A high-throughput method for predicting drug effects on gut transit time using larval zebrafish

Journal of Pharmacological and Toxicological Methods

Volumn 76, Issue , 2015, Pages 72-75

  Cassar, Steven ^a   Huang, Xin ^a   Cole, Todd ^a  

^a ABBVIE INC   (United States)

Author keywords

Drug; Gastrointestinal; Methods; Safety; Zebrafish

Indexed keywords

AMITRIPTYLINE; ATROPINE; METOCLOPRAMIDE; TEGASEROD; NEW DRUG;

ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG SOLUBILITY; EMBRYO; FECES ANALYSIS; FLUORESCENCE ANALYSIS; FLUORESCENCE MICROSCOPY; HIGH THROUGHPUT FLUORESCENCE ASSAY; INTESTINE TRANSIT TIME; LARVA; NONHUMAN; PREDICTION; PREDICTIVE VALUE; SENSITIVITY AND SPECIFICITY; SPECTROPHOTOMETRY; ZEBRA FISH; ANIMAL; DRUG EFFECTS; EMBRYOLOGY; GASTROINTESTINAL TRACT; GASTROINTESTINAL TRANSIT; HIGH THROUGHPUT SCREENING; MAXIMUM TOLERATED DOSE; NONMAMMALIAN EMBRYO; PHYSIOLOGY; PRECLINICAL STUDY; PROCEDURES;

DANIO RERIO; MAMMALIA; VERTEBRATA;

ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG EVALUATION, PRECLINICAL; DRUGS, INVESTIGATIONAL; EMBRYO, NONMAMMALIAN; GASTROINTESTINAL TRACT; GASTROINTESTINAL TRANSIT; HIGH-THROUGHPUT SCREENING ASSAYS; MAXIMUM TOLERATED DOSE; MICROSCOPY, FLUORESCENCE; PREDICTIVE VALUE OF TESTS; ZEBRAFISH;

EID: 84940104373     PISSN: 10568719     EISSN: 1873488X     Source Type: Journal    
DOI: 10.1016/j.vascn.2015.08.156     Document Type: Article

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