Therapeutic role of Trigonella foenum-Graecum [fenugreek] - A review

International Journal of Pharmaceutical Sciences Review and Research

Volumn 27, Issue 2, 2014, Pages 74-80

  Nathiya, S ^a   Durga, M ^a   Devasena, T ^a  

^a ANNA UNIVERSITY   (India)

Author keywords

Anti Cancer activity; Anti Toxic activity; Immunomodulatory; Pharmacological activity

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; CATALASE; CHOLINESTERASE INHIBITOR; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; CYPERMETHRIN; DIOSGENIN; GALACTOMANNAN; GLUTATHIONE; GLUTATHIONE PEROXIDASE; GLUTATHIONE TRANSFERASE; GLYCOSIDE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INTERLEUKIN 6; LACTATE DEHYDROGENASE; LOW DENSITY LIPOPROTEIN CHOLESTEROL; MALONALDEHYDE; PHYTOSTEROL; SAPONIN; SUPEROXIDE DISMUTASE; THIOBARBITURIC ACID REACTIVE SUBSTANCE; TRIGONELLA FOENUM GRAECUM EXTRACT; TUMOR NECROSIS FACTOR ALPHA; VERY LOW DENSITY LIPOPROTEIN CHOLESTEROL;

ANTICATARACT ACTIVITY; ANTIDIABETIC ACTIVITY; ANTINEOPLASTIC ACTIVITY; ANTIOXIDANT ACTIVITY; ARTHRITIS; ASTHMA; ATHEROSCLEROSIS; BLOOD GLUCOSE MONITORING; BRONCHITIS; COLON CARCINOGENESIS; CORONARY ARTERY DISEASE; DIARRHEA; DPPH RADICAL SCAVENGING ASSAY; DRUG ACTIVITY; ENDOCRINE DISEASE; ENZYME INHIBITION ASSAY; HYPERCHOLESTEROLEMIA; IMMUNOMODULATION; IMMUNOSTIMULATION; INSULIN DEPENDENT DIABETES MELLITUS; LIPID METABOLISM; LIVER PROTECTION; NAUSEA; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; ORAL GLUCOSE TOLERANCE TEST; PHYTOCHEMISTRY; RASH; REVIEW; SORE THROAT; WOUND;

EID: 84940230529     PISSN: 0976044X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (72)

