Recombinant ADAMTS 13 Attenuates Brain Injury after Intracerebral Hemorrhage

Stroke

Volumn 46, Issue 9, 2015, Pages 2647-2653

  Cai, Ping ^a,b   Luo, Haiyu ^a   Xu, Haochen ^a   Zhu, Ximin ^a   Xu, Wenfang ^a   Dai, Yiqin ^a   Xiao, Jin ^a   Cao, Yongliang ^a   Zhao, Yuwu ^c   Zhao, Bing Qiao ^a   Fan, Wenying ^a  

^a FUDAN UNIVERSITY   (China)

^b FUJIAN MEDICAL UNIVERSITY   (China)

^c SHANGHAI JIAO TONG UNIVERSITY AFFILIATED SIXTH PEOPLE S HOSPITAL   (China)

Author keywords

ADAMTS 13; blood brain barrier disruption; edema and brain injury; inflammation; intracerebral hemorrhage

Indexed keywords

CHEMOKINE RECEPTOR CCR1; CXCL1 CHEMOKINE; FRACTALKINE; GELATINASE B; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 1BETA; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; RECOMBINANT ENZYME; RECOMBINANT VON WILLEBRAND FACTOR; VON WILLEBRAND FACTOR CLEAVING PROTEINASE; ADAMTS13 PROTEIN, MOUSE; ANTIINFLAMMATORY AGENT; METALLOPROTEINASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BLOOD BRAIN BARRIER; BRAIN EDEMA; BRAIN HEMORRHAGE; BRAIN INJURY; CELL ACTIVATION; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INACTIVATION; ENZYME INDUCTION; ENZYME INHIBITION; GENE EXPRESSION; MICROGLIA; MOUSE; NEUTROPHIL; NONHUMAN; PERICYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; ANIMAL; BRAIN INJURIES; CEREBRAL HEMORRHAGE; COMPLICATION; DRUG EFFECTS; IMMUNOLOGY; INFLAMMATION; PATHOPHYSIOLOGY;

ANIMALS; ANTI-INFLAMMATORY AGENTS; BLOOD-BRAIN BARRIER; BRAIN EDEMA; BRAIN INJURIES; CEREBRAL HEMORRHAGE; INFLAMMATION; METALLOENDOPEPTIDASES; MICE;

EID: 84940371967     PISSN: 00392499     EISSN: 15244628     Source Type: Journal    
DOI: 10.1161/STROKEAHA.115.009526     Document Type: Article

References (34)

