Accumulation of phosphorylated tyrosine hydroxylase into insoluble protein aggregates by inhibition of an ubiquitin-proteasome system in PC12D cells

Journal of Neural Transmission

Volumn 116, Issue 12, 2009, Pages 1571-1578

  Kawahata, Ichiro ^a   Tokuoka, Hirofumi ^a   Parvez, Hasan ^b   Ichinose, Hiroshi ^a  

^a TOKYO INSTITUTE OF TECHNOLOGY   (Japan)

^b CNRS   (France)

Author keywords

MG 132; Okadaic acid; Parkinson's disease; Tyrosine hydroxylase; Ubiquitin proteasome system

Indexed keywords

20S PROTEASOME; 26S PROTEASOME; CHOLINE ACETYLTRANSFERASE; DOPAMINE; PHOSPHOPROTEIN PHOSPHATASE 2A; PROTEASOME; SERINE; THIOFLAVINE; TYROSINE 3 MONOOXYGENASE; UBIQUITIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL STRAIN; CONTROLLED STUDY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; NERVE CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN AGGREGATION; RAT;

ANIMALS; CHOLINE O-ACETYLTRANSFERASE; CYSTEINE PROTEINASE INHIBITORS; ENZYME INHIBITORS; LEUPEPTINS; NEURONS; OKADAIC ACID; OLIGOPEPTIDES; PC12 CELLS; PHOSPHORYLATION; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN MULTIMERIZATION; PROTEIN PHOSPHATASE 2; RATS; TIME FACTORS; TYROSINE 3-MONOOXYGENASE; UBIQUITIN;

EID: 70949084763     PISSN: 03009564     EISSN: 14351463     Source Type: Journal    
DOI: 10.1007/s00702-009-0304-z     Document Type: Article

References (28)