1. Joy PP, Thomas J, Mathew S, Baby P Skaria, Medicinal plants, Kerala agricultural university, Aromatic and Medicinal plants research station, Kerala.
2. Srinivasan K, Fenugreek (Trigonella foenum-graecum): A review of health beneficial physiological effects, Food-Reviews-International, 22, 2006, 203-224.
3. Vikas S, Indian Agriculture, Economic Data Research Center, New Delhi, India, 2003, 585-587.
4. Acharya SN, Thomas JE, Bas SK, Fenugreek: an "old world" crop for the "New world", Biodiversity,7, 2006, 3-4.
5. Sharma RD, Raghuram TC, Rao NS, Effect of fenugreek seeds on blood glucose and serum lipids in type I diabetes, Eur. J. Clin. Nutr, 44, 1990, 301-306.
6. Zia T, Nazrul Hasnain S, Hasan SK, Evaluation of the oral hypoglycaemic effect of Trigonella foenum-graecum L. in normal mice, Journal of Ethnopharmacology, 75, 2001,191-195.
7. Stark A, Madar Z, The effect of an ethanol extract derived from fenugreek (Trigonella foenum-graecum) on bile acid absorption and cholesterol levels in rats, British Journal of Nutrition, 69, 1993, 277-287.
8. Suja Pandian R, Anuradha CV, Viswanathan P, Gastroprotective Effect of fenugreek seeds (Trigonella foenum graecum) on experimental gastric ulcer in rats, J Ethnopharmacol, 81, 2002, 393-397.
9. Amin A, Alkaabi A, Al-Falasi S, Daoud SA, Chemopreventive activities of Trigonella foenum-graecum (Fenugreek) against breast cancer, Cell Biology International, 29, 2005, 687-694.
10. Hettiarachchy NS, Glenn KC, Gnanasambandam R, Johnson MG, Natural antioxidant extract from fenugreek (Trigonella foenumgraecum) for ground beef patties, Journal of Food Science, 61, 1996, 516-519.
11. Kaviarasan S, Viswanathan P, Anuradha W, Fenugreek seed (Trigonella foenum graecum) polyphenols inhibit ethanol-induced collagen and lipid accumulation in rat liver, Cell Biol Toxicol, 23, 2007, 373-383.
12. Riad S, El-Baradie AA, Fenugreek mucilage and its relation to the reputed laxative action of this seed. Egyptian Journal of Chemistry, 2, 1959, 163-168.
13. Petit P, Sauvaire Y, Ponsin G, Manteghetti M, Fave A, Ribes G, Effect offenugreek seed extraction on feeding behavior in the rat: metabolic-endocrine correlates, Pharmacology, Biochemistry and Behavior, 45, 1993, 369-374.
14. Jain SC, Madhu A, Regulation oftrigonellin in Trigonella species by chemical mutagenic treatments, Indian Drugs, 26, 1988, 14-16.
15. Kamal R, Yadav R, Flavonoids from Trigonella polycertain-vivo and invitro. Journal of Phytological Research, 4, 1991, 161-165.
16. Swain AR, Dutton SP, Truswell AS, Salicylates in foods. Journal of American Dietary Association, 85, 1985, 950-960.
17. Rajalaksmi R, Nanavaty K, Gumashta A, Effect of cooking procedures on the free and total niacin content of certain food. Journal of Nutrition and Dietetics, 1, 1964, 276-280.
18. Mehrafarin A, Qaderi A, Rezazadeh Sh, Naghdi Badi H, Noormohammadi Gh, Zand E, Bioengineering of Important Secondary Metabolites and Metabolic Pathways in Fenugreek (Trigonella foenum-graecum L.), J. of Medicinal Plants,9(35), 2010, 1-18.
19. Budavari S, The merck index: An encyclopedia of chemicals, drugs, and biologicals, 12th ed. Whitehouse Station, N.J. Merk & Co Inc. 1996.
20. Newall CA, Anderson LA, Phillipson JD, Herbal medicines: A guide for healthcare professionals. London: The Pharmaceutical Press, 1996.
21. Kozlowski J, Nowak A, Krajewska A. Effects of fertilizer rates and ratios on the mucilage value and diosgenin yield of fenugreek, Herba Polonica, 28(3-4), 1982, 159-70.
22. Mohamed MA, Differences in growth, Seed yield and chemical constituents of fenugreek plants (Trigonella foenum-graecum L.) due to some agricultural treatments, Egyptian J. of Agronomy,15(1- 2), 1990, 117-23.
23. Hardman R, Fazli FRY, Methods of screening the genus Trigonella for steroidal sapogenins, Planta Medica,21, 1972, 131-138.
24. Elujoba AA, Hardman R, Fermentation of fenugreek plants (Trigonella foenum-graecum L.) due to some agricultural treatments, Egyptian J. of Agronomy,15(1-2), 1990, 117-23.
25. Khanna P, Jain SC, Diosgenin, gitogenin and tigogenin from Trigonella foenum graecum tissue cultures, Lloydia,36, 1973, 96-98.
26. Trisonthi P, Baccou JC, and Sauvaire Y, Trial to improve production of steroidal sapogenin by fenugreek (Trigonella foenum-graecum L.) tissue grown in in vitro, C.R. séances, Acad. Sci. Ser D, 291(3), 190, 357-360.
27. Petropoulos GA, Fenugreek, The genus powdered fenugreek seeds for increased sapogenin yields, Fitoterapia, 56 (6), 1985, 368-70.
