Expression of vasoactive proteins in gastric antral mucosa reflects vascular dysfunction in patients with cirrhosis and portal hypertension

Liver International

Volumn 35, Issue 4, 2015, Pages 1393-1402

  Trebicka, Jonel ^a,b   Wix, Cyrus ^a   von Heydebrand, Matthias ^a   Hittatiya, Kanishka ^a   Reiberger, Thomas ^d   Klein, Sabine ^a   Schierwagen, Robert ^a   Kristiansen, Glen ^a   Peck Radosavljevic, Markus ^d   Fischer, Hans Peter ^a   Møller, Søren ^b   Bendtsen, Flemming ^b   Krag, Aleksander ^c   Sauerbruch, Tilman ^a  

^a UNIVERSITY OF BONN   (Germany)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

^c ODENSE UNIVERSITY HOSPITAL   (Denmark)

^d MEDICAL UNIVERSITY OF VIENNA   (Austria)

Author keywords

Cirrhosis; Portal hypertension; Transjugular intrahepatic portosystemic shunt; Vascular dysfunction; Vasoactive pathways

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; BETA ARRESTIN 2; CD31 ANTIGEN; CREATININE; CYCLIC GMP DEPENDENT PROTEIN KINASE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; MESSENGER RNA; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; BETA ARRESTIN; NOS3 PROTEIN, HUMAN; RETINA S ANTIGEN; RHO KINASE; RHOA PROTEIN, HUMAN;

ADULT; AGED; ARTICLE; ASCITES; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DOWN REGULATION; ESOPHAGUS VARICES; FEMALE; GENETIC TRANSCRIPTION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INTRACELLULAR SIGNALING; LIVER CIRRHOSIS; LIVER DYSFUNCTION; MAJOR CLINICAL STUDY; MALE; PORTAL HYPERTENSION; PORTAL VEIN BLOOD PRESSURE; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STOMACH ANTRUM; STOMACH BIOPSY; STOMACH MUCOSA; UPREGULATION; VASCULAR DISEASE; WESTERN BLOTTING; BIOPSY; CASE CONTROL STUDY; CHEMISTRY; CLINICAL TRIAL; COMPLICATION; DENMARK; GASTRIC MUCOSA; GENETICS; HYPERTENSION, PORTAL; METABOLISM; MIDDLE AGED; MULTICENTER STUDY; PATHOPHYSIOLOGY; POLYMERASE CHAIN REACTION; SPLANCHNIC BLOOD FLOW; TRANSJUGULAR INTRAHEPATIC PORTOSYSTEMIC SHUNT; YOUNG ADULT;

ADULT; AGED; ARRESTINS; BIOPSY; BLOTTING, WESTERN; CASE-CONTROL STUDIES; DENMARK; FEMALE; GASTRIC MUCOSA; HUMANS; HYPERTENSION, PORTAL; IMMUNOHISTOCHEMISTRY; LIVER CIRRHOSIS; MALE; MIDDLE AGED; NITRIC OXIDE SYNTHASE TYPE III; POLYMERASE CHAIN REACTION; PORTAL PRESSURE; PORTASYSTEMIC SHUNT, TRANSJUGULAR INTRAHEPATIC; PYLORIC ANTRUM; RHO-ASSOCIATED KINASES; RHOA GTP-BINDING PROTEIN; RNA, MESSENGER; SPLANCHNIC CIRCULATION; YOUNG ADULT;

EID: 84940364646     PISSN: 14783223     EISSN: 14783231     Source Type: Journal    
DOI: 10.1111/liv.12613     Document Type: Article

References (28)

