Fibroblast Angiotensin II type 1a receptors contribute to Angiotensin II-induced medial hyperplasia in the ascending aorta

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 35, Issue 9, 2015, Pages 1995-2002

  Poduri, Aruna ^a   Rateri, Debra L ^a   Howatt, Deborah A ^a   Balakrishnan, Anju ^a   Moorleghen, Jessica J ^a   Cassis, Lisa A ^b   Daugherty, Alan ^a  

^a UNIVERSITY OF KENTUCKY   (United States)

^b UNIVERSITY OF KENTUCKY   (United States)

Author keywords

angiotensin II; angiotensin II type 1 receptor; endothelium; fibroblasts; medial thickening; smooth muscle

Indexed keywords

ANGIOTENSIN 1A RECEPTOR; ANGIOTENSIN II; ENOLASE; MESSENGER RNA; ANGIOTENSIN 1 RECEPTOR; DNA;

ADVENTITIA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA ENDOTHELIUM; AORTA MEDIA; ARTICLE; ASCENDING AORTA; BODY WEIGHT; CELL COUNT; CELL LINEAGE; CONTROLLED STUDY; DESCENDING AORTA; ENDOTHELIUM CELL; FIBROBLAST; GENOTYPE; HYPERPLASIA; MALE; MOUSE; NERVE CELL; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROMOTER REGION; SMOOTH MUSCLE FIBER; SYSTOLIC BLOOD PRESSURE; ANIMAL; ATHEROSCLEROSIS; BIOSYNTHESIS; C57BL MOUSE; DISEASE MODEL; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; INTRAVENOUS DRUG ADMINISTRATION; KNOCKOUT MOUSE; METABOLISM; PATHOLOGY; THORACIC AORTA; TUNICA MEDIA;

ANGIOTENSIN II; ANIMALS; AORTA, THORACIC; ATHEROSCLEROSIS; DISEASE MODELS, ANIMAL; DNA; FIBROBLASTS; GENE EXPRESSION REGULATION; GENOTYPE; HYPERPLASIA; INFUSIONS, INTRAVENOUS; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; RECEPTOR, ANGIOTENSIN, TYPE 1; RNA, MESSENGER; TUNICA MEDIA;

EID: 84940434477     PISSN: 10795642     EISSN: 15244636     Source Type: Journal    
DOI: 10.1161/ATVBAHA.115.305995     Document Type: Article

References (37)

