Clinical Presentation and Five-Year Therapeutic Management of Very Early-Onset Inflammatory Bowel Disease in a Large North American Cohort

Journal of Pediatrics

Volumn 167, Issue 3, 2015, Pages 527-532.e3

  Oliva Hemker, Maria ^a   Hutfless, Susan ^b   Al Kazzi, Elie S ^b   Lerer, Trudy ^c   Mack, David ^d   Leleiko, Neal ^e   Griffiths, Anne ^f   Cabrera, Jose ^g   Otley, Anthony ^h   Rick, James ⁱ   Bousvaros, Athos ^j   Rosh, Joel ^k   Grossman, Andrew ^l   Saeed, Shehzad ^m   Kay, Marsha ⁿ   Carvalho, Ryan ^o   Keljo, David ^p   Pfefferkorn, Marian ^q   Faubion, William ^r   Kappelman, Michael ^s   Sudel, Boris ^t   Schaefer, Marc E ^u   Markowitz, James ^v   Hyams, Jeffrey S ^c   more..

^a JOHNS HOPKINS HOSPITAL   (United States)

^b JOHNS HOPKINS UNIVERSITY   (United States)

^c Division of Pediatric Infectious Diseases   (United States)

^d CHILDREN S HOSPITAL OF EASTERN ONTARIO   (Canada)

^e HASBRO CHILDREN'S HOSPITAL   (United States)

^f HOSPITAL FOR SICK CHILDREN   (Canada)

^g MEDICAL COLLEGE OF WISCONSIN   (United States)

^h IWK HEALTH CENTRE   (Canada)

ⁱ Dayton Children's Hospital   (United States)

^j BOSTON CHILDREN S HOSPITAL   (United States)

^k Goryeb Children's Hospital   (United States)

^l CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

^m CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

ⁿ LERNER RESEARCH INSTITUTE   (United States)

^o NATIONWIDE CHILDREN S HOSPITAL   (United States)

^p CHILDREN S HOSPITAL OF PITTSBURGH   (United States)

^q RILEY HOSPITAL FOR CHILDREN   (United States)

^r MAYO CLINIC   (United States)

^s UNIVERSITY OF NORTH CAROLINA   (United States)

^t UNIVERSITY OF MINNESOTA   (United States)

^u PENN STATE CHILDREN S HOSPITAL   (United States)

^v Northwell Health   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

CORTICOSTEROID; IMMUNOMODULATING AGENT; MERCAPTOPURINE; MESALAZINE; METHOTREXATE; THIOPURINE IMMUNOMODULATOR; UNCLASSIFIED DRUG;

ARTICLE; CHILD; COHORT ANALYSIS; COLON DISEASE; CORTICOSTEROID THERAPY; CROHN DISEASE; DISEASE ACTIVITY; HUMAN; INFLAMMATORY BOWEL DISEASE; MAJOR CLINICAL STUDY; MULTICENTER STUDY; NORTH AMERICA; NORTH AMERICAN; OBSERVATIONAL STUDY; OUTCOME ASSESSMENT; PHENOTYPE; PRESCHOOL CHILD; PRIORITY JOURNAL; PROSPECTIVE STUDY; REGISTER; ULCERATIVE COLITIS; ADOLESCENT; CLINICAL TRIAL; DISEASE COURSE; FEMALE; FOLLOW UP; INFANT; INFLAMMATORY BOWEL DISEASES; MALE; ONSET AGE; PROGNOSIS;

ADOLESCENT; AGE OF ONSET; CHILD; CHILD, PRESCHOOL; DISEASE PROGRESSION; FEMALE; FOLLOW-UP STUDIES; HUMANS; INFANT; INFLAMMATORY BOWEL DISEASES; MALE; NORTH AMERICA; PHENOTYPE; PROGNOSIS; PROSPECTIVE STUDIES; REGISTRIES;

EID: 84940451244     PISSN: 00223476     EISSN: 10976833     Source Type: Journal    
DOI: 10.1016/j.jpeds.2015.04.045     Document Type: Article

References (28)

