric motility in patients with Parkinson's disease. Mov Disord 2001;16:1041-1047.
    • (2001) Mov Disord , vol.16 , pp. 1041-1047
    • Hardoff, R.1    Sula, M.2    Tamir, A.3
  • 50
    • 84860794549 scopus 로고    scopus 로고
    • Helicobacter pylori eradication for Parkinson's disease
    • Rees K, Stowe R, Patel S, et al. Helicobacter pylori eradication for Parkinson's disease. Cochrane Database Syst Rev 2011;11:CD008453.
    • (2011) Cochrane Database Syst Rev , vol.11 , pp. CD008453
    • Rees, K.1    Stowe, R.2    Patel, S.3
  • 51
    • 84890787955 scopus 로고    scopus 로고
    • Motor fluctuations and Helicobacter pylori in Parkinson's disease
    • Rahne KE, Tagesson C, Nyholm D. Motor fluctuations and Helicobacter pylori in Parkinson's disease. J Neurol 2013;260:2974-2980.
    • (2013) J Neurol , vol.260 , pp. 2974-2980
    • Rahne, K.E.1    Tagesson, C.2    Nyholm, D.3
  • 52
    • 84911994347 scopus 로고    scopus 로고
    • Pharmacokinetics of levodopa in patients with Parkinson disease and motor fluctuations depending on the presence of Helicobacter pylori infection
    • Narozańska E, Bialecka M, Adamiak-Giera U, et al. Pharmacokinetics of levodopa in patients with Parkinson disease and motor fluctuations depending on the presence of Helicobacter pylori infection. Clin Neuropharmacol 2014;37:96-99.
    • (2014) Clin Neuropharmacol , vol.37 , pp. 96-99
    • Narozańska, E.1    Bialecka, M.2    Adamiak-Giera, U.3
  • 53
    • 84883559371 scopus 로고    scopus 로고
    • The role of small intestinal bacterial overgrowth in Parkinson's disease
    • Fasano A, Bove F, Gabrielli M, et al. The role of small intestinal bacterial overgrowth in Parkinson's disease. Mov Disord 2013;28:1241-1249.
    • (2013) Mov Disord , vol.28 , pp. 1241-1249
    • Fasano, A.1    Bove, F.2    Gabrielli, M.3
  • 54
    • 0036116903 scopus 로고    scopus 로고
    • Levodopa pharmacokinetics and motor performance during activities of daily living in patients with Parkinson's disease on individual drug combinations
    • Nyholm D, Lennernas H, Gomes-Trolin C, et al. Levodopa pharmacokinetics and motor performance during activities of daily living in patients with Parkinson's disease on individual drug combinations. Clin Neuropharmacol 2002;25:89-96.
    • (2002) Clin Neuropharmacol , vol.25 , pp. 89-96
    • Nyholm, D.1    Lennernas, H.2    Gomes-Trolin, C.3
  • 55
    • 0021359568 scopus 로고
    • The "on-off" phenomenon in Parkinson's disease: relation to levodopa absorption and transport
    • Nutt JG, Woodward WR, Hammerstad JP, et al. The "on-off" phenomenon in Parkinson's disease: relation to levodopa absorption and transport. N Engl J Med 1984;310:483-488.
    • (1984) N Engl J Med , vol.310 , pp. 483-488
    • Nutt, J.G.1    Woodward, W.R.2    Hammerstad, J.P.3
  • 56
    • 0024393058 scopus 로고
    • The effect of age on the pharmacokinetics of levodopa in patients with Parkinson's disease
    • Robertson DR, Wood ND, Everest H, et al. The effect of age on the pharmacokinetics of levodopa in patients with Parkinson's disease. Eur J Clin Pharmacol 1989;28:61-69.
    • (1989) Eur J Clin Pharmacol , vol.28 , pp. 61-69
    • Robertson, D.R.1    Wood, N.D.2    Everest, H.3
  • 57
    • 0025988169 scopus 로고
    • Effect of age on the pharmacokinetics of oral levodopa in patients with Parkinson's disease
    • Contin M, Riva R, Martinelli P, et al. Effect of age on the pharmacokinetics of oral levodopa in patients with Parkinson's disease. Eur J Clin Pharmacol 1991;41:463-466.
