Glucagon-like peptide-1 reduces the pulsatile component of testosterone secretion in healthy males

European Journal of Clinical Investigation

Volumn 35, Issue 9, 2005, Pages 565-572

  Jeibmann, A ^a   Zahedi, S ^a   Simoni, M ^a   Nieschlag, E ^a   Byrne, Maria M ^a,b  

^a UNIVERSITY OF MÜNSTER   (Germany)

^b ST JAMES S HOSPITAL   (Ireland)

Author keywords

Glucagon like peptide 1; Insulin sensitivity; Luteinizing hormone; Pulsatile hormone secretion; Testosterone

Indexed keywords

FOLLITROPIN; GLUCAGON LIKE PEPTIDE 1; GLUCOSE; LEPTIN; LUTEINIZING HORMONE; TESTOSTERONE;

ADULT; ARTICLE; CONTROLLED STUDY; GLUCOSE HOMEOSTASIS; HUMAN; HUMAN EXPERIMENT; HYPOTHALAMUS HYPOPHYSIS SYSTEM; MALE; NORMAL HUMAN; ORAL GLUCOSE TOLERANCE TEST; PRIORITY JOURNAL; STATISTICAL ANALYSIS; TESTOSTERONE BLOOD LEVEL; TESTOSTERONE RELEASE;

ADMINISTRATION, ORAL; ADULT; BLOOD GLUCOSE; GLUCAGON; GLUCAGON-LIKE PEPTIDE 1; GLUCAGON-LIKE PEPTIDES; GLUCOSE; GLUCOSE CLAMP TECHNIQUE; GLUCOSE TOLERANCE TEST; HUMANS; INFUSIONS, INTRAVENOUS; INSULIN; LEPTIN; LUTEINIZING HORMONE; MALE; PEPTIDE FRAGMENTS; TESTOSTERONE;

EID: 24144480908     PISSN: 00142972     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-2362.2005.01542.x     Document Type: Article

References (40)

