Acute decrease in serum testosterone after a mixed glucose and protein beverage in obese peripubertal boys

Clinical Endocrinology

Volumn 83, Issue 3, 2015, Pages 332-338

  Schwartz, Alexander ^a,b   Patel, Barkha P ^a   Vien, Shirley ^a   McCrindle, Brian W ^b   Anderson, G Harvey ^a   Hamilton, Jill ^a,b  

^a UNIVERSITY OF TORONTO   (Canada)

^b HOSPITAL FOR SICK CHILDREN   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

FOLLITROPIN; GHRELIN; GLUCAGON LIKE PEPTIDE 1; GLUCOSE; LUTEINIZING HORMONE; PROTEIN; TESTOSTERONE; WHEY PROTEIN;

ADOLESCENT; APPETITE; ARTICLE; BEVERAGE; BLOOD SAMPLING; BODY COMPOSITION; BODY MASS; CHILD; CLINICAL ARTICLE; COMPARATIVE STUDY; CROSS-SECTIONAL STUDY; GLUCOSE BEVERAGE; GLUCOSE TOLERANCE TEST; HORMONE DETERMINATION; HORMONE RESPONSE; HUMAN; INGESTION; INSULIN SENSITIVITY; MALE; OBESITY; ORAL GLUCOSE TOLERANCE TEST; PRIORITY JOURNAL; PROTEIN BEVERAGE; PUBERTY; TESTOSTERONE BLOOD LEVEL; ANALYSIS OF VARIANCE; BLOOD; CLINICAL TRIAL; DIET RESTRICTION; PATHOPHYSIOLOGY; PHYSIOLOGY;

ADOLESCENT; ANALYSIS OF VARIANCE; BEVERAGES; CHILD; CROSS-SECTIONAL STUDIES; FASTING; GHRELIN; GLUCAGON-LIKE PEPTIDE 1; GLUCOSE; HUMANS; LUTEINIZING HORMONE; MALE; OBESITY; PUBERTY; TESTOSTERONE; WHEY PROTEINS;

EID: 84940102854     PISSN: 03000664     EISSN: 13652265     Source Type: Journal    
DOI: 10.1111/cen.12630     Document Type: Article

References (40)