    • (1991) Eur J Clin Pharmacol , vol.41 , pp. 463-466
    • Contin, M.1    Riva, R.2    Martinelli, P.3
  • 58
    • 0024521415 scopus 로고
    • Pharmacokinetic and pharmacodynamic modeling of levodopa plasma concentrations and clinical effects in Parkinson's disease after Sinemet
    • Nelson MV, Berchou RC, LeWitt PA, et al. Pharmacokinetic and pharmacodynamic modeling of levodopa plasma concentrations and clinical effects in Parkinson's disease after Sinemet Clin Neuropharmacol 1989;12:91-97.
    • (1989) Clin Neuropharmacol , vol.12 , pp. 91-97
    • Nelson, M.V.1    Berchou, R.C.2    LeWitt, P.A.3
  • 59
    • 0029972115 scopus 로고    scopus 로고
    • Pharmacokinetic optimization in the treatment of Parkinson's disease
    • Contin M, Riva R, Albani F, et al. Pharmacokinetic optimization in the treatment of Parkinson's disease. Clin Pharmacokinet 1996;30:463-481.
    • (1996) Clin Pharmacokinet , vol.30 , pp. 463-481
    • Contin, M.1    Riva, R.2    Albani, F.3
  • 60
    • 0025162198 scopus 로고
    • Pharmacodynamic modeling of concentration-effect relationships after controlled-release carbidopa /levodopa (Sinemet CR4) in Parkinson's disease
    • Nelson MV, Berchou RC, LeWitt PA, et al. Pharmacodynamic modeling of concentration-effect relationships after controlled-release carbidopa /levodopa (Sinemet CR4) in Parkinson's disease. Neurology 1990;40:70-74.
    • (1990) Neurology , vol.40 , pp. 70-74
    • Nelson, M.V.1    Berchou, R.C.2    LeWitt, P.A.3
  • 61
    • 0015043830 scopus 로고
    • L-dopa therapy of Parkinson's disease: plasma L-dopa concentration, therapeutic response, and side effects
    • Muenter MD, Tyce GM. L-dopa therapy of Parkinson's disease: plasma L-dopa concentration, therapeutic response, and side effects. Mayo Clin Proc 1971;46:231-239.
    • (1971) Mayo Clin Proc , vol.46 , pp. 231-239
    • Muenter, M.D.1    Tyce, G.M.2
  • 62
    • 0033541125 scopus 로고    scopus 로고
    • Loss of long-duration response to levodopa over time in PD: implications for wearing-off
    • Zappia M, Oliveri RL, Montesanti R, et al. Loss of long-duration response to levodopa over time in PD: implications for wearing-off. Neurology 1999;52:763-767.
    • (1999) Neurology , vol.52 , pp. 763-767
    • Zappia, M.1    Oliveri, R.L.2    Montesanti, R.3
  • 63
    • 80052351842 scopus 로고    scopus 로고
    • The long-duration response to levodopa: phenomenology, potential mechanisms and clinical implications
    • Anderson E, Nutt J. The long-duration response to levodopa: phenomenology, potential mechanisms and clinical implications. Parkinsonism Relat Disord. 2011;17:587-592.
    • (2011) Parkinsonism Relat Disord. , vol.17 , pp. 587-592
    • Anderson, E.1    Nutt, J.2
  • 64
    • 0029149437 scopus 로고
    • The subacute levodopa test for evaluating long-duration response in Parkinson's disease
    • Quattrone A, Zappia M, Agualia U, et al. The subacute levodopa test for evaluating long-duration response in Parkinson's disease. Ann Neurol 1995;38:389-395.
    • (1995) Ann Neurol , vol.38 , pp. 389-395
    • Quattrone, A.1    Zappia, M.2    Agualia, U.3
  • 65
    • 0018892695 scopus 로고
    • Changes in neocortical dopamine concentrations in response to levodopa infusions
    • Doller HJ, Connor JD. Changes in neocortical dopamine concentrations in response to levodopa infusions. J Neurochem 1980;34:1264-1269.
