Synthesis and inhibitory effects of novel pyrimido-pyrrolo-quinoxalinedione analogues targeting nucleoproteins of influenza A virus H1N1

European Journal of Medicinal Chemistry

Volumn 102, Issue , 2015, Pages 477-486

  Lin, Meng I ^a   Su, Bo Han ^b   Lee, Chia Hsin ^c   Wang, Suz Ting ^c   Wu, Wen Chun ^c   Dangate, Prasad ^c   Wang, Shi Yun ^a   Huang, Wen I ^a   Cheng, Ting Jen ^a   Lin, Olivia A ^b   Cheng, Yih Shyun E ^a   Tseng, Yufeng Jane ^b   Sun, Chung Ming ^c  

^a GENOMICS RESEARCH CENTER   (Taiwan)

^b NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^c NATIONAL CHIAO TUNG UNIVERSITY   (Taiwan)

Author keywords

Anti influenza; Influenza nucleoprotein; Pyrimido pyrrolo quinoxalinedione (PPQ); RNA dependent RNA polymerase

Indexed keywords

ANTIVIRUS AGENT; OSELTAMIVIR; PYRIMIDO PYRROLO QUINOXALINEDIONE DERIVATIVE; PYRIMIDO[4',5':3,4]PYRROLO[2,1 C][1,4]OXAZINEDIONE; PYRROLOPYRIMIDINE DERIVATIVE; PYRROLO[3,4 D]PYRIMIDINE 2,4 DIONE; QUINOXALINE DERIVATIVE; RNA DIRECTED RNA POLYMERASE; UNCLASSIFIED DRUG; VIRUS NUCLEOPROTEIN; VIRUS RNA; NUCLEOPROTEIN; PYRIMIDINE DERIVATIVE; PYRROLE DERIVATIVE; VIRUS PROTEIN;

ANIMAL CELL; ANTIVIRAL ACTIVITY; ARTICLE; BINDING SITE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOPATHOGENIC EFFECT; CYTOPLASM; DRUG IDENTIFICATION; DRUG SYNTHESIS; DRUG TARGETING; EC50; EMBRYO; FEMALE; HIGH THROUGHPUT SCREENING; HYDROGEN BOND; INFLUENZA A (H1N1); INFLUENZA A VIRUS (H1N1); MDCK CELL LINE; MOLECULAR DOCKING; MUTATION; NONHUMAN; PROTEIN AGGREGATION; PROTEIN TRANSPORT; VIRUS DETECTION; VIRUS ISOLATION; VIRUS NEUTRALIZATION; VIRUS REPLICATION; VIRUS RESISTANCE; VIRUS STRAIN; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; METABOLISM; MICROBIAL SENSITIVITY TEST; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ANTIVIRAL AGENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; INFLUENZA A VIRUS, H1N1 SUBTYPE; MICROBIAL SENSITIVITY TESTS; MOLECULAR STRUCTURE; NUCLEOPROTEINS; PYRIMIDINES; PYRROLES; QUINOXALINES; STRUCTURE-ACTIVITY RELATIONSHIP; VIRAL PROTEINS;

EID: 84940213008     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2015.08.016     Document Type: Article

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