1. G Carrard AL Bulteau I Petropoulos B Friguet 2002 Impairment of proteasome structure and function in aging Int J Biochem Cell Biol 34 1461 1474 10.1016/S1357-2725(02)00085-7 1:CAS:528:DC%2BD38XmsVertrw%3D 12200039 (Pubitemid 35245402)
2. SC Daubner C Lauriano JW Haycock PF Fitzpatrick 1992 Site-directed mutagenesis of serine 40 of rat tyrosine hydroxylase J Biol Chem 267 12639 12646 1:CAS:528:DyaK38Xks1Gns7o%3D 1352289
3. AP Døskeland T Flatmark 2002 Ubiquitination of soluble and membrane-bound tyrosine hydroxylase and degradation of the soluble form Eur J Biochem 269 1561 1569 10.1046/j.1432-1033.2002.02808.x 11874472 (Pubitemid 34227098)
4. PR Dunkley L Bobrovskaya ME Graham EI Nagy-Felsobuki PW Dickson 2004 Tyrosine hydroxylase phosphorylation: regulation and consequences J Neurochem 91 1025 1043 10.1111/j.1471-4159.2004.02797.x 1:CAS:528:DC%2BD2cXhtFSisbfO 15569247 (Pubitemid 39587442)
5. H Fujisawa S Okuno 2005 Regulatory mechanism of tyrosine hydroxylase activity Biochem Biophys Res Commun 338 271 276 10.1016/j.bbrc.2005.07.183 1:CAS:528:DC%2BD2MXhtFyksr%2FM 16105651 (Pubitemid 41540566)
6. J Haavik DL Schelling DG Campbell KK Andersson T Flatmark P Cohen 1989 Identification of protein phosphatase 2A as the major tyrosine hydroxylase phosphatase in adrenal medulla and corpus striatum: evidence from the effects of okadaic acid FEBS Lett 251 36 42 10.1016/0014-5793(89)81424-3 1:CAS:528:DyaL1MXltFalsro%3D 2568951 (Pubitemid 19181848)
7. JW Haycock 1990 Phosphorylation of tyrosine hydroxylase in situ at serine 8, 19, 31, and 40 J Biol Chem 265 11682 11691 1:CAS:528:DyaK3cXkslGnt7g%3D 1973163
8. JW Haycock DA Haycock 1991 Tyrosine hydroxylase in rat brain dopaminergic nerve terminals J Biol Chem 266 5650 5657 1:CAS:528:DyaK3MXitVCmuro%3D 1672315
9. R Katoh-Semba S Kitajima Y Yamazaki M Sano 1987 Neuritic growth from a new subline of PC12 pheochromocytoma cells: cyclic AMP mimics the action of nerve growth factor J Neurosci Res 17 36 44 10.1002/jnr.490170106 1:CAS:528:DyaL2sXhtlagtbY%3D 3033256 (Pubitemid 17058735)
10. Kawahata I, Yagishita S, Hasegawa K, Natatsu I, Nagatsu T, Ichinose H (2009) Immunohistochemical analyses of human brain-stem type Lewy bodies and the localization of phosphorylated tyrosine hydroxylase in the midbrain. Biogenic Amines (in press)
11. JN Keller J Gee Q Ding 2002 The proteasome in brain aging Ageing Res Rev 1 279 293 10.1016/S1568-1637(01)00006-X 1:CAS:528:DC%2BD38XosFSmtbo%3D 12039443 (Pubitemid 38340346)
12. RO Kuljis P Martín-Vasallo NS Peress 1989 Lewy bodies in tyrosine hydroxylase-synthesizing neurons of the human cerebral cortex Neurosci Lett 20 49 54 10.1016/0304-3940(89)90200-0
13. B Le Bourdellès P Horellou JP Le Caer P Denèfle M Latta J Haavik B Guibert JF Mayaux J Mallet 1991 Phosphorylation of human recombinant tyrosine hydroxylase isoforms 1 and 2: an additional phosphorylated residue in isoform 2, generated through alternative splicing J Biol Chem 266 17124 17130 1680128
14. RB Leal AT Sim CA Gonçalves PR Dunkley 2002 Tyrosine hydroxylase dephosphorylation by protein phosphatase 2A in bovine adrenal chromaffin cells Neurochem Res 27 207 213 10.1023/A:1014880403970 1:CAS:528:DC%2BD38XivVCis7g%3D 11958518 (Pubitemid 34275680)
15. L Maroteaux JT Campanelli RH Scheller 1988 Synuclein: a neuron-specific protein localized to the nucleus and presynaptic nerve terminal J Neurosci 8 2804 2815 1:CAS:528:DyaL1MXhsVyqsbY%3D 3411354
16. KS McNaught CW Olanow 2003 Proteolytic stress: a unifying concept for the etiopathogenesis of Parkinson's disease Ann Neurol 53 Suppl. 3 73 86 10.1002/ana.10512 (Pubitemid 36368564)
17. KS McNaught CW Olanow B Halliwell O Isacson P Jenner 2001 Failure of the ubiquitin-proteasome system in Parkinson's disease Nat Rev Neurosci 2 589 594 10.1038/35086067 1:CAS:528:DC%2BD3MXmtVaqtbc%3D 11484002 (Pubitemid 33679832)
18. T Nagatsu M Levitt S Udenfriend 1964 Tyrosine hydroxylase the initial step in norepinephrine biosynthesis J Biol Chem 239 2910 2917 1:CAS:528:DyaF2cXksVWltr0%3D 14216443
19. S Nakashima F Ikuta 1984 Tyrosine hydroxylase protein in Lewy bodies of parkinsonian and senile brains J Neurol Sci 66 91 96 10.1016/0022-510X(84)90144- 8 1:CAS:528:DyaL2MXktlyrsg%3D%3D 6151589 (Pubitemid 15211016)
20. A Nakashima N Hayashi YS Kaneko K Mori H Egusa T Nagatsu A Ota 2005 Deletion of N-terminus of human tyrosine hydroxylase type 1 enhances stability of the enzyme in AtT-20 cells J Neurosci Res 81 110 120 10.1002/jnr.20540 1:CAS:528:DC%2BD2MXlvFCks7s%3D 15898085 (Pubitemid 41139116)
21. S Okuno H Fujisawa 1985 A new mechanism for regulation of tyrosine 3-monooxygenase by end product and cyclic AMP dependent protein kinase J Biol Chem 260 2633 2635 1:CAS:528:DyaL2MXhs1arsLw%3D 2857715
22. M Royo PF Fitzpatrick SC Daubner 2005 Mutation of regulatory serines of rat tyrosine hydroxylase to glutamate: effects on enzyme stability and activity Arch Biochem Biophys 434 266 274 10.1016/j.abb.2004.11.007 1:CAS:528: DC%2BD2MXhvFyltQ%3D%3D 15639226 (Pubitemid 40082034)
23. MG Spillantini ML Schmidt VM Lee JQ Trojanowski R Jakes M Goedert 1997 α-Synuclein in Lewy bodies Nature 388 839 840 10.1038/42166 1:CAS:528:DyaK2sXlslWru7o%3D 9278044 (Pubitemid 27377048)
24. MG Spillantini RA Crowther R Jakes M Hasegawa M Goedert 1998 α-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with Lewy bodies Proc Natl Acad Sci USA 95 6469 6473 10.1073/pnas.95.11.6469 1:CAS:528:DyaK1cXjtlKgtLo%3D 9600990 (Pubitemid 28249037)
25. K Ueda H Fukushima E Masliah Y Xia A Iwai M Yoshimoto DA Otero J Kondo Y Ihara T Saitoh 1993 Molecular cloning of cDNA encoding an unrecognized component of amyloid in Alzheimer disease Proc Natl Acad Sci USA 90 11282 11286 10.1073/pnas.90.23.11282 1:CAS:528:DyaK2cXitFCgsL4%3D 8248242 (Pubitemid 23354413)
26. F Urano N Hayashi F Arisaka H Kurita S Murata H Ichinose 2006 Molecular mechanism for pterin-mediated inactivation of tyrosine hydroxylase: formation of insoluble aggregates of tyrosine hydroxylase J Biochem 139 625 635 10.1093/jb/mvj073 1:CAS:528:DC%2BD28XlsVGku70%3D 16672262 (Pubitemid 43973908)
27. C Wersinger A Sidhu 2002 Inflammation and Parkinson's disease Curr Drug Targets Inflamm Allergy 1 221 242 10.2174/1568010023344580 1:CAS:528: DC%2BD38XmtF2rs7k%3D 14561187
28. NY Zhang Z Tang CW Liu 2008 α-Synuclein protofibrils inhibit 26 S proteasome-mediated protein degradation: understanding the cytotoxicity of protein protofibrils in neurodegenerative disease pathogenesis J Biol Chem 283 20288 20298 10.1074/jbc.M710560200 1:CAS:528:DC%2BD1cXotlOiu78%3D 18502751