    • (1980) J Neurochem , vol.34 , pp. 1264-1269
    • Doller, H.J.1    Connor, J.D.2
  • 66
    • 0032835969 scopus 로고    scopus 로고
    • Changes in the regional and compartmental distribution of FosB- and JunB-like immunoreactivity induced in the dopamine-denervated rat striatum by acute or chronic L-dopa treatment
    • Cenci MA, Tranberg A, Andersson M, Hilbertson A. Changes in the regional and compartmental distribution of FosB- and JunB-like immunoreactivity induced in the dopamine-denervated rat striatum by acute or chronic L-dopa treatment. Neuroscience 1999;94:515-527.
    • (1999) Neuroscience , vol.94 , pp. 515-527
    • Cenci, M.A.1    Tranberg, A.2    Andersson, M.3    Hilbertson, A.4
  • 67
    • 79955729001 scopus 로고    scopus 로고
    • Differential expression of FosB, c-Fos, and Zif268 in forebrain regions after acute or chronic L-DOPA treatment in a rat model of Parkinson's disease
    • Ebihara K, Ishida Y, Takeda R, et al. Differential expression of FosB, c-Fos, and Zif268 in forebrain regions after acute or chronic L-DOPA treatment in a rat model of Parkinson's disease. Neurosci Lett 2011;496:90-94.
    • (2011) Neurosci Lett , vol.496 , pp. 90-94
    • Ebihara, K.1    Ishida, Y.2    Takeda, R.3
  • 68
    • 84887013222 scopus 로고    scopus 로고
    • Levodopa induces long-lasting modification in the functional activity of the nigrostriatal pathway
    • Riverol M, Ordóñez C, Collantes M, et al. Levodopa induces long-lasting modification in the functional activity of the nigrostriatal pathway. Neurobiol Dis 2014;62:250-259.
    • (2014) Neurobiol Dis , vol.62 , pp. 250-259
    • Riverol, M.1    Ordóñez, C.2    Collantes, M.3
  • 69
    • 77956188939 scopus 로고    scopus 로고
    • Movement chunking during sequence learning. Is a dopamine-dependent process: a study conducted in Parkinson's disease
    • Tremblay PL, Bedard MA, Langlois D et al. Movement chunking during sequence learning. Is a dopamine-dependent process: a study conducted in Parkinson's disease. Exp Brain Res 2010; 205:375-385.
    • (2010) Exp Brain Res , vol.205 , pp. 375-385
    • Tremblay, P.L.1    Bedard, M.A.2    Langlois, D.3
  • 70
    • 57349093766 scopus 로고    scopus 로고
    • Levodopa for the treatment of Parkinson's disease
    • LeWitt PA. Levodopa for the treatment of Parkinson's disease. N Engl J Med 2008;359:2468-2476.
    • (2008) N Engl J Med , vol.359 , pp. 2468-2476
    • LeWitt, P.A.1
  • 71
    • 84875271113 scopus 로고    scopus 로고
    • Extended-release carbidopa-levodopa (IPX066) compared with immediate-release carbidopa-levodopa in patients with Parkinson's disease and motor fluctuations: a phase 3 randomised, double-blind trial
    • Hauser RA, Hsu A, Kell S, et al. Extended-release carbidopa-levodopa (IPX066) compared with immediate-release carbidopa-levodopa in patients with Parkinson's disease and motor fluctuations: a phase 3 randomised, double-blind trial. Lancet Neurol 2013;12:346-356.
    • (2013) Lancet Neurol , vol.12 , pp. 346-356
    • Hauser, R.A.1    Hsu, A.2    Kell, S.3
  • 72
    • 84892931747 scopus 로고    scopus 로고
    • Double-blind study of an actively-transported levodopa prodrug, XP21279, in Parkinson disease
    • LeWitt PA, Huff FJ, Hauser R, et al. Double-blind study of an actively-transported levodopa prodrug, XP21279, in Parkinson disease. Mov Disord 2014;29:75-82.
