Proteasome inhibition suppresses schwann cell dedifferentiation in vitro and in vivo

GLIA

Volumn 57, Issue 16, 2009, Pages 1825-1834

  Lee, Hyun Kyoung ^a   Shin, Yoon Kyung ^a   Jung, Junyang ^a   Seo, Su Yeong ^a   Baek, Sun Yong ^b   Park, Hwan Tae ^a  

^a Dong A University   (South Korea)

^b Pusan National University School of Medicine   (South Korea)

Author keywords

Demyelination; Glial fibrillary acidic protein; Nerve injury; p75; Ubiquitin

Indexed keywords

GLIAL FIBRILLARY ACIDIC PROTEIN; LYSOSOME ASSOCIATED MEMBRANE PROTEIN 1; MYELIN; NEUROTROPHIN RECEPTOR P75; PROTEASOME; PROTEASOME INHIBITOR; PROTEINASE; SERINE PROTEINASE; UBIQUITIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOPHAGY; CELL CYCLE ARREST; CELL DEDIFFERENTIATION; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; EXPLANT; IN VITRO STUDY; IN VIVO STUDY; LYSOSOME; MOUSE; MYELIN SHEATH; NERVE CELL CULTURE; NERVE DEGENERATION; NONHUMAN; PERIPHERAL NERVE INJURY; PHENOTYPE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INDUCTION; RAT; SCHWANN CELL; SCIATIC NERVE; UBIQUITINATION;

ANIMALS; AUTOPHAGY; AXOTOMY; BLOTTING, WESTERN; CELL CYCLE; CELL DEDIFFERENTIATION; CELL PROLIFERATION; CELLS, CULTURED; CYSTEINE PROTEINASE INHIBITORS; FLUORESCENT ANTIBODY TECHNIQUE; IMAGE PROCESSING, COMPUTER-ASSISTED; LEUPEPTINS; LYSOSOMAL-ASSOCIATED MEMBRANE PROTEIN 1; LYSOSOMES; MICE; NERVE FIBERS, MYELINATED; PROTEASOME ENDOPEPTIDASE COMPLEX; SCHWANN CELLS; SCIATIC NERVE; UBIQUITINATION; WALLERIAN DEGENERATION;

EID: 71249137660     PISSN: 08941491     EISSN: 10981136     Source Type: Journal    
DOI: 10.1002/glia.20894     Document Type: Article

References (29)