1. Drucker DJ. The glucagon-like peptides. Diabetes 1998;47:159-69.
2. Shimizu I, Hirota M, Ohboshi C, Shima K. Identification and localization of glucagon-like peptide-1 and its receptor in rat brain. Endocrinology 1987;121:1076-82.
3. Drucker DJ, Asa S. Glucagon gene expression in vertebrate brain. J Biol Chem 1988;263:13475-8.
4. Turton MD, O'Shea D, Gunn I, Beak SA, Edwards CM, Meeran K et al. A role of glucagon-like peptide-1 in the central regulation of feeding. Nature 1996;379:69-72.
5. Flint A, Raben A, Astrup A, Holst JJ. Glucagon-like peptide-1 promotes satiety and suppresses energy intake in humans. J Clin Invest 1998;101:515-20.
6. Zander M, Madsbad S, Madsen JL, Holst JJ. Effect of 6-week course of glucagon-like peptide-1 on glycaemic control, insulin sensitivity, and beta-cell function in type 2 diabetes: a parallel-group study. Lancet 2002;359:824-30.
7. Beak SA, Heath MH, Small CJ, Morgan DGA, Ghatei MA, Taylor AD et al. Glucagon-like peptide-1 stimulates luteinizing hormone-releasing hormone secretion in a rodent hypothalamic neuronal cell line. J Clin Invest 1998;101:1334-41.
8. Kalra SP, Kalra PS. Nutritional infertility: the role of the interconnected hypothalamic neuropeptide Y-Galanin-Opioid network. In: Ganong WF, Martini L, editors. Frontiers in Neuroendocrinology. New York: Raven Press Ltd; 1996. pp. 371-401.
9. Schreihofer DA, Amico JA, Cameron JL. Reversal of fasting-induced suppression of luteinizing hormone (LH) secretion in male rhesus monkeys by intragastric nutrient infusion: evidence for rapid stimulation of LH by nutritional signals. Endocrinology 1993;132:1890-7.
10. Schreihofer DA, Renda F, Cameron JL. Feeding-induced stimulation of luteinizing hormone secretion in male rhesus monkeys is not dependent on a rise in blood glucose concentration. Endocrinology 1996;137:3770-6.
11. Oltmanns KM, Fruehwald-Schultes B, Kern W, Born J, Fehm HL, Peters A. Hypoglycemia, but not insulin, acutely decreases LH and T secretion in men. J Clin Endocrinol Metab 2001;86:4913-9.
12. Lado-Abeal J, Hickox JR, Cheung TL, Veldhuis JD, Hardy DM, Norman RL. Neuroendocrine consequences of fasting in adult male macaques: effects of recombinant rhesus macaque leptin infusion. Neuroendocrinology 2000;71:196-208.
13. MacLusky NJ, Cook S, Scrocchi L, Shin J, Kirn J, Vaccarino F et al. Neuroendocrine function and response to stress in mice with complete disruption of glucagon-like peptide-1 receptor signaling. Endocrinology 2000;141:752-62.
14. Simoni M. Methodology for measuring testosterone, DHT and SHBG in a clinical setting. In: Nieschlag E, Behre H, editors. Testosterone:Action, Deficiency, Substitution, 3rd edn. Cambridge UK: Cambridge University Press; 2004. pp. 641-64.
15. Von Eckardstein S, Schmidt A, Kamischke A, Simoni M, Gromoll J, Nieschlag E. CAG repeat length in the androgen receptor gene and gonadotrophin suppression influence the effectiveness of hormonal male contraception. Clin Endocrinol (Oxf) 2002;57:647-55.
16. Brandt A, Katschinski M, Arnold R, Polonsky KS, Goke B, Byrne MM. GLP-1-induced alterations in the glucose-stimulated insulin secretory dose-response curve. Am J Physiol Endocrinol Metab 2001; 281:E242-7.
17. Vermeulen A, Verdonck L, Kaufman JM. A critical evaluation of simple methods for the estimation of free testosterone in serum. J Clin Endocrinol Metab 1999;84:3666-72.
18. Mari A, Pacini G, Murphy E, Ludvik B, Nolan JJ. A model-based method for assessing insulin sensitivity from the oral glucose tolerance test. Diabetes Care 2001;24:539-48.
19. Van Cauter E. Estimating false-positive and false-negative errors in analysis of hormonal pulsatility. Am J Physiol 1989;254:E786-94.
20. American Diabetes Association. Report of the expert committee on the diagnosis and classification of diabetes mellitus. Diabetes Care 1997;7:1183-97.
21. Wall JR, Jarrett RJ, Zimmet PZ, Bailes M, Ramage CM. Fall in plasma testosterone levels in normal male subjects in response to an oral glucose load. Lancet 1973;1: 967-8.
22. Selvage DJ, Rivier C. Importance of the paraventricular nucleus of the hypothalamus as a component of a neural pathway between the brain and the testes that modulates testosterone secretion independently of the pituitary. Endocrinology 2003;144:594-8.
23. Ogilvie K, Hales K, Roberts M, Hales D, Rivier C. The inhibitory effect of intracerebroventricularly injected interleukin 1β on testosterone secretion in the rat: role of steroidogenic acute regulatory protein. Biol Reprod 1999;60:527-33.
24. Selvage DJ, Lee SY, Parsons LH, Seo DO, Rivier CL. A hypothalamic- testicular neural pathway is influenced by brain catecholamines, but not testicular blood flow. Endocrinology 2004;145:1750-9.
25. Kastin AJ, Akterstrom V, Pan W. Interactions of glucagon-like peptide-1 (GLP-1) with the blood-brain barrier. J Mol Neurosci 2002;18:7-14.
26. Orskov C, Poulsen SS, Moller M, Holst JJ. GLP-1 receptors in the subfornical organs and the area postrema are accessible to circulating glucagon-like peptide. Diabetes 1996;45:832-5.
27. Yamamoto H, Kishi T, Lee CE, Choi BJ, Fang H, Hollenberg AN et al. Glucagon-like peptide-1-responsive catecholamine neurons in the area postrema link peripheral glucagon-like peptide-1 with central autonomic control sites. J Neurosci 2003;23:2939-46.
28. Yamamoto H, Lee CE, Marcus JN, Williams TD, Overton JM, Lopez ME et al. Glucagon-like peptide-1 receptor stimulation increases blood pressure and heart rate and activates autonomic regulatory neurons. J Clin Invest 2002;110:43-52.
29. Wang C, Catlin DH, Starcevic B, Leung A, DiStefano E, Lucas G et al. Testosterone metabolic clearance and production rates determined by stable isotope dilution/tandem mass spectrometry in normal men: influence of ethnicity and age. J Clin Endocrinol Metab 2004;89:2936-41.
30. Ibberson M, Uldry M, Thorens B. GLUTX1, a novel mammalian glucose transporter expressed in the central nervous system and insulin-sensitive tissues. J Biol Chem 2000;275:4607-12.
31. Ibberson M, Riederer BM, Uldry M, Guhl B, Roth J, Thorens B. Immunolocalization of GLUTX1 in the testis and to specific brain areas and vasopressin-containing neurons. Endocrinology 2002;143:276-84.
32. Williams NI, Lancas MJ, Cameron JL. Stimulation of luteinizing hormone secretion by food intake: evidence against a role for insulin. Endocrinology 1996;137:2565-71.
33. Marin P, Holmang S, Jonsson L, Sjostrom L, Kvist H, Holm G et al. The effects of testosterone treatment on body composition and metabolism in middle-aged obese men. Int J Obes Relat Metab Disord 1992;16:991-7.
34. Holmang A, Bjorntorp P. The effects of testosterone on insulin sensitivity in male rats. Acta Physiol Scand 1992;146:505-10.
35. Pitteloud N, Hardin M, Dwyer AA, Valassi E, Yialamas M, Elahi D et al. Increasing insulin resistaince is associated with a decrease in Leydig cell testosterone secretion in men. J Clin Endocrinol Metab 2005;90:2636-41.
36. Laaksonen DE, Niskanen L, Punnonen K, Nyyssonen K, Tuomainen T-K, Valkonen V-P et al. Testosterone and sex hormone-binding globulin predict the metabolic syndrome and diabetes in middle-aged men. Diabetes Care 2004;27:1036-41.
37. Stellato RK, Feldman HA, Hamdy O, Horton ES, McKinlay JB. Testosterone, sex-hormone binding globulin, and the development of type 2 diabetes in middle-aged men: prospective results from the Massachusetts male aging study. Diabetes Care 2000;23:490-4.
38. Vierhapper H, Nowotny P, Waldhausl W. Reduced production rates of testosterone and dihydrotestosterone in healthy men treated with rosiglitazone. Metabolism 2003;52:230-2.
39. Fürnsinn C, Nowotny P, Brunmair B, Gras F, Roden M, Waldhausl W et al. Thiazolidindiones influence plasma steroids of male obese zucker rats. Endocrinology 2002;143:327-30.
40. Shegem NS, Nasir AM, Jbour AK, Batieha AM, El-Khateeb MS, Ajlouni KM. Effects of short term metformin administration on androgens in normal men. Saudi Med J 2002;23:934-7.