1. E.I. Benchimol, K.J. Fortinsky, P. Gozdyra, M. Van den Heuvel, J. Van Limbergen, and A.M. Griffiths Epidemiology of pediatric inflammatory bowel disease: a systematic review of international trends Inflamm Bowel Dis 17 2011 423 439
2. S. Kugathasan, R.H. Judd, R.G. Hoffmann, J. Heikenen, G. Telega, F. Khan, and et al. Epidemiologic and clinical characteristics of children with newly diagnosed inflammatory bowel disease in Wisconsin: a statewide population-based study J Pediatr 143 2003 525 531
3. G. Marx, E.G. Seidman, S.R. Martin, and C. Deslandres Outcome of Crohn's disease diagnosed before two years of age J Pediatr 140 2002 470 473
4. M.B. Heyman, B.S. Kirschner, B.D. Gold, G. Ferry, R. Baldassano, S.A. Cohen, and et al. Children with early-onset inflammatory bowel disease (IBD): analysis of a pediatric IBD consortium registry J Pediatr 146 2005 35 40
5. S.H. Ein, M.J. Lynch, and C.A. Stephens Ulcerative colitis in children under one year: a twenty-year review J Pediatr Surg 6 1971 264 271
6. K. Uchida, C. Miki, M. Inoue, K. Otake, S. Yoshiyama, T. Araki, and et al. Surgical intervention for neonatal and infantile-onset severe colonic Crohn's disease: report of three cases Dis Colon Rectum 51 2008 247 250
7. P. Mamula, G.W. Telega, J.E. Markowitz, K.A. Brown, D.A. Piccoli, and R.N. Baldassano Inflammatory bowel disease in children 5 years of age and younger Am J Gastroenterol 97 2002 2005 2010
8. N. Gupta, A.G. Bostrom, B.S. Kirschner, S.A. Cohen, O. Abramson, G.D. Ferry, and et al. Presentation and disease course in early- compared to later-onset pediatric Crohn's disease Am J Gastroenterol 103 2008 2092 2098
9. K.R. Engelhardt, N. Shah, I. Faizura-Yeop, D.F. Kocacik Uygun, N. Frede, A.M. Muise, and et al. clinical outcome in IL-10 and IL-10 receptor-deficient patients with or without hematopoietic stem cell transplantation J Allergy Clin Immunol 131 2013 825 830
10. S. Kugathasan, R.N. Baldassano, J.P. Bradfield, P.M. Sleiman, M. Imielinski, S.L. Guthery, and et al. Loci on 20q13 and 21q22 are associated with pediatric-onset inflammatory bowel disease Nat Genet 40 2008 1211 1215
11. M. Imielinski, R.N. Baldassano, A. Griffiths, R.K. Russel, V. Annese, M. Dubinsky, and et al. Common variants at five new loci associated with early-onset inflammatory bowel disease Nat Genet 41 2009 1335 1340
12. J. Punati, J. Markowitz, T. Lerer, J. Hyams, S. Kugathasan, A. Griffiths, and et al. Effect of early immunomodulator use in moderate to severe pediatric Crohn disease Inflamm Bowel Dis 14 2008 949 954
13. J. Hyams, J. Markowitz, A. Otley, J. Rosh, D. Mack, A. Bousvaros, and et al. Evaluation of the pediatric Crohn disease activity index: a prospective multicenter experience J Pediatr Gastroenterol Nutr 41 2005 416 421
14. A. Otley, H. Loonen, N. Parekh, M. Corey, P.M. Sherman, and A.M. Griffiths Assessing activity of pediatric Crohn's disease: which index to use? Gastroenterology 116 1999 527 531
15. J. Satsangi, M.S. Silverberg, S. Vermeire, and J.F. Colombel The Montreal classification of inflammatory bowel disease: controversies, consensus, and implications Gut 55 2006 749 753
16. M.M. Tschudy, and K.M. Arcara The Harriet Lane handbook 19th ed. 2012 Elsevier Mosby Philadelphia
17. M.E. Schaefer, J.T. Machan, D. Kawatu, C.R. Langton, J. Markowtiz, W. Crandall, and et al. Factors that determine risk for surgery in pediatric patients with Crohn's disease Clin Gastroenterol Hepatol 8 2010 789 794
18. A. Levine, S. Kugathasan, V. Annese, V. Biank, E. Leshinsky-Silver, O. Davidovich, and et al. Pediatric onset Crohn's colitis is characterized by genotype-dependent age-related susceptibility Inflamm Bowel Dis 13 2007 1509 1515
19. A. Levine, A. Griffiths, J. Markowitz, D.C. Wilson, D. Turner, R.K. Russell, and et al. Pediatric modification of the Montreal classification for inflammatory bowel disease: the Paris classification Inflamm Bowel Dis 17 2011 1314 1321
20. M. Aloi, P. Lionetti, A. Barabino, G. Guariso, S. Costa, M. Fontana, and et al. Phenotype and disease course of early-onset pediatric inflammatory bowel disease Inflamm Bowel Dis 20 2014 597 605
21. R.G. Farmer, G. Whelan, and V.W. Fazio Long-term follow-up of patients with Crohn's disease: relationship between the clinical pattern and prognosis Gastroenterology 88 1985 1818 1825
22. A.M. Griffiths Specificities of inflammatory bowel disease in childhood Best Pract Res Clin Gastroenterol 18 2004 509 523
23. E.I. Benchimol, D.R. Mack, G.C. Nguyen, S.B. Snapper, W. Li, N. Mojaverian, and et al. Incidence, outcomes and health services burden of very early onset inflammatory bowel disease Gastroenterology 20 2014 1761 1769
24. L. de Ridder, R.K. Weersma, G. Dijkstra, G. van der Steege, M.A. Benninga, I.M. Nolte, and et al. Genetic susceptibility has a more important role in pediatric-onset Crohn's disease than in adult-onset Crohn's disease Inflamm Bowel Dis 13 2007 1083 1092
25. F.M. Ruemmele, M.G. El Khoury, C. Talbotec, C. Maurage, J.F. Mougenot, J. Schmitz, and et al. Characteristics of inflammatory bowel disease with onset during the first year of life J Pediatr Gastroenterol Nutr 43 2006 603 609
26. M. Uchida, H. Iwasa, and K. Nemoto A case of perforation of the small intestine in Crohn's disease Nippon Geka Gakkai Zasshi 84 1983 1101 1106
27. E.O. Glocker, D. Kotlarz, K. Boztug, E.M. Gertz, A.A. Schaffer, F. Noyan, and et al. Inflammatory bowel disease and mutations affecting the interleukin-10 receptor N Engl J Med 361 2009 2033 2045
28. C.J. Moran, T.D. Walters, C.H. Guo, S. Kugathasan, C. Klein, D. Turner, and et al. IL-10R polymorphisms are associated with very-early-onset ulcerative colitis Inflamm Bowel Dis 19 2013 115 123