Hyperglycemia promotes Schwann cell de-differentiation and de-myelination via sorbitol accumulation and Igf1 protein down-regulation

Journal of Biological Chemistry

Volumn 290, Issue 28, 2015, Pages 17106-17115

  Hao, Wu ^a   Tashiro, Syoichi ^a   Hasegawa, Tomoka ^b   Sato, Yuiko ^a   Kobayashi, Tami ^a   Tando, Toshimi ^a   Katsuyama, Eri ^a   Fujie, Atsuhiro ^a   Watanabe, Ryuichi ^a   Morita, Mayu ^a   Miyamoto, Kana ^a   Morioka, Hideo ^a   Nakamura, Masaya ^a   Matsumoto, Morio ^a   Amizuka, Norio ^b   Toyama, Yoshiaki ^a   Miyamoto, Takeshi ^a  

^a KEIO UNIVERSITY   (Japan)

^b HOKKAIDO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOLS; CELLS; CYTOLOGY; NEURONS;

ALDOSE REDUCTASE INHIBITORS; CONDUCTION VELOCITY; DE-DIFFERENTIATION; DIABETES MELLITUS; DOWN-REGULATION; NERVE FUNCTION; PATHOLOGICAL CHANGES; PERIPHERAL NERVES;

BIOINFORMATICS;

CALCITRIOL; ELDECALCITOL; EPALRESTAT; GLUCOSE; MYELIN ASSOCIATED GLYCOPROTEIN; MYELIN BASIC PROTEIN; MYELIN PROTEIN; NEUROTROPHIN RECEPTOR P75; SOMATOMEDIN C; SORBITOL; 2-(3-HYDROXYPROPOXY)-1,25-DIHYDROXYVITAMIN D3; ALDEHYDE REDUCTASE; ENZYME INHIBITOR; RHODANINE; THIAZOLIDINE DERIVATIVE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DEDIFFERENTIATION; CONTROLLED STUDY; DEMYELINATION; DIABETIC NEUROPATHY; DOWN REGULATION; DRUG MECHANISM; GENE EXPRESSION; HYPERGLYCEMIA; IN VITRO STUDY; IN VIVO STUDY; INSULIN DEPENDENT DIABETES MELLITUS; MOUSE; NERVE CONDUCTION VELOCITY; NERVE FUNCTION; NEUROBLAST; NEUROPATHOLOGY; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SCHWANN CELL; ANALOGS AND DERIVATIVES; ANIMAL; ANTAGONISTS AND INHIBITORS; BIOLOGICAL MODEL; C57BL MOUSE; CELL CULTURE; DEMYELINATING DISEASE; DRUG EFFECTS; EXPERIMENTAL DIABETES MELLITUS; METABOLISM; PATHOLOGY; PHYSIOLOGY; SCIATIC NERVE;

ALDEHYDE REDUCTASE; ANIMALS; CALCITRIOL; CELL DEDIFFERENTIATION; CELLS, CULTURED; DEMYELINATING DISEASES; DIABETES MELLITUS, EXPERIMENTAL; DIABETIC NEUROPATHIES; DOWN-REGULATION; ENZYME INHIBITORS; GLUCOSE; HYPERGLYCEMIA; IN VITRO TECHNIQUES; INSULIN-LIKE GROWTH FACTOR I; MICE; MICE, INBRED C57BL; MODELS, NEUROLOGICAL; RATS; RHODANINE; SCHWANN CELLS; SCIATIC NERVE; SORBITOL; THIAZOLIDINES;

EID: 84940099939     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.631291     Document Type: Article

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