1. Kaufman, J.M., &, Vermeulen, A., (2005) The decline of androgen levels in elderly men and its clinical and therapeutic implications. Endocrine Reviews, 26, 833-876.
2. Mogri, M., Dhindsa, S., Quattrin, T., et al,. (2013) Testosterone concentrations in young pubertal and post-pubertal obese males. Clinical Endocrinology (Oxford), 78, 593-599.
3. Wagner, I.V., Sabin, M.A., Pfaffle, R.W., et al,. (2012) Effects of obesity on human sexual development. Nature Reviews: Endocrinology, 8, 246-254.
4. Cohen, P.G., (1999) The hypogonadal-obesity cycle: role of aromatase in modulating the testosterone-estradiol shunt-a major factor in the genesis of morbid obesity. Medical Hypotheses, 52, 49-51.
5. Kahn, S.E., Hull, R.L., &, Utzschneider, K.M., (2006) Mechanisms linking obesity to insulin resistance and type 2 diabetes. Nature, 444, 840-846.
6. Lewis, J.G., Shand, B.I., Elder, P.A., et al,. (2004) Plasma sex hormone-binding globulin rather than corticosteroid-binding globulin is a marker of insulin resistance in obese adult males. Diabetes, Obesity & Metabolism, 6, 259-263.
7. Isidori, A.M., Caprio, M., Strollo, F., et al,. (1999) Leptin and androgens in male obesity: evidence for leptin contribution to reduced androgen levels. Journal of Clinical Endocrinology and Metabolism, 84, 3673-3680.
8. Myers, M.G. Jr, Leibel, R.L., Seeley, R.J., et al,. (2010) Obesity and leptin resistance: distinguishing cause from effect. Trends in Endocrinology and Metabolism, 21, 643-651.
9. Yu, W.H., Kimura, M., Walczewska, A., et al,. (1997) Role of leptin in hypothalamic-pituitary function. Proceedings of the National Academy of Sciences of the USA, 94, 1023-1028.
10. Nestler, J.E., Clore, J.N., Strauss, J.F. 3rd, et al,. (1987) The effects of hyperinsulinemia on serum testosterone, progesterone, dehydroepiandrosterone sulfate, and cortisol levels in normal women and in a woman with hyperandrogenism, insulin resistance, and acanthosis nigricans. Journal of Clinical Endocrinology and Metabolism, 64, 180-184.
11. Pasquali, R., Casimirri, F., De Iasio, R., et al,. (1995) Insulin regulates testosterone and sex hormone-binding globulin concentrations in adult normal weight and obese men. Journal of Clinical Endocrinology and Metabolism, 80, 654-658.
12. Caronia, L.M., Dwyer, A.A., Hayden, D., et al,. (2013) Abrupt decrease in serum testosterone levels after an oral glucose load in men: implications for screening for hypogonadism. Clinical Endocrinology (Oxford), 78, 291-296.
13. Jeibmann, A., Zahedi, S., Simoni, M., et al,. (2005) Glucagon-like peptide-1 reduces the pulsatile component of testosterone secretion in healthy males. European Journal of Clinical Investigation, 35, 565-572.
14. Baggio, L.L., &, Drucker, D.J., (2007) Biology of incretins: GLP-1 and GIP. Gastroenterology, 132, 2131-2157.
15. Kojima, M., Hosoda, H., Date, Y., et al,. (1999) Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature, 402, 656-660.
16. Wren, A.M., Seal, L.J., Cohen, M.A., et al,. (2001) Ghrelin enhances appetite and increases food intake in humans. Journal of Clinical Endocrinology and Metabolism, 86, 5992.
17. Whatmore, A.J., Hall, C.M., Jones, J., et al,. (2003) Ghrelin concentrations in healthy children and adolescents. Clinical Endocrinology (Oxford), 59, 649-654.
18. Ishikawa, T., Fujioka, H., Ishimura, T., et al,. (2007) Ghrelin expression in human testis and serum testosterone level. Journal of Andrology, 28, 320-324.
19. Patel, B.P., Anderson, G.H., Vien, S., et al,. Obesity, sex and pubertal status affect appetite hormone responses to a mixed glucose and whey protein drink in adolescents. Clinical Endocrinology (Oxford) 2014, 81, 63-70.
20. Center for Disease Control and Prevention (2000) CDC growth charts for the United States: methods and development. Vital and Health Statistics, 11, 1-190.
21. Bellissimo, N., Thomas, S.G., Pencharz, P.B., et al,. (2008) Reproducibility of short-term food intake and subjective appetite scores after a glucose preload, ventilation threshold, and body composition in boys. Applied Physiology, Nutrition and Metabolism, 33, 326-337.
22. Anderson, G.H., &, Moore, S.E., (2004) Dietary proteins in the regulation of food intake and body weight in humans. Journal of Nutrition, 134, 974S-979S.