1. Balami JS, Buchan AM. Complications of intracerebral haemorrhage. Lancet Neurol. 2012;11:101-118. doi: 10.1016/S1474-4422(11)70264-2.
2. Gebel JM Jr, Jauch EC, Brott TG, Khoury J, Sauerbeck L, Salisbury S, et al. Relative edema volume is a predictor of outcome in patients with hyperacute spontaneous intracerebral hemorrhage. Stroke. 2002;33:2636-2641.
3. Wang J, Doré S. Inflammation after intracerebral hemorrhage. J Cereb Blood Flow Metab. 2007;27:894-908. doi: 10.1038/sj.jcbfm.9600403.
4. Ma Q, Huang B, Khatibi N, Rolland W II, Suzuki H, Zhang JH, et al. PDGFR-α inhibition preserves blood-brain barrier after intracerebral hemorrhage. Ann Neurol. 2011;70:920-931. doi: 10.1002/ana.22549.
5. Nieswandt B, Stoll G. The smaller, the better: VWF in stroke. Blood. 2010;115:1477-1478. doi: 10.1182/blood-2009-12-255000.
6. Dong JF, Moake JL, Nolasco L, Bernardo A, Arceneaux W, Shrimpton CN, et al. ADAMTS-13 rapidly cleaves newly secreted ultralarge von Willebrand factor multimers on the endothelial surface under flowing conditions. Blood. 2002;100:4033-4039. doi: 10.1182/blood-2002-05-1401.
7. Petri B, Broermann A, Li H, Khandoga AG, Zarbock A, Krombach F, et al. von Willebrand factor promotes leukocyte extravasation. Blood. 2010;116:4712-4719. doi: 10.1182/blood-2010-03-276311.
8. Hillgruber C, Steingräber AK, Pöppelmann B, Denis CV, Ware J, Vestweber D, et al. Blocking von Willebrand factor for treatment of cutaneous inflammation. J Invest Dermatol. 2014;134:77-86. doi: 10.1038/jid.2013.292.
9. Zhao BQ, Chauhan AK, Canault M, Patten IS, Yang JJ, Dockal M, et al. von Willebrand factor-cleaving protease ADAMTS13 reduces ischemic brain injury in experimental stroke. Blood. 2009;114:3329-3334. doi: 10.1182/blood-2009-03-213264.
10. Muroi C, Fujioka M, Mishima K, Irie K, Fujimura Y, Nakano T, et al. Effect of ADAMTS-13 on cerebrovascular microthrombosis and neuronal injury after experimental subarachnoid hemorrhage. J Thromb Haemost. 2014;12:505-514. doi: 10.1111/jth.12511.
11. Chauhan AK, Kisucka J, Brill A, Walsh MT, Scheiflinger F, Wagner DD. ADAMTS13: a new link between thrombosis and inflammation. J Exp Med. 2008;205:2065-2074. doi: 10.1084/jem.20080130.
12. Wang L, Fan W, Cai P, Fan M, Zhu X, Dai Y, et al. Recombinant ADAMTS13 reduces tissue plasminogen activator-induced hemorrhage after stroke in mice. Ann Neurol. 2013;73:189-198. doi: 10.1002/ana.23762.
13. Rynkowski MA, Kim GH, Komotar RJ, Otten ML, Ducruet AF, Zacharia BE, et al. A mouse model of intracerebral hemorrhage using autologous blood infusion. Nat Protoc. 2008;3:122-128. doi: 10.1038/nprot.2007.513.
14. Zhao BQ, Ikeda Y, Ihara H, Urano T, Fan W, Mikawa S, et al. Essential role of endogenous tissue plasminogen activator through matrix metalloproteinase 9 induction and expression on heparin-produced cerebral hemorrhage after cerebral ischemia in mice. Blood. 2004;103:2610-2616. doi: 10.1182/blood-2003-03-0835.
15. Wang X, Lee SR, Arai K, Lee SR, Tsuji K, Rebeck GW, et al. Lipoprotein receptor-mediated induction of matrix metalloproteinase by tissue plasminogen activator. Nat Med. 2003;9:1313-1317. doi: 10.1038/nm926.
16. Fan W, Dai Y, Xu H, Zhu X, Cai P, Wang L, et al. Caspase-3 modulates regenerative response after stroke. Stem Cells. 2014;32:473-486. doi: 10.1002/stem.1503.
17. Zhao BQ, Wang S, Kim HY, Storrie H, Rosen BR, Mooney DJ, et al. Role of matrix metalloproteinases in delayed cortical responses after stroke. Nat Med. 2006;12:441-445. doi: 10.1038/nm1387.
18. Xi G, Strahle J, Hua Y, Keep RF. Progress in translational research on intracerebral hemorrhage: is there an end in sight? Prog Neurobiol. 2014;115:45-63. doi: 10.1016/j.pneurobio.2013.09.007.
