Bastimolide A, a Potent Antimalarial Polyhydroxy Macrolide from the Marine Cyanobacterium Okeania hirsuta

Journal of Organic Chemistry

Volumn 80, Issue 16, 2015, Pages 7849-7855

  Shao, Chang Lun ^a,b   Linington, Roger G ^a,c,d   Balunas, Marcy J ^a,d,f   Centeno, Argelis ^d   Boudreau, Paul ^a   Zhang, Chen ^a   Engene, Niclas ^e   Spadafora, Carmenza ^d   Mutka, Tina S ^g   Kyle, Dennis E ^g   Gerwick, Lena ^a   Wang, Chang Yun ^b   Gerwick, William H ^a,h  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^b OCEAN UNIVERSITY OF CHINA   (China)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d INSTITUTO DE INVESTIGACIONES CIENTÍFICAS Y SERVICIOS DE ALTA TECNOLOGÍA   (Panama)

^e FLORIDA INTERNATIONAL UNIVERSITY   (United States)

^f UNIVERSITY OF CONNECTICUT   (United States)

^g UNIVERSITY OF SOUTH FLORIDA   (United States)

^h UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMISTRY; METABOLITES; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; X RAY DIFFRACTION ANALYSIS;

ABSOLUTE CONFIGURATION; ANTIMALARIAL ACTIVITY; ANTIMALARIAL DRUG; MARINE CYANOBACTERIUM; MOLECULAR ARRANGEMENTS; PLASMODIUM FALCIPARUM; RESISTANT STRAINS; TERT-BUTYL GROUP;

DRUG PRODUCTS;

ANTIMALARIAL AGENT; BASTIMOLIDE A; MACROLIDE; POLYHYDROXY MACROLIDE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIMALARIAL ACTIVITY; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CHEMICAL REACTION; COLUMN CHROMATOGRAPHY; CYANOBACTERIUM; DRUG CYTOTOXICITY; ELECTROSPRAY MASS SPECTROMETRY; HETERONUCLEAR MULTIPLE BOND CORRELATION; HETERONUCLEAR SINGLE QUANTUM COHERENCE; IC50; LIQUID CHROMATOGRAPHY; NONHUMAN; OKEANIA HIRSUTA; PLASMODIUM FALCIPARUM; PROTON NUCLEAR MAGNETIC RESONANCE; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; VERO CELL LINE; X RAY DIFFRACTION; CHEMISTRY; CONFORMATION; DRUG EFFECTS; DRUG RESISTANCE; DRUG SENSITIVITY; ISOLATION AND PURIFICATION; STRUCTURE ACTIVITY RELATION;

ANTIMALARIALS; CYANOBACTERIA; DRUG RESISTANCE; MACROLIDES; MOLECULAR CONFORMATION; PARASITIC SENSITIVITY TESTS; PLASMODIUM FALCIPARUM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84940200853     PISSN: 00223263     EISSN: 15206904     Source Type: Journal    
DOI: 10.1021/acs.joc.5b01264     Document Type: Article

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