Magnetic resonance elastography for staging liver fibrosis in non-alcoholic fatty liver disease: a diagnostic accuracy systematic review and individual participant data pooled analysis

European Radiology

Volumn 26, Issue 5, 2016, Pages 1431-1440

  Singh, Siddharth ^a   Venkatesh, Sudhakar K ^b   Loomba, Rohit ^c   Wang, Zhen ^a   Sirlin, Claude ^d   Chen, Jun ^b   Yin, Meng ^b   Miller, Frank H ^e   Low, Russell N ^f   Hassanein, Tarek ^g   Godfrey, Edmund M ^h   Asbach, Patrick ⁱ   Murad, Mohammad Hassan ^a   Lomas, David J ^h   Talwalkar, Jayant A ^a   Ehman, Richard L ^b  

^a MAYO CLINIC   (United States)

^b Mayo Clinic   (United States)

^c UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e NORTHWESTERN UNIVERSITY   (United States)

^f Sharp and Children s MRI Center   (United States)

^g Southern California Liver Centers   (United States)

^h ADDENBROOKE S HOSPITAL   (United Kingdom)

ⁱ CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

Biomarker; Cirrhosis; Diagnostic performance; Elastography; Fibrosis

Indexed keywords

ADULT; ARTICLE; CONTROLLED STUDY; DIAGNOSTIC ACCURACY; DIAGNOSTIC TEST ACCURACY STUDY; DISEASE CLASSIFICATION; ELASTOGRAPHY; FEMALE; HUMAN; HUMAN TISSUE; LIVER BIOPSY; LIVER CIRRHOSIS; LIVER FIBROSIS; MAGNETIC RESONANCE ELASTOGRAPHY; MAJOR CLINICAL STUDY; MALE; NONALCOHOLIC FATTY LIVER; NUCLEAR MAGNETIC RESONANCE; NUCLEAR MAGNETIC RESONANCE SCANNER; OBESITY; PRIORITY JOURNAL; SENSITIVITY AND SPECIFICITY; SEX; SYSTEMATIC REVIEW (TOPIC); BIOPSY; DIAGNOSTIC IMAGING; HEPATITIS; LIVER; META ANALYSIS; MIDDLE AGED; PATHOLOGY; PROCEDURES; STANDARDS;

BIOPSY; ELASTICITY IMAGING TECHNIQUES; FEMALE; HEPATITIS; HUMANS; LIVER; LIVER CIRRHOSIS; MALE; MIDDLE AGED; NON-ALCOHOLIC FATTY LIVER DISEASE; OBESITY; SENSITIVITY AND SPECIFICITY;

EID: 84940069011     PISSN: 09387994     EISSN: 14321084     Source Type: Journal    
DOI: 10.1007/s00330-015-3949-z     Document Type: Article

References (56)

1. Lazo M, Hernaez R, Eberhardt MS et al (2013) Prevalence of nonalcoholic fatty liver disease in the United States: the Third National Health and Nutrition Examination Survey, 1988–1994. Am J Epidemiol 178:38–45
2. Vernon G, Baranova A, Younossi ZM (2011) Systematic review: the epidemiology and natural history of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis in adults. Aliment Pharmacol Ther 34:274–285
3. Chalasani N, Younossi Z, Lavine JE et al (2012) The diagnosis and management of non-alcoholic fatty liver disease: practice guideline by the American Gastroenterological Association, American Association for the Study of Liver Diseases, and American College of Gastroenterology. Gastroenterology 142:1592–1609
4. Loomba R, Sanyal AJ (2013) The global NAFLD epidemic. Nat Rev Gastroenterol Hepatol 10:686–690
5. Bravo AA, Sheth SG, Chopra S (2001) Liver biopsy. N Engl J Med 344:495–500
6. Regev A, Berho M, Jeffers LJ et al (2002) Sampling error and intraobserver variation in liver biopsy in patients with chronic HCV infection. Am J Gastroenterol 97:2614–2618
7. Castera L (2012) Noninvasive methods to assess liver disease in patients with hepatitis B or C. Gastroenterology 142:1293–1302 e1294
8. Castera L, Foucher J, Bernard PH et al (2010) Pitfalls of liver stiffness measurement: a 5-year prospective study of 13,369 examinations. Hepatology 51:828–835
9. Bota S, Sporea I, Sirli R et al (2014) Factors associated with the impossibility to obtain reliable liver stiffness measurements by means of Acoustic Radiation Force Impulse (ARFI) elastography: analysis of a cohort of 1,031 subjects. Eur J Radiol 83:268–272
10. Venkatesh SK, Yin M, Ehman RL (2013) Magnetic resonance elastography of liver: technique, analysis, and clinical applications. J Magn Reson Imaging 37:544–555
11. Singh S, Venkatesh SK, Wang Z et al (2014) Diagnostic performance of magnetic resonance elastography in staging liver fibrosis: A systematic review and meta-analysis of individual participant data. Clin Gastroenterol Hepatol. doi:10.1016/j.cgh.2014.09.046
12. Kim D, Kim WR, Talwalkar JA, Kim HJ, Ehman RL (2013) Advanced fibrosis in nonalcoholic fatty liver disease: noninvasive assessment with MR elastography. Radiology 268:411–419
13. Loomba R, Wolfson T, Ang B et al (2014) Magnetic resonance elastography predicts advanced fibrosis in patients with nonalcoholic fatty liver disease: a prospective study. Hepatology. doi:10.1002/hep.27362
14. Moher D, Liberati A, Tetzlaff J, Altman DG, Group P (2009) Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. Ann Intern Med 151:264–269, W264
15. Riley RD, Lambert PC, Abo-Zaid G (2010) Meta-analysis of individual participant data: rationale, conduct, and reporting. BMJ 340:c221
16. Bedossa P, Poynard T (1996) An algorithm for the grading of activity in chronic hepatitis C. The METAVIR Cooperative Study Group. Hepatology 24:289–293
17. Whiting P, Rutjes AW, Reitsma JB, Bossuyt PM, Kleijnen J (2003) The development of QUADAS: a tool for the quality assessment of studies of diagnostic accuracy included in systematic reviews. BMC Med Res Methodol 3:25
18. Pepe MS (2000) Receiver operating characteristic methodology. J Am Stat Assoc 95:308–311
19. Youden WJ (1950) Index for rating diagnostic tests. Cancer 3:32–35
20. Jaeschke R, Guyatt GH, Sackett DL (1994) Users’ guides to the medical literature. III. How to use an article about a diagnostic test. B. What are the results and will they help me in caring for my patients? The Evidence-Based Medicine Working Group. JAMA 271:703–707
21. Altman DG, Bland JM (2003) Interaction revisited: the difference between two estimates. BMJ 326:219
22. Asbach P, Klatt D, Hamhaber U et al (2008) Assessment of liver viscoelasticity using multifrequency MR elastography. Magn Reson Med 60:373–379
23. Asbach P, Klatt D, Schlosser B et al (2010) Viscoelasticity-based staging of hepatic fibrosis with multifrequency MR elastography. Radiology 257:80–86
24. Chen J, Talwalkar JA, Yin M, Glaser KJ, Sanderson SO, Ehman RL (2011) Early detection of nonalcoholic steatohepatitis in patients with nonalcoholic fatty liver disease by using MR elastography. Radiology 259:749–756
25. Godfrey EM, Patterson AJ, Priest AN et al (2012) A comparison of MR elastography and 31P MR spectroscopy with histological staging of liver fibrosis. Eur Radiol 22:2790–2797
26. Low RN, Hassanein T (2012) MR elastography: validation and reproducibility of measurements of mean liver stiffness and fibrosis. J Hepatol 56:S415
27. Rustogi R, Horowitz J, Harmath C et al (2012) Accuracy of MR elastography and anatomic MR imaging features in the diagnosis of severe hepatic fibrosis and cirrhosis. J Magn Reson Imaging 35:1356–1364
28. Wang Y, Ganger DR, Levitsky J et al (2011) Assessment of chronic hepatitis and fibrosis: comparison of MR elastography and diffusion-weighted imaging. AJR Am J Roentgenol 196:553–561
29. Yin M, Talwalkar JA, Glaser KJ et al (2007) Assessment of hepatic fibrosis with magnetic resonance elastography. Clin Gastroenterol Hepatol 5:1207–1213.e1202
30. Batheja MJ, Silva AC, De Petris G, Vargas H (2011) Role of magnetic resonance elastography in assessing hepatic fibrosis. Gastroenterology (1):S927
31. Bohte AE, de Niet A, Jansen L et al (2014) Non-invasive evaluation of liver fibrosis: a comparison of ultrasound-based transient elastography and MR elastography in patients with viral hepatitis B and C. Eur Radiol 24:638–648
32. Choi YR, Lee JM, Yoon JH, Han JK, Choi BI (2013) Comparison of magnetic resonance elastography and gadoxetate disodium-enhanced magnetic resonance imaging for the evaluation of hepatic fibrosis. Investig Radiol 48:607–613
33. Crespo S, Bridges MD, Nakhleh R, McPhail A, Pungpapong S, Keaveny AP (2010) Magnetic resonance elastography compared with liver biopsy in evaluating fibrosis due to recurrent HCV after liver transplantation. Am J Transplant 10:157
34. Huwart L, Peeters F, Sinkus R et al (2006) Liver fibrosis: non-invasive assessment with MR elastography. NMR Biomed 19:173–179
35. Huwart L, Sempoux C, Salameh N et al (2007) Liver fibrosis: noninvasive assessment with MR elastography versus aspartate aminotransferase-to-platelet ratio index. Radiology 245:458–466
36. Huwart L, Sempoux C, Vicaut E et al (2008) Magnetic resonance elastography for the noninvasive staging of liver fibrosis. Gastroenterology 135:32–40
37. Ichikawa S, Motosugi U, Ichikawa T et al (2012) Magnetic resonance elastography for staging liver fibrosis in chronic hepatitis C. Magn Reson Med Sci 11:291–297
38. Kim BH, Lee JM, Lee YJ et al (2011) MR elastography for noninvasive assessment of hepatic fibrosis: experience from a tertiary center in Asia. J Magn Reson Imaging 34:1110–1116
39. Klatt DAP, Kamphues C, Hirsch S, Papazoglou S, Braun J, Sack I (2011) MR elastography of liver transplant patients using parallel imaging techniques. Proc Int Soc Magn Reson Med 19:1485
40. Lee VS, Miller FH, Omary RA et al (2011) Magnetic resonance elastography and biomarkers to assess fibrosis from recurrent hepatitis C in liver transplant recipients. Transplantation 92:581–586
41. Nguyen D, Talwalkar JA, Yin M, Lindor KD, Ehman RL (2011) Assessment of hepatic fibrosis by magnetic resonance elastography in patients with sclerosing cholangitis. Gastroenterology (1):S919
42. Venkatesh SK, Wang G, Lim SG, Wee A (2013) Magnetic resonance elastography for the detection and staging of liver fibrosis in chronic hepatitis B. Eur Radiol. doi:10.1007/s00330-013-2978-8:1-9
43. Yoon JH, Lee JM, Woo HS et al (2013) Staging of hepatic fibrosis: comparison of magnetic resonance elastography and shear wave elastography in the same individuals. Korean J Radiol 14:202–212
44. Rouviere O, Yin M, Dresner MA et al (2006) MR elastography of the liver: preliminary results. Radiology 240:440–448
45. Xanthakos SA, Podberesky DJ, Serai SD et al (2014) Use of magnetic resonance elastography to assess hepatic fibrosis in children with chronic liver disease. J Pediatr 164:186–188
46. Wong VW, Vergniol J, Wong GL et al (2010) Diagnosis of fibrosis and cirrhosis using liver stiffness measurement in nonalcoholic fatty liver disease. Hepatology 51:454–462
47. Naveau S, Lamouri K, Pourcher G et al (2014) The diagnostic accuracy of transient elastography for the diagnosis of liver fibrosis in bariatric surgery candidates with suspected NAFLD. Obes Surg 24:1693–1701
48. Kwok R, Tse YK, Wong GL et al (2014) Systematic review with meta-analysis: non-invasive assessment of non-alcoholic fatty liver disease: the role of transient elastography and plasma cytokeratin-18 fragments. Aliment Pharmacol Ther 39:254–269
49. Myers RP, Pomier-Layrargues G, Kirsch R et al (2012) Discordance in fibrosis staging between liver biopsy and transient elastography using the FibroScan XL probe. J Hepatol 56:564–570
50. Petta S, Di Marco V, Camma C, Butera G, Cabibi D, Craxi A (2011) Reliability of liver stiffness measurement in non-alcoholic fatty liver disease: the effects of body mass index. Aliment Pharmacol Ther 33:1350–1360
51. Myers RP, Pomier-Layrargues G, Kirsch R et al (2012) Feasibility and diagnostic performance of the FibroScan XL probe for liver stiffness measurement in overweight and obese patients. Hepatology 55:199–208
52. Kim SU, Kim JK, Park YN, Han KH (2012) Discordance between liver biopsy and Fibroscan(R) in assessing liver fibrosis in chronic hepatitis b: risk factors and influence of necroinflammation. PLoS One 7, e32233
53. Tapper EB, Cohen EB, Patel K et al (2012) Levels of alanine aminotransferase confound use of transient elastography to diagnose fibrosis in patients with chronic hepatitis C virus infection. Clin Gastroenterol Hepatol 10:932–937 e931
54. Ichikawa S, Motosugi U, Nakazawa T et al (2014) Hepatitis activity should be considered a confounder of liver stiffness measured with MR elastography. J Magn Reson Imaging. doi:10.1002/jmri.24666
55. Singh S, Fujii LL, Murad MH et al (2013) Liver stiffness is associated with risk of decompensation, liver cancer, and death in patients with chronic liver diseases: a systematic review and meta-analysis. Clin Gastroenterol Hepatol 11:1573–1584 e1-2, quiz e1588–1579
56. Loomba R, Sirlin CB, Ang B et al (2014) Ezetimibe for the treatment of nonalcoholic steatohepatitis: assessment by novel MRI and MRE in a randomized trial (MOZART Trial). Hepatology. doi:10.1002/hep.27647