19. Moxon-Emre I, Schlichter LC. Neutrophil depletion reduces blood-brain barrier breakdown, axon injury, and inflammation after intracerebral hemorrhage. J Neuropathol Exp Neurol. 2011;70:218-235. doi: 10.1097/NEN.0b013e31820d94a5.
20. Xue M, Yong VW. Matrix metalloproteinases in intracerebral hemorrhage. Neurol Res. 2008;30:775-782. doi: 10.1179/174313208X341102.
21. Bell RD, Winkler EA, Singh I, Sagare AP, Deane R, Wu Z, et al. Apolipoprotein E controls cerebrovascular integrity via cyclophilin A. Nature. 2012;485:512-516. doi: 10.1038/nature11087.
22. Armulik A, Genové G, Mäe M, Nisancioglu MH, Wallgard E, Niaudet C, et al. Pericytes regulate the blood-brain barrier. Nature. 2010;468:557-561. doi: 10.1038/nature09522.
23. Ziai WC. Hematology and inflammatory signaling of intracerebral hemorrhage. Stroke. 2013;44(6 suppl 1):S74-S78. doi: 10.1161/STROKEAHA.111.000662.
24. Nguyen HX, O'Barr TJ, Anderson AJ. Polymorphonuclear leukocytes promote neurotoxicity through release of matrix metalloproteinases, reactive oxygen species, and TNF-alpha. J Neurochem. 2007;102:900-912. doi: 10.1111/j.1471-4159.2007.04643.x.
25. Ramirez SH, Haskó J, Skuba A, Fan S, Dykstra H, McCormick R, et al. Activation of cannabinoid receptor 2 attenuates leukocyte-endothelial cell interactions and blood-brain barrier dysfunction under inflammatory conditions. J Neurosci. 2012;32:4004-4016. doi: 10.1523/JNEUROSCI.4628-11.2012.
26. Dole VS, Bergmeier W, Mitchell HA, Eichenberger SC, Wagner DD. Activated platelets induce Weibel-Palade-body secretion and leukocyte rolling in vivo: role of P-selectin. Blood. 2005;106:2334-2339. doi: 10.1182/blood-2005-04-1530.
27. Fujioka M, Nakano T, Hayakawa K, Irie K, Akitake Y, Sakamoto Y, et al. ADAMTS13 gene deletion enhances plasma high-mobility group box1 elevation and neuroinflammation in brain ischemia-reperfusion injury. Neurol Sci. 2012;33:1107-1115. doi: 10.1007/s10072-011-0913-9.
28. De Meyer SF, Savchenko AS, Haas MS, Schatzberg D, Carroll MC, Schiviz A, et al. Protective anti-inflammatory effect of ADAMTS13 on myocardial ischemia/reperfusion injury in mice. Blood. 2012;120:5217-5223. doi: 10.1182/blood-2012-06-439935.
29. Power C, Henry S, Del Bigio MR, Larsen PH, Corbett D, Imai Y, et al. Intracerebral hemorrhage induces macrophage activation and matrix metalloproteinases. Ann Neurol. 2003;53:731-742. doi: 10.1002/ana.10553.
30. Aid S, Silva AC, Candelario-Jalil E, Choi SH, Rosenberg GA, Bosetti F. Cyclooxygenase-1 and -2 differentially modulate lipopolysaccharideinduced blood-brain barrier disruption through matrix metalloproteinase activity. J Cereb Blood Flow Metab. 2010;30:370-380. doi: 10.1038/jcbfm.2009.223.
31. Zhang L, Zhang ZG, Ding GL, Jiang Q, Liu X, Meng H, et al. Multitargeted effects of statin-enhanced thrombolytic therapy for stroke with recombinant human tissue-type plasminogen activator in the rat. Circulation. 2005;112:3486-3494. doi: 10.1161/CIRCULATIONAHA.104.516757.
32. Xue M, Fan Y, Liu S, Zygun DA, Demchuk A, Yong VW. Contributions of multiple proteases to neurotoxicity in a mouse model of intracerebral haemorrhage. Brain. 2009;132(pt 1):26-36. doi: 10.1093/brain/awn215.
33. Ducruet AF, Zacharia BE, Hickman ZL, Grobelny BT, Yeh ML, Sosunov SA, et al. The complement cascade as a therapeutic target in intracerebral hemorrhage. Exp Neurol. 2009;219:398-403. doi: 10.1016/j. expneurol.2009.07.018.
34. Keep RF, Xiang J, Ennis SR, Andjelkovic A, Hua Y, Xi G, et al. Bloodbrain barrier function in intracerebral hemorrhage. Acta Neurochir Suppl. 2008;105:73-77.