23. Nuttall, F.Q., Mooradian, A.D., Gannon, M.C., et al,. (1984) Effect of protein ingestion on the glucose and insulin response to a standardized oral glucose load. Diabetes Care, 7, 465-470.
24. Callahan, H.S., Cummings, D.E., Pepe, M.S., et al,. (2004) Postprandial suppression of plasma ghrelin level is proportional to ingested caloric load but does not predict intermeal interval in humans. Journal of Clinical Endocrinology and Metabolism, 89, 1319-1324.
25. Dempster, P., &, Aitkens, S., (1995) A new air displacement method for the determination of human body composition. Medicine and Science in Sports and Exercise, 27, 1692-1697.
26. Tanner, J.M., (1962) Growth at Adolescence: With a General Consideration of the Effects of Hereditary and Environmental Factors upon Growth and Maturation from Birth to Maturity, 2nd edn. Blackwell Scientific Publications, Springfield, MA.
27. Canadian Diabetes Association, Dietitians of Canada, Diabète Québec, Ordre professionnel des diététistes du Québec. (2006) Recommendations for nutrition best practice in the management of gestational diabetes mellitus. Executive summary (1). Canadian Journal of Dietetic Practice and Research, 67, 206-208.
28. Canadian Diabetes Association Clinical Practice Guidelines Expert Committee. (2013) Canadian Diabetes Association 2013 clinical practice guidelines for the prevention and management of diabetes in Canada. Canadian Journal of Diabetes, S1-S212.
29. Wall, J.R., Jarrett, R.J., Zimmet, P.Z., et al,. (1973) Fall in plasma-testosterone levels in normal male subjects in response to an oral glucose load. Lancet, 1, 967-968.
30. Hjalmarsen, A., Aasebo, U., Aakvaag, A., et al,. (1996) Sex hormone responses in healthy men and male patients with chronic obstructive pulmonary disease during an oral glucose load. Scandinavian Journal of Clinical and Laboratory Investigation, 56, 635-640.
31. Kulle, A.E., Riepe, F.G., Melchior, D., et al,. (2010) A novel ultrapressure liquid chromatography tandem mass spectrometry method for the simultaneous determination of androstenedione, testosterone, and dihydrotestosterone in pediatric blood samples: age- and sex-specific reference data. Journal of Clinical Endocrinology and Metabolism, 95, 2399-2409.
32. Iranmanesh, A., Lawson, D., &, Veldhuis, J.D., (2012) Glucose ingestion acutely lowers pulsatile LH and basal testosterone secretion in men. American Journal of Physiology. Endocrinology and Metabolism, 302, E724-E730.
33. Foresta, C., Bordon, P., Rossato, M., et al,. (1997) Specific linkages among luteinizing hormone, follicle-stimulating hormone, and testosterone release in the peripheral blood and human spermatic vein: evidence for both positive (feed-forward) and negative (feedback) within-axis regulation. Journal of Clinical Endocrinology and Metabolism, 82, 3040-3046.
34. Chari, M., Yang, C.S., Lam, C.K., et al,. (2011) Glucose transporter-1 in the hypothalamic glial cells mediates glucose sensing to regulate glucose production in vivo. Diabetes, 60, 1901-1906.
35. Ashley Blackshaw, L., &, Young, R.L., (2011) Detection and signaling of glucose in the intestinal mucosa-vagal pathway. Neurogastroenterology and Motility, 23, 591-594.
36. Akhavan, T., Luhovyy, B.L., Panahi, S., et al,. (2014) Mechanism of action of pre-meal consumption of whey protein on glycemic control in young adults. Journal of Nutritional Biochemistry, 25, 36-43.
37. Lebenthal, Y., Gat-Yablonski, G., Shtaif, B., et al,. (2006) Effect of sex hormone administration on circulating ghrelin levels in peripubertal children. Journal of Clinical Endocrinology and Metabolism, 91, 328-331.
38. Gaytan, F., Barreiro, M.L., Caminos, J.E., et al,. (2004) Expression of ghrelin and its functional receptor, the type 1a growth hormone secretagogue receptor, in normal human testis and testicular tumors. Journal of Clinical Endocrinology and Metabolism, 89, 400-409.
39. English, P.J., Ghatei, M.A., Malik, I.A., et al,. (2002) Food fails to suppress ghrelin levels in obese humans. Journal of Clinical Endocrinology and Metabolism, 87, 2984.
40. Habito, R.C., &, Ball, M.J., (2001) Postprandial changes in sex hormones after meals of different composition. Metabolism, 50, 505-511.