28. Ramadan G, El-Beih NM, Abd El-Ghffar EA, Modulatory effects of black v. green tea aqueous extract on hyperglycaemia, hyperlipidaemia and liver dysfunction in diabetic and obese rat models, Br J Nutr, 102, 2009, 1611-1619.
29. Mowla A, Alauddin M, Rahman MA, Antihyperglycemic effect of Trigonella foenum-graecum (fenugreek) mucilage value and diosgenin yield of fenugreek, Herba Polonica,28, 2009, 3-4.
30. Seo YJ, Gweon OC, Lee YM, Effect of garlic and aged black garlic on hyperglycemia and dyslipidemia in animal model of type 2 diabetes mellitus, J Food Sci Nutr, 14, 2009, 1-7.
31. Srichamroen A, Thomson ABR, Field CJ, Basu TK, In vitro intestinal glucose uptake is inhibited by galactomannan from Canadian fenugreek seed (Trigonella foenum graecum L) in genetically lean and obese rats, Nutrition Research, 29, 2008, 49-54.
32. Hannan JMA, Ali L, Rodeya B, Khaleque J, Alchter M, Flatt PR, Abdel Wahab YHA, Soluble dietry fibre fractions of Trigonella foenumgraecum (fenugreek) seed improves glucose homeostatis in animal models of type 1 and type 2 diabetes by delaying carbohydrate digestion and absorption and enhancing insulin action, British Journal of Nutrition, 97, 2006, 514-521.
33. Raju J, Gupta D, Araga R, Rao, Yadav PK, Boquer NZ, Trigonella foenum-graecum (fenugreek) seed powder improves glucose homeostatis in alloxan diabetic rat tissues by reversing the altered glycolytic, gluconeogenic and lipogenic enzymes, Molecular and Cellular Biochemistry, 224, 2001, 45-51.
34. Sauvaire Y, Baissac Y, Leconte O, Petit P, Ribes G: Steroid saponins from fenugreek and some of their biological properties, Adv Exp Med Biol, 405, 1996, 37-46.
35. Yoshikawa M, Murakami T, Komatsu H, Murakami N, Yamahara J, Matsuda H, Medicinal Foodstuffs. IV. Fenugreek Seed. (1): Structures of trigoneosides Ia, Ib, IIa, IIb, IIIa and IIIb, new furostanol saponins from the seeds of Indian Trigonella foenum-graecum L. Chem Pharm Bull, 45, 1997, 81-97.
36. Taylor WG, Elder JL, Chang PR, Richards KW, Microdetermination of diosgenin from fenugreek (Trigonella foenum-graecum) seeds, J Agric Food Chem, 48, 2000, 5206-5210.
37. Petit P, Sauvaire Y, Ponsin G, Manteghetti M, Fave A, Ribes G, Effect of a fenugreek seed extraction on feeding behavior in the rat: metabolic-endocrine correlates, Pharmacology, Biochemistry and Behavior, 45, 1993, 369-374.
38. Puri D, Prabhu KM, Murthy PS, Antidiabetic effect of GII compound purified from fenugreek (Trigonella foenum-graecum Linn) seeds in Diabetic Rabbits, Ind J Clin Biochem 2011.
39. Hamden K, Jaoudi B, Salami T, Carreau S, Bejar S, Elfeki A, Modulatory effect of fenugreek saponins on the activites of intestinal and hepatic Disaccharidase and glycogen and liver function of Diabetic rats, Biotechnology and Bioprocess engineering, 15, 2010, 745-753.
40. Witztum JL, Steinberg D, The oxidative modification hypothesis of atherosclerosis. Does it hold for humans? Trend Cardiovasc Med, 11, 2001, 93-102.
41. Sato K, Niki E, Shimasaki H, Free radical mediated chain oxidation of low-density lipoprotein and its synergistic inhibition by vitamin E and vitamin C, Arch Biochem Biophys, 279, 1990, 402-405.
42. Bordia A, Verma SK, Srivastava KC, Effect of ginger (Zingiber officinale Rosc.) and fenugreek (Trigonella foenum graecumL.) on blood lipids, blood sugar and platelet aggregation in patients with Coronary artery disease, Prostaglandis, Leucotrienes and Essential Fatty acids, 56(5), 1997, 379-384.
43. Stark A, Madar Z, The effect of an ethanol extract derived from fenugreek (Trigonella foenum-graecum) on bile acid absorption and cholesterol levels in rats, Br J Nutr, 69(1), 1993, 277-87.
44. Birk Y, Saponins H, In Toxic Constiluents of Plant Foodstuffs, [I.E. Liener, editor]. New York and London: Academic Press 1969, 169,210.
45. Sharma RD, Hypocholesterolemic activity of fenugreek (Trigonella foenum graecum): an experimental study in rats. Nutrition Reports International, 30, 1984, 221-232.
46. Bhat GB, Sambaiah K, Chandrasekhara N, The effect of feeding fenugreek and ginger on bile composition in the albino rat, Nutrition Reports International, 32, 1985, 1145-1151.
47. Boban Puthenpura T, Sudhakaran Bala Nambisan Perumana R, Hypolipidaemic effect of chemically different mucilages in rats: a comparative study, Br J Nutr, 96, 2003, 1021-1029.
48. Sharma RD, Raghuram TC, Rao NS, Effect of fenugreek seeds on blood glucose and serum lipids in type I diabetes, Eur. J. Clin. Nutr, 44, 1990, 301-306.