    • (2014) Mov Disord , vol.29 , pp. 75-82
    • LeWitt, P.A.1    Huff, F.J.2    Hauser, R.3
  • 73
    • 77955172381 scopus 로고    scopus 로고
    • Factors associated with motor fluctuations and dyskinesia in Parkinson disease: potential role of a new melevodopa plus carbidopa formulation (Sirio)
    • Stocchi F, Marconi S. Factors associated with motor fluctuations and dyskinesia in Parkinson disease: potential role of a new melevodopa plus carbidopa formulation (Sirio). Clin Neuropharmacol 2010;33:198-203.
    • (2010) Clin Neuropharmacol , vol.33 , pp. 198-203
    • Stocchi, F.1    Marconi, S.2
  • 74
    • 84946183922 scopus 로고    scopus 로고
    • Accordion Pill carbidopa/levodopa (AP CD/LD) for treatment of advanced Parkinson's disease (PD)
    • LeWitt PA, Giladi N, Gurevich T, et al. Accordion Pill carbidopa/levodopa (AP CD/LD) for treatment of advanced Parkinson's disease (PD). Mov Disord. 2014;29(suppl 1): S248.
    • (2014) Mov Disord. , vol.29 , pp. S248
    • LeWitt, P.A.1    Giladi, N.2    Gurevich, T.3
  • 75
    • 84862802754 scopus 로고    scopus 로고
    • Pharmacokinetics and pharmacodynamics of gastroretentive delivery of levodopa/carbidopa in patients with Parkinson disease
    • Chen C, Cowles VE, Sweeney M, Stolyarov ID, Illarioshkin SN. Pharmacokinetics and pharmacodynamics of gastroretentive delivery of levodopa/carbidopa in patients with Parkinson disease. Clin Neuropharmacol. 012;35:67-72.
    • Clin Neuropharmacol. , vol.12 , Issue.35 , pp. 67-72
    • Chen, C.1    Cowles, V.E.2    Sweeney, M.3    Stolyarov, I.D.4    Illarioshkin, S.N.5
  • 76
    • 84946181278 scopus 로고    scopus 로고
    • Pharmacokinetics (PK) following inhaled levodopa delivery with CVT-301: Rapid augmentation of systemic levodopa (LD) levels and improvement in motor function in PD patients with motor fluctuations
    • CVT-301-002 Study Investigators.
    • Freed MI, Moore JA, Batycky R, Tia D-F, CVT-301-002 Study Investigators. Pharmacokinetics (PK) following inhaled levodopa delivery with CVT-301: Rapid augmentation of systemic levodopa (LD) levels and improvement in motor function in PD patients with motor fluctuations. Mov Disord. 2014;29(suppl 1):S239.
    • (2014) Mov Disord. , vol.29 , pp. S239
    • Freed, M.I.1    Moore, J.A.2    Batycky, R.3    Tia, D.-F.4
  • 77
    • 84920928081 scopus 로고    scopus 로고
    • Constant therapeutic levodopa (LD) plasma concentrations maintained by continuous subcutaneous (SC) administration of ND-0612, a novel formulation of LD/carbidopa (CD)
    • Caraco Y, Oren S, LeWitt P. Constant therapeutic levodopa (LD) plasma concentrations maintained by continuous subcutaneous (SC) administration of ND-0612, a novel formulation of LD/carbidopa (CD). Mov Disord 2013;28(suppl 1):S162.
    • (2013) Mov Disord , vol.28 , pp. S162
    • Caraco, Y.1    Oren, S.2    LeWitt, P.3
  • 78
    • 84908374082 scopus 로고    scopus 로고
    • The modern pre-levodopa era of Parkinson's disease: insights into motor complications from sub-Saharan Africa
    • Cilia R, Akpalu A, Sarfo FS, et al. The modern pre-levodopa era of Parkinson's disease: insights into motor complications from sub-Saharan Africa. Brain 2014; 137; 2731-2742.
    • (2014) Brain , vol.137 , pp. 2731-2742
    • Cilia, R.1    Akpalu, A.2    Sarfo, F.S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.