1. Auld KL, Silver PA. 2006. Transcriptional regulation by the proteasome as a mechanism for cellular protein homeostasis. Cell Cycle 5:1503-1505. (Pubitemid 44091968)
2. Bence NF, Sampat RM, Kopito RR. 2001. Impairment of the ubiquitin-proteasome system by protein aggregation. Science 292:1552-1555.
3. Cavaletti G, Gilardini A, Canta A, Rigamonti L, Rodriguez-Menendez V, Ceresa C, Marmiroli P, Bossi M, Oggioni N, D'Incalci M, De Coster R. 2007. Bortezomib-induced peripheral neurotoxicity: A neuro-physiological and pathological study in the rat. Exp Neurol 204:317-325. (Pubitemid 46330280)
4. Chauhan D, Hideshima T, Anderson KC. 2008. Targeting proteasomes as therapy in multiple myeloma. Adv Exp Med Biol 615:251-260.
5. Decker L, Desmarquet-Trin-Dinh C, Taillebourg E, Ghislain J, Vallat JM, Charnay P. 2006. Peripheral myelin maintenance is a dynamic process requiring constant Krox20 expression. J Neurosci 26:9771-9779. (Pubitemid 44427716)
6. Fortun J, Dunn WA Jr., Joy S, Li J, Notterpek L. 2003. Emerging role for autophagy in the removal of aggresomes in Schwann cells. J Neurosci 23:10672-10680. (Pubitemid 37485281)
7. Fortun J, Li J, Go J, Fenstermaker A, Fletcher BS, Notterpek L. 2005. Impaired proteasome activity and accumulation of ubiquitinated substrates in a hereditary neuropathy model. J Neurochem 92:1531-1541. (Pubitemid 40389221)
8. Filosto M, Rossi G, Pelizzari AM, Buzio S, Tentorio M, Broglio L, Mancuso M, Rinaldi M, Scarpelli M, Padovani A. 2007. A high-dose bortezomib neuropathy with sensory ataxia and myelin involvement. J Neurol Sci 263:40-43. (Pubitemid 350029826)
9. Fu SY, Gordon T. 1997. The cellular and molecular basis of peripheral nerve regeneration. Mol Neurobiol 14:67-116. (Pubitemid 127720197)
10. Gao X, Daugherty RL, Tourtellotte WG. 2007. Regulation of low affinity neurotrophin receptor (p75(NTR)) by early growth response (Egr) transcriptional regulators. Mol Cell Neurosci 36:501-514. (Pubitemid 47633975)
11. Holtzman E, Novikoff AB. 1965. Lysosomes in the rat sciatic nerve following crush. J Cell Biol 27:651-669.
12. Jessen KR, Mirsky R. 2008. Negative regulation of myelination: Relevance for development, injury, and demyelinating disease. Glia 56: 1552-1565.
13. Jirsova K, Sodaar P, Mandys V, Bar PR. 1997. Cold jet: A method to obtain pure Schwann cell cultures without the need for cytotoxic, apoptosis- inducing drug treatment. J Neurosci Methods 78:133-137. (Pubitemid 28094012)
14. Harrisingh MC, Perez-Nadales E, Parkinson DB, Malcolm DS, Mudge AW, Lloyd AC. 2004. The Ras/Raf/ERK signalling pathway drives Schwann cell dedifferentiation. EMBO J 23:3061-3071. (Pubitemid 39093600)
15. Lassmann H, Ammerer HP, Jurecka W, Kulnig W. 1978. Ultrastructural sequence of myelin degradation. II. Wallerian degeneration in the rat femoral nerve Acta Neuropathol 44:103-109.
16. Lee HK, Seo IA, Park HK, Park YM, Ahn KJ, Yoo YH, Park HT. 2007. Nidogen is a prosurvival and promigratory factor for adult Schwann cells. J Neurochem 102:686-698.
17. Lee HK, Seo IA, Suh DJ, Hong JI, Yoo YH, Park HT. 2009. Interleukin- 6 is required for the early induction of glial fibrillary acidic protein in Schwann cells during Wallerian degeneration. J Neurochem 108:776-786.
18. Lemke G, Chao M. 1988. Axons regulate Schwann cell expression of the major myelin and NGF receptor genes. Development 102:499-504. (Pubitemid 18084933)
19. Lindsten K, de Vrij FM, Verhoef LG, Fischer DF, van Leeuwen FW, Hol EM, Masucci MG, Dantuma NP. 2002. Mutant ubiquitin found in neurodegenerative disorders is a ubiquitin fusion degradation substrate that blocks proteasomal degradation. J Cell Biol 157:417-427. (Pubitemid 34839806)
20. Lucas J, Lobo D, Terry E, Hogan EL, Banik NL. 1992. Susceptibility of myelin proteins to a neutral endoproteinase: The degradation of myelin basic protein (MBP) and P2 protein by purified bovine brain multicatalytic proteinase complex (MPC). Neurochem Res 17:1261-1266.
21. Mizushima N, Levine B, Cuervo AM, Klionsky DJ. 2008. Autophagy fights disease through cellular self-digestion. Nature 451:1069-1075. (Pubitemid 351317450)
22. Notterpek L, Shooter EM, Snipes GJ. 1997. Upregulation of the endosomal- lysosomal pathway in the trembler-J neuropathy. J Neurosci 17: 4190-4200. (Pubitemid 27220610)
23. Thomson CE, Griffiths IR, McCulloch MC, Kyriakides E, Barrie JA, Montague P. 1993. In vitro studies of axonally-regulated Schwann cell genes during Wallerian degeneration. J Neurocytol 22:590-602.
24. Tomita K, Kubo T, Matsuda K, Fujiwara T, Yano K, Winograd JM, Tohyama M, Hosokawa K. 2007. The neurotrophin receptor p75NTR in Schwann cells is implicated in remyelination and motor recovery after peripheral nerve injury. Glia 15:1199-1208. (Pubitemid 47204211)
25. Triolo D, Dina G, Lorenzetti I. Malaguti M, Morana P, Del Carro U, Comi G, Messing A, Quattrini A, Previtali SC. 2006. Loss of glial fibrillary acidic protein (GFAP) impairs Schwann cell proliferation and delays nerve regeneration after damage. J. Cell Sci 119:3981-3993. (Pubitemid 44650871)
26. Weissman AM. 2001. Themes and variations on ubiquitylation. Nat Rev Mol Cell Biol 2:169-178.
27. Weller RO, Mellick RS. 1996. Acid phosphatase and lysosome activity in diphtheritic neuropathy and Wallerian degeneration. Br J Exp Pathol 47:425-434.
28. Yang Y, Fukui K, Koike T, Zheng X. 2007. Induction of autophagy in neurite degeneration of mouse superior cervical ganglion neurons. Eur J Neurosci 26:2979-2988. (Pubitemid 350115519)
29. Zhai Q, Wang J, Kim A, Liu Q, Watts R, Hoopfer E, Mitchison T, Luo L, He Z. 2003. Involvement of the ubiquitin-proteasome system in the early stages of wallerian degeneration. Neuron 39:217-225. (Pubitemid 36897545)