49. Sowmya P, Rajalakshmi P, Hypocholesterolemic effect of germinated fenugreek seeds in human subjects, Plant foods for Human Nutrition, 53, 1999, 359-365.
50. Venkatesan N, Devaraj SN, Devaraj H, A fibre cocktail of fenugreek, guar gum and wheat bran reduces oxidative modification of LDL induced by an atherogenic diet in rats, Molecular and Cellular Biochemistry, 294, 2006, 145-153.
51. VanFurt R, Current view on the mononuclear phagocyte system, Immunobiology, 161, 1982, 178-85.
52. Hafeez BB, Haque R, Parvez S, Pandey S, Sayeed I, Raisuddin S, Immunomodulatory effects of fenugreek (Trigonella foenum graecum L) extract in mice, International Immunopharmacology, 3, 2003, 257-265.
53. Sushma N, Devasena T, Aqueous extract of Trigonella foenum graecum(fenugreek) prevents cypermethrin-induced hepatotoxicity and nephrotoxicity, Human and Experimental Toxicology, 29(4), 2010, 311-319.
54. Bhatia K, Kaur M, Atif F, Ali M, Rehman H, Rahman S, Aqueous extract of Trigonella foenumgraecum L. ameliorates additive urotoxicity of buthionine sulfoximine and cyclophosphamide in mice, Food Chem Toxicol, 44, 2006, 1744-1750.
55. Shetty AK, Salimath PV, Reno-protective effects of fenugreek (Trigonella foenum greacum) during experimental diabetes, e-SPEN, The European e-Journal of Clinical Nutrition and Metabolism, 2009, e137-e14.
56. Devasena T, Christinal J, Inhibition of fenvalerate toxicity in vitro by fenugreek, Biomedicine, 30(3), 2010, 282-285.
57. WHO (2005), Prevention of avoidable blindness and visual impairment, Provisional agenda item 4.9. EB117/35, 117th session 22 December.
58. Varma SD, Kavita RH, Susceptibility of the ocular lens to nitric oxide: implications in cataractogenesis, J Ocular Pharmacol Therap, 23, 2007, 188-195.
59. Gupta SK, Kalaiselvam V, Srivasta S, Saxena R, Agarwal SS, Trigonella foenum graecum (fenugreek) protects against selenite-Induced oxidative stress in experimental cataractogenesis, Biol Trace Elem Res, 136, 2009, 258-268.
60. Billaud C, Adrian J, Fenugreek: Composition, nutritional value and physiologicalproperties. Sciences-des-ailments, 21(1), 2001, 3-26.
61. Sauvaire Y, Ribes G, Baccou JC, Loubatieres Mariani MM, Implication of steroid saponins and sapogenins in the hypocholesterolemic effect of fenugreek, Lipids, 26, 1991, 191-197.
62. Ribes G, Sauvaire Y, Costa CD, Baccou JC, Loubatieres-Mariani MM, Antidiabetic effects of subfraction from fenugreek seeds in diabetic dogs, Proc Soc Exp Biol Med, 182, 1986, 159-166.
63. Bukari SB, Bhanger MI, Memon S, Antioxidative activity of extracts from fenugreek seeds (Trigonella foenum graecum), Pak.J.Anal.Environ.Chem,9(2), 2008, 78-83.
64. Choudhary D, Chandra D, Choudhary, S, Kale, RK, Modulation of glyoxalase, glutathione-S-transferase and Antioxidant enzymes in liver,spleen and erythrocytes of mice by dietary administration of fenugreek seeds, Food and Chemical Toxicology, 39, 2001, 989-997.
65. Basch E, Ulbricht C, Kuo G, Szapary P, Smith M, Therapeutic applications of fenugreek, Altern Med Rev,8, 2003 20-27.
66. Boban Puthenpura T, Bala Nambisan, Sudhakaran Perumana R, Dietary mucilage promotes regression of atheromatous lesions in hypercholesterolemic rabbits, Phyto Res, 23, 2009, 725-30.
67. Kaviarasan S, Naik GH, Gangabhagirathi R, Anuradha W, Priyadarsini KI, In vitro studies on anti radical and antioxidant activities of fenugreek (Trigonella foenum graecum) seeds, Food Chemistry, 103, 2006, 31-37.
68. Anuradha CV, Ravikumar P, Restoration on tissue antioxidants by fenugreek seeds (T.foenum-graecum) in alloxan-diabetic rats, Ind. J. Physiol. Pharmacol, 45, 2001, 408-420.
69. Yunbao Liu, Rajesh Kakani, Muraleedharan Nair G, Compounds in functional food fenugreek spice exhibit anti-inflammatory and antioxidant activities, Food Chemistry, 131, 2011, 1187-1192.
70. Doshi M, Mirza A, Umarji B, Karambelkar R, Effect of Trigonella foenum graecum (Fenugreek/Methi) on Hemoglobin levels in females of Child Bearing Age, Biomedical Research, 23(1), 2001, 47-50.
71. Devasena T, Venugopal Menon P, Fenugreek seeds modulate 1,2-dimethylhydrazine-induced hepatic oxidative stress during colon carcinogenesis, The Italian Journal of Biochemistry, 56(1), 2007, 28-34.
72. Satheesh Kumar N, Pulok K, Mukherjee S, Bhadra BP, Saha, Acetylcholinesterase enzyme inhibitory potential of standardized extract of Trigonella foenum graecum L and its constituents Phytomedicine, 17, 2010, 292-295.