Ipso substitution of bisphenol A catalyzed by microsomal cytochrome P450 and enhancement of estrogenic activity

Toxicology Letters

Volumn 203, Issue 1, 2011, Pages 92-95

  Nakamura, Shigeo ^a   Tezuka, Yoshito ^a   Ushiyama, Atsuko ^a   Kawashima, Chiaki ^a   Kitagawara, Yumina ^a   Takahashi, Kyoko ^a   Ohta, Shigeru ^b   Mashino, Tadahiko ^a  

^a KEIO UNIVERSITY   (Japan)

^b HIROSHIMA UNIVERSITY   (Japan)

Author keywords

Bisphenol A; Cytochrome P450; Estrogenic activity; Metabolic activation

Indexed keywords

4,4' ISOPROPYLIDENEDIPHENOL; ALCOHOL DERIVATIVE; CYTOCHROME P450; CYTOCHROME P450 1A1; CYTOCHROME P450 1A2; CYTOCHROME P450 2B6; CYTOCHROME P450 2C19; CYTOCHROME P450 2C9; CYTOCHROME P450 2D6; CYTOCHROME P450 2E1; CYTOCHROME P450 3A4; CYTOCHROME P450 3A5; CYTOCHROME P450 3A7; CYTOCHROME P450 4A11; ESTROGEN RECEPTOR; HYDROQUINONE; HYDROXYCUMYLALCOHOL; ISOPROPENYLPHENOL; PHENOL DERIVATIVE; UNCLASSIFIED DRUG;

ADDITION REACTION; ARTICLE; CATALYSIS; CHEMICAL BOND; ENZYME ACTIVITY; ESTROGEN ACTIVITY; FEMALE; HUMAN; MALE; METABOLIC ACTIVATION; METABOLITE; MOLECULAR STABILITY; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR BINDING; SUBSTITUTION REACTION;

ANIMALS; BINDING SITES; BIOTRANSFORMATION; CELL LINE, TUMOR; ENDOCRINE DISRUPTORS; ESTROGENS, NON-STEROIDAL; FEMALE; GENES, REPORTER; HUMANS; HYDROQUINONES; ISOENZYMES; MALE; MICROSOMES, LIVER; PHENOLS; RATS; RATS, WISTAR; RESPONSE ELEMENTS; TRANSFECTION;

EID: 79954919689     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxlet.2011.03.010     Document Type: Article

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