Novel bioactivation pathway of benzbromarone mediated by cytochrome P450

Drug Metabolism and Disposition

Volumn 43, Issue 9, 2015, Pages 1303-1306

  Kitagawara, Yumina ^a   Ohe, Tomoyuki ^a   Tachibana, Kumiko ^a   Takahashi, Kyoko ^a   Nakamura, Shigeo ^b   Mashino, Tadahiko ^a  

^a KEIO UNIVERSITY   (Japan)

^b NIPPON MEDICAL SCHOOL   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

2 ETHYL 3 (3 BROMO 4,5 DIHYDROXYBENZOYL)BENZOFURAN; 2,6 DIBROMOBENZOQUINONE; 2,6 DIBROMOHYDROQUINONE; 6 HYDROXYBENZBROMARONE; BENZBROMARONE; CATECHOL; CYTOCHROME P450; CYTOCHROME P450 1A1; CYTOCHROME P450 2C9; CYTOCHROME P450 2D6; CYTOCHROME P450 2E1; CYTOCHROME P450 3A4; HYDROQUINONE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CHEMICAL MODIFICATION; CHEMICAL REACTION; CONTROLLED STUDY; CYTOTOXICITY; HEPG2 CELL LINE; HUMAN; HUMAN CELL; LIVER MICROSOME; NONHUMAN; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION; ANIMAL; METABOLIC ACTIVATION; METABOLISM; SPRAGUE DAWLEY RAT;

RATTUS;

ACTIVATION, METABOLIC; ANIMALS; BENZBROMARONE; CYTOCHROME P-450 ENZYME SYSTEM; HEP G2 CELLS; HUMANS; MICROSOMES, LIVER; RATS; RATS, SPRAGUE-DAWLEY;

EID: 84940385524     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.115.065037     Document Type: Article

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