Dopamine or biopterin deficiency potentiates phosphorylation at 40Ser and ubiquitination of tyrosine hydroxylase to be degraded by the ubiquitin proteasome system

Biochemical and Biophysical Research Communications

Volumn 465, Issue 1, 2015, Pages 53-58

  Kawahata, Ichiro ^a,b   Ohtaku, Shiori ^a   Tomioka, Yoshihisa ^a   Ichinose, Hiroshi ^b   Yamakuni, Tohru ^a  

^a TOHOKU UNIVERSITY   (Japan)

^b TOKYO INSTITUTE OF TECHNOLOGY   (Japan)

Author keywords

Dopa responsive dystonia; Dopamine; Parkinson's disease; Proteasome; Tyrosine hydroxylase; Ubiquitin

Indexed keywords

BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; BIOPTERIN; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLOHEXIMIDE; DOPAMINE; DOPAMINE 2 RECEPTOR; PROTEASOME; SERINE; TETRAHYDROBIOPTERIN; TYROSINE 3 MONOOXYGENASE; UBIQUITIN; BENZYLOXYCARBONYLLEUCYL-LEUCYL-LEUCINE ALDEHYDE; CYSTEINE PROTEINASE INHIBITOR; ISOQUINOLINE DERIVATIVE; LEUPEPTIN; N-(2-(4-BROMOCINNAMYLAMINO)ETHYL)-5-ISOQUINOLINESULFONAMIDE; SAPROPTERIN; SULFONAMIDE;

ANIMAL CELL; ARTICLE; IMMUNOPRECIPITATION; NERVE CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT; UBIQUITINATION; ANALOGS AND DERIVATIVES; ANIMAL; CYTOLOGY; DEFICIENCY; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; MESENCEPHALON; METABOLISM; PC12 CELL LINE; PHOSPHORYLATION; PRIMARY CELL CULTURE; PROTEIN DEGRADATION; SIGNAL TRANSDUCTION;

ANIMALS; BIOPTERIN; CYCLIC AMP-DEPENDENT PROTEIN KINASES; CYCLOHEXIMIDE; CYSTEINE PROTEINASE INHIBITORS; DOPAMINE; GENE EXPRESSION REGULATION; ISOQUINOLINES; LEUPEPTINS; MESENCEPHALON; NEURONS; PC12 CELLS; PHOSPHORYLATION; PRIMARY CELL CULTURE; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEOLYSIS; RATS; RECEPTORS, DOPAMINE D2; SERINE; SIGNAL TRANSDUCTION; SULFONAMIDES; TYROSINE 3-MONOOXYGENASE; UBIQUITIN; UBIQUITINATION;

EID: 84940440623     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2015.07.125     Document Type: Article

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