1. Hennenberg M, Biecker E, Trebicka J, et al. Defective RhoA/Rho-kinase signaling contributes to vascular hypocontractility and vasodilation in cirrhotic rats. Gastroenterology 2006; 130: 838-54.
2. Hennenberg M, Trebicka J, Biecker E, et al. Vascular dysfunction in human and rat cirrhosis: role of receptor-desensitizing and calcium-sensitizing proteins. Hepatology 2007; 45: 495-506.
3. Hennenberg M, Trebicka J, Sauerbruch T, Heller J. Mechanisms of extrahepatic vasodilation in portal hypertension. Gut 2008; 57: 1300-14.
4. Blendis L, Wong F. The hyperdynamic circulation in cirrhosis: an overview. Pharmacol Ther 2001; 89: 221-31.
5. Wong F. Recent advances in our understanding of hepatorenal syndrome. Nat Rev Gastroenterol Hepatol 2012; 9: 382-91.
6. Trebicka J, Leifeld L, Hennenberg M, et al. Hemodynamic effects of urotensin II and its specific receptor antagonist palosuran in cirrhotic rats. Hepatology 2008; 47: 1264-76.
7. Pateron D, Tazi KA, Sogni P, et al. Role of aortic nitric oxide synthase 3 (eNOS) in the systemic vasodilation of portal hypertension. Gastroenterology 2000; 119: 196-200.
8. Tazi KA, Barriere E, Moreau R, et al. Role of shear stress in aortic eNOS up-regulation in rats with biliary cirrhosis. Gastroenterology 2002; 122: 1869-77.
9. Reiberger T, Payer BA, Schwabl P, et al. Nebivolol treatment increases splanchnic blood flow and portal pressure in cirrhotic rats via modulation of nitric oxide signalling. Liver Int 2013; 33: 561-8.
10. Primignani M, Carpinelli L, Preatoni P, et al. Natural history of portal hypertensive gastropathy in patients with liver cirrhosis. The New Italian Endoscopic Club for the study and treatment of esophageal varices (NIEC). Gastroenterology 2000; 119: 181-7.
11. Sarin SK, Shahi HM, Jain M, et al. The natural history of portal hypertensive gastropathy: influence of variceal eradication. Am J Gastroenterol 2000; 95: 2888-93.
12. Perini RF, Camara PR, Ferraz JG. Pathogenesis of portal hypertensive gastropathy: translating basic research into clinical practice. Nat Clin Pract Gastroenterol Hepatol 2009; 6: 150-8.
13. Reiberger T, Ulbrich G, Ferlitsch A, et al. Carvedilol for primary prophylaxis of variceal bleeding in cirrhotic patients with haemodynamic non-response to propranolol. Gut 2013; 62: 1634-41.
14. Trebicka J, Krag A, Gansweid S, et al. Endotoxin and tumor necrosis factor-receptor levels in portal and hepatic vein of patients with alcoholic liver cirrhosis receiving elective transjugular intrahepatic portosystemic shunt. Eur J Gastroenterol Hepatol 2011; 23: 1218-25.
15. Reiberger T, Ferlitsch A, Payer BA, et al. Noninvasive screening for liver fibrosis and portal hypertension by transient elastography-a large single center experience. Wien Klin Wochenschr 2012; 124: 395-402.
16. Trebicka J, Hennenberg M, Laleman W, et al. Atorvastatin lowers portal pressure in cirrhotic rats by inhibition of RhoA/Rho-kinase and activation of endothelial nitric oxide synthase. Hepatology 2007; 46: 242-53.
17. Trebicka J, Hennenberg M, Schulze Probsting A, et al. Role of beta3-adrenoceptors for intrahepatic resistance and portal hypertension in liver cirrhosis. Hepatology 2009; 50: 1924-35.
18. Trebicka J, Racz I, Siegmund SV, et al. Role of cannabinoid receptors in alcoholic hepatic injury: steatosis and fibrogenesis are increased in CB(2) receptor-deficient mice and decreased in CB(1) receptor knockouts. Liver Int 2011; 31: 862-72.
19. Huss S, Schmitz J, Goltz D, et al. Development and evaluation of an open source Delphi-based software for morphometric quantification of liver fibrosis. Fibrogenesis Tissue Repair 2011; 3: 10.
20. Westerhoff M, Tretiakova M, Hovan L, et al. CD61, CD31, and CD34 improve diagnostic accuracy in gastric antral vascular ectasia and portal hypertensive gastropathy: an immunohistochemical and digital morphometric study. Am J Surg Pathol 2010; 34: 494-501.
21. Bosch J, Garcia-Pagan JC. Complications of cirrhosis. Portal hypertension. J Hepatol 2000; 32: 141-56.
22. Ripoll C, Garcia-Tsao G. The management of portal hypertensive gastropathy and gastric antral vascular ectasia. Dig Liver Dis 2011; 43: 345-51.
23. Wiest R, Garcia-Tsao G. Bacterial translocation (BT) in cirrhosis. Hepatology 2005; 41: 422-33.
24. Mezawa S, Homma H, Ohta H, et al. Effect of transjugular intrahepatic portosystemic shunt formation on portal hypertensive gastropathy and gastric circulation. Am J Gastroenterol 2001; 96: 1155-9.
25. Wong F, Sniderman K, Liu P, Blendis L. The mechanism of the initial natriuresis after transjugular intrahepatic portosystemic shunt. Gastroenterology 1997; 112: 899-907.
26. Kamath PS, Lacerda M, Ahlquist DA, et al. Gastric mucosal responses to intrahepatic portosystemic shunting in patients with cirrhosis. Gastroenterology 2000; 118: 905-11.
27. Urata J, Yamashita Y, Tsuchigame T, et al. The effects of transjugular intrahepatic portosystemic shunt on portal hypertensive gastropathy. J Gastroenterol Hepatol 1998; 13: 1061-7.
28. Vignali C, Bargellini I, Grosso M, et al. TIPS with expanded polytetrafluoroethylene-covered stent: results of an Italian multicenter study. AJR Am J Roentgenol 2005; 185: 472-80.