1. Geisterfer AA, Peach MJ, Owens GK, Angiotensin II induces hypertrophy, not hyperplasia, of cultured rat aortic smooth muscle cells. Circ Res 1988 62 749 756
2. Zhang Y, Griendling KK, Dikalova A, Owens GK, Taylor WR, Vascular hypertrophy in angiotensin II-induced hypertension is mediated by vascular smooth muscle cell-derived H2O2. Hypertension 2005 46 732 737. doi: 10.1161/01.HYP.0000182660.74266.6d
3. Owens AP III, Subramanian V, Moorleghen JJ, Guo Z, McNamara CA, Cassis LA, Daugherty A, Angiotensin II induces a region-specific hyperplasia of the ascending aorta through regulation of inhibitor of differentiation 3. Circ Res 2010 106 611 619. doi: 10.1161/CIRCRESAHA.109.212837
4. Su EJ, Lombardi DM, Siegal J, Schwartz SM, Angiotensin II induces vascular smooth muscle cell replication independent of blood pressure. Hypertension 1998 31 1331 1337
5. Sparks MA, Parsons KK, Stegbauer J, Gurley SB, Vivekanandan-Giri A, Fortner CN, Snouwaert J, Raasch EW, Griffiths RC, Haystead TA, Le TH, Pennathur S, Koller B, Coffman TM, Angiotensin II type 1A receptors in vascular smooth muscle cells do not influence aortic remodeling in hypertension. Hypertension 2011 57 577 585. doi: 10.1161/HYPERTENSIONAHA.110.165274
6. Griendling KK, Minieri CA, Ollerenshaw JD, Alexander RW, Angiotensin II stimulates NADH and NADPH oxidase activity in cultured vascular smooth muscle cells. Circ Res 1994 74 1141 1148
7. Stouffer GA, Owens GK, Angiotensin II-induced mitogenesis of spontaneously hypertensive rat-derived cultured smooth muscle cells is dependent on autocrine production of transforming growth factor-beta. Circ Res 1992 70 820 828
8. Touyz RM, He G, Deng LY, Schiffrin EL, Role of extracellular signal-regulated kinases in angiotensin II-stimulated contraction of smooth muscle cells from human resistance arteries. Circulation 1999 99 392 399
9. Sabri A, Levy BI, Poitevin P, Caputo L, Faggin E, Marotte F, Rappaport L, Samuel JL, Differential roles of AT1 and AT2 receptor subtypes in vascular trophic and phenotypic changes in response to stimulation with angiotensin II. Arterioscler Thromb Vasc Biol 1997 17 257 264
10. Zhu Z, Zhang SH, Wagner C, Kurtz A, Maeda N, Coffman T, Arendshorst WJ, Angiotensin AT1B receptor mediates calcium signaling in vascular smooth muscle cells of AT1A receptor-deficient mice. Hypertension 1998 31 1171 1177
11. Poduri A, Owens AP III, Howatt DA, Moorleghen JJ, Balakrishnan A, Cassis LA, Daugherty A, Regional variation in aortic AT1b receptor mRNA abundance is associated with contractility but unrelated to atherosclerosis and aortic aneurysms. PLoS One 2012 7 e48462. doi: 10.1371/journal.pone.0048462
12. Rateri DL, Moorleghen JJ, Balakrishnan A, Owens AP III, Howatt DA, Subramanian V, Poduri A, Charnigo R, Cassis LA, Daugherty A, Endothelial cell-specific deficiency of Ang II type 1a receptors attenuates Ang II-induced ascending aortic aneurysms in LDL receptor-/-mice. Circ Res 2011 108 574 581. doi: 10.1161/CIRCRESAHA.110.222844
13. Rateri DL, Moorleghen JJ, Knight V, Balakrishnan A, Howatt DA, Cassis LA, Daugherty A, Depletion of endothelial or smooth muscle cell-specific angiotensin II type 1a receptors does not influence aortic aneurysms or atherosclerosis in LDL receptor deficient mice. PLoS One 2012 7 e51483. doi: 10.1371/journal.pone.0051483
14. Zhang JC, Kim S, Helmke BP, Yu WW, Du KL, Lu MM, Strobeck M, Yu Q, Parmacek MS, Analysis of SM22alpha-deficient mice reveals unanticipated insights into smooth muscle cell differentiation and function. Mol Cell Biol 2001 21 1336 1344. doi: 10.1128/MCB.2001.21.4.1336-1344.2001
15. Zhou Y, Dirksen WP, Babu GJ, Periasamy M, Differential vasoconstrictions induced by angiotensin II: role of AT1 and AT2 receptors in isolated C57BL/6J mouse blood vessels. Am J Physiol Heart Circ Physiol 2003 285 H2797 H2803. doi: 10.1152/ajpheart.00466.2003
16. Swafford AN Jr, Harrison-Bernard LM, Dick GM, Knockout mice reveal that the angiotensin II type 1B receptor links to smooth muscle contraction. Am J Hypertens 2007 20 335 337. doi: 10.1016/j.amjhyper.2006.09.007
17. Herrera M, Sparks MA, Alfonso-Pecchio AR, Harrison-Bernard LM, Coffman TM, Response to lack of specificity of commercial antibodies leads to misidentification of angiotensin type-1 receptor protein. Hypertension 2013 61 e32
18. Benicky J, Hafko R, Sanchez-Lemus E, Aguilera G, Saavedra JM, Six commercially available angiotensin II AT1 receptor antibodies are non-specific. Cell Mol Neurobiol 2012 32 1353 1365. doi: 10.1007/s10571-012-9862-y
19. Kühbandner S, Brummer S, Metzger D, Chambon P, Hofmann F, Feil R, Temporally controlled somatic mutagenesis in smooth muscle. Genesis 2000 28 15 22
20. Higuchi S, Ohtsu H, Suzuki H, Shirai H, Frank GD, Eguchi S, Angiotensin II signal transduction through the AT1 receptor: novel insights into mechanisms and pathophysiology. Clin Sci (Lond) 2007 112 417 428. doi: 10.1042/CS20060342
21. Nickenig G, Jung O, Strehlow K, Zolk O, Linz W, Schölkens BA, Böhm M, Hypercholesterolemia is associated with enhanced angiotensin AT1-receptor expression. Am J Physiol 1997 272 6 pt 2 H2701 H2707
22. Daugherty A, Rateri DL, Lu H, Inagami T, Cassis LA, Hypercholesterolemia stimulates angiotensin peptide synthesis and contributes to atherosclerosis through the AT1A receptor. Circulation 2004 110 3849 3857. doi: 10.1161/01.CIR.0000150540.54220.C4
23. Morimoto S, Cassell MD, Sigmund CD, The brain renin-Angiotensin system in transgenic mice carrying a highly regulated human renin transgene. Circ Res 2002 90 80 86
24. Lazartigues E, Dunlay SM, Loihl AK, Sinnayah P, Lang JA, Espelund JJ, Sigmund CD, Davisson RL, Brain-selective overexpression of angiotensin (AT1) receptors causes enhanced cardiovascular sensitivity in transgenic mice. Circ Res 2002 90 617 624
25. Cinato E, Mirotsou M, Sablitzky F, Cre-mediated transgene activation in the developing and adult mouse brain. Genesis 2001 31 118 125
26. Majesky MW, Dong XR, Hoglund V, Daum G, Mahoney WM Jr., The adventitia: a progenitor cell niche for the vessel wall. Cells Tissues Organs 2012 195 73 81. doi: 10.1159/000331413
27. Tieu BC, Lee C, Sun H, Lejeune W, Recinos A III, Ju X, Spratt H, Guo DC, Milewicz D, Tilton RG, Brasier AR, An adventitial IL-6/MCP1 amplification loop accelerates macrophage-mediated vascular inflammation leading to aortic dissection in mice. J Clin Invest 2009 119 3637 3651. doi: 10.1172/JCI38308
28. Tieu BC, Ju X, Lee C, Sun H, Lejeune W, Recinos A III, Brasier AR, Tilton RG, Aortic adventitial fibroblasts participate in angiotensin-induced vascular wall inflammation and remodeling. J Vasc Res 2011 48 261 272. doi: 10.1159/000320358
29. Jones JA, Beck C, Barbour JR, Zavadzkas JA, Mukherjee R, Spinale FG, Ikonomidis JS, Alterations in aortic cellular constituents during thoracic aortic aneurysm development: myofibroblast-mediated vascular remodeling. Am J Pathol 2009 175 1746 1756. doi: 10.2353/ajpath.2009.081141
30. Sugimoto H, Mundel TM, Kieran MW, Kalluri R, Identification of fibroblast heterogeneity in the tumor microenvironment. Cancer Biol Ther 2006 5 1640 1646
31. Kendall RT, Feghali-Bostwick CA, Fibroblasts in fibrosis: novel roles and mediators. Front Pharmacol 2014 5 123. doi: 10.3389/fphar.2014.00123
32. Kong P, Christia P, Saxena A, Su Y, Frangogiannis NG, Lack of specificity of fibroblast-specific protein 1 in cardiac remodeling and fibrosis. Am J Physiol Heart Circ Physiol 2013 305 H1363 H1372. doi: 10.1152/ajpheart.00395.2013
33. Österreicher CH, Penz-Österreicher M, Grivennikov SI, Guma M, Koltsova EK, Datz C, Sasik R, Hardiman G, Karin M, Brenner DA, Fibroblast-specific protein 1 identifies an inflammatory subpopulation of macrophages in the liver. Proc Natl Acad Sci U S A 2011 108 308 313. doi: 10.1073/pnas.1017547108
34. Cheng J, Wang Y, Liang A, Jia L, Du J, FSP-1 silencing in bone marrow cells suppresses neointima formation in vein graft. Circ Res 2012 110 230 240. doi: 10.1161/CIRCRESAHA.111.246025
35. Tang Y, Harrington A, Yang X, Friesel RE, Liaw L, The contribution of the Tie2+ lineage to primitive and definitive hematopoietic cells. Genesis 2010 48 563 567. doi: 10.1002/dvg.20654
36. Shi Y, O'Brien JE Jr, Mannion JD, Morrison RC, Chung W, Fard A, Zalewski A, Remodeling of autologous saphenous vein grafts The role of perivascular myofibroblasts. Circulation 1997 95 2684 2693
37. Nguyen AT, Gomez D, Bell RD, Smooth muscle cell plasticity: fact or fiction? Circ Res 2013 112 17 22. doi: 10.1161/CIRCRESAHA.112.281048