MicroRNA-195 inhibits the proliferation, migration and invasion of cervical cancer cells via the inhibition of CCND2 and MYB expression

Oncology Letters

Volumn 10, Issue 4, 2015, Pages 2639-2643

  Du, Xinjie ^a,b   Lin, Li ^c   Zhang, Lijun ^b   Jiang, Jie ^a  

^a SHANDONG UNIVERSITY   (China)

^b Women Children s Health Care Hospital of Linyi   (China)

^c LIAOCHENG PEOPLE'S HOSPITAL   (China)

Author keywords

Cervical cancer; Invasion; MicroRNA 195; Migration; Proliferation

Indexed keywords

CYCLIN D2; MICRORNA; MICRORNA 195; PROTEIN MYB; UNCLASSIFIED DRUG;

ARTICLE; CELL CYCLE; CELL INVASION; CELL MIGRATION; CELL PROLIFERATION; CONTROLLED STUDY; DOWN REGULATION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOBLOTTING; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; UTERINE CERVIX CANCER;

EID: 84940050718     PISSN: 17921074     EISSN: 17921082     Source Type: Journal    
DOI: 10.3892/ol.2015.3541     Document Type: Article

References (20)

1. Jemal A, Bray F, Center MM, Ferlay J, Ward E and Forman D: Global cancer statistics. CA Cancer J Clin 61: 69-90, 2011.
2. Jemal A, Siegel R, Ward E, Hao Y, Xu J and Thun MJ: Cancer statistics, 2009. CA Cancer J Clin 59: 225-249, 2009.
3. Dunne EF and Park IU: HPV and HPV-associated diseases. Infect Dis Clin North Am 27: 765-778, 2013.
4. Bartel DP: MicroRNAs: Genomics, biogenesis, mechanism and function. Cell 116: 281-297, 2004.
5. Esquela-Kerscher A and Slack FJ: Oncomirs-microRNAs with a role in cancer. Nat Rev Cancer 6: 259-269, 2006.
6. Lin PY, Yu SL and Yang PC: MicroRNA in lung cancer. Br J Cancer 103: 1144-1148, 2010.
7. Amer M, Elhefnawi M, El-Ahwany E, Awad AF, Gawad NA, Zada S and Tawab FM: Hsa-miR-195 targets PCMT1 in hepatocellular carcinoma that increases tumor life span. Tumour Biol 35: 11301-11309, 2014.
8. Yang Y, Li M, Chang S, Wang L, Song T, Gao L, Hu L, Li Z, Liu L, Yao J and Huang C: MicroRNA-195 acts as a tumor suppressor by directly targeting Wnt3a in HepG2 hepatocellular carcinoma cells. Mol Med Rep 10: 2643-2648, 2014.
9. Yongchun Z, Linwei T, Xicai W, Lianhua Y, Guangqiang Z, Ming Y, Guanjian L, Yujie L and Yunchao H: MicroRNA-195 inhibits non-small cell lung cancer cell proliferation, migration and invasion by targeting MYB. Cancer Lett 347: 65-74, 2014.
10. Zhang QQ, Xu H, Huang MB, Ma LM, Huang QJ, Yao Q, Zhou H and Qu LH: MicroRNA-195 plays a tumor-suppressor role in human glioblastoma cells by targeting signaling pathways involved in cellular proliferation and invasion. Neuro Oncol 14: 278-287, 2012.
11. Luo Q, Wei C, Li X, Li J, Chen L, Huang Y, Song H, Li D and Fang L: MicroRNA-195-5p is a potential diagnostic and therapeutic target for breast cancer. Oncol Rep 31: 1096-1102, 2014.
12. Liu L, Chen L, Xu Y, Li R and Du X: MicroRNA-195 promotes apoptosis and suppresses tumorigenicity of human colorectal cancer cells. Biochem Biophys Res Commun 400: 236-240, 2010.
13. Xiong Y, Menninger J, Beach D and Ward DC: Molecular cloning and chromosomal mapping of CCND genes encoding human D-type cyclins. Genomics 13: 575-584, 1992.
14. Chen Y, Xu H, Liu J, Zhang C, Leutz A and Mo X: The c-Myb functions as a downstream target of PDGF-mediated survival signal in vascular smooth muscle cells. Biochem Biophys Res Commun 360: 433-436, 2007.
15. Nigg EA: Cyclin-dependent protein kinases: Key regulators of the eukaryotic cell cycle. Bioessays 17: 471-480, 1995.
16. Meyerson M and Harlow E: Identification of G1 kinase activity for cdk6, a novel cyclin D partner. Mol Cell Biol 14: 2077-2086, 1994.
17. Ortega S, Malumbres M and Barbacid M: Cyclin D-dependent kinases, INK4 inhibitors and cancer. Biochim Biophys Acta 1602: 73-87, 2002.
18. Sato T, Yamamoto T and Sehara-Fujisawa A: MiR-195/497 induce postnatal quiescence of skeletal muscle stem cells. Nat Commun 5: 4597, 2014.
19. Roussel M, Saule S, Lagrou C, Rommens C, Beug H, Graf T and Stehelin D: Three new types of viral oncogene of cellular origin specific for haematopoietic cell transformation. Nature 281: 452-455, 1979.
20. Ramsay RG and Gonda TJ: MYB function in normal and cancer cells. Nat Rev Cancer 